Abstract：
:It is well established that during early life the thymus gland and the neuroendocrine system influence each other's maturation. Furthermore, there is a growing body of evidence indicating that the immune and neuroendocrine systems also function as a bidirectional network during adult life. In order to assess possible changes in the thymic-neuroendocrine network during aging, we undertook to measure and correlate the circulating levels of several neuroendocrine and thymic hormones in young (3 month) and old (26 month) male Sprague-Dawley rats. Sequential plasma samples were obtained from chronically cannulated, nonstressed animals every 30 min for 5 h. Two days later rats were killed between 11:30 a.m. and 1:30 p.m. and trunk serum was obtained. All hormones were measured by radioimmunoassay. Growth hormone (GH), prolactin (PRL), thyrotropin (TSH) and corticosterone were measured in plasma, whereas thyroxine (T4), triiodothyronine (T3), thymosin alpha 1 (T alpha 1) and thymosin beta 4 (T beta 4) were determined in trunk serum. The circulating levels of T3, PRL, corticosterone and T beta 4 did not show significant differences between young and old rats, whereas GH, T4, T alpha 1, and thymus weight showed a significant age-related reduction. The anterior pituitary (AP) weight and plasma TSH were significantly higher in old than in young rats. Three pairs of parameters showed highly significant levels of linear correlation: AP weight vs. T alpha 1; thymus weight vs. T4 and T alpha 1 vs. T4 (p less than 0.01, p less than 0.001 and p less than 0.001, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Goya RG,Naylor PH,Goldstein AL,Meites Jdoi
10.1016/0531-5565(90)90046-5subject
Has Abstractpub_date
1990-01-01 00:00:00pages
149-57issue
2eissn
0531-5565issn
1873-6815journal_volume
25pub_type
杂志文章abstract：:This article gives some information on the French research on aging using a survey of the European Commission on research on aging in Europe and the answers to a questionnaire sent to the laboratories involved in aging research. France is involved in the European effort, but to a lesser degree than could be expected f...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(00)00164-9
更新日期：2000-10-01 00:00:00
abstract：:Aging is associated with a decline in immune functions. Among them, T-cell activation is altered at several points of the signaling cascade following TCR engagement. Recent findings suggest that lipid rafts act as a platform in the initiation of T-cell activation. We have previously demonstrated that cholesterol conte...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2003.10.031
更新日期：2004-04-01 00:00:00
abstract：:There is accumulating evidence that oxidative stress plays an important role in aging. Our previous phosphoproteomic study of the human neuroblastoma cell line SH-SY5Y revealed changes in the phosphorylation of several proteins such as lamin A/C during 6-hydroxydopamine-induced oxidative stress. The present study empl...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2009.02.009
更新日期：2009-06-01 00:00:00
abstract：:Diseases of the elderly, including neurodegenerative and cardiovascular disorders and cancer, may develop through the accumulation of "hits" composed of genetic and epigenetic risk factors. The "iceberg" buildup of these hits over time may exceed the tolerance threshold of a particular tissue, thus precipitating disea...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(96)00156-8
更新日期：1997-07-01 00:00:00
abstract：:Even though Alzheimer's disease (AD) is the most common cause of dementia, the mechanisms governing the establishment and progression of the disease remain largely unknown. Here, we investigated the implication of the neuroprotective protein BMI1 (B lymphoma Mo-MLV insertion region 1 homolog) in AD and the possibility...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2020.111178
更新日期：2021-02-01 00:00:00
abstract：BACKGROUND:The proportion of elderly individuals is growing and the prevalence of chronic kidney disease (CKD) among elderly people undergoing cardiac surgery is increasing constantly. The aim of this study was to determine the influence of different degrees of preoperative renal dysfunction on postoperative outcomes i...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.01.012
更新日期：2013-03-01 00:00:00
abstract：:Spectrins are a part of cytoskeletal platform that lines the intracellular side of plasma membrane, which can be proteolyzed by calcium-sensitive enzymes including calpains and caspases. Caspase-3 mediated αII-spectrin proteolysis results in the release of a 120kDa spectrin breakdown product (SBDP120), known to occur ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2015.06.003
更新日期：2015-09-01 00:00:00
abstract：:Studying the changes of serum N-glycome during mouse aging is beneficial to explore the molecular basis behind the alterations reported in human. However, such studies remainscarce and lack some information such as sialylation due to the method limitation. Here, we introduced Bionic Glycome method to quantify the seru...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2020.111098
更新日期：2020-11-01 00:00:00
abstract：:The maximal lifespan (MLS) of mammals is inversely correlated with the peroxidation index, a measure of the proportion and level of unsaturation of polyunsaturated fatty acids (PUFA) in membranes. This relationship is likely related to the fact that PUFA are highly susceptible to damage by peroxidation. Previous compa...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2015.08.011
更新日期：2015-10-01 00:00:00
abstract：:Non-insulin dependent diabetes mellitus (NIDDM) has been associated with a number of physiological consequences including neuropathy, retinopathy and incidence of vascular disease. Recently, several authors reviewed studies that suggested that NIDDM is associated with cognitive impairments leading to a higher incidenc...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(03)00153-0
更新日期：2003-09-01 00:00:00
abstract：:Coenzyme Q10 supplementation increases life-span of rats fed on a diet enriched with polyunsaturated fatty acids (Quiles, J.L., Ochoa, J.J., Huertas, J.R., Mataix, J., 2004b. Coenzyme Q supplementation protects from age-related DNA double-strand breaks and increased lifespan in rats fed on a PUFA-rich diet. Exp. Geron...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2005.07.003
更新日期：2005-08-01 00:00:00
abstract：:The intrinsic contractile properties of papillary muscles isolated from female Wistar rats during post-natal development were examined. In addition, the myocardial responsiveness to certain inotropic interventions was studied. In muscles from 60-day-old animals, the velocity of shortening was markedly greater than mus...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(82)90025-0
更新日期：1982-01-01 00:00:00
abstract：:A summary of the Eleventh International Symposium on the Neurobiology and Neuroendocrinology of Aging that was held in July 29-August 3 in Bregenz, Austria, is presented. Sixteen of the speakers who presented at the conference submitted review papers covering the topic of their presentation as well as an overview of t...
journal_title：Experimental gerontology
pub_type： 社论
doi：10.1016/j.exger.2013.01.003
更新日期：2013-07-01 00:00:00
abstract：:Melatonin, the main product synthesized by the pineal gland, modulates several brain functions through different mechanisms, some of them involving the activation or participation of calcium binding intracellular proteins, such as the alpha calcium dependent protein kinase C and calmodulin. Another calcium-binding pro...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2014.10.014
更新日期：2014-12-01 00:00:00
abstract：:Alpha-synuclein (α-Syn) accumulation is significantly correlated with motor deficits and mitochondrial dysfunction in Parkinson's disease (PD), but the molecular mechanism underlying its pathogenesis is unclear. In this study, we investigated the effects of treadmill exercise on motor deficits and mitochondrial dysfun...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2017.01.001
更新日期：2017-03-01 00:00:00
abstract：OBJECTIVE:To assess the effect of genetic and non-genetic factors on indicators derived from waist circumference (WC) and body mass index (BMI) as well as inter-indicator differences in risk assessment age-related diseases including diabetes mellitus, coronary heart disease and liver cancer. METHODS:Height, weight and...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2014.10.005
更新日期：2014-12-01 00:00:00
abstract：OBJECTIVES:To evaluate the effects of elastic band resistance training in combination with nutrient supplementation on muscular strength and the ability to perform mobility-related activities of daily living in older adults living in retirement care facilities. DESIGN:Randomized controlled trial, with a 6-month interv...
journal_title：Experimental gerontology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.exger.2015.08.013
更新日期：2015-12-01 00:00:00
abstract：:Aging is a physiological process characterized by an age-progressive decline in intrinsic physiological functions, with an increased risk of developing chronic metabolic conditions, such as insulin resistance and diabetes. Furthermore, from a physiopathological point of view, several authors describe an association be...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2019.03.011
更新日期：2019-07-01 00:00:00
abstract：INTRODUCTION:Age-related decreases in cerebral blood flow (CBF) may lead to cognitive decline, while physical activity (PA) can maintain CBF and cognition in aging. The intensity of PA needed to affect CBF in aging, and the independent effects of sedentary time on CBF are currently unknown. Moreover, research conducted...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2019.110679
更新日期：2019-10-01 00:00:00
abstract：:The echidna Tachyglossus aculeatus is a monotreme mammal from Australia that is exceptionally long-living. Its documented maximum lifespan of 50 years is 3.7 times that predicted from its body mass. Other exceptionally long-living mammals (naked mole-rats and humans) are known to have peroxidation-resistant membrane c...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2008.05.015
更新日期：2008-08-01 00:00:00
abstract：BACKGROUND:Self-report questionnaires are widely used to assess physical function in older adults. However, they often lack a clear frame of reference and hence interpreting and rating task difficulty levels can be problematic for the responder. Consequently, the usefulness of traditional self-report questionnaires for...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2016.04.022
更新日期：2016-08-01 00:00:00
abstract：:The A3243G mutation, one of the changes of human mitochondrial DNA (mtDNA) that accumulates in cells during aging, is a useful marker for investigating the aging of cells. We measured the mutation level of the mtDNA A3243G mutation using DNAs from two different tissues (esophageal epithelium and myocardium) from advan...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(02)00020-7
更新日期：2002-07-01 00:00:00
abstract：:While influenza immunization significantly reduces the risk of pneumonia and associated deaths, vaccination of elderly only affords 30-50% protection against influenza disease. The purpose of this study was to: (1) evaluate the consistency of immune responses across multiple years in young and elderly; (2) determine t...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(01)00210-8
更新日期：2002-01-01 00:00:00
abstract：OBJECTIVES:To date studies evaluating the relation between circulating aldosterone levels and mortality in elderly female individuals are lacking. We therefore aimed to assess the relationship between circulating aldosterone levels and mortality in a population-based cohort study of female nursing home residents. METH...
journal_title：Experimental gerontology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.exger.2013.01.004
更新日期：2013-03-01 00:00:00
abstract：:Aging is known to be associated with a decrease of learning and memory. Little is known on the specificity of this process. In Drosophila, two forms of consolidated memory have been observed. Anesthesia-resistant memory (ARM) is formed after one or several consecutive training sessions whereas long-term memory (LTM) i...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2006.06.004
更新日期：2007-01-01 00:00:00
abstract：:Injured skeletal muscle generally regenerates less efficiently with age, but little is understood about the effects of ageing on the very early inflammatory and neovascular events in the muscle repair process. This study used a total of 174 whole muscle grafts transplanted within and between young and old mice to anal...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2008.02.005
更新日期：2008-06-01 00:00:00
abstract：:Whereas biological rhythms are now fairly well documented in young healthy adults, reports in elderly are relatively few for obvious reasons, including the difficulty of setting groups matched in age, sociological and professional background, medical history, and not in need of specific medication. Aging may modify on...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(96)00161-1
更新日期：1997-07-01 00:00:00
abstract：:Fish provide enormous spectrum of longevity and thus present the possibility of multiple mechanisms of senescence. Oxidative stress as a causative agent of senescence and the protective role of antioxidant enzymes were tested in the teleost, Channa punctatus taking peroxidase (POD) (EC 1.1 1.1.7) as the representative...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(99)00021-2
更新日期：1999-06-01 00:00:00
abstract：:We develop a theoretical model from an energetic viewpoint for unraveling the entangled effects of metabolic and biosynthetic rates on oxidative cellular damage accumulation during animal's growth, and test the model by experiments in hornworms. The theoretical consideration suggests that most of the cellular damages ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2016.05.015
更新日期：2016-09-01 00:00:00
abstract：:Several papers reported in recent years on a change in the age population distribution of the circulating erythrocytes in old mice, rats, rabbits, and humans. The results indicate the presence of a chronologically younger cell population in old animals and humans. The cells are typically lower in density and larger. I...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(92)90055-5
更新日期：1992-01-01 00:00:00
