Effects of age and manganese (II) chloride on peroxidase activity of brain and liver of the teleost, Channa punctatus.

abstract：:Life history theory proposes that menopause is either an epiphenomenon or an adaptation. The most recent adaptive hypothesis proposes that menopause in humans has evolved because of conflict between reproducing generations (RCH). Overlapping reproduction between generations may impose fitness costs to older and younge...

journal_title：Experimental gerontology

authors： Skjærvø GR,Røskaft E

更新日期：2013-04-01 00:00:00

abstract：:Post-translational oxidative protein modifications which are more marked during aging and/or high-calorie (HC) diets affect protein function and metabolism. Protein function and metabolism are different according to the type of muscle proteins. Oxidative muscle protein modifications may thus be associated with age-rel...

journal_title：Experimental gerontology

authors： Murakami H,Guillet C,Tardif N,Salles J,Migné C,Boirie Y,Walrand S

更新日期：2012-02-01 00:00:00

abstract：:Age-related bone loss is thought to be due to impaired osteoblast functions. Insulin-like growth factors (IGFs) have been shown to be important stimulators of bone formation and osteoblast activities in vitro and in vivo. We tested the hypothesis that in vitro osteoblast senescence is associated with changes in compon...

journal_title：Experimental gerontology

authors： Kveiborg M,Flyvbjerg A,Rattan SI,Kassem M

更新日期：2000-10-01 00:00:00

abstract：:SIRT1 is a highly conserved NAD(+)-dependent protein deacetylase known to have protective effects against a variety of age-related diseases. However, there is a lack of information concerning SIRT1 expression in the cochlea and auditory cortex of C57BL/6 mice, a mouse model of age-related hearing loss. Using RT-PCR an...

journal_title：Experimental gerontology

authors： Xiong H,Dai M,Ou Y,Pang J,Yang H,Huang Q,Chen S,Zhang Z,Xu Y,Cai Y,Liang M,Zhang X,Lai L,Zheng Y

更新日期：2014-03-01 00:00:00

abstract：:The Tokyo Metropolitan Institute of Gerontology (TMIG) celebrates its 30th anniversary in 2002. Since its establishment, TMIG has been carrying out inter-disciplinary research on aging as a core institute in Japan and functions as a knowledge bank and a source for capable researchers of gerontology. The proportion of ...

journal_title：Experimental gerontology

authors： Suzuki K

更新日期：2002-12-01 00:00:00

abstract：:It is well established that during early life the thymus gland and the neuroendocrine system influence each other's maturation. Furthermore, there is a growing body of evidence indicating that the immune and neuroendocrine systems also function as a bidirectional network during adult life. In order to assess possible ...

journal_title：Experimental gerontology

authors： Goya RG,Naylor PH,Goldstein AL,Meites J

更新日期：1990-01-01 00:00:00

abstract：:Maintaining physical mobility is important for preventing age-related comorbidities in older adults. Endurance and resistance training prevent mobility loss in aging, but exercise alone does not always achieve the expected improvements in physical and cardiopulmonary function. Recent preclinical evidence suggests that...

journal_title：Experimental gerontology

authors： Custodero C,Saini SK,Shin MJ,Jeon YK,Christou DD,McDermott MM,Leeuwenburgh C,Anton SD,Mankowski RT

更新日期：2020-08-01 00:00:00

abstract：:Mouse models have been widely used in the research of human diseases. Aging, just as cancer, is influenced by the interaction of various genetic and environmental factors. Currently, aging could be induced by many mechanism, including telomere dysfunction, oxidase stress, DNA damage and epigenetic changes. Many of the...

journal_title：Experimental gerontology

authors： Li H,Wei C,Zhou R,Wang B,Zhang Y,Shao C,Luo Y

更新日期：2019-06-01 00:00:00

abstract：:The adult blowfly, Phormia regina, reveals a substantial homeostatic capability when examined for its ability to regulate externally administered additions to its blood sugar. As well, results of experiments done at intervals throughout the entire adult life of the fly show that there is no decrease over time in the e...

journal_title：Experimental gerontology

authors： Anelli CM,Friedman S

更新日期：1986-01-01 00:00:00

abstract：:Aging-related changes to biological structures such as cardiovascular and musculoskeletal systems contribute to the development of comorbid conditions including cardiovascular disease and frailty, and ultimately lead to premature death. Although, frail older adults often demonstrate both cardiovascular and musculoskel...

journal_title：Experimental gerontology

authors： Jeon YK,Shin MJ,Saini SK,Custodero C,Aggarwal M,Anton SD,Leeuwenburgh C,Mankowski RT

更新日期：2021-03-01 00:00:00

abstract：INTRODUCTION:Right ventricular dysfunction (RVD), submassive pulmonary embolism (PE), elevated systolic pulmonary artery pressure (sPAP), elevated cardiac troponin I (cTnI) and old age are well-known risk factors for poor outcome in acute normotensive PE. The aim of this analysis was to calculate age cut-off values to ...

journal_title：Experimental gerontology

authors： Keller K,Beule J,Coldewey M,Geyer M,Balzer JO,Dippold W

更新日期：2015-09-01 00:00:00

abstract：:In order to establish the role of calcitonin (CT) in postmenopausal bone loss, we studied CT metabolism in 25 pre- and postmenopausal women. Postmenopausal women presented a highly significant reduction of CT basal levels compared to premenopausal females (p less than 0.01). Also, production rates of CT in osteoporoti...

journal_title：Experimental gerontology

authors： Reginster JY,Deroisy R,Lecart MP,Sarlet N,Fontaine MA,Albert A,Franchimont P

更新日期：1990-01-01 00:00:00

abstract：:Calorie restriction (CR) may affect glucose tolerance via modulation of the insulin action in skeletal muscle. The present study investigated the effect of CR initiated at middle age in rats bearing glucose intolerance, in comparison with CR at a younger age. Male F344 rats at 2.5 and 18months (mo) of age were fed ad ...

journal_title：Experimental gerontology

authors： Park S,Komatsu T,Hayashi H,Yamaza H,Chiba T,Higami Y,Kuramoto K,Shimokawa I

更新日期：2006-09-01 00:00:00

abstract：:Heat shock proteins (HSP's) closely interact with 20S proteasome and have been shown to maintain catalytic activity, responsible for the prevention of protein aggregation. A decrease in both proteasome activity and heat shock proteins (HSP's) has been observed with age. We investigated whether life-long calorie restri...

journal_title：Experimental gerontology

authors： Selsby JT,Judge AR,Yimlamai T,Leeuwenburgh C,Dodd SL

更新日期：2005-01-01 00:00:00

abstract：:Reactive oxygen species (ROS) are formed in all living organisms as a by-product of normal metabolism (endogenous sources) and as a consequence of exposure to environmental compounds (exogenous sources). Endogenous ROS are largely formed during oxidative phosphorylation in the mitochondria and, therefore, mitochondria...

journal_title：Experimental gerontology

authors： Stevnsner T,Thorslund T,de Souza-Pinto NC,Bohr VA

更新日期：2002-10-01 00:00:00

abstract：:Senescence accelerated mice (SAM) are susceptible to developing vascular dysfunction and remodeling. Food intake and type of diet have also been identified as determining factors in vascular remodeling. However, the interplay between senescence and diet in vascular remodeling is largely unknown. We aimed to analyze st...

journal_title：Experimental gerontology

authors： Dantas AP,Onetti Y,Oliveira MA,Carvalho MH,Heras M,Vila E,Jiménez-Altayó F

更新日期：2014-07-01 00:00:00

abstract：:The effect of DL-alpha-lipoic acid on lipid peroxidation and antioxidant enzymes were evaluated in various brain regions of young and aged rats. Lipoate contents of discrete brain regions were also measured. In aged rats, the activities of superoxide dismutase, glutathione peroxidase, glutathione reductase and glucose...

journal_title：Experimental gerontology

authors： Arivazhagan P,Shila S,Kumaran S,Panneerselvam C

更新日期：2002-06-01 00:00:00

abstract：:The TOR kinase pathway is central in modulating aging in a variety of animal models. The target of rapamycin (TOR) integrates a complex network of signals from growth conditions, nutrient availability, energy status, and physiological stresses and matches an organism's growth rate to the resource environment. Importan...

journal_title：Experimental gerontology

authors： Snell TW,Johnston RK,Rabeneck B,Zipperer C,Teat S

更新日期：2014-04-01 00:00:00

abstract：:Telomeres are specialised structures located at the end of eukaryotic chromosomes, that get short during progressive cell divisions. Therefore, telomere may be an indicator of the mitotic history of a cell and it is also a determining factor for the residual cell life span. One mechanism, compensating for the telomere...

journal_title：Experimental gerontology

authors： Mariani E,Meneghetti A,Formentini I,Neri S,Cattini L,Ravaglia G,Forti P,Facchini A

更新日期：2003-06-01 00:00:00

abstract：:Chronic low-grade elevations in circulating levels of interleukin (IL)-6 act as a marker of subclinical cardiovascular diseases (CVD) and provide an independent predictor of increased mortality in elderly populations. The purpose of the present study was to test the hypothesis that the IL-6 -174G>C promoter polymorphi...

journal_title：Experimental gerontology

authors： Bruunsgaard H,Christiansen L,Pedersen AN,Schroll M,Jørgensen T,Pedersen BK

更新日期：2004-02-01 00:00:00

abstract：:Although galanin has been shown to increase GLUT4 expression in the cardiac muscle of rats, there is no literature available about the effect of GalR1 on GLUT4 expression in the cardiac muscle of type 2 diabetic rats. The aim of this study was to determine whether intracerebroventricular injection of GalR1 agonist M61...

journal_title：Experimental gerontology

authors： Fang P,Shi M,Zhu Y,Zhang Z,Bo P

更新日期：2015-05-01 00:00:00

abstract：:Diabetes mellitus (DM) is considered a risk factor for the development of Alzheimer disease (AD); however, how DM favors evolution of AD is still insufficiently understood. Hyperglycemia in DM is associated to an increase in mitochondrial reactive oxygen species (ROS) generation, as well as damage of hippocampal cells...

journal_title：Experimental gerontology

authors： Lozano L,Lara-Lemus R,Zenteno E,Alvarado-Vásquez N

更新日期：2014-10-01 00:00:00

abstract：:Concanavalin-A (Con-A) reactivity was studied to identify the tissue-specificity of cells established from various normal human tissues. Cells were treated with Con-A-labelled human red blood cells (C-RBC). C-RBC was not absorbed on the cells derived from the bone marrow, skin and liver. Lung-derived fibroblast cells ...

journal_title：Experimental gerontology

authors： Ban S,Iida S

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:Sarcopenic obesity is a combination of both sarcopenia and obesity, which potentiate each other and maximize the negative influences of each, such as physical disability, morbidity, or even mortality. OBJECTIVES:To describe the criteria used to identify people with sarcopenic obesity and the components of t...

journal_title：Experimental gerontology

authors： Yin YH,Liu JYW,Välimäki M

更新日期：2020-07-01 00:00:00

abstract：:Synaptic disturbances may play a key role in the pathophysiology of Alzheimer's disease. To characterize differential synaptic alterations in the brains of Alzheimer patients, chromogranin A, chromogranin B and secretoneurin were applied as soluble constituents for large dense core vesicles, synaptophysin as a vesicle...

journal_title：Experimental gerontology

authors： Lechner T,Adlassnig C,Humpel C,Kaufmann WA,Maier H,Reinstadler-Kramer K,Hinterhölzl J,Mahata SK,Jellinger KA,Marksteiner J

更新日期：2004-01-01 00:00:00

abstract：:Age-associated thymic involution manifests its effects in a variety of ways that are related to a loss of T cell function. These include the appearance of a non-functional subset of T cells that increase in representation with age. Moreover there is a loss of T cell proliferative ability, a decline in the synthesis an...

journal_title：Experimental gerontology

authors： Song L,Kim YH,Chopra RK,Proust JJ,Nagel JE,Nordin AA,Adler WH

更新日期：1993-07-01 00:00:00

abstract：:Evolutionary aspects of menopause are considered from several perspectives. First, the programmed exhaustion of ovarian oocytes appears to be a general trait of mammals that is not as widely found in other vertebrates. Second, studies on mice suggest that the maternal age effect that accelerates the incidence of Down ...

journal_title：Experimental gerontology

authors： Finch CE

更新日期：1994-05-01 00:00:00

abstract：:The leucine-rich repeat transmembrane 3 (LRRTM3) has been defined as a positional and functional candidate gene for Alzheimer's disease. Recently, four novel variants (rs16923760, rs1925608, rs1925609 and rs10997477) within LRRTM3 were reported to be associated with late-onset Alzheimer's disease (LOAD) in Caucasians....

journal_title：Experimental gerontology

authors： Wang J,Yu JT,Jiang T,Tan MS,Wang HF,Tan L,Hu N,Sun L,Zhang W,Tan L

更新日期：2014-04-01 00:00:00

abstract：:To understand the mechanisms that control life span and age-related phenotypes, we used two-dimensional (2D) gel electrophoresis to study the intracellular proteins whose amounts change during the process of cellular aging. We found that the amount of an alpha-2-macroglobulin (A2M) fragment derived from culture medium...

journal_title：Experimental gerontology

authors： Kondo T,Sakaguchi M,Namba M

更新日期：2001-03-01 00:00:00

abstract：:The CG9940 gene, which encodes the NAD(+) synthase protein in Drosophila, is conserved in human, zebra fish, and mosquito. NAD(+) synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD(+)) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic a...

journal_title：Experimental gerontology

authors： Wen DT,Zheng L,Ni L,Wang H,Feng Y,Zhang M

更新日期：2016-10-01 00:00:00