Abstract:
:Diseases of the elderly, including neurodegenerative and cardiovascular disorders and cancer, may develop through the accumulation of "hits" composed of genetic and epigenetic risk factors. The "iceberg" buildup of these hits over time may exceed the tolerance threshold of a particular tissue, thus precipitating disease. Resistance to apoptosis, a self-eliminating cellular program, is one risk factor; it is attributed to persistent survival factors, or the absence of killer factors, which form a "Yin-Yang" mechanism directing cells to either live or die. Most apoptosis-associated genes can be categorized into four groups, providing signals, signal processors, activators, or substrates for the apoptotic pathway. Senescent human fibroblasts resist apoptosis, perhaps through the lack of key G1-phase gene expressions, also necessary for apoptosis initiation; they also lack key proteolytic activity, and maintain high levels of survival factor bcl2, reflecting a triple blockage to apoptosis. Accumulations of these apoptosis-resistant fibroblasts in aging individuals may impair proper tissue function, not only as noncontributing members, but also as the seed for the buildup of further hits. With time, these cells with multiple hits and apoptosis resistance may induce susceptibility to developing age-dependent diseases.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Wang Edoi
10.1016/s0531-5565(96)00156-8subject
Has Abstractpub_date
1997-07-01 00:00:00pages
471-84issue
4-5eissn
0531-5565issn
1873-6815pii
S0531-5565(96)00156-8journal_volume
32pub_type
杂志文章,评审abstract:PURPOSE:Aging changes the balance of sex hormones and causes endothelial dysfunction in the penis, both of which are important determinants of erectile dysfunction (ED). The purpose of this study was to evaluate whether exercise training could protect against erectile dysfunction by increasing serum testosterone and pe...
journal_title:Experimental gerontology
pub_type: 杂志文章
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更新日期:2018-07-15 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
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journal_title:Experimental gerontology
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journal_title:Experimental gerontology
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doi:10.1016/j.exger.2010.11.007
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/s0531-5565(00)00210-2
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journal_title:Experimental gerontology
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更新日期:2018-07-15 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2003.09.010
更新日期:2003-11-01 00:00:00
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pub_type: 杂志文章
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journal_title:Experimental gerontology
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journal_title:Experimental gerontology
pub_type: 杂志文章
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2014.09.019
更新日期:2014-12-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(02)00149-3
更新日期:2003-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.exger.2016.03.008
更新日期:2016-06-15 00:00:00
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journal_title:Experimental gerontology
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doi:10.1016/s0531-5565(00)00164-9
更新日期:2000-10-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(94)90037-x
更新日期:1994-09-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(01)00210-8
更新日期:2002-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
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journal_title:Experimental gerontology
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journal_title:Experimental gerontology
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journal_title:Experimental gerontology
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journal_title:Experimental gerontology
pub_type: 历史文章,杂志文章
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2005.01.004
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2020.110871
更新日期:2020-02-06 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2008.05.015
更新日期:2008-08-01 00:00:00
abstract::The hypotheses were: HISS-dependent insulin resistance (HDIR) accounts for insulin resistance that occurs with aging; HDIR is the initiating metabolic defect that leads progressively to type 2 diabetes and the metabolic syndrome; a synergistic antioxidant cocktail in chow confers protection against HDIR, subsequent sy...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2008.04.013
更新日期:2008-08-01 00:00:00
abstract::In order to clarify immunogenetic markers contributing to successful aging, HLA and cytokine gene profiles were analyzed in healthy elderly Bulgarians. Family segregation analysis was performed to define combined effect of haplotypes and immunophenotype profiles. The results of this study did not reveal any statistica...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2003.08.014
更新日期:2004-04-01 00:00:00
abstract::Studying renal function in subjects with a familial propensity for longevity may provide insight in (un)known mechanisms that determine the age-related decline in renal function of normal subjects. In the Leiden Longevity Study, middle-aged offspring of non-agenarian siblings and their partners as environmentally matc...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2013.12.012
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Epidemiological and objective studies report an association between sedentary time and lower risk of the metabolic syndrome (MetS) and its risk factors in young and middle-age adults. To date, there is a lack of objective data on the association between sedentary time and MetS among older adults. METHODS:Th...
journal_title:Experimental gerontology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.exger.2015.06.018
更新日期:2015-10-01 00:00:00