Abstract:
:Telomeres serve as a mitotic clock and biological marker of senescence. Diabetes mellitus (DM) is associated with damage to target organs and premature aging. We assessed the effect of glycemic control on telomere dynamics in arterial cells of 58 patients undergoing coronary artery bypass and in mononuclear blood cells of other diabetic (32 type I and 47 type II) patients comparing well controlled to uncontrolled patients. All were compared to age-dependent curve of healthy controls. Telomeres were significantly shorter in the arteries of diabetic versus non-diabetic patients (p=0.049) and in mononuclear cells of both type I and type II diabetes. In all study groups good glycemic control attenuated shortening of the telomeres. In arterial cells good glycemic control attenuated, but not abolished, the telomere shortening. In type II DM the mononuclear telomere attrition was completely prevented by adequate glycemic control. Telomere shortening in mononuclear cells of type I diabetic patients was attenuated but not prevented by good glycemic control. Results of this study suggest that diabetes is associated with premature cellular senescence which can be prevented by good glycemic control in type II DM and reduced in type I DM.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Uziel O,Singer JA,Danicek V,Sahar G,Berkov E,Luchansky M,Fraser A,Ram R,Lahav Mdoi
10.1016/j.exger.2007.07.005subject
Has Abstractpub_date
2007-10-01 00:00:00pages
971-8issue
10eissn
0531-5565issn
1873-6815pii
S0531-5565(07)00164-7journal_volume
42pub_type
杂志文章abstract::A revolution has occurred in the attitude of biologists toward their intellectual property rights. What today is patentable and highly profitable was, 20 years ago, unpatentable and given away for nothing. The history of this revolution began in the early 1960s when we made the first effort to have self-duplicating ce...
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2014.03.026
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journal_title:Experimental gerontology
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2005.07.006
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(03)00007-x
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doi:10.1016/s0531-5565(01)00118-8
更新日期:2001-08-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.exger.2018.04.018
更新日期:2018-07-15 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.exger.2015.03.011
更新日期:2015-06-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2005.10.006
更新日期:2006-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0531-5565(02)00149-3
更新日期:2003-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
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journal_title:Experimental gerontology
pub_type: 临床试验,杂志文章
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2006.09.003
更新日期:2007-03-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(86)90058-6
更新日期:1986-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2019.110663
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(99)00021-2
更新日期:1999-06-01 00:00:00
abstract::Mitochondrial proton leak may modulate reactive oxygen species (ROS) production and play a role in aging. The purpose of this study was to determine proton leak across the life span in skeletal mitochondria from calorie-restricted and UCP2/3 overexpressing mice. Proton leak in isolated mitochondria and markers of oxid...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2008.09.010
更新日期:2008-12-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2015.10.009
更新日期:2015-12-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.exger.2015.08.013
更新日期:2015-12-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2010.05.004
更新日期:2010-09-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2005.06.009
更新日期:2005-08-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2020.110950
更新日期:2020-07-15 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2015.12.002
更新日期:2016-02-01 00:00:00