Abstract:
BACKGROUND:Geriatric depression is common due to the high rate of chronic diseases suffered by the older population. There is a well-established effect of exercise on one's wellbeing, however, for the elderly females there is dearth in research addressing exercise and its effect on their neurotransmitters and depression score. Therefore, this study aimed to investigate the effects of 24 weeks of the Growing Stronger program on neurotransmitter and depression of older women. METHODS:Twenty-one older women, aged between 67 and 81, participated in this study. The participants were randomly assigned into a strength exercise (n = 11) and control group (n = 10) (age 76.40 ± 3.27, height 152.77 ± 5.63 kg, Weight 52.35 ± 2.86Kg, BMI 22.50 ± 1.88). The strength exercise group (age 76.10 ± 3.85, height 151.14 ± 5.42 kg, Weight 54.74 ± 6.73Kg, BMI 23.96 ± 2.70) participated for 50-80 min a day three times per week for a total of 24 weeks. All participants had their height, weight, blood testing and depression score tested before and after the training program. Two-way ANOVA with effect sizes was used to identify differences between times in each group and the statistical significance was set at 0.05. RESULTS:In neurotransmitter factor, serotonin, dopamine, epinephrine, and norepinephrine significantly decreased in the strength exercise group but not for the control group. Notably, one participant whose serotonin level was lower than normal range before the exercise program showed normal level in serotonin after the program. In depression factor, there were no significant differences for both the strength exercise group and control group. CONCLUSION:The results suggest that the effect of strength exercise on neurotransmitter and depression score remain unclear, but highlight the need for future studies investigating the relationship between strength training and depression.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Kim YS,O'Sullivan DM,Shin SKdoi
10.1016/j.exger.2018.11.009subject
Has Abstractpub_date
2019-01-01 00:00:00pages
62-68eissn
0531-5565issn
1873-6815pii
S0531-5565(18)30417-0journal_volume
115pub_type
杂志文章,随机对照试验abstract::Homeostenosis (i.e. decline in stress resistance and resilience with age) is a fundamental notion of the biogerontology and physiology of aging. Stressful situations typically challenge metabolic homeostasis and the capacity to recover from a stress-induced metabolic disorder might be particularly compromised in senes...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2017.08.021
更新日期:2018-02-01 00:00:00
abstract::Melatonin, the main product synthesized by the pineal gland, modulates several brain functions through different mechanisms, some of them involving the activation or participation of calcium binding intracellular proteins, such as the alpha calcium dependent protein kinase C and calmodulin. Another calcium-binding pro...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2014.10.014
更新日期:2014-12-01 00:00:00
abstract::The maximal lifespan (MLS) of mammals is inversely correlated with the peroxidation index, a measure of the proportion and level of unsaturation of polyunsaturated fatty acids (PUFA) in membranes. This relationship is likely related to the fact that PUFA are highly susceptible to damage by peroxidation. Previous compa...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2015.08.011
更新日期:2015-10-01 00:00:00
abstract::To understand the mechanisms that control life span and age-related phenotypes, we used two-dimensional (2D) gel electrophoresis to study the intracellular proteins whose amounts change during the process of cellular aging. We found that the amount of an alpha-2-macroglobulin (A2M) fragment derived from culture medium...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(00)00256-4
更新日期:2001-03-01 00:00:00
abstract::Menopause is associated with a decline in overall health in women. One health aspect impacted is glucose metabolism. As women experience menopause, their metabolism declines dramatically. The current study addressed the influence of ovarian somatic cells on the improvement of metabolic health through transplantations ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2019.110686
更新日期:2019-10-15 00:00:00
abstract::Mistiming of circadian rhythms impairs quality of life. The sleep fragmentation that results can lead to fatigue, mood alteration, and short-term memory problems. Unfortunately, this suite occurs in humans as we age. In the current study, we used high-resolution monitors to track how circadian patterns of locomotor ac...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2018.12.010
更新日期:2019-02-01 00:00:00
abstract::The effect of deleting both catalase genes and of increased oxygen as well as paraquat (a pro-oxidant) on the replicative life span of yeast mother cells has been investigated to test the so-called oxygen theory of aging. This is well established in higher organisms, but has not been extensively tested in the unicellu...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(99)00087-x
更新日期:2000-02-01 00:00:00
abstract::As the analysis of apoptosis is of interest in many basic and clinically oriented investigations, we intend to give a brief overview on the recently most-used methods for detection of apoptotic cells, including the study of morphology, analysis of DNA degradation, DNA end-labeling techniques, flow cytometric analysis,...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/s0531-5565(98)00031-x
更新日期:1998-09-01 00:00:00
abstract::The purpose of this study was to examine the effect of a mentally fatiguing task on postural responses to unexpected backward perturbations in sixteen young and sixteen older women. Postural responses were characterized by center of pressure (COP) displacement, corrective COP peak velocity, and electromyography (EMG) ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2020.110840
更新日期:2020-04-01 00:00:00
abstract::The abundance of a selection of transcript species involved in inflammation, immunosenescence and stress response was compared between PBMC of 35 geriatric patients with hip fracture in acute phase (days 2-4 after hospitalization) or convalescence phase (days 7-10) and 28 healthy aged controls. Twenty-nine differentia...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2010.10.012
更新日期:2011-04-01 00:00:00
abstract::Telomeres are specialised structures located at the end of eukaryotic chromosomes, that get short during progressive cell divisions. Therefore, telomere may be an indicator of the mitotic history of a cell and it is also a determining factor for the residual cell life span. One mechanism, compensating for the telomere...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(03)00058-5
更新日期:2003-06-01 00:00:00
abstract::Whereas biological rhythms are now fairly well documented in young healthy adults, reports in elderly are relatively few for obvious reasons, including the difficulty of setting groups matched in age, sociological and professional background, medical history, and not in need of specific medication. Aging may modify on...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/s0531-5565(96)00161-1
更新日期:1997-07-01 00:00:00
abstract::Evolutionary aspects of menopause are considered from several perspectives. First, the programmed exhaustion of ovarian oocytes appears to be a general trait of mammals that is not as widely found in other vertebrates. Second, studies on mice suggest that the maternal age effect that accelerates the incidence of Down ...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/0531-5565(94)90009-4
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND:An intermission in the training routine, in which older adults refrain from regular structured exercise, may have deleterious effects on muscle performance and bioelectric phase angle (PhA), which is a predictive marker for cellular integrity. PURPOSE:To determine the effects of a 2-week detraining period o...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2020.111175
更新日期:2021-02-01 00:00:00
abstract::Prior to three months of age there is little melatonin (MLT) secretion in humans. MLT production then commences, becomes circadian, and reaches its highest nocturnal blood levels between the ages of one to three years. During the remainder of childhood, nocturnal peak levels drop progressively by 80%. In adults, these...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/s0531-5565(98)00054-0
更新日期:1998-11-01 00:00:00
abstract::For more than 60 years the only dietary manipulation known to retard aging was caloric restriction, in which a variety of species respond to a reduction in energy intake by demonstrating extended median and maximum life span. More recently, two alternative dietary manipulations have been reported to also extend surviv...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(02)00149-3
更新日期:2003-01-01 00:00:00
abstract::Coenzyme Q10 supplementation increases life-span of rats fed on a diet enriched with polyunsaturated fatty acids (Quiles, J.L., Ochoa, J.J., Huertas, J.R., Mataix, J., 2004b. Coenzyme Q supplementation protects from age-related DNA double-strand breaks and increased lifespan in rats fed on a PUFA-rich diet. Exp. Geron...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2005.07.003
更新日期:2005-08-01 00:00:00
abstract::The concept that lifespan is a function of the capacity to withstand extrinsic stress is very old. In concordance with this, long-lived individuals often have increased resistance against a variety of stresses throughout life. Genes underlying the stress response may therefore have the ability to affect lifespan. The ...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2006.09.014
更新日期:2007-03-01 00:00:00
abstract::Aging has a profound effect on the immune system, and both innate and adaptive arms of the immune system show functional decline with age. In response to infection with intracellular microorganisms, old animals mobilize decreased numbers of antigen-specific CD8+ T cells with reduced production of effector molecules an...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2018.01.011
更新日期:2018-05-01 00:00:00
abstract::Alzheimer's disease (AD) is characterized by the accumulation and aggregation of misfolded proteins. The presence of misfolded proteins in the endoplasmic reticulum (ER) triggers a cellular stress response called the unfolded protein response (UPR). Previously, we have shown that the UPR is activated in AD neurons. In...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2006.01.013
更新日期:2006-04-01 00:00:00
abstract::Apoptosis plays an important role in atrophy and sarcopenia in skeletal muscle. Recent evidence suggests that insufficient heat shock proteins (HSPs) may contribute to apoptosis and muscle wasting. In addition, long-term caloric restriction (CR) and lifelong wheel running exercise (WR) with CR provide significant prot...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2015.06.007
更新日期:2015-09-01 00:00:00
abstract:INTRODUCTION:The actual mechanisms leading to a reduced muscle power and functional ability in older adults are poorly understood. We investigated the association between different force-velocity (F-V) profiles and impaired muscle power, physical and cognitive function, frailty, and health-related quality of life (HRQo...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2018.03.015
更新日期:2018-07-15 00:00:00
abstract:OBJECTIVE:Depression is common in hemodialysis patients. Reduced DHEA-S levels have been shown to be associated with depression in general population. Abnormalities in hormone production and metabolism are found in hemodialysis patients. However, the association between DHEA-S levels and depression in hemodialysis pati...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2009.08.009
更新日期:2009-11-01 00:00:00
abstract::Coronary heart disease is less prevalent in pre-menopausal women than in men, but increases at the onset of menopause. This delay is due to estrogen protective effects. The rise of cholesterolemia is one of the main risk factors for coronary disease. Since 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) is the ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2009.10.014
更新日期:2010-02-01 00:00:00
abstract::SIRT1 is a highly conserved NAD(+)-dependent protein deacetylase known to have protective effects against a variety of age-related diseases. However, there is a lack of information concerning SIRT1 expression in the cochlea and auditory cortex of C57BL/6 mice, a mouse model of age-related hearing loss. Using RT-PCR an...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2013.12.006
更新日期:2014-03-01 00:00:00
abstract:INTRODUCTION:Chronically elevated circulating inflammatory markers are common in older persons but mechanisms are unclear. Many blood transcripts (>800 genes) are associated with interleukin-6 protein levels (IL6) independent of age. We aimed to identify gene transcripts statistically mediating, as drivers or responder...
journal_title:Experimental gerontology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.exger.2015.05.012
更新日期:2015-10-01 00:00:00
abstract::Average life expectancy at birth is a rough measure of the span of healthy, productive life--the functional life span. In the developed countries average life expectancies at birth now range from 76-79 years, six to nine years less than the limit of about 85 years imposed by aging. Aging is the accumulation of changes...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/s0531-5565(97)00059-4
更新日期:1998-01-01 00:00:00
abstract::The results of life table experiments to determine the effects of artificial impairment (leg amputation) in 7500 Drosophila melanogaster adults revealed that the extent to which life expectancy was reduced in impaired individuals was conditional on: (1) leg location and number amputated--front leg had greatest impact ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2006.10.002
更新日期:2007-03-01 00:00:00
abstract::Measuring physiological dysregulation during aging could be a key tool both to understand underlying aging mechanisms and to predict clinical outcomes in patients. However, most existing indices are either circular or hard to interpret biologically. Recently, we showed that statistical distance of 14 common blood biom...
journal_title:Experimental gerontology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.exger.2014.04.016
更新日期:2014-09-01 00:00:00
abstract::We studied the contractile, histological and biochemical characteristics of regenerating slow (soleus) muscles of aged rats and the effect of IGF-1 treatment on these parameters. Regenerating soleus muscles were studied 21 days after myotoxic injury. In senescent rats (24 month old), the in situ isometric maximal teta...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(03)00007-x
更新日期:2003-05-01 00:00:00