A search for principles of disability using experimental impairment of Drosophila melanogaster.

abstract：:Pioglitazone (Piog) activates peroxisome proliferator activated receptor-γ (PPARγ) and is widely used in clinic for the treatment of diabetes mellitus. PPARγ in various tissues has the essential regulatory role of multiple metabolic function, suggest that PPARγ signaling may contribute to aging processes. However, lit...

journal_title：Experimental gerontology

authors： Shen D,Li H,Zhou R,Liu MJ,Yu H,Wu DF

更新日期：2018-02-01 00:00:00

abstract：:Numerous trials have shown that physical activity and exercise training have beneficial effects in general older populations. However, few have studied its effectiveness among people with dementia. The aim of this systematic review is to examine the efficacy of trials using a rigorous randomised, controlled design and...

journal_title：Experimental gerontology

authors： Pitkälä K,Savikko N,Poysti M,Strandberg T,Laakkonen ML

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to compare the effects of 12 weeks of traditional resistance training (TRT) or resistance training using Cluster-set (CS) on functional performance and physical fitness of postmenopausal and elderly women. METHODS:Participants (61.1 ± 4.9 years, body mass 64.5 ± 1.8 kg, height 155.7...

journal_title：Experimental gerontology

authors： Dias RKN,Penna EM,Noronha ASN,de Azevedo ABC,Barbalho M,Gentil PV,Coswig VS

更新日期：2020-09-01 00:00:00

abstract：:Fragility fractures due to osteoporosis and its most dreaded complication - hip fractures - are the cause of disability, high mortality and place a considerable burden on global health economics. Although much work has been done to accurately predict mortality and find risk factors for poor health outcome, little atte...

journal_title：Experimental gerontology

authors： Dovjak P,Heinze G,Rainer A,Sipos W,Pietschmann P

更新日期：2017-10-01 00:00:00

abstract：:The goal of these experiments was to determine if the increased longevity characteristics of our genetically selected long lived line of Drosophila could be attributed to metabolic differences. The data shows an inverse relationship between life span and temperature for both the long lived (L) and normal (R) strains; ...

journal_title：Experimental gerontology

authors： Arking R,Buck S,Wells RA,Pretzlaff R

更新日期：1988-01-01 00:00:00

abstract：:The effects of long-term treatment with both antioxidants and a program of behavioral enrichment were studied as part of a longitudinal investigation of cognitive aging in beagle dogs. Baseline performance on a battery of cognitive tests was used to assign 48 aged dogs (9-12 years) into four cognitively equivalent gro...

journal_title：Experimental gerontology

authors： Milgram NW,Head E,Zicker SC,Ikeda-Douglas C,Murphey H,Muggenberg BA,Siwak CT,Tapp PD,Lowry SR,Cotman CW

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND/OBJECTIVES:To explore the impact of diabetic peripheral neuropathy (DPN) on the recovery of older persons with diabetes mellitus (DM) after hip-fracture surgery. DESIGN, SETTING, PARTICIPANTS:Secondary data for this study came from a clinical trial on the effectiveness of a DM-specific care model for 176 ol...

journal_title：Experimental gerontology

authors： Tseng MY,Huang YF,Liang J,Wang JS,Yang CT,Wu CC,Cheng HS,Chen CY,Lin YE,Wang WS,Shyu YL

更新日期：2019-05-01 00:00:00

abstract：:Dietary restriction (DR) extends lifespan in a wide range of organisms. DR also reduces daily and lifetime fecundity. The latter may be an evolutionary adaptation to survive periods of food shortage. Reproductive rate is often negatively correlated with lifespan, and a reduced cost of reproduction could be the mechani...

journal_title：Experimental gerontology

authors： Mair W,Sgrò CM,Johnson AP,Chapman T,Partridge L

更新日期：2004-07-01 00:00:00

abstract：:The effect of 3-(4-pyridyl)-1,2,4-thiotriazolyl 5-mercaptoacetic acid kalium salt (Rumosol) and 3-(4-pyridyl)-1,2,4-thiotriazolyl 5-mercaptoacetic acid morpholinium salt (drug 2) on the concentration of Schiff base in myocardium of adult (10-12 months) and old (22-25 months) Wistar rats during immobilized stress were ...

journal_title：Experimental gerontology

authors： Davydov VV,Shvets VN

更新日期：2002-04-01 00:00:00

abstract：:Engineering of fetal tissue has a high potential for the treatment of acute and chronic wounds of the skin in humans as these cells have high expansion capacity under simple culture conditions and one organ donation can produce Master Cell Banks which can fabricate over 900 million biological bandages (9 x 12cm). In a...

journal_title：Experimental gerontology

authors： Ramelet AA,Hirt-Burri N,Raffoul W,Scaletta C,Pioletti DP,Offord E,Mansourian R,Applegate LA

更新日期：2009-03-01 00:00:00

abstract：:Protein nitration occurs as a result of oxidative stress induced by reactive oxygen (ROS) and reactive nitrogen species (RNS). Therefore, protein nitration serves as a hallmark for protein oxidation in vivo. We have previously reported on age dependent protein nitration in cardiac tissue of Fisher 344 BN-F1 rats analy...

journal_title：Experimental gerontology

authors： Hong SJ,Gokulrangan G,Schöneich C

更新日期：2007-07-01 00:00:00

abstract：:The effect of DL-alpha-lipoic acid on lipid peroxidation and antioxidant enzymes were evaluated in various brain regions of young and aged rats. Lipoate contents of discrete brain regions were also measured. In aged rats, the activities of superoxide dismutase, glutathione peroxidase, glutathione reductase and glucose...

journal_title：Experimental gerontology

authors： Arivazhagan P,Shila S,Kumaran S,Panneerselvam C

更新日期：2002-06-01 00:00:00

abstract：:Culturing Caenorhabditis elegans in axenic medium leads to a twofold increase in lifespan and considering the similar phenotypical traits with dietary restricted animals, it is referred to as axenic dietary restriction (ADR). The free radical theory of aging has suggested a pivotal role for mitochondria in the aging p...

journal_title：Experimental gerontology

authors： Castelein N,Muschol M,Dhondt I,Cai H,De Vos WH,Dencher NA,Braeckman BP

更新日期：2014-08-01 00:00:00

abstract：:Aging in a given individual can be characterized by the number of deficits (symptoms, signs, laboratory abnormalities, disabilities) that they accumulate. The number of accumulated deficits, more than their nature, well characterizes health status in individuals - the proportion of deficits present in an individual to...

journal_title：Experimental gerontology

authors： Mitnitski A,Song X,Rockwood K

更新日期：2012-12-01 00:00:00

abstract：:Stem cells are located throughout the adult body of higher organisms, supporting a continuous renewal and repair of tissues. Unique abilities of stem cells are self-renewal and multipotential differentiation. It is, therefore, of critical importance for an organism to maintain and control quantity and quality of stem ...

journal_title：Experimental gerontology

authors： Fehrer C,Lepperdinger G

更新日期：2005-12-01 00:00:00

abstract：:Studies have suggested that older individuals are more fatigable than young adults when power loss, measured during single-joint contractions, is considered the fatigue index; however, age-related differences in fatigue considering power measurements during multi-joint movements (e.g., cycling) have not been fully elu...

journal_title：Experimental gerontology

authors： Krüger RL,Aboodarda SJ,Jaimes LM,Vaz MA,Samozino P,Millet GY

更新日期：2020-05-01 00:00:00

abstract：:We suggest that the processes that protect the turtle brain against anoxia and subsequent reoxygenation might also contribute to turtle longevity since many of them are linked to age related neurodegeneration. In the turtle the mechanisms for conserving ion channel function are particularly robust. The anoxic turtle b...

journal_title：Experimental gerontology

authors： Lutz PL,Prentice HM,Milton SL

更新日期：2003-07-01 00:00:00

abstract：:Aging in Brown Norway rats is accompanied by the reduced production of testosterone by the Leydig cells, the testicular cells responsible for synthesizing and secreting this essential steroid. As yet, the mechanism by which Leydig cell steroidogenesis is reduced is unknown. Herein we assess the production of mitochond...

journal_title：Experimental gerontology

authors： Chen H,Cangello D,Benson S,Folmer J,Zhu H,Trush MA,Zirkin BR

更新日期：2001-08-01 00:00:00

abstract：:DNA binding of the ku protein was investigated in peripheral blood mononuclear cells (PBMC) from 24 subjects of different ages (20-89 years old) displaying age-related changes in DNA repair, mitotic responsiveness, and cytokine production. Ku is an heterodimeric protein composed of two subunits of 70 and 80 kDa, which...

journal_title：Experimental gerontology

authors： Frasca D,Barattini P,Tirindelli D,Guidi L,Bartoloni C,Errani A,Costanzo M,Tricerri A,Pierelli L,Doria G

更新日期：1999-08-01 00:00:00

abstract：:We investigated the telomere lengths of individual cell types in lingual mucosa using an improved tissue quantitative fluorescence in situ hybridization (Q-FISH) method. Our tissue Q-FISH method compensates for partially cut nuclei in a tissue section by using the telomere:centromere ratio (TCR). We normalized our TCR...

journal_title：Experimental gerontology

authors： Aida J,Izumiyama-Shimomura N,Nakamura K,Ishikawa N,Poon SS,Kammori M,Sawabe M,Arai T,Matsuura M,Fujiwara M,Kishimoto H,Takubo K

更新日期：2008-09-01 00:00:00

abstract：:Mitochondria isolated from the livers of old rats (26-30 months) were found to incorporate 41% less leucine into mitochondrial proteins as compared to those from young rats (2-3 months). The initial rates of incorporation of label were 145 cpm/mg/min for the "old" animals, and 320 cpm/mg/min for the young animal. No d...

journal_title：Experimental gerontology

authors： Marcus DL,Lew G,Gruenspecht-Faham N,Freedman ML

更新日期：1982-01-01 00:00:00

abstract：:The loss of bone mineral with aging and subsequent development of osteoporosis is a common problem in elderly women, and as life expectancy increases, in elderly men as well. Space flight also causes bone loss and could be a limiting factor for long duration missions, such as, a Mars expedition or extended occupation ...

journal_title：Experimental gerontology

authors： LeBlanc A,Schneider V

更新日期：1991-01-01 00:00:00

abstract：:Homeostenosis (i.e. decline in stress resistance and resilience with age) is a fundamental notion of the biogerontology and physiology of aging. Stressful situations typically challenge metabolic homeostasis and the capacity to recover from a stress-induced metabolic disorder might be particularly compromised in senes...

journal_title：Experimental gerontology

authors： Colinet H,Renault D

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The cortisol awakening response (CAR) is a useful endocrine marker for the hypothalamic-pituitary-adrenal axis activity. Recent studies suggest that the cortisol level influences the expression of the hPER1 clock gene which is involved in the generation of biological rhythms. This study aimed t...

journal_title：Experimental gerontology

authors： Olbrich D,Dittmar M

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Sarcopenic obesity is a combination of both sarcopenia and obesity, which potentiate each other and maximize the negative influences of each, such as physical disability, morbidity, or even mortality. OBJECTIVES:To describe the criteria used to identify people with sarcopenic obesity and the components of t...

journal_title：Experimental gerontology

authors： Yin YH,Liu JYW,Välimäki M

更新日期：2020-07-01 00:00:00

abstract：:Indigenous DNA adducts (I-compounds) are considered to be a biomarker of aging tissues. Thus far, few studies have been conducted to investigate the accumulation patterns of I-compounds in the brain during aging. Particularly, identities of age-dependent I-compounds have largely remained unknown. In the current study,...

journal_title：Experimental gerontology

authors： Cai Q,Tian L,Wei H

更新日期：1996-05-01 00:00:00

abstract：:Calorie restriction (CR) may affect glucose tolerance via modulation of the insulin action in skeletal muscle. The present study investigated the effect of CR initiated at middle age in rats bearing glucose intolerance, in comparison with CR at a younger age. Male F344 rats at 2.5 and 18months (mo) of age were fed ad ...

journal_title：Experimental gerontology

authors： Park S,Komatsu T,Hayashi H,Yamaza H,Chiba T,Higami Y,Kuramoto K,Shimokawa I

更新日期：2006-09-01 00:00:00

abstract：:Temporal discounting occurs when a greater delayed reward is forsaken for a smaller immediate reward, and has been associated with a number of financial and health care outcomes important for older adults. Using resting-state fMRI and seed regions of interest in the left and right fronto-insular (FI) cortices, we expl...

journal_title：Experimental gerontology

authors： Han SD,Boyle PA,Yu L,Fleischman DA,Arfanakis K,Bennett DA

更新日期：2013-12-01 00:00:00

abstract：:Aging is associated with altered immune responses, particularly with a diminished CD8 T cell response. Although both intrinsic and extrinsic factors are hypothesized to impact this decreased T cell response, the direct evidence of an intrinsic deficiency in virus-specific CD8 T cells is limited. In this study, a TCR t...

journal_title：Experimental gerontology

authors： Jiang J,Fisher EM,Murasko DM

更新日期：2013-06-01 00:00:00

abstract：:A series of theoretical analyses of mortality were performed on recent data for Mediterranean fruit flies (Ceratitus capitata). Best fit computations were performed using the Marquardt-Levenburg technique on: 1) the classic Gompertz model, 2) the Johnson-Mehl-Avrami (JMA) model from chemical kinetics theory, which is ...

journal_title：Experimental gerontology

authors： Hirsh AG,Williams RJ,Mehl P

更新日期：1994-03-01 00:00:00