Abstract：
:Dietary restriction (DR) extends lifespan in a wide range of organisms. DR also reduces daily and lifetime fecundity. The latter may be an evolutionary adaptation to survive periods of food shortage. Reproductive rate is often negatively correlated with lifespan, and a reduced cost of reproduction could be the mechanism by which DR extends lifespan. We tested this hypothesis in Drosophila melanogaster females, by directly suppressing different aspects of reproduction and measuring the effect on the response of lifespan and age-specific mortality to DR. DR resulted in lifespan extension in females kept with males, in females kept without males, in females with vitellogenesis blocked by the mutant ovoD1 and in females with no germline as a result of X-irradiation. Moreover, rapid (48 h) changes in age-specific mortality, previously seen in fertile females switched between full feeding and DR, were also seen in ovoD1 females. Furthermore, these rapid changes in age-specific mortality in cohorts of fertile wild type females were not accompanied by concurrent changes in egg-production. These results indicate either that reduced reproduction is not necessary for lifespan extension by DR in Drosophila females, or that the relevant aspects of reproduction act upstream of our interventions and were therefore not blocked in our experiments.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Mair W,Sgrò CM,Johnson AP,Chapman T,Partridge Ldoi
10.1016/j.exger.2004.03.018keywords:
subject
Has Abstractpub_date
2004-07-01 00:00:00pages
1011-9issue
7eissn
0531-5565issn
1873-6815pii
S053155650400124Xjournal_volume
39pub_type
杂志文章abstract：:We previously demonstrated that in vitro stimulated splenic B cells from senescent mice are deficient in production of multiple class switch isotypes, class switch recombination (CSR), induction of the E2A-encoded transcription factor E47, and activation-induced cytidine deaminase (AID) which is necessary for CSR and ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2006.09.003
更新日期：2007-03-01 00:00:00
abstract：OBJECTIVES:The present study investigated whether the performance on executive function tasks of patients with type 2 diabetes mellitus (T2DM) is as impaired as that of Alzheimer's disease (AD) patients and to compare their performance with that of a group of cognitively healthy older adults. We also investigated wheth...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2016.07.013
更新日期：2016-10-01 00:00:00
abstract：INTRODUCTION:Right ventricular dysfunction (RVD), submassive pulmonary embolism (PE), elevated systolic pulmonary artery pressure (sPAP), elevated cardiac troponin I (cTnI) and old age are well-known risk factors for poor outcome in acute normotensive PE. The aim of this analysis was to calculate age cut-off values to ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2015.05.007
更新日期：2015-09-01 00:00:00
abstract：:We investigated the telomere lengths of individual cell types in lingual mucosa using an improved tissue quantitative fluorescence in situ hybridization (Q-FISH) method. Our tissue Q-FISH method compensates for partially cut nuclei in a tissue section by using the telomere:centromere ratio (TCR). We normalized our TCR...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2008.06.001
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abstract：:Post-viral pneumococcal pneumonia is a leading morbidity and mortality in older patients (≥65years of age). The goal of our current study is to understand the impact of chronological aging on innate immune responses to a secondary, post viral infection with Streptococcus pneumoniae, a causative agent of bacterial pneu...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2017.11.010
更新日期：2018-05-01 00:00:00
abstract：:The purpose of this study was to examine the effect of a mentally fatiguing task on postural responses to unexpected backward perturbations in sixteen young and sixteen older women. Postural responses were characterized by center of pressure (COP) displacement, corrective COP peak velocity, and electromyography (EMG) ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2020.110840
更新日期：2020-04-01 00:00:00
abstract：:There have been some observations that low body weight and a low level of some hormones (e.g. IGF-1) during the first half of life are predictors of longer life in mice. However, contradictions in the available data on the biomarkers of aging and predictors of longevity have shown that the research in these fields has...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2003.12.007
更新日期：2004-03-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2010.03.013
更新日期：2010-06-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.02.027
更新日期：2013-06-01 00:00:00
abstract：:Several papers reported in recent years on a change in the age population distribution of the circulating erythrocytes in old mice, rats, rabbits, and humans. The results indicate the presence of a chronologically younger cell population in old animals and humans. The cells are typically lower in density and larger. I...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(92)90055-5
更新日期：1992-01-01 00:00:00
abstract：:A longitudinal study was performed to confirm the inverse relationship between in vivo age and in vitro proliferative capacity previously observed in a cross-sectional study, and to investigate the relationship between the growth of dermal fibroblasts in vitro and a physiological function (i.e., wound repair) that is ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(91)90058-t
更新日期：1991-01-01 00:00:00
abstract：:There is an age-associated reduction in the bone healing activity of bone morphogenetic protein-2 (BMP-2) that is currently addressed by administering higher doses of BMP-2 in elderly patients. The unwanted medical complications from high dose BMP-2 motivated this investigation to determine whether the addition of a l...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2015.02.006
更新日期：2015-04-01 00:00:00
abstract：:Adult Premature Aging Mice (PAM) show premature immunosenescence, oxidative and inflammatory stress and consequently a shorter lifespan than Exceptional Non-Prematurely Aging Mice (E-NPAM) at the same age. Indeed, adult female PAM exhibit behavioral age-related declines and abnormalities in its brain neurochemistry. N...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2020.111224
更新日期：2020-12-31 00:00:00
abstract：:A micromethod was used to study myelin from individual rat optic nerves as a function of age. Protein and galactolipid content as well as 2',3'-cyclic nucleotide phosphohydrolase (CNPase) activity at ages 2, 4, 22, and 28 months were determined. Protein content increased significantly at 22 months and decreased at adv...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(89)90013-2
更新日期：1989-01-01 00:00:00
abstract：:There is growing concern over the increasing use of opioids to treat chronic pain in the elderly primarily because of the potential increased sensitivity to the adverse side effects. Here, we use a preclinical model (male Brown Norway X F344 rats aged 12, 18, 24, and 30 months) to describe the outcome of chronic fenta...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2010.10.004
更新日期：2011-01-01 00:00:00
abstract：:In order to establish the role of calcitonin (CT) in postmenopausal bone loss, we studied CT metabolism in 25 pre- and postmenopausal women. Postmenopausal women presented a highly significant reduction of CT basal levels compared to premenopausal females (p less than 0.01). Also, production rates of CT in osteoporoti...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(90)90072-a
更新日期：1990-01-01 00:00:00
abstract：:The geriatric populations of many countries are growing rapidly and they present major problems to healthcare infrastructures from both medical and economic perspectives. The elderly are predisposed to a variety of diseases, which contribute to a marked increase in morbidity in this subpopulation. The incidence of liv...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2005.06.009
更新日期：2005-08-01 00:00:00
abstract：:Aging is associated with a change in membrane composition that includes a decrease in membrane polyunsaturated fatty acids, including arachidonic acid, and an increase in membrane cholesterol. Alterations in membrane structure are likely to impact on transmitter release, which relies on the fusion of synaptic plasma a...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(97)00130-7
更新日期：1998-06-01 00:00:00
abstract：:Reproductive senescence occurs in all female mammals with resultant changes in numerous body functional systems and several important features may be species-specific. Those features that appear to parallel human menopause and aging include general similarity of hormone profiles across the menopausal transition, progr...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2005.10.010
更新日期：2006-02-01 00:00:00
abstract：:Light and electron microscope comparisons were made of parotid and submandibular glands from male Swiss-Webster white mice 3, 13, and 18 months old. The glands from the 13- and 18-month-old mice were less organized and the parenchyma was not as dense. Fibrous connective tissue, intracellular lipofuscin granules, and r...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(88)90007-1
更新日期：1988-01-01 00:00:00
abstract：:Neural correlates of placebo analgesia (PA) in patients with neurocognitive disorders have not yet been elucidated. The present study aimed to evaluate how and to what extent executive (dys)functions of the medial prefrontal cortex (MPFC) may be related to PA. To this end, twenty-three subjects complaining of differen...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2019.01.011
更新日期：2019-04-01 00:00:00
abstract：:Diseases of the elderly, including neurodegenerative and cardiovascular disorders and cancer, may develop through the accumulation of "hits" composed of genetic and epigenetic risk factors. The "iceberg" buildup of these hits over time may exceed the tolerance threshold of a particular tissue, thus precipitating disea...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(96)00156-8
更新日期：1997-07-01 00:00:00
abstract：:Progressive neuronal deterioration accompanied by sensory functions decline is typically observed during aging. On the other hand, structural or functional alterations of specific sensory neurons extend lifespan in the nematode Caenorhabditis elegans. Hormesis is a phenomenon by which the body benefits from moderate s...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2014.03.026
更新日期：2014-08-01 00:00:00
abstract：:Age-related declines in human skeletal muscle performance may be caused, in part, by decreased responsivity of muscle fibers to calcium (Ca2+). This study examined the contractile properties of single vastus lateralis muscle fibers with various myosin heavy chain (MHC) isoforms (I, I/IIA, IIA and IIAX) across a range ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2017.12.007
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:The proportion of elderly individuals is growing and the prevalence of chronic kidney disease (CKD) among elderly people undergoing cardiac surgery is increasing constantly. The aim of this study was to determine the influence of different degrees of preoperative renal dysfunction on postoperative outcomes i...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.01.012
更新日期：2013-03-01 00:00:00
abstract：:Initial velocity of GABA uptake in hypothalamic synaptosomes has been measured in aged animals as a function of both sodium and GABA concentration and compared to previous studies in young animals. The data give good fit to the model found previously to give minimal best fit to control data. Thus it appears that aging...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(83)90005-0
更新日期：1983-01-01 00:00:00
abstract：:In the present study, using RNA gel-blot analysis, we characterized the developmental changes in the prevalence of mRNA coding for fibronectin (FN), glial fibrillary acidic protein (GFAP), neurotrophic protein S100 beta, and beta-actin mRNA in rat hippocampus and forebrain from 1 to 720 days of age. We found that the ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(93)90003-v
更新日期：1993-03-01 00:00:00
abstract：:Mitochondrial DNA 5178 adenine/cytosine (mt5178 A/C) polymorphism is one of the longevity-associated mitochondrial DNA polymorphisms. The frequency of the mt5178A genotype is significantly higher in Japanese centenarians than in the general population. We previously reported that serum high-density lipoprotein cholest...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(03)00211-0
更新日期：2003-10-01 00:00:00
abstract：:In mammals, the relationship between reproductive function and health has been particularly difficult to define. Previously, in old, postreproductive-aged mice, replacement of senescent ovaries with new ovaries from young, actively cycling mice increased life span. We hypothesized that the same factors that increased ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2017.03.002
更新日期：2017-06-01 00:00:00
abstract：:Aging is associated with changes in several metabolic pathways affecting liver function including the adaptive unfolded protein response (UPR). On the other hand, exercise training has been shown to exert beneficial effects on metabolism in the liver and exercise training has been reported to affect hepatic UPR. PGC-1...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2017.08.006
更新日期：2017-11-01 00:00:00
