Abstract:
:Initial velocity of GABA uptake in hypothalamic synaptosomes has been measured in aged animals as a function of both sodium and GABA concentration and compared to previous studies in young animals. The data give good fit to the model found previously to give minimal best fit to control data. Thus it appears that aging has not resulted in a change in fundamental mechanism by which carrier, sodium, and GABA interact in the process of transport. However, changes were found in the constants which quantitate the model. As a consequence, there is a reduction in transport capability in the aged animals which is particularly apparent at the higher sodium concentrations. The best fit constants were used along with the rate equation from the model to calculate several kinetic parameters which are useful in comparing transport mechanisms. In the physiological range of sodium concentration, those kinetic parameters related to maximal transport capabilities declined with age, while apparent carrier affinities increased with age. Similar results were found in previous studies of GABA (Wheeler, 1982) and glutamic acid (Wheeler, 1980a) transport in cortical synaptosomes.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Wheeler DDdoi
10.1016/0531-5565(83)90005-0subject
Has Abstractpub_date
1983-01-01 00:00:00pages
125-35issue
2eissn
0531-5565issn
1873-6815pii
0531-5565(83)90005-0journal_volume
18pub_type
杂志文章abstract::The purpose of this study was to examine the relative contributions of changes in muscle quality and body composition to changes in lower-extremity physical function (LEPF) following a 6-month exercise and weight loss intervention in overweight and obese older women. Thirty-eight overweight and obese (BMI = 30.0 ± 4.4...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2018.04.011
更新日期:2018-07-15 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
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journal_title:Experimental gerontology
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journal_title:Experimental gerontology
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2011.02.010
更新日期:2011-07-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
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abstract::Given the increased concerns about the degenerative decline in the physical performance of the elderly, there is a need for developing effective strategies to suppress the age-related loss of skeletal muscle mass and functional capacity through a lifestyle intervention. This randomized controlled trial examined whethe...
journal_title:Experimental gerontology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.exger.2016.11.003
更新日期:2017-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(86)90039-2
更新日期:1986-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2018.10.020
更新日期:2018-12-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,随机对照试验
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更新日期:2018-07-15 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2019.03.011
更新日期:2019-07-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(03)00111-6
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(89)90013-2
更新日期:1989-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2007.10.017
更新日期:2008-03-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(83)90040-2
更新日期:1983-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(93)90046-g
更新日期:1993-11-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(84)90011-1
更新日期:1984-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/s0531-5565(98)00028-x
更新日期:1998-11-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2013.06.008
更新日期:2013-09-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2003.12.014
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2004.06.023
更新日期:2004-11-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2013.08.003
更新日期:2013-11-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(99)00026-1
更新日期:1999-08-01 00:00:00
abstract::Age-related bone loss is thought to be due to impaired osteoblast functions. Insulin-like growth factors (IGFs) have been shown to be important stimulators of bone formation and osteoblast activities in vitro and in vivo. We tested the hypothesis that in vitro osteoblast senescence is associated with changes in compon...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(00)00125-x
更新日期:2000-10-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(02)00239-5
更新日期:2003-04-01 00:00:00
abstract::The effect of deleting both catalase genes and of increased oxygen as well as paraquat (a pro-oxidant) on the replicative life span of yeast mother cells has been investigated to test the so-called oxygen theory of aging. This is well established in higher organisms, but has not been extensively tested in the unicellu...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(99)00087-x
更新日期:2000-02-01 00:00:00
abstract:INTRODUCTION:Chronically elevated circulating inflammatory markers are common in older persons but mechanisms are unclear. Many blood transcripts (>800 genes) are associated with interleukin-6 protein levels (IL6) independent of age. We aimed to identify gene transcripts statistically mediating, as drivers or responder...
journal_title:Experimental gerontology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.exger.2015.05.012
更新日期:2015-10-01 00:00:00
abstract::The effect of aging was tested on experimental ventricular arrhythmias in isolated heart preparations from normal Wistar rats (NWR), Wistar Kyoto rats (WKY), and spontaneously hypertensive rats (SHR). Delayed afterdepolarizations and triggered activity induced by high-calcium perfusion (16 mM) in isolated papillary mu...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(90)90061-6
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVE:This study aimed to evaluate the effect of vitamin D3 megadose supplementation and influence of BsmI polymorphism in the VDR gene on the inflammatory profile and oxidative stress in elderly women with vitamin D deficiency. METHODS:A double blind, randomized, placebo-controlled trial was conducted with 40 eld...
journal_title:Experimental gerontology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.exger.2015.03.011
更新日期:2015-06-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2019.110721
更新日期:2019-11-01 00:00:00