Abstract:
:We suggest that the processes that protect the turtle brain against anoxia and subsequent reoxygenation might also contribute to turtle longevity since many of them are linked to age related neurodegeneration. In the turtle the mechanisms for conserving ion channel function are particularly robust. The anoxic turtle brain avoids excitatory neurotransmitter toxicity by maintaining a balance between dopamine and glutamate-release and still active uptake mechanisms. In the anoxic turtle brain the inhibitory tone is strengthened through a sustained rise in extracellular GABA, and a corresponding increase in the density of GABA(A) receptors. The turtle has enhanced mechanisms that protect against the formation of ROS and mechanisms to protect from ROS damage. As many of these may be selectively activated during anoxia and recovery, the turtle could serve as a useful model to identify and investigate mechanisms for activating key protection and rescue mechanisms implicated in aging.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Lutz PL,Prentice HM,Milton SLdoi
10.1016/s0531-5565(03)00111-6keywords:
subject
Has Abstractpub_date
2003-07-01 00:00:00pages
797-800issue
7eissn
0531-5565issn
1873-6815pii
S0531556503001116journal_volume
38pub_type
杂志文章abstract::We determined the contribution of body fat distribution, peak VO2, fat mass, and dietary intake to variation in plasma lipids in elderly individuals. Volunteers were a healthy cohort of older Caucasian women (n = 75, mean age +/- SD, 72 +/- 5 years) and older men (n = 101, 72 +/- 5 years). We determined fat mass from ...
journal_title:Experimental gerontology
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journal_title:Experimental gerontology
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pub_type: 临床试验,杂志文章
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
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journal_title:Experimental gerontology
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(88)90031-9
更新日期:1988-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
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更新日期:2000-02-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2010.11.007
更新日期:2011-04-01 00:00:00
abstract::The mechanisms responsible for age-associated hearing loss are still incompletely characterized. In this study, we used a murine model of age-dependent hearing loss and evaluated whether this condition is associated with vascular modifications of the structures of the inner ear. We used old C57BL/6J mice that are affe...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2004.06.003
更新日期:2004-08-01 00:00:00
abstract::The effect of DL-alpha-lipoic acid on lipid peroxidation and antioxidant enzymes were evaluated in various brain regions of young and aged rats. Lipoate contents of discrete brain regions were also measured. In aged rats, the activities of superoxide dismutase, glutathione peroxidase, glutathione reductase and glucose...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(02)00015-3
更新日期:2002-06-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2013.10.003
更新日期:2013-12-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2020.110950
更新日期:2020-07-15 00:00:00
abstract::Male F344 rats, 3, 12, and 24 months of age, were acclimated to either 5 degrees C (CA) or 23 degrees C (non-CA). At the end of acclimation, all CA rats exhibited higher basal oxygen uptake than the non-CA when measured at 28 degrees C. When challenged by a 3-hour exposure to -10 degrees C, significant difference in t...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(85)90038-5
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The cortisol awakening response (CAR) is a useful endocrine marker for the hypothalamic-pituitary-adrenal axis activity. Recent studies suggest that the cortisol level influences the expression of the hPER1 clock gene which is involved in the generation of biological rhythms. This study aimed t...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2012.04.009
更新日期:2012-07-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2013.01.012
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journal_title:Experimental gerontology
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journal_title:Experimental gerontology
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2016.10.002
更新日期:2016-12-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2017.11.010
更新日期:2018-05-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/s0531-5565(97)00115-0
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to compare the effects of 12 weeks of traditional resistance training (TRT) or resistance training using Cluster-set (CS) on functional performance and physical fitness of postmenopausal and elderly women. METHODS:Participants (61.1 ± 4.9 years, body mass 64.5 ± 1.8 kg, height 155.7...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2020.111011
更新日期:2020-09-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2006.03.012
更新日期:2006-07-01 00:00:00
abstract::Long-term caloric restriction (CR) has been shown to extend maximum life span in laboratory rodents. We investigated the activities of gluconeogenic and transaminase enzymes in the livers of old and young mice fed either control or calorie-restricted diets. Livers were sampled 48 h after the last scheduled feeding tim...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(02)00202-4
更新日期:2003-03-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2003.08.003
更新日期:2003-10-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2006.03.004
更新日期:2006-05-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2011.11.011
更新日期:2012-02-01 00:00:00