当前位置： SCI文献检索 > EXPERIMENTAL GERONTOLOGY期刊下所有文献 > Physical activity in midlife and telomere length measured in old age.

Physical activity in midlife and telomere length measured in old age.

Abstract：

:Physical activity has been associated with alterations in telomere length, a potential indicator of biological aging, but several inconsistencies exist. Our aim was to investigate the associations between physical activity in midlife and leukocyte telomere length (LTL) measured in old age in the Helsinki Businessmen Study, Finland. At entry, in 1974, 782 men (mean age 47) completed a questionnaire about their physical activity and this was collapsed into 3 categories: low (n=148), moderate (n=398) and high physical activity (n=236, 7 of whom had a competitive activity level). After 29-year follow-up in 2003, mean LTL and the proportion of short (<5 kB) telomeres were measured from DNA samples of a random subcohort of survivors (n=204, mean age 76) using the Southern blot technique. Adjusted for age, body mass index (BMI), cholesterol and smoking in 1974, the moderate physical activity group had longer mean LTL (8.27 kB, SE 0.05) than the low (8.10 kB, SE 0.07), or high (8.10 kB, SE 0.05) physical activity groups (P=0.03 between groups). Conversely, the proportion of short telomeres was lowest in the moderate physical activity group (11.35%, SE 0.25), and higher in the high (12.39%, SE 0.29), and the low physical activity (12.21%, SE 0.39) groups (P=0.02 between groups). We conclude that the results of this observational cohort study give support to the idea that both low and high physical activity is in the long-term associated with factors shortening LTL.

journal_name

Exp Gerontol

journal_title

Experimental gerontology

authors

Savela S,Saijonmaa O,Strandberg TE,Koistinen P,Strandberg AY,Tilvis RS,Pitkälä KH,Miettinen TA,Fyhrquist F

doi

10.1016/j.exger.2012.02.003

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

81-4

issue

1

eissn

0531-5565

issn

1873-6815

pii

S0531-5565(12)00034-4

journal_volume

48

pub_type

杂志文章

相关文献

EXPERIMENTAL GERONTOLOGY文献大全
  • Urea synthesis in hepatocytes isolated from young and old rats.

    abstract：:Effects of glucagon and epinephrine stimulation on urea synthesis from lactate, pyruvate, NH4Cl, and ornithine in isolated rat hepatocytes from young and old rats were compared. It was found that the production of urea from those substrates was almost the same in both age groups. The concentrations of hormones that ca...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/0531-5565(85)90052-x

    authors： Kmieć Z,Myśliwski A

    更新日期：1985-01-01 00:00:00

  • Age-dependent increase of indigenous DNA adducts in rat brain is associated with a lipid peroxidation product.

    abstract：:Indigenous DNA adducts (I-compounds) are considered to be a biomarker of aging tissues. Thus far, few studies have been conducted to investigate the accumulation patterns of I-compounds in the brain during aging. Particularly, identities of age-dependent I-compounds have largely remained unknown. In the current study,...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/0531-5565(95)02027-6

    authors： Cai Q,Tian L,Wei H

    更新日期：1996-05-01 00:00:00

  • Effects of vitamin D and resveratrol on metabolic associated markers in liver and adipose tissue from SAMP8 mice.

    abstract：:SAMP8 mice exhibit multiple metabolic characteristics associated with age, and it is a suitable candidate for researching aging associated metabolic dysfunction. OBJECTIVES:We aimed to 1) explore how key metabolic markers will be altered in both liver and adipose tissue with aging in SAMP8 mice; and 2) how the combin...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2017.03.017

    authors： Rui Y,Cheng J,Qin L,Shan C,Chang J,Wang G,Wan Z

    更新日期：2017-07-01 00:00:00

  • Cellular functions of the dual-targeted catalytic subunit of telomerase, telomerase reverse transcriptase--potential role in senescence and aging.

    abstract：:Over the last 40 years it has become clear that telomeres, the end of the chromosomes, and the enzyme telomerase reverse transcriptase (TERT), which is required to counteract their shortening, play a pivotal role in senescence and aging. However, over the last years several studies demonstrated that TERT belongs to th...

    journal_title：Experimental gerontology

    pub_type： 杂志文章,评审

    doi：10.1016/j.exger.2014.02.011

    authors： Ale-Agha N,Dyballa-Rukes N,Jakob S,Altschmied J,Haendeler J

    更新日期：2014-08-01 00:00:00

  • Telomere dynamics in arteries and mononuclear cells of diabetic patients: effect of diabetes and of glycemic control.

    abstract：:Telomeres serve as a mitotic clock and biological marker of senescence. Diabetes mellitus (DM) is associated with damage to target organs and premature aging. We assessed the effect of glycemic control on telomere dynamics in arterial cells of 58 patients undergoing coronary artery bypass and in mononuclear blood cell...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2007.07.005

    authors： Uziel O,Singer JA,Danicek V,Sahar G,Berkov E,Luchansky M,Fraser A,Ram R,Lahav M

    更新日期：2007-10-01 00:00:00

  • Extension of life span and stress resistance of Drosophila melanogaster by long-term supplementation with melatonin.

    abstract：:According to the free radical theory of aging, free radicals are involved in the production of changes in cellular metabolism that lead to a time-dependent functional decline in all living beings. Consequently, antioxidant and/or free radicals scavengers may retard the aging process. We explored the effect of melatoni...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/s0531-5565(01)00229-7

    authors： Bonilla E,Medina-Leendertz S,Díaz S

    更新日期：2002-05-01 00:00:00

  • Innovations in Geroscience to enhance mobility in older adults.

    abstract：:Aging is the primary risk factor for functional decline; thus, understanding and preventing disability among older adults has emerged as an important public health challenge of the 21st century. The science of gerontology - or geroscience - has the practical purpose of "adding life to the years." The overall goal of g...

    journal_title：Experimental gerontology

    pub_type： 杂志文章,评审

    doi：10.1016/j.exger.2020.111123

    authors： Anton SD,Cruz-Almeida Y,Singh A,Alpert J,Bensadon B,Cabrera M,Clark DJ,Ebner NC,Esser KA,Fillingim RB,Goicolea SM,Han SM,Kallas H,Johnson A,Leeuwenburgh C,Liu AC,Manini TM,Marsiske M,Moore F,Qiu P,Mankowski RT,M

    更新日期：2020-12-01 00:00:00

  • Life long calorie restriction increases heat shock proteins and proteasome activity in soleus muscles of Fisher 344 rats.

    abstract：:Heat shock proteins (HSP's) closely interact with 20S proteasome and have been shown to maintain catalytic activity, responsible for the prevention of protein aggregation. A decrease in both proteasome activity and heat shock proteins (HSP's) has been observed with age. We investigated whether life-long calorie restri...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2004.08.012

    authors： Selsby JT,Judge AR,Yimlamai T,Leeuwenburgh C,Dodd SL

    更新日期：2005-01-01 00:00:00

  • The transition to reproductive senescence is characterized by increase in A6 and AVPV neuron activity with attenuation of noradrenaline content.

    abstract：:During the course of life, cyclic females face a state of midlife transition that occurs in a fully functioning neurological system, and results in reproductive senescence. The authors' hypothesis was that changes in the activity noradrenergic neurons may be one of the factors involved in this phenomenon. The aim of t...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2016.04.015

    authors： Nicola AC,Leite CM,Nishikava MM,de Castro JC,Anselmo-Franci JA,Dornelles RC

    更新日期：2016-08-01 00:00:00

  • Re-expression of senescent markers in deinduced reversibly immortalized cells.

    abstract：:We have developed a simian virus 40 (SV40) T-antigen immortalized human cell line, 1MR90-D305.2H4 (IDH4), in which the expression of T-antigen is controlled by the mouse mammary tumor virus (MMTV) promoter and thus regulated by steroids such as dexamethasone. Studies on the regulation of proliferation by T-antigen led...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/0531-5565(92)90003-i

    authors： Shay JW,West MD,Wright WE

    更新日期：1992-09-01 00:00:00

  • Analysis of the effect of membrane arachidonic acid concentration on modulation of glutamate release by interleukin-1: an age-related study.

    abstract：:Aging is associated with a change in membrane composition that includes a decrease in membrane polyunsaturated fatty acids, including arachidonic acid, and an increase in membrane cholesterol. Alterations in membrane structure are likely to impact on transmitter release, which relies on the fusion of synaptic plasma a...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/s0531-5565(97)00130-7

    authors： McGahon B,Murray CA,Clements MP,Lynch MA

    更新日期：1998-06-01 00:00:00

  • Bidirectional factors impact the migration of NK cells to draining lymph node in aged mice during influenza virus infection.

    abstract：:Natural killer (NK) cells play an important role in controlling several viral diseases. Our previous studies demonstrated an age-dependent susceptibility to mousepox due to defective NK cell responses and trafficking. However, the mechanisms that underlie the age-related impairment in NK cell migration have yet to be ...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2017.06.021

    authors： Duan X,Lu J,Wang H,Liu X,Wang J,Zhou K,Jiang W,Wang Y,Fang M

    更新日期：2017-10-01 00:00:00

  • CSF protein changes associated with hippocampal sclerosis risk gene variants highlight impact of GRN/PGRN.

    abstract：OBJECTIVE:Hippocampal sclerosis of aging (HS-Aging) is a common cause of dementia in older adults. We tested the variability in cerebrospinal fluid (CSF) proteins associated with previously identified HS-Aging risk single nucleotide polymorphisms (SNPs). METHODS:Alzheimer's Disease Neuroimaging Initiative cohort (ADNI...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2017.01.025

    authors： Fardo DW,Katsumata Y,Kauwe JSK,Deming Y,Harari O,Cruchaga C,Alzheimer's Disease Neuroimaging Initiative.,Nelson PT

    更新日期：2017-04-01 00:00:00

  • Synergistic effect of exercise and statins on femoral strength in rats.

    abstract：:It is now widely recognized that in order to optimize bone health in the later years, bone healthy behaviors should begin at a young age and continue throughout life. Prescribed orally to lower lipid levels in adults of all ages, statins have also been shown to stimulate bone formation in vitro by promoting bone morph...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2013.04.007

    authors： Starnes JW,Neidre DB,Nyman JS,Roy A,Nelson MJ,Gutierrez G,Wang X

    更新日期：2013-08-01 00:00:00

  • Anthropometry, bioimpedance and densitometry: Comparative methods for lean mass body analysis in elderly outpatients from a tertiary hospital.

    abstract：OBJECTIVES:To evaluate lean mass index (LMI) measured by bioimpedance (BIA) and anthropometry compared to densitometry (DXA) in elderly outpatients from a tertiary care hospital. METHODS:Participants were over 60-year-old men, presenting no dementia or disability, from a tertiary geriatric ambulatory. LMI obtained by ...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2020.111020

    authors： Zambone MA,Liberman S,Garcia MLB

    更新日期：2020-09-01 00:00:00

  • Decreased NLRP3 inflammasome expression in aged lung may contribute to increased susceptibility to secondary Streptococcus pneumoniae infection.

    abstract：:Post-viral pneumococcal pneumonia is a leading morbidity and mortality in older patients (≥65years of age). The goal of our current study is to understand the impact of chronological aging on innate immune responses to a secondary, post viral infection with Streptococcus pneumoniae, a causative agent of bacterial pneu...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2017.11.010

    authors： Cho SJ,Plataki M,Mitzel D,Lowry G,Rooney K,Stout-Delgado H

    更新日期：2018-05-01 00:00:00

  • Lack of association between plasma dehydroepiandrosterone sulfate (DHEA-S) levels and depression in hemodialysis patients: a cross-sectional study.

    abstract：OBJECTIVE:Depression is common in hemodialysis patients. Reduced DHEA-S levels have been shown to be associated with depression in general population. Abnormalities in hormone production and metabolism are found in hemodialysis patients. However, the association between DHEA-S levels and depression in hemodialysis pati...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2009.08.009

    authors： Hsu HJ,Chen CK,Hsiao CC,Wu IW,Sun CY,Chou CC,Lee CC,Tsai CJ,Wu MS

    更新日期：2009-11-01 00:00:00

  • Cardiorespiratory and cerebrovascular responses to head-up tilt II: influence of age, training status and acute exercise.

    abstract：:The purpose of this study was to examine the combined cardiorespiratory and cerebrovascular responses to head-up tilt (HUT) in young and older trained and untrained humans following moderate-duration exercise. Middle cerebral artery blood flow velocity (MCAv; transcranial Doppler ultrasound), blood pressure (BP; Finom...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2010.06.004

    authors： Murrell CJ,Cotter JD,George K,Shave R,Wilson L,Thomas K,Williams MJ,Ainslie PN

    更新日期：2011-01-01 00:00:00

  • Aging-related changes in human T-cell repertoire over 20years delineated by deep sequencing of peripheral T-cell receptors.

    abstract：:Recent deep sequencing studies on T-cell receptor (TCR) repertoire have provided robust data to characterize diversity of T-cell immune responsiveness to a wide variety of peptide antigens, including viral and tumor antigens. The human TCR repertoire declines with age, but this decline has not been fully investigated ...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2017.05.015

    authors： Yoshida K,Cologne JB,Cordova K,Misumi M,Yamaoka M,Kyoizumi S,Hayashi T,Robins H,Kusunoki Y

    更新日期：2017-10-01 00:00:00

  • Depletion of oxaloacetate decarboxylase FAHD1 inhibits mitochondrial electron transport and induces cellular senescence in human endothelial cells.

    abstract：:In this study we report the identification of FAH domain containing protein 1 (FAHD1), a recently described member of the fumarylacetoacetate hydrolase (FAH) superfamily of metabolic enzymes, as a novel player in the regulation of cellular senescence. FAHD1 was found in a proteomic screen searching for mitochondrial p...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2017.03.004

    authors： Petit M,Koziel R,Etemad S,Pircher H,Jansen-Dürr P

    更新日期：2017-06-01 00:00:00

  • Age-dependent response of lymphocytes in the induction of the linker histone variant, H1 degrees and histone H4 acetylation after treatment with the histone deacetylase inhibitor, trichostatin A.

    abstract：:In the present study we investigated the age-related response of Phytohemaglutinin (PHA)-activated S phase human lymphocytes isolated from peripheral blood from donors of four different age groups, namely young (25-30 years), mid-aged (40-45 years), senior (60-65 years) and elderly (80-95 years) on the induction of th...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2003.12.014

    authors： Kypreou KP,Sourlingas TG,Sekeri-Pataryas KE

    更新日期：2004-04-01 00:00:00

  • Longevity-associated mitochondrial DNA 5178 A/C polymorphism modulates effects of daily drinking and cigarette consumption on serum triglyceride levels in middle-aged Japanese men.

    abstract：:Mitochondrial DNA 5178 adenine/cytosine (mt5178 A/C) polymorphism is one of the longevity-associated mitochondrial DNA polymorphisms. The frequency of the mt5178A genotype is significantly higher in Japanese centenarians than in the general population. We previously reported that serum high-density lipoprotein cholest...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/s0531-5565(03)00211-0

    authors： Kokaze A,Ishikawa M,Matsunaga N,Yoshida M,Sekine Y,Sekiguchi K,Satoh M,Harada M,Teruya K,Takeda N,Uchida Y,Tsunoda T,Takashima Y

    更新日期：2003-10-01 00:00:00

  • Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs.

    abstract：:The effects of long-term treatment with both antioxidants and a program of behavioral enrichment were studied as part of a longitudinal investigation of cognitive aging in beagle dogs. Baseline performance on a battery of cognitive tests was used to assign 48 aged dogs (9-12 years) into four cognitively equivalent gro...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2004.01.007

    authors： Milgram NW,Head E,Zicker SC,Ikeda-Douglas C,Murphey H,Muggenberg BA,Siwak CT,Tapp PD,Lowry SR,Cotman CW

    更新日期：2004-05-01 00:00:00

  • Intermittent bout exercise training down-regulates age-associated inflammation in skeletal muscles.

    abstract：:Aging is characterized by the progressive decline in mass and function of the skeletal muscle along with increased susceptibility to inflammation, oxidative stress, and atrophy. In this study, we investigate the effect of intermittent bout and single bout exercise training on inflammatory molecules in young (3 months)...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2015.11.001

    authors： Kim JS,Yi HK

    更新日期：2015-12-01 00:00:00

  • The brain: a vulnerable target.

    abstract：:This article addresses the description of several endocrine-related functions of the brain. It has emerged that steroids and growth factors may influence brain functions, and that brain cells may metabolize sex steroids. The crosstalk between different types of brain cells (neurons, astrocytes, the LHRH (luteinizing h...

    journal_title：Experimental gerontology

    pub_type： 杂志文章,评审

    doi：10.1016/s0531-5565(96)00172-6

    authors： Martini L,Melcangi RC

    更新日期：1997-07-01 00:00:00

  • Aging-related changes in myocardial purine metabolism and ischemic tolerance.

    abstract：:Impaired tolerance to ischemia-reperfusion in older hearts may stem in part from alterations in purine catabolism, impacting on maintenance of energy state and protective signaling via extracellular adenosine. We characterized effects of aging on normoxic and post-ischemic purine metabolism in hearts from young (2-4 m...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2003.08.003

    authors： Willems L,Garnham B,Headrick JP

    更新日期：2003-10-01 00:00:00

  • Different rates of telomere shortening and telomerase activity reduction in CD8 T and CD16 NK lymphocytes with ageing.

    abstract：:Telomeres are specialised structures located at the end of eukaryotic chromosomes, that get short during progressive cell divisions. Therefore, telomere may be an indicator of the mitotic history of a cell and it is also a determining factor for the residual cell life span. One mechanism, compensating for the telomere...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/s0531-5565(03)00058-5

    authors： Mariani E,Meneghetti A,Formentini I,Neri S,Cattini L,Ravaglia G,Forti P,Facchini A

    更新日期：2003-06-01 00:00:00

  • Effect of age on DNA binding of the ku protein in irradiated human peripheral blood mononuclear cells (PBMC).

    abstract：:DNA binding of the ku protein was investigated in peripheral blood mononuclear cells (PBMC) from 24 subjects of different ages (20-89 years old) displaying age-related changes in DNA repair, mitotic responsiveness, and cytokine production. Ku is an heterodimeric protein composed of two subunits of 70 and 80 kDa, which...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/s0531-5565(99)00026-1

    authors： Frasca D,Barattini P,Tirindelli D,Guidi L,Bartoloni C,Errani A,Costanzo M,Tricerri A,Pierelli L,Doria G

    更新日期：1999-08-01 00:00:00

  • Effects of estrogen replacement therapy on the circadian rhythms of serum cortisol and body temperature in postmenopausal women.

    abstract：:Estrogen replacement therapy (ERT) seems to enhance longevity in women. Both gender and aging have been shown to influence the regulation of circadian rhythms, yet little is known about the effect of ERT on circadian regulation. The aim of this study was to determine the effects of ERT (oral conjugated estrogen: Prema...

    journal_title：Experimental gerontology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0531-5565(99)00044-3

    authors： Gudmundsson A,Goodman B,Lent S,Barczi S,Grace A,Boyle L,Ershler WB,Carnes M

    更新日期：1999-09-01 00:00:00

  • Cognitive behavior and sensory function were significantly influenced by restoration of active ovarian function in postreproductive mice.

    abstract：:In mammals, the relationship between reproductive function and health has been particularly difficult to define. Previously, in old, postreproductive-aged mice, replacement of senescent ovaries with new ovaries from young, actively cycling mice increased life span. We hypothesized that the same factors that increased ...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2017.03.002

    authors： Parkinson KC,Peterson RL,Mason JB

    更新日期：2017-06-01 00:00:00