Abstract：
:Effects of glucagon and epinephrine stimulation on urea synthesis from lactate, pyruvate, NH4Cl, and ornithine in isolated rat hepatocytes from young and old rats were compared. It was found that the production of urea from those substrates was almost the same in both age groups. The concentrations of hormones that caused the maximum effect were the same for both groups of rats. The effectiveness of the stimulation of urea synthesis by glucagon and epinephrine was the same in hepatocytes isolated from young and old rats.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Kmieć Z,Myśliwski Adoi
10.1016/0531-5565(85)90052-xsubject
Has Abstractpub_date
1985-01-01 00:00:00pages
271-5issue
5eissn
0531-5565issn
1873-6815journal_volume
20pub_type
杂志文章abstract：:Atrophy of the thymus, the primary site of T lymphocyte generation, is a hallmark of the aging immune system. Age-associated thymic atrophy results in diminished output of new, naïve T cells, with immune sequelae that include diminished responses to novel pathogenic challenge and vaccines, as well as diminished tumor ...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2017.12.022
更新日期：2018-05-01 00:00:00
abstract：:Temporal discounting occurs when a greater delayed reward is forsaken for a smaller immediate reward, and has been associated with a number of financial and health care outcomes important for older adults. Using resting-state fMRI and seed regions of interest in the left and right fronto-insular (FI) cortices, we expl...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.10.003
更新日期：2013-12-01 00:00:00
abstract：:The age-dependent modifications of both basal and lymphokine-induced natural killer (NK) activity were analyzed in Balb/c inbred mice by measuring either the percentage of specific lytic activity in a 51 Cr release assay or the percentage of cells capable of binding the YAC-1 target cells. The basal lytic activity of ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(89)90014-4
更新日期：1989-01-01 00:00:00
abstract：:Since the reproducible production of microscope objectives was enabled by the lens calculations of Ernst Abbe in 1872, various attempts have been made to further increase the resolution of light microscopes. Apart from the improvements on the optical side, especially the introduction of fluorescence methods, the use o...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(01)00087-0
更新日期：2001-07-01 00:00:00
abstract：:Delirium is an acute-onset syndrome that exacerbates patients' condition and significantly increases consequential morbidity and mortality. There is no comprehensive, cellular and tissue-level, pathophysiological theory. The melatonin hormone imbalance has been shown to be linked to circadian rhythms, sleep-wake cycle...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2015.09.007
更新日期：2015-12-01 00:00:00
abstract：:Calorie restriction (CR) and a reduced growth hormone (GH) signal affect insulin sensitivity and lifespan in mammals in a similar manner. We investigated the effects of CR and moderate inhibition of GH on glucose-stimulated activation of insulin signaling and the expression of genes related to fat metabolism in white ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2009.07.002
更新日期：2009-10-01 00:00:00
abstract：:Reductive stress, which is due to a paradoxical excess of antioxidants such as reduced glutathione (GSH) and GSH-related enzymes associated with decreased oxidant levels, has emerged as a pathogenetic mechanism of myocardial damage in pathological conditions such as protein aggregation cardiomyopathy. Notably, in the ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2020.110871
更新日期：2020-02-06 00:00:00
abstract：:Maintaining physical mobility is important for preventing age-related comorbidities in older adults. Endurance and resistance training prevent mobility loss in aging, but exercise alone does not always achieve the expected improvements in physical and cardiopulmonary function. Recent preclinical evidence suggests that...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2020.110972
更新日期：2020-08-01 00:00:00
abstract：:Lipids constitute a significant group of biological metabolites and the building blocks of all cell membranes. The abundance and stoichiometries of different lipid species are known to vary across the lifespan and metabolic state, yet the functional effects of these changes have been challenging to understand. Here we...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2019.110817
更新日期：2020-03-01 00:00:00
abstract：OBJECTIVE:Aging has been reported to be associated with changes in immune function. Although frequent infection and the development of malignancy suggest the decline of immune function with aging, changes toward proinflammatory conditions also develop at the same time. Th17 cells are well known CD4(+) T cell subpopulat...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.10.006
更新日期：2014-01-01 00:00:00
abstract：:There is accumulating evidence that oxidative stress plays an important role in aging. Our previous phosphoproteomic study of the human neuroblastoma cell line SH-SY5Y revealed changes in the phosphorylation of several proteins such as lamin A/C during 6-hydroxydopamine-induced oxidative stress. The present study empl...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2009.02.009
更新日期：2009-06-01 00:00:00
abstract：:Reflective of age-associated decline in immune function among elderly individuals is a decrease in in vitro T cell proliferative ability. Impaired T cell proliferation in the elderly may result from disruption of the well-balanced network of regulatory cytokines produced during an immune response. The purpose of this ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(98)00064-3
更新日期：1999-04-01 00:00:00
abstract：BACKGROUND:Oxidative stress and inflammation may contribute to anabolic resistance in response to protein and exercise in older adults. We investigated whether consumption of montmorency cherry concentrate (MCC) increased anabolic sensitivity to protein ingestion and resistance exercise in healthy older men. METHODS:S...
journal_title：Experimental gerontology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.exger.2018.06.007
更新日期：2018-09-01 00:00:00
abstract：:Aging is characterized by the progressive decline in mass and function of the skeletal muscle along with increased susceptibility to inflammation, oxidative stress, and atrophy. In this study, we investigate the effect of intermittent bout and single bout exercise training on inflammatory molecules in young (3 months)...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2015.11.001
更新日期：2015-12-01 00:00:00
abstract：:The observation that long-lived and relatively healthy animals can be obtained by simple genetic manipulation prompts the search for chemical compounds that have similar effects. Since aging is the most important risk factor for many socially and economically important diseases, the discovery of a wide range of chemic...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2008.08.049
更新日期：2008-10-01 00:00:00
abstract：:A summary of the Eleventh International Symposium on the Neurobiology and Neuroendocrinology of Aging that was held in July 29-August 3 in Bregenz, Austria, is presented. Sixteen of the speakers who presented at the conference submitted review papers covering the topic of their presentation as well as an overview of t...
journal_title：Experimental gerontology
pub_type： 社论
doi：10.1016/j.exger.2013.01.003
更新日期：2013-07-01 00:00:00
abstract：:Accumulation of altered proteins is the most common molecular symptom of ageing. Altered proteins are also associated with many age-related pathologies. Altered proteins are continuously produced but are normally selectively degraded by cellular proteases; their accumulation during ageing may be explained by either or...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2006.03.004
更新日期：2006-05-01 00:00:00
abstract：:The intrinsic contractile properties of papillary muscles isolated from female Wistar rats during post-natal development were examined. In addition, the myocardial responsiveness to certain inotropic interventions was studied. In muscles from 60-day-old animals, the velocity of shortening was markedly greater than mus...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(82)90025-0
更新日期：1982-01-01 00:00:00
abstract：:Rodent animal models take at least 18months to develop aging phenotypes for researchers to investigate the mechanism of age-related metabolic complications. Senescence-accelerated mouse prone 8 (SAMP8) shortens the process of aging and may facilitate an alternative model for studying age-related insulin resistance. Th...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2017.08.023
更新日期：2017-12-01 00:00:00
abstract：:Every organism must adapt and respond appropriately to the source of nutrients available in its environment. Different mechanisms and pathways are involved in detecting the intracellular and extracellular levels of macronutrients including amino acids. Detection of amino acids in food sources is provided by taste cell...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2018.11.021
更新日期：2019-01-01 00:00:00
abstract：:Adult Premature Aging Mice (PAM) show premature immunosenescence, oxidative and inflammatory stress and consequently a shorter lifespan than Exceptional Non-Prematurely Aging Mice (E-NPAM) at the same age. Indeed, adult female PAM exhibit behavioral age-related declines and abnormalities in its brain neurochemistry. N...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2020.111224
更新日期：2020-12-31 00:00:00
abstract：BACKGROUND:Low muscle strength (dynapenia) is a primary characteristic of sarcopenia, the age-related loss of muscle mass and strength or low walking speed. New evidence suggests that muscle strength positively affects blood pressure (BP) responses to exercise. As older adults with lowest handgrip strength also have lo...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2020.110984
更新日期：2020-09-01 00:00:00
abstract：:Aging is associated with a progressive decline of muscle mass, strength, and quality, a condition described as sarcopenia of aging. Despite the significance of skeletal muscle atrophy, the mechanisms responsible for the deterioration of muscle performance are only partially understood. The purpose of this review is to...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2008.05.003
更新日期：2009-01-01 00:00:00
abstract：:The mechanisms responsible for age-associated hearing loss are still incompletely characterized. In this study, we used a murine model of age-dependent hearing loss and evaluated whether this condition is associated with vascular modifications of the structures of the inner ear. We used old C57BL/6J mice that are affe...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2004.06.003
更新日期：2004-08-01 00:00:00
abstract：:Histological surveys of the hearts of guppies Poecilia reticulatus throughout their lifespan showed no aging changes until the fish were three years old. In younger fishes the hearts were healthy, even in three individuals with "wasting" disease, where there was considerable loss of muscle throughout the body. There w...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(84)90048-2
更新日期：1984-01-01 00:00:00
abstract：:Several papers reported in recent years on a change in the age population distribution of the circulating erythrocytes in old mice, rats, rabbits, and humans. The results indicate the presence of a chronologically younger cell population in old animals and humans. The cells are typically lower in density and larger. I...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(92)90055-5
更新日期：1992-01-01 00:00:00
abstract：:This article gives some information on the French research on aging using a survey of the European Commission on research on aging in Europe and the answers to a questionnaire sent to the laboratories involved in aging research. France is involved in the European effort, but to a lesser degree than could be expected f...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(00)00164-9
更新日期：2000-10-01 00:00:00
abstract：THE AIM:The aim of this study was to determine whether polymorphisms of the VDR gene may increase the risk of Alzheimer disease (AD) development in Lower Silesian patients in comparison with other populations. MATERIAL AND METHODS:108 AD patients (aged 73.7±8.6) vs 77 healthy volunteers (aged 64.5±7.8) in the Lower Si...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2015.06.012
更新日期：2015-09-01 00:00:00
abstract：:Dystrophin-deficiency causes cardiomyopathies and shortens the life expectancy of Duchenne and Becker muscular dystrophy patients. Restoring Dystrophin expression in the heart by gene transfer is a promising avenue to explore as a therapy. Truncated Dystrophin gene constructs have been engineered and shown to alleviat...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.10.015
更新日期：2014-01-01 00:00:00
abstract：:Life history theory proposes that menopause is either an epiphenomenon or an adaptation. The most recent adaptive hypothesis proposes that menopause in humans has evolved because of conflict between reproducing generations (RCH). Overlapping reproduction between generations may impose fitness costs to older and younge...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.02.001
更新日期：2013-04-01 00:00:00
