Abstract：
:Estrogen replacement therapy (ERT) seems to enhance longevity in women. Both gender and aging have been shown to influence the regulation of circadian rhythms, yet little is known about the effect of ERT on circadian regulation. The aim of this study was to determine the effects of ERT (oral conjugated estrogen: Premarin, 0.625 mg) for 6-8 weeks on circadian serum cortisol by continuous blood sampling every 15 min for 24 h with simultaneous measurements of body temperature in six healthy postmenopausal women (range, 54-61 years). The results are presented as median values (range in quartiles). The circadian amplitude of cortisol increased during ERT from 20.20 (18.35, 23.61) to 25.97 (24.94, 27.74) microg/dL (p = 0.016), whereas the timing of nocturnal nadir and morning acrophase did not differ significantly. ERT lowered the 24-h body temperature from 37.03 degrees C (36.95 degrees C, 37.07 degrees C) to 36.90 degrees C (36.77 degrees C, 36.97 degrees C) (p = 0.038), but did not alter the peak and trough body temperatures significantly. These findings are noteworthy because the increased circadian amplitude of serum cortisol during ERT contrasts with the reduction in circadian amplitude seen with normal aging. The reduction in body temperature confirms the regulatory effect of ERT in thermoregulation and has implications regarding the correlation between basal metabolic rate and life span.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Gudmundsson A,Goodman B,Lent S,Barczi S,Grace A,Boyle L,Ershler WB,Carnes Mdoi
10.1016/s0531-5565(99)00044-3keywords:
subject
Has Abstractpub_date
1999-09-01 00:00:00pages
809-18issue
6eissn
0531-5565issn
1873-6815pii
S0531-5565(99)00044-3journal_volume
34pub_type
临床试验,杂志文章abstract：OBJECTIVES:To investigate whether the implementation of a multifactorial falls intervention in nursing homes is cost-beneficial and alleviates the professional workload. DESIGN:A comprehensive quantitative model was developed to calculate the impact of investments in multifactorial falls prevention in nursing homes in...
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pub_type： 杂志文章
doi：10.1016/j.exger.2020.111173
更新日期：2021-01-01 00:00:00
abstract：:Long-term caloric restriction (CR) has been shown to extend maximum life span in laboratory rodents. We investigated the activities of gluconeogenic and transaminase enzymes in the livers of old and young mice fed either control or calorie-restricted diets. Livers were sampled 48 h after the last scheduled feeding tim...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(02)00202-4
更新日期：2003-03-01 00:00:00
abstract：:Aging is an independent risk factor for the development of atherosclerosis, a vascular abnormality that plays a significant role in the development of many cardiovascular disorders. Animal experiments have demonstrated that aging predisposes the vasculature to advanced atherosclerotic disease and vessel injury and tha...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(99)00036-4
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2016.09.007
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2010.11.007
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
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更新日期：1997-07-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(00)00210-2
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/0531-5565(94)90009-4
更新日期：1994-05-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2018.09.011
更新日期：2018-10-02 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2018-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2017-10-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2009.07.002
更新日期：2009-10-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2015.06.007
更新日期：2015-09-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(90)90020-3
更新日期：1990-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2008.05.015
更新日期：2008-08-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(97)00113-7
更新日期：1998-05-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2004.10.002
更新日期：2005-03-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2015.08.008
更新日期：2015-11-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.07.015
更新日期：2013-11-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
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更新日期：2017-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2012-09-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2004.03.036
更新日期：2004-07-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2009.06.008
更新日期：2009-09-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
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更新日期：2007-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：1987-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(96)00172-6
更新日期：1997-07-01 00:00:00
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journal_title：Experimental gerontology
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更新日期：2005-07-01 00:00:00
