Abstract:
:Acute illness requiring hospitalization is a sentinel event leading to functional decline and frequently, long-term disability in older adults. Although functional decline has become a key outcome during and after hospitalization, there is currently no gold standard for measuring functional impairment. The purpose of this study was to compare gait characteristics and muscle performance endpoints of hospitalized older adults based on the Short Physical Performance Battery (SPPB) score (0-12 points) obtained at admission, and to determine the association underlying the gait impairment. A total of 130 hospitalized older adults (aged ≥75) were included. The primary endpoints were differences in functional capacity between groups, assessed with the 6-m Gait Velocity Test (GVT), verbal and arithmetic GVT, followed by gait pattern data recorded using an inertial sensor unit. Maximal muscle strength (MS) and muscle power (MP) were also measured as muscle performance endpoints. A mediation analysis was performed to understand gait disorders. The walking parameters measured at admission were related to functional status and showed significant differences among phenotype groups (disabled, frail, and prefrail groups), as well as muscle performance endpoints (p < 0.05). Finally, the indirect effect was significant (-0.27; 95%CI, -0.59 to -0.05), confirming the mediation role of MP between gait variability and gait velocity in this model. MP slightly weakens the relationship between gait variability and gait velocity. In addition to MS and MP, gait velocity and gait pattern parameters are distinguishing factors among acutely hospitalized older adults.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Sáez de Asteasu ML,Martínez-Velilla N,Zambom-Ferraresi F,Casas-Herrero Á,Ramirez-Vélez R,Izquierdo Mdoi
10.1016/j.exger.2019.110631subject
Has Abstractpub_date
2019-09-01 00:00:00pages
110631eissn
0531-5565issn
1873-6815pii
S0531-5565(19)30339-0journal_volume
124pub_type
杂志文章abstract::Physical activity has been associated with alterations in telomere length, a potential indicator of biological aging, but several inconsistencies exist. Our aim was to investigate the associations between physical activity in midlife and leukocyte telomere length (LTL) measured in old age in the Helsinki Businessmen S...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2012.02.003
更新日期:2013-01-01 00:00:00
abstract::Coenzyme Q10 supplementation increases life-span of rats fed on a diet enriched with polyunsaturated fatty acids (Quiles, J.L., Ochoa, J.J., Huertas, J.R., Mataix, J., 2004b. Coenzyme Q supplementation protects from age-related DNA double-strand breaks and increased lifespan in rats fed on a PUFA-rich diet. Exp. Geron...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2005.07.003
更新日期:2005-08-01 00:00:00
abstract::A crucial assumption of evolutionary theories of aging is that age-specific differences of life history traits may have genetic causes. The present study focuses on the existence of such differences between eight freshly caught populations of Drosophila melanogaster. A highly significant differentiation of the populat...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(96)00073-3
更新日期:1996-11-01 00:00:00
abstract::For more than 60 years the only dietary manipulation known to retard aging was caloric restriction, in which a variety of species respond to a reduction in energy intake by demonstrating extended median and maximum life span. More recently, two alternative dietary manipulations have been reported to also extend surviv...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(02)00149-3
更新日期:2003-01-01 00:00:00
abstract::MCP-1 and RANTES are molecules that regulate monocyte and T-lymphocyte recruitment towards sites of inflammation. We sought to evaluate the role of these chemokines in Alzheimer's disease (AD), and the effect of acetylcholinesterase inhibitor (AchEI) therapy on their release from peripheral blood mononuclear cells (PB...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2005.04.007
更新日期:2005-07-01 00:00:00
abstract::The effect of 3-(4-pyridyl)-1,2,4-thiotriazolyl 5-mercaptoacetic acid kalium salt (Rumosol) and 3-(4-pyridyl)-1,2,4-thiotriazolyl 5-mercaptoacetic acid morpholinium salt (drug 2) on the concentration of Schiff base in myocardium of adult (10-12 months) and old (22-25 months) Wistar rats during immobilized stress were ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(01)00181-4
更新日期:2002-04-01 00:00:00
abstract::Rodent animal models take at least 18months to develop aging phenotypes for researchers to investigate the mechanism of age-related metabolic complications. Senescence-accelerated mouse prone 8 (SAMP8) shortens the process of aging and may facilitate an alternative model for studying age-related insulin resistance. Th...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2017.08.023
更新日期:2017-12-01 00:00:00
abstract::It is now widely recognized that in order to optimize bone health in the later years, bone healthy behaviors should begin at a young age and continue throughout life. Prescribed orally to lower lipid levels in adults of all ages, statins have also been shown to stimulate bone formation in vitro by promoting bone morph...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2013.04.007
更新日期:2013-08-01 00:00:00
abstract::Orally-administered catechin has long been known to have several beneficial effects on the mammalian host, however, the effects of orally supplemented catechin on the host through gingival tissues have not yet been established. Here, we elucidated the effects of orally supplemented catechin in the rat heart blood mito...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2013.08.014
更新日期:2013-11-01 00:00:00
abstract::We determined the contribution of body fat distribution, peak VO2, fat mass, and dietary intake to variation in plasma lipids in elderly individuals. Volunteers were a healthy cohort of older Caucasian women (n = 75, mean age +/- SD, 72 +/- 5 years) and older men (n = 101, 72 +/- 5 years). We determined fat mass from ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(97)00052-1
更新日期:1997-11-01 00:00:00
abstract::Fatigue is a common complaint in older people. Laboratory-induced muscle fatigue has been found to affect physical functions in older populations but these protocols are rigorous and are unlikely to accurately reflect daily activities. This study used an ecological approach to determine the effects of a busy day on se...
journal_title:Experimental gerontology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.exger.2018.03.009
更新日期:2018-06-01 00:00:00
abstract::Aging is characterized by the progressive decline in mass and function of the skeletal muscle along with increased susceptibility to inflammation, oxidative stress, and atrophy. In this study, we investigate the effect of intermittent bout and single bout exercise training on inflammatory molecules in young (3 months)...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2015.11.001
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVES:The present study investigated whether the performance on executive function tasks of patients with type 2 diabetes mellitus (T2DM) is as impaired as that of Alzheimer's disease (AD) patients and to compare their performance with that of a group of cognitively healthy older adults. We also investigated wheth...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2016.07.013
更新日期:2016-10-01 00:00:00
abstract::While it may be possible to employ panels of molecular parameters which correlate with senescence in vivo or in vitro, in a manner analogous to the use of mutagenesis assays for economic carcinogen screening, such an endeavor would at present be impeded by the absence of a clear mechanistic rationale for focusing on p...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/0531-5565(88)90030-7
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVES:We explored the male-female health-survival paradox in the context of health expectancy (HE) at age 65 and thereafter, using three different morbidity measures and different severity cut-offs with and without adjustments for the share of nursing home residents. METHODS:HE at ages 65, 70, 75, 80, and 85 was ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2020.111196
更新日期:2021-03-01 00:00:00
abstract:OBJECTIVES:To investigate whether the implementation of a multifactorial falls intervention in nursing homes is cost-beneficial and alleviates the professional workload. DESIGN:A comprehensive quantitative model was developed to calculate the impact of investments in multifactorial falls prevention in nursing homes in...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2020.111173
更新日期:2021-01-01 00:00:00
abstract::The TOR kinase pathway is central in modulating aging in a variety of animal models. The target of rapamycin (TOR) integrates a complex network of signals from growth conditions, nutrient availability, energy status, and physiological stresses and matches an organism's growth rate to the resource environment. Importan...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2014.01.022
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:The World Health Organization (WHO) recently proposed an innovative model of care focusing on functional rather than disease-based perspectives, based on a construct of intrinsic capacity (IC). OBJECTIVE:This study aimed to analyze if low-grade inflammation (LGI) (chronically raised C-reactive protein - CRP...
journal_title:Experimental gerontology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.exger.2019.110716
更新日期:2019-11-01 00:00:00
abstract::Aging is one of the most basic properties of living organisms. Abundant evidence supports the idea that cell senescence underlies organismal aging in higher mammals. Therefore, examining the molecular mechanisms that control cell and replicative senescence is of great interest for biology and medicine. Several discove...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2010.01.009
更新日期:2010-03-01 00:00:00
abstract::There are three general categories of causes of the cognitive decline associated with aging: disuse, disease, and aging per se. People tend to use certain skills or abilities less with age and, thus, those skills decline due to the disuse. Physical illnesses tend to increase with age, which will tend to compromise cog...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/0531-5565(94)00066-c
更新日期:1995-05-01 00:00:00
abstract::A colony of male Lakeview Golden (LVG) Syrian hamsters has been maintained for the last nine years as a source of various tissues for cellular aging studies. Observations on this colony also yielded data on survival time and physical and pathological manifestations of aging in this strain. Based on 150 spontaneous dea...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(90)90032-w
更新日期:1990-01-01 00:00:00
abstract::Apolipoprotein E knockout (apoE-KO) mice have been utilized for decades as a model of atherosclerosis. However, in addition to atherosclerosis, apoE-KO mice develop extensive cutaneous xanthomatosis, accelerated skin aging and frailty when fed a high fat diet. Granzyme B (GrB) is a pro-apoptotic serine protease that h...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2011.02.004
更新日期:2011-06-01 00:00:00
abstract::Alterations in heparan sulfate, the principal glycosaminoglycan species in glomerular basement membrane, have been proposed as contributory to permeability changes in nephropathic disorders. In the present study, the extent of sulfation of glycosaminoglycans isolated from pronase digests of human glomerular basement m...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(83)90023-2
更新日期:1983-01-01 00:00:00
abstract::We develop a theoretical model from an energetic viewpoint for unraveling the entangled effects of metabolic and biosynthetic rates on oxidative cellular damage accumulation during animal's growth, and test the model by experiments in hornworms. The theoretical consideration suggests that most of the cellular damages ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2016.05.015
更新日期:2016-09-01 00:00:00
abstract::The leucine-rich repeat transmembrane 3 (LRRTM3) has been defined as a positional and functional candidate gene for Alzheimer's disease. Recently, four novel variants (rs16923760, rs1925608, rs1925609 and rs10997477) within LRRTM3 were reported to be associated with late-onset Alzheimer's disease (LOAD) in Caucasians....
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2014.01.013
更新日期:2014-04-01 00:00:00
abstract::Intrinsic exercise capacity is predictive of both lifespan and healthspan but whether adaptive exercise capacity influences the benefits achieved from aerobic training implemented later in life is not known. AIM:To determine if exercise late in life provides any functional improvements or underlying beneficial bioche...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2019.110657
更新日期:2019-10-01 00:00:00
abstract::There is currently no test to directly and easily measure dynamic balance during walking in old adults. We examined the idea that distance of beam walking with and without cognitive dual-tasking could detect age differences in dynamic balance. Healthy old (n = 16, 71.2 y) and young (n = 20, 22.0 y) volunteers walked 3...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2018.10.016
更新日期:2018-12-01 00:00:00
abstract::Previous studies have indicated that genetic variations in the factors of insulin/insulin-like growth factor 1 (IGF-1) signaling pathway could influence human life-span by affecting IGF-1 levels. The promoter region of the IGF-1 gene is an obvious candidate and has not been studied clearly. To explore the potential ro...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2008.08.004
更新日期:2008-10-01 00:00:00
abstract::SAMP8 mice exhibit multiple metabolic characteristics associated with age, and it is a suitable candidate for researching aging associated metabolic dysfunction. OBJECTIVES:We aimed to 1) explore how key metabolic markers will be altered in both liver and adipose tissue with aging in SAMP8 mice; and 2) how the combin...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2017.03.017
更新日期:2017-07-01 00:00:00
abstract::While influenza immunization significantly reduces the risk of pneumonia and associated deaths, vaccination of elderly only affords 30-50% protection against influenza disease. The purpose of this study was to: (1) evaluate the consistency of immune responses across multiple years in young and elderly; (2) determine t...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(01)00210-8
更新日期:2002-01-01 00:00:00