Abstract：
:We determined the contribution of body fat distribution, peak VO2, fat mass, and dietary intake to variation in plasma lipids in elderly individuals. Volunteers were a healthy cohort of older Caucasian women (n = 75, mean age +/- SD, 72 +/- 5 years) and older men (n = 101, 72 +/- 5 years). We determined fat mass from underwater weighing, fat patterning from waist circumference, as well as peripheral and truncal skinfolds, exercise capacity from peak VO2, and dietary intake from three-day food diaries. Plasma lipid levels were measured in the fasting state and included total cholesterol, high density lipoprotein (HDL-C), low density lipoprotein (LDL-C), and fasting triglycerides. Older women weighted less than older men, but had higher fat mass, truncal, and peripheral skinfolds. Waist circumference and peak VO2 were lower in older women than older men. Older women had higher total cholesterol (217 +/- 31 vs. 197 +/- 30; p < 0.01), HDL-C (54 +/- 12 vs. 49 +/- 14; p < 0.05), and LDL-C (133 +/- 26 vs. 121 +/- 27; p < 0.01) when compared with older men. No gender differences were noted in fasting triglycerides. Truncal skinfolds were the best predictor of plasma lipids in older men, accounting for between 9% and 30% (r2) of the variation in plasma lipids. Similarly, in older women, central markers of fatness (i.e., waist circumference and truncal skinfolds) were the best predictors of plasma lipids (r2 = 3% to 24%). Total fat mass, peak VO2 and dietary intake were not independent predictors of plasma lipids in older men and women. Indices of central body fatness, rather than total fat mass, peak VO2 or dietary intake are stronger predictors of plasma lipids in healthy older men and women.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Obisesan TO,Toth MJ,Ades PA,Poehlman ETdoi
10.1016/s0531-5565(97)00052-1subject
Has Abstractpub_date
1997-11-01 00:00:00pages
643-51issue
6eissn
0531-5565issn
1873-6815pii
S0531556597000521journal_volume
32pub_type
杂志文章abstract：:The effect of age on brain muscarinic receptor density is unclear. Some in vivo neuroimaging studies have reported a large age-related reduction in muscarinic receptor density; however, others have reported increases or no change. The variability in these results most likely arises because of the heterogeneity of the ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2004.10.002
更新日期：2005-03-01 00:00:00
abstract：:Diabetic peripheral neuropathy (DPN) is associated with peripheral arterial disease and endothelial dysfunction. We investigated the effect of exercise training on the measures of superficial femoral artery (SFA) and neuropathic symptoms in patients with DPN. In a randomized-controlled trial, 31 volunteers with establ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2019.110799
更新日期：2020-03-01 00:00:00
abstract：:This article gives some information on the French research on aging using a survey of the European Commission on research on aging in Europe and the answers to a questionnaire sent to the laboratories involved in aging research. France is involved in the European effort, but to a lesser degree than could be expected f...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(00)00164-9
更新日期：2000-10-01 00:00:00
abstract：OBJECTIVES:We explored the male-female health-survival paradox in the context of health expectancy (HE) at age 65 and thereafter, using three different morbidity measures and different severity cut-offs with and without adjustments for the share of nursing home residents. METHODS:HE at ages 65, 70, 75, 80, and 85 was ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2020.111196
更新日期：2021-03-01 00:00:00
abstract：:Male F344 rats, 3, 12, and 24 months of age, were acclimated to either 5 degrees C (CA) or 23 degrees C (non-CA). At the end of acclimation, all CA rats exhibited higher basal oxygen uptake than the non-CA when measured at 28 degrees C. When challenged by a 3-hour exposure to -10 degrees C, significant difference in t...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(85)90038-5
更新日期：1985-01-01 00:00:00
abstract：:Methionine restriction (MR) extends lifespan across different species. The main responses of rodent models to MR are well-documented in adipose tissue (AT) and liver, which have reduced mass and improved insulin sensitivity, respectively. Recently, molecular mechanisms that improve healthspan have been identified in b...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2017.01.012
更新日期：2017-08-01 00:00:00
abstract：:Alterations in the hypothalamic-pituitary-gonadal axis in females determine the transition from regular to irregular reproductive cycles, with loss of fertility. Stimulation of noradrenergic neurons of the anteroventral periventricular neurons (AVPV) is essential for regular reproductive cycles. Therefore, we examined...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2015.10.003
更新日期：2015-12-01 00:00:00
abstract：:While it may be possible to employ panels of molecular parameters which correlate with senescence in vivo or in vitro, in a manner analogous to the use of mutagenesis assays for economic carcinogen screening, such an endeavor would at present be impeded by the absence of a clear mechanistic rationale for focusing on p...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/0531-5565(88)90030-7
更新日期：1988-01-01 00:00:00
abstract：:Effects of glucagon and epinephrine stimulation on urea synthesis from lactate, pyruvate, NH4Cl, and ornithine in isolated rat hepatocytes from young and old rats were compared. It was found that the production of urea from those substrates was almost the same in both age groups. The concentrations of hormones that ca...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(85)90052-x
更新日期：1985-01-01 00:00:00
abstract：:Rapamycin consistently increases longevity in mice although the mechanism of action of this drug is unknown. In the present investigation we studied the effect of rapamycin on mitochondrial oxidative stress at the same dose that is known to increase longevity in mice (14mgofrapamycin/kg of diet). Middle aged mice (16m...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2016.08.002
更新日期：2016-10-01 00:00:00
abstract：:Lipids constitute a significant group of biological metabolites and the building blocks of all cell membranes. The abundance and stoichiometries of different lipid species are known to vary across the lifespan and metabolic state, yet the functional effects of these changes have been challenging to understand. Here we...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2019.110817
更新日期：2020-03-01 00:00:00
abstract：AIM:Sirtuins are proteins that connect energy metabolism, oxidative stress and aging. Expression of heat shock proteins (Hsps) is regulated by heat shock factors (HSFs) in response to various environmental and physiological stresses, such as oxidative stress. Oxidative stress accumulates during aging which makes cells ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2016.03.015
更新日期：2016-06-15 00:00:00
abstract：:The long life spans and slow aging rates of birds relative to mammals are paradoxical in view of birds' high metabolic rates, body temperatures and blood glucose levels, all of which are predicted to be liabilities by current biochemical theories of aging. Available avian life-table data show that most birds undergo r...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(00)00247-3
更新日期：2001-04-01 00:00:00
abstract：:We investigated the effect of resistance training on irisin expression with improvement in muscle strength and function in aged mice and human. In the mice study, 19 months old male C57BL/6 mice were randomly assigned into two groups; control group and resistance exercise group. Ladder climbing exercise with tail weig...
journal_title：Experimental gerontology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.exger.2015.07.006
更新日期：2015-10-01 00:00:00
abstract：:Increasing evidence suggests an important role of mitochondrial dysfunction in the pathogenesis of many common age-related neurodegenerative diseases, including Alzheimer's disease (AD). AD is the most common neurodegenerative disorder characterized by dementia, memory loss, neuronal apoptosis and eventually death of ...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2006.03.012
更新日期：2006-07-01 00:00:00
abstract：:The essentiality of zinc for humans was recognized only 40 years ago. Zinc deficiency was suspected to occur in Iranian patients with growth retardation, hypogonadism in males, hepato-splenomegaly, rough and dry skin, geophagia and severe iron deficiency anemia. Later we documented zinc deficiency in similar patients ...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2007.10.013
更新日期：2008-05-01 00:00:00
abstract：:Aging is associated with changes in several metabolic pathways affecting liver function including the adaptive unfolded protein response (UPR). On the other hand, exercise training has been shown to exert beneficial effects on metabolism in the liver and exercise training has been reported to affect hepatic UPR. PGC-1...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2017.08.006
更新日期：2017-11-01 00:00:00
abstract：:Stiffening of large elastic arteries with age increases the risk of cardiovascular diseases (CVD), but the underlying mechanisms are incompletely understood. We investigated the role of mitochondrial quality control (QC, i.e., mitophagy and biogenesis) in arterial stiffening with aging. In C57BL6 mice, aging was assoc...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2014.07.008
更新日期：2014-10-01 00:00:00
abstract：:There are three general categories of causes of the cognitive decline associated with aging: disuse, disease, and aging per se. People tend to use certain skills or abilities less with age and, thus, those skills decline due to the disuse. Physical illnesses tend to increase with age, which will tend to compromise cog...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/0531-5565(94)00066-c
更新日期：1995-05-01 00:00:00
abstract：:Initial velocity of GABA uptake in hypothalamic synaptosomes has been measured in aged animals as a function of both sodium and GABA concentration and compared to previous studies in young animals. The data give good fit to the model found previously to give minimal best fit to control data. Thus it appears that aging...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(83)90005-0
更新日期：1983-01-01 00:00:00
abstract：:According to the free radical theory of aging, free radicals are involved in the production of changes in cellular metabolism that lead to a time-dependent functional decline in all living beings. Consequently, antioxidant and/or free radicals scavengers may retard the aging process. We explored the effect of melatoni...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(01)00229-7
更新日期：2002-05-01 00:00:00
abstract：:The leucine-rich repeat transmembrane 3 (LRRTM3) has been defined as a positional and functional candidate gene for Alzheimer's disease. Recently, four novel variants (rs16923760, rs1925608, rs1925609 and rs10997477) within LRRTM3 were reported to be associated with late-onset Alzheimer's disease (LOAD) in Caucasians....
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2014.01.013
更新日期：2014-04-01 00:00:00
abstract：:Life history theory proposes that menopause is either an epiphenomenon or an adaptation. The most recent adaptive hypothesis proposes that menopause in humans has evolved because of conflict between reproducing generations (RCH). Overlapping reproduction between generations may impose fitness costs to older and younge...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.02.001
更新日期：2013-04-01 00:00:00
abstract：:We have isolated a senescence-specific clone (pSEN) from a cDNA library constructed from late passage WI-38 human diploid fibroblast that accounts for approximately 1% of the recombinants. Nucleotide sequence analysis of the partial cDNA clone has led to the identification of pSEN as elongation factor I alpha. Norther...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(89)90056-9
更新日期：1989-01-01 00:00:00
abstract：:Despite general belief that the mechanical properties of bone material contribute to whole bone strength, it is still obscure what the age effects are on mechanical behavior of the bone material, particularly in the case of the femoral neck trabeculae. In this study, atomic force microscopy was used for imaging and me...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2011.11.011
更新日期：2012-02-01 00:00:00
abstract：:Collagens and elastin are 'building blocks' of tissues and extracellular matrix. Mutations in these proteins cause severe congenital syndromes. Adverse genetic variations may accelerate the aging process in adults contributing to premature morbidity, disability and/or mortality. Favorable variants may contribute to lo...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2019.110781
更新日期：2020-01-01 00:00:00
abstract：:SAMP8 mice exhibit multiple metabolic characteristics associated with age, and it is a suitable candidate for researching aging associated metabolic dysfunction. OBJECTIVES:We aimed to 1) explore how key metabolic markers will be altered in both liver and adipose tissue with aging in SAMP8 mice; and 2) how the combin...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2017.03.017
更新日期：2017-07-01 00:00:00
abstract：:Replicative senescence appears after a finite number of cell divisions. After proliferation has ceased, senescent cells remain viable for long periods and metabolic modifications are observed such as lipofuscin accumulation. In order to understand this phenomenon, we examined the emergence of subcellular modifications...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(03)00132-3
更新日期：2003-08-01 00:00:00
abstract：:Dystrophin-deficiency causes cardiomyopathies and shortens the life expectancy of Duchenne and Becker muscular dystrophy patients. Restoring Dystrophin expression in the heart by gene transfer is a promising avenue to explore as a therapy. Truncated Dystrophin gene constructs have been engineered and shown to alleviat...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.10.015
更新日期：2014-01-01 00:00:00
abstract：:Several factors involved in regulation of bone mineral metabolism were compared in male and female Fischer 344 rats of different ages (1, 2.5, 6, and 18 months). Plasma 1,25-(OH)2D3 concentrations decreased with age in rats of both genders. Abundance of calbindin-D28K and its mRNA in kidney and calbindin-D9K and its m...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(95)00014-3
更新日期：1995-11-01 00:00:00
