Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins.

abstract：:Maintaining physical mobility is important for preventing age-related comorbidities in older adults. Endurance and resistance training prevent mobility loss in aging, but exercise alone does not always achieve the expected improvements in physical and cardiopulmonary function. Recent preclinical evidence suggests that...

journal_title：Experimental gerontology

authors： Custodero C,Saini SK,Shin MJ,Jeon YK,Christou DD,McDermott MM,Leeuwenburgh C,Anton SD,Mankowski RT

更新日期：2020-08-01 00:00:00

abstract：:Life table aging rate (LAR) is defined as the age-specific rate of mortality change with age and corresponds to the first derivative or slope of the mortality schedule at each age. We computed the sex-specific LARs for 167 Medfly cohorts, containing a total of approximately 600,000 individuals of each sex. We found th...

journal_title：Experimental gerontology

authors： Carey JR,Liedo P

更新日期：1995-05-01 00:00:00

abstract：OBJECTIVES:To examine the individual association between BMI and level of serum uric acid (SUA) among the very elderly Chinese population. METHODS:A survey was conducted on 870 long-lived subjects (aged ≥90years). Subjects were divided into four groups according to quartile of BMI (<16.6, 16.6-18.9, 18.9-21.1, ≥21.1kg...

journal_title：Experimental gerontology

authors： Yue JR,Huang CQ,Dong BR

更新日期：2012-08-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common cause of dementia accounting for 60-70% of all demented cases and one of the leading sources of morbidity and mortality in the aging population. Most of the recent literature regards the relationship between plasma oxidative stress and AD, showing that markers of lipid perox...

journal_title：Experimental gerontology

authors： Vignini A,Alia S,Pugnaloni S,Giulietti A,Bacchetti T,Mazzanti L,Luzzi S,Fiorini R

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND/OBJECTIVES:To explore the impact of diabetic peripheral neuropathy (DPN) on the recovery of older persons with diabetes mellitus (DM) after hip-fracture surgery. DESIGN, SETTING, PARTICIPANTS:Secondary data for this study came from a clinical trial on the effectiveness of a DM-specific care model for 176 ol...

journal_title：Experimental gerontology

authors： Tseng MY,Huang YF,Liang J,Wang JS,Yang CT,Wu CC,Cheng HS,Chen CY,Lin YE,Wang WS,Shyu YL

更新日期：2019-05-01 00:00:00

abstract：:There is an age-associated reduction in the bone healing activity of bone morphogenetic protein-2 (BMP-2) that is currently addressed by administering higher doses of BMP-2 in elderly patients. The unwanted medical complications from high dose BMP-2 motivated this investigation to determine whether the addition of a l...

journal_title：Experimental gerontology

authors： Charles LF,Woodman JL,Ueno D,Gronowicz G,Hurley MM,Kuhn LT

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Stroke associated infection (within the first seven days) occurs in approximately half of stroke patients and is associated with a worse prognosis, especially in the elderly. It is uncertain what factors predict stroke associated infection, yet identification of a suitable biomarker for infection...

journal_title：Experimental gerontology

authors： Kwan J,Horsfield G,Bryant T,Gawne-Cain M,Durward G,Byrne CD,Englyst NA

更新日期：2013-09-01 00:00:00

abstract：:Telomeres are specialised structures located at the end of eukaryotic chromosomes, that get short during progressive cell divisions. Therefore, telomere may be an indicator of the mitotic history of a cell and it is also a determining factor for the residual cell life span. One mechanism, compensating for the telomere...

journal_title：Experimental gerontology

authors： Mariani E,Meneghetti A,Formentini I,Neri S,Cattini L,Ravaglia G,Forti P,Facchini A

更新日期：2003-06-01 00:00:00

abstract：:At 11 and 30 degrees C there was no change in the amount or in the buoyant density of nuclear DNA of male Oregon R Drosophila melanogaster with aging. When normal flies were maintained at 11 degrees C (at which temperature they do not fly), mitochondrial DNA content declined gradually with aging and 39.4% of the origi...

journal_title：Experimental gerontology

authors： Massie HR,Williams TR

更新日期：1987-01-01 00:00:00

abstract：:Age-related hearing loss (AHL) is a progressive neurodegenerative disease that is largely silent in its initial stages. There is no sensitive blood biomarker for diagnosis or early detection of AHL. MicroRNAs (miRNAs or miRs) are abundant and highly stable in blood, and have been recently described as powerful circula...

journal_title：Experimental gerontology

authors： Pang J,Xiong H,Yang H,Ou Y,Xu Y,Huang Q,Lai L,Chen S,Zhang Z,Cai Y,Zheng Y

更新日期：2016-04-01 00:00:00

abstract：:The hypotheses were: HISS-dependent insulin resistance (HDIR) accounts for insulin resistance that occurs with aging; HDIR is the initiating metabolic defect that leads progressively to type 2 diabetes and the metabolic syndrome; a synergistic antioxidant cocktail in chow confers protection against HDIR, subsequent sy...

journal_title：Experimental gerontology

authors： Lautt WW,Ming Z,Macedo MP,Legare DJ

更新日期：2008-08-01 00:00:00

abstract：:Age-related bone loss is thought to be due to impaired osteoblast functions. Insulin-like growth factors (IGFs) have been shown to be important stimulators of bone formation and osteoblast activities in vitro and in vivo. We tested the hypothesis that in vitro osteoblast senescence is associated with changes in compon...

journal_title：Experimental gerontology

authors： Kveiborg M,Flyvbjerg A,Rattan SI,Kassem M

更新日期：2000-10-01 00:00:00

abstract：:The CG9940 gene, which encodes the NAD(+) synthase protein in Drosophila, is conserved in human, zebra fish, and mosquito. NAD(+) synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD(+)) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic a...

journal_title：Experimental gerontology

authors： Wen DT,Zheng L,Ni L,Wang H,Feng Y,Zhang M

更新日期：2016-10-01 00:00:00

abstract：:Caloric restriction (CR) without malnutrition in mice and rats reduces the incidence of spontaneous tumors and delays their appearance while increasing maximum life span. These results depend largely on CR per se, and not on low intakes of fat or other nutrients. Although most studies have tested CR imposed early in l...

journal_title：Experimental gerontology

authors： Weindruch R

更新日期：1992-09-01 00:00:00

abstract：:The antioxidant 2-mercaptoethylamine (MEA) was added to the culture medium of WI-38 cells throughout their lifespan. MEA concentrations of 0.5 microM, 5 microM and 50 microM were used. The presence of 5 microM or 50 microM MEA decreased the fraction of rapidly dividing cells and slightly reduced cell density at conflu...

journal_title：Experimental gerontology

authors： Golczewski JA

更新日期：1984-01-01 00:00:00

abstract：:Women who seek medical care around the time of menopause frequently report changes in one or more aspects of psychological functioning. The etiology of these symptoms is likely multifactorial and, undoubtedly, individual and sociocultural factors are important determinants. The known psychotropic properties of the sex...

journal_title：Experimental gerontology

authors： Sherwin BB

更新日期：1994-05-01 00:00:00

abstract：:Senescent cells accumulate with age and contribute to pathologies associated to old age. The senescent program can be induced by pro-cancer stimuli or is developmentally controlled. In cells forced to senesce by expression of oncogenes or short telomeres, aberrant activation of the ERK/MAP kinase signaling pathway lea...

journal_title：Experimental gerontology

authors： Ferbeyre G

更新日期：2018-07-01 00:00:00

abstract：:An age-related increase of DNA damage/mutation has been previously reported in human lymphocytes. The high copy number and mutation rate make the mtDNA genome an ideal candidate for assessing damage and to act as a potential biomarker of ageing. In the present study, two assays were developed to evaluate the level of ...

journal_title：Experimental gerontology

authors： Ross OA,Hyland P,Curran MD,McIlhatton BP,Wikby A,Johansson B,Tompa A,Pawelec G,Barnett CR,Middleton D,Barnett YA

更新日期：2002-01-01 00:00:00

abstract：:Arterial stiffness, an independent predictor of cardiovascular disease, is increased in aging, but the underlying mechanisms are not completely understood. Mineralocorticoid receptors (MR) may contribute to oxidative stress and arterial stiffness in healthy older adults. To test the hypothesis that short-term MR block...

journal_title：Experimental gerontology

authors： Hwang MH,Yoo JK,Luttrell M,Kim HK,Meade TH,English M,Nichols WW,Christou DD

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVES:1) To determine if there was a practice effect associated with walk tests performed by frail older adults with and without dementia, 2) to examine the role of systematic cueing in the walk tests for those with dementia, and 3) to make recommendations to testing protocols of the walk tests for frail older adu...

journal_title：Experimental gerontology

authors： Chan WLS,Pin TW

更新日期：2019-09-01 00:00:00

abstract：:Every organism must adapt and respond appropriately to the source of nutrients available in its environment. Different mechanisms and pathways are involved in detecting the intracellular and extracellular levels of macronutrients including amino acids. Detection of amino acids in food sources is provided by taste cell...

journal_title：Experimental gerontology

authors： Lushchak O,Strilbytska OM,Yurkevych I,Vaiserman AM,Storey KB

更新日期：2019-01-01 00:00:00

abstract：:Cellular aging plays a role in longevity and senescence, and has been implicated in medical and psychiatric conditions, including heart disease, cancer, major depression and posttraumatic stress disorder. Telomere shortening and mitochondrial dysfunction are thought to be central to the cellular aging process. The pre...

journal_title：Experimental gerontology

authors： Tyrka AR,Carpenter LL,Kao HT,Porton B,Philip NS,Ridout SJ,Ridout KK,Price LH

更新日期：2015-06-01 00:00:00

abstract：:Plantar-flexor muscles are key muscles in the control of postural sway. Older fallers present lower maximal plantar-flexor performance than older non-fallers; however, the mechanisms underlying this motor impairment remain to be elucidated. This study aimed to determine whether muscular and neural factors are both inv...

journal_title：Experimental gerontology

authors： Cattagni T,Harnie J,Jubeau M,Hucteau E,Couturier C,Mignardot JB,Deschamps T,Berrut G,Cornu C

更新日期：2018-10-02 00:00:00

abstract：:Aging associates with a decline of physiological functions, including the function of the nervous and the immune system. These aged-related changes occur in various degrees in different members of a mouse outbred population. Accordingly, we have proposed a model of premature immunosenescence in mice, based on the demo...

journal_title：Experimental gerontology

authors： Guayerbas N,Puerto M,Víctor VM,Miquel J,De la Fuente M

更新日期：2002-01-01 00:00:00

abstract：:Mitochondrial superoxide production is an important source of reactive oxygen species in cells, and may cause or contribute to ageing and the diseases of ageing. Seven major sites of superoxide production in mammalian mitochondria are known and widely accepted. In descending order of maximum capacity they are the ubiq...

journal_title：Experimental gerontology

authors： Brand MD

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVE:This study aimed to evaluate the effect of vitamin D3 megadose supplementation and influence of BsmI polymorphism in the VDR gene on the inflammatory profile and oxidative stress in elderly women with vitamin D deficiency. METHODS:A double blind, randomized, placebo-controlled trial was conducted with 40 eld...

journal_title：Experimental gerontology

authors： de Medeiros Cavalcante IG,Silva AS,Costa MJ,Persuhn DC,Issa CT,de Luna Freire TL,da Conceição Rodrigues Gonçalves M

更新日期：2015-06-01 00:00:00

abstract：:Collagens and elastin are 'building blocks' of tissues and extracellular matrix. Mutations in these proteins cause severe congenital syndromes. Adverse genetic variations may accelerate the aging process in adults contributing to premature morbidity, disability and/or mortality. Favorable variants may contribute to lo...

journal_title：Experimental gerontology

authors： Romero-Ortuno R,Kenny RA,McManus R

更新日期：2020-01-01 00:00:00

abstract：:The cold-induced enhancement of non-shivering thermogenesis (NST), involving brown-adipose tissue (BAT) metabolism, could participate to impair energy balance in the aged gray mouse lemur (Microcebus murinus). We first investigated the age-related modulations of cold-stimulated BAT cell morphology and contents. Then, ...

journal_title：Experimental gerontology

authors： Terrien J,Ambid L,Nibbelink M,Saint-Charles A,Aujard F

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Epidemiological and objective studies report an association between sedentary time and lower risk of the metabolic syndrome (MetS) and its risk factors in young and middle-age adults. To date, there is a lack of objective data on the association between sedentary time and MetS among older adults. METHODS:Th...

journal_title：Experimental gerontology

authors： Mankowski RT,Aubertin-Leheudre M,Beavers DP,Botoseneanu A,Buford TW,Church T,Glynn NW,King AC,Liu C,Manini TM,Marsh AP,McDermott M,Nocera JR,Pahor M,Strotmeyer ES,Anton SD,LIFE Research Group.

更新日期：2015-10-01 00:00:00

abstract：:The age-associated decline in the regenerative abilities of mesenchymal stem cells (MSCs) may be due to age-related changes in reduction in number, intrinsic properties of MSCs and extrinsic factors of the extracellular environment (the stem cell niche). The effect of age on the efficacy of MSC transplantation on rege...

journal_title：Experimental gerontology

authors： Iohara K,Murakami M,Nakata K,Nakashima M

更新日期：2014-04-01 00:00:00