Abstract：
:This article gives some information on the French research on aging using a survey of the European Commission on research on aging in Europe and the answers to a questionnaire sent to the laboratories involved in aging research. France is involved in the European effort, but to a lesser degree than could be expected from its population size, and this picture has not changed during the last decade. The answers to the questionnaire allow us to know the opinion of colleagues on the strengths and weaknesses of French research: the lack of money and institutional recognition seem to hinder the development of experimental gerontology in France.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Le Bourg Edoi
10.1016/s0531-5565(00)00164-9keywords:
subject
Has Abstractpub_date
2000-10-01 00:00:00pages
917-25issue
8eissn
0531-5565issn
1873-6815pii
S0531556500001649journal_volume
35pub_type
杂志文章abstract：:Lipid hydroperoxides are formed in vivo through free radical pathways from the action of reactive oxygen species on polyunsaturated fatty acids. They are also formed as specific products of lipoxygenases and cyclooxygenases. Homolytic decomposition of lipid hydroperoxides to the alpha,beta-unsaturated aldehyde genotox...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(01)00133-4
更新日期：2001-09-01 00:00:00
abstract：:The achievement that cytokines and all the related "transducing machinery" are expressed within the central nervous system and play a consistent role in the modulation of neurological functions and dysfunctions, has allowed a novel interpretation of brain behaviour. In this view, neuroinflammation and cytokines produc...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2010.09.008
更新日期：2011-02-01 00:00:00
abstract：:Spectrins are a part of cytoskeletal platform that lines the intracellular side of plasma membrane, which can be proteolyzed by calcium-sensitive enzymes including calpains and caspases. Caspase-3 mediated αII-spectrin proteolysis results in the release of a 120kDa spectrin breakdown product (SBDP120), known to occur ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2015.06.003
更新日期：2015-09-01 00:00:00
abstract：:Previous studies have demonstrated that fecundity, like mortality, plateaus at late ages in cohorts of Drosophila melanogaster. Although evolutionary theory can explain the decline and plateau in cohort fecundity at late ages, it is conceivable that lifelong heterogeneity in individual female fecundity is producing th...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2005.06.006
更新日期：2005-08-01 00:00:00
abstract：:The age-dependent modifications of both basal and lymphokine-induced natural killer (NK) activity were analyzed in Balb/c inbred mice by measuring either the percentage of specific lytic activity in a 51 Cr release assay or the percentage of cells capable of binding the YAC-1 target cells. The basal lytic activity of ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(89)90014-4
更新日期：1989-01-01 00:00:00
abstract：:Accumulation of myeloid-derived suppressor cells (MDSCs) in aged hosts contribute to the age-related increase of susceptibility to murine breast adenocarcinoma and co-stimulatory molecules expressed in MDSCs are essential for MDSCs-mediated immune suppression. However, the co-stimulatory molecules that exert a direct ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2014.12.001
更新日期：2015-01-01 00:00:00
abstract：:We tested the hypothesis that hesperidin would reverse age-related aortic stiffness, perivascular adipose (PVAT) mediated-arterial stiffening and PVAT advanced glycation end-products (AGE) accumulation. Aortic pulse wave velocity (aPWV) and intrinsic mechanical stiffness, two measures of arterial stiffness, were asses...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2017.08.003
更新日期：2017-10-15 00:00:00
abstract：:A colony of male Lakeview Golden (LVG) Syrian hamsters has been maintained for the last nine years as a source of various tissues for cellular aging studies. Observations on this colony also yielded data on survival time and physical and pathological manifestations of aging in this strain. Based on 150 spontaneous dea...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(90)90032-w
更新日期：1990-01-01 00:00:00
abstract：:The importance of maintaining physical fitness by engaging in exercise in a life-long perspective as well as the avoidance of obesity has been emphasised in recent years by epidemiological studies on human populations as well as studies on laboratory rodents. In laboratory studies, voluntary running in wheels and forc...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(01)00145-0
更新日期：2001-11-01 00:00:00
abstract：:The echidna Tachyglossus aculeatus is a monotreme mammal from Australia that is exceptionally long-living. Its documented maximum lifespan of 50 years is 3.7 times that predicted from its body mass. Other exceptionally long-living mammals (naked mole-rats and humans) are known to have peroxidation-resistant membrane c...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2008.05.015
更新日期：2008-08-01 00:00:00
abstract：:The content and synthesis of GABA were measured in the cortex and striatum of young adult (4 months), mature (14 months), and old (24 months) male Wistar rats. GABA synthesis was determined from the GABA accumulation induced by aminooxyacetic acid (AOAA). Aging did not affect GABA content in the cortex (1.03 +/- 0.04 ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(90)90020-3
更新日期：1990-01-01 00:00:00
abstract：BACKGROUND AND PURPOSE:Stroke associated infection (within the first seven days) occurs in approximately half of stroke patients and is associated with a worse prognosis, especially in the elderly. It is uncertain what factors predict stroke associated infection, yet identification of a suitable biomarker for infection...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.07.003
更新日期：2013-09-01 00:00:00
abstract：:Aging is associated with a decline in muscle force that exceeds loss of muscle mass, suggesting that factors other than sarcopenia affect age-related muscle weakness. Here, we investigate in situ muscle force and sarcoplasmic reticulum (SR) properties in gastrocnemius muscles of adult (6-8 months) and aged (24 months)...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.11.018
更新日期：2014-02-01 00:00:00
abstract：:Age- and sex-associated differences in lipid peroxidation (LPO), and total sialic acid content (TSA) in response to abuse of drugs have been reported both in humans and experimental animals. However, no data on the influence of gender and age on these parameters have been reported for methionine-enkephalin (MENK). In ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(02)00118-3
更新日期：2002-12-01 00:00:00
abstract：:The goal of these experiments was to determine if the increased longevity characteristics of our genetically selected long lived line of Drosophila could be attributed to metabolic differences. The data shows an inverse relationship between life span and temperature for both the long lived (L) and normal (R) strains; ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(88)90020-4
更新日期：1988-01-01 00:00:00
abstract：:Aging-related changes to biological structures such as cardiovascular and musculoskeletal systems contribute to the development of comorbid conditions including cardiovascular disease and frailty, and ultimately lead to premature death. Although, frail older adults often demonstrate both cardiovascular and musculoskel...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2020.111220
更新日期：2021-03-01 00:00:00
abstract：:It is well established that during early life the thymus gland and the neuroendocrine system influence each other's maturation. Furthermore, there is a growing body of evidence indicating that the immune and neuroendocrine systems also function as a bidirectional network during adult life. In order to assess possible ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(90)90046-5
更新日期：1990-01-01 00:00:00
abstract：BACKGROUND:Sarcopenic obesity is a combination of both sarcopenia and obesity, which potentiate each other and maximize the negative influences of each, such as physical disability, morbidity, or even mortality. OBJECTIVES:To describe the criteria used to identify people with sarcopenic obesity and the components of t...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2020.110937
更新日期：2020-07-01 00:00:00
abstract：OBJECTIVE:To assess the 24-h endogenous secretory growth hormone (GH) profile and serum insulin-like growth factor-I (IGF-I) response to exogenous recombinant human growth hormone (rhGH) in a patient with Werner's syndrome. DESIGN:Blood sampling every 20 min for 24 h followed by three daily injections of growth hormon...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(96)00031-9
更新日期：1996-09-01 00:00:00
abstract：:A series of theoretical analyses of mortality were performed on recent data for Mediterranean fruit flies (Ceratitus capitata). Best fit computations were performed using the Marquardt-Levenburg technique on: 1) the classic Gompertz model, 2) the Johnson-Mehl-Avrami (JMA) model from chemical kinetics theory, which is ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(94)90051-5
更新日期：1994-03-01 00:00:00
abstract：:Natural killer (NK) cells play an important role in controlling several viral diseases. Our previous studies demonstrated an age-dependent susceptibility to mousepox due to defective NK cell responses and trafficking. However, the mechanisms that underlie the age-related impairment in NK cell migration have yet to be ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2017.06.021
更新日期：2017-10-01 00:00:00
abstract：:Cytogenetic analysis of the X chromosome in phytohaemagglutinin stimulated peripheral blood lymphocytes was evaluated in 12 sporadic Alzheimer disease (AD) patients and in 11 healthy subjects. For chromosome analysis two methods were used: (1) standard analysis of G-banded metaphase chromosomes and; (2) fluorescent in...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2004.01.012
更新日期：2004-05-01 00:00:00
abstract：:Changes associated with the age-related decline of physiological functions, and their relation with mortality rates, are thoroughly being investigated in the aging research field. We used the Mediterranean fruit fly Ceratitis capitata, largely studied by biodemographers, as a model for functional senescence studies. T...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2012.04.001
更新日期：2012-06-01 00:00:00
abstract：:Maintaining physical mobility is important for preventing age-related comorbidities in older adults. Endurance and resistance training prevent mobility loss in aging, but exercise alone does not always achieve the expected improvements in physical and cardiopulmonary function. Recent preclinical evidence suggests that...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2020.110972
更新日期：2020-08-01 00:00:00
abstract：:Ethanol ingestion has been implicated in accidental hypothermia of the elderly, but there is no prior data on the relative sensitivity to alcohol of aged homeotherms that might account for disproportionate dysthermia in this age group. To assess their sensitivity, ethanol (0.5-2.0 g/kg) or H20 was given by gavage to s...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(83)90047-5
更新日期：1983-01-01 00:00:00
abstract：:The purpose of this study was to examine the relative contributions of changes in muscle quality and body composition to changes in lower-extremity physical function (LEPF) following a 6-month exercise and weight loss intervention in overweight and obese older women. Thirty-eight overweight and obese (BMI = 30.0 ± 4.4...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2018.04.011
更新日期：2018-07-15 00:00:00
abstract：AIM:The present study investigated whether hypertension, blood pressure, and antihypertensive therapy were associated with frailty status in community-dwelling older adults. In addition, we tested whether such associations were consistent across different frailty instruments. MATERIAL AND METHODS:Two-hundred older adu...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2021.111245
更新日期：2021-01-19 00:00:00
abstract：:Degeneration of tongue muscles with aging may contribute to swallowing deficits observed in elderly people. However, the capacity for tongue muscle stem cells (SCs) to regenerate and repair the aged tongue and improve tongue strength following tongue exercise (a current clinical treatment) has never been examined. We ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2020.111104
更新日期：2020-12-01 00:00:00
abstract：:Impaired tolerance to ischemia-reperfusion in older hearts may stem in part from alterations in purine catabolism, impacting on maintenance of energy state and protective signaling via extracellular adenosine. We characterized effects of aging on normoxic and post-ischemic purine metabolism in hearts from young (2-4 m...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2003.08.003
更新日期：2003-10-01 00:00:00
abstract：:According to the free radical theory of aging, free radicals are involved in the production of changes in cellular metabolism that lead to a time-dependent functional decline in all living beings. Consequently, antioxidant and/or free radicals scavengers may retard the aging process. We explored the effect of melatoni...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(01)00229-7
更新日期：2002-05-01 00:00:00
