IL-6 is a predictive biomarker for stroke associated infection and future mortality in the elderly after an ischemic stroke.

Abstract:

BACKGROUND AND PURPOSE:Stroke associated infection (within the first seven days) occurs in approximately half of stroke patients and is associated with a worse prognosis, especially in the elderly. It is uncertain what factors predict stroke associated infection, yet identification of a suitable biomarker for infection may allow early and appropriate intervention with antibiotics. The aims of this study were to: a) identify independent risk factors for stroke associated infection, and b) test relationships between these risk factors and mortality at 2 years. METHODS:Eight-two elderly patients were assessed within 72 h of stroke. Data on stroke severity (Barthel Index), stroke associated infection and mortality at 2 years were collected. Inflammatory biomarkers at baseline and 6 months were measured by ELISA. Logistic regression was used to identify risk factors for stroke associated infection and death. RESULTS:Patients with stroke associated infection, especially pneumonia, had increased IL-6, more severe strokes, and higher mortality. IL-6 was independently associated with stroke associated infection (OR = 19.2, [95%CI 3.68, 100], p < 0.001), after adjustment for other risk factors and cytokines. IL-6 was also independently associated with 2 year mortality (OR = 9.2, [1.0, 85.1], p = 0.031). CONCLUSIONS:These data suggest that IL-6 may be a key biomarker for predicting stroke associated infection and mortality in the first two years post stroke.

journal_name

Exp Gerontol

journal_title

Experimental gerontology

authors

Kwan J,Horsfield G,Bryant T,Gawne-Cain M,Durward G,Byrne CD,Englyst NA

doi

10.1016/j.exger.2013.07.003

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

960-5

issue

9

eissn

0531-5565

issn

1873-6815

pii

S0531-5565(13)00224-6

journal_volume

48

pub_type

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