Abstract：
:Degeneration of tongue muscles with aging may contribute to swallowing deficits observed in elderly people. However, the capacity for tongue muscle stem cells (SCs) to regenerate and repair the aged tongue and improve tongue strength following tongue exercise (a current clinical treatment) has never been examined. We found that the expression of regenerative, myogenic markers were impaired with age and may be related to increased expression of senescent marker p16INK4a. Tongue strength increased in young adult and old rats following exercise and was related to the expression of Pax7, MyoD, myogenin, and p16INK4a. Our study also suggests that strengthening of tongue muscles via clinical rehabilitation strategies also increased the expression of SC regenerative markers in the tongue throughout the exercise duration.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Kletzien H,Kelm-Nelson CA,Wang S,Suzuki M,Connor NPdoi
10.1016/j.exger.2020.111104subject
Has Abstractpub_date
2020-12-01 00:00:00pages
111104eissn
0531-5565issn
1873-6815pii
S0531-5565(20)30452-6journal_volume
142pub_type
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