Compounds that confer thermal stress resistance and extended lifespan.

abstract：:The effects of long-term treatment with both antioxidants and a program of behavioral enrichment were studied as part of a longitudinal investigation of cognitive aging in beagle dogs. Baseline performance on a battery of cognitive tests was used to assign 48 aged dogs (9-12 years) into four cognitively equivalent gro...

journal_title：Experimental gerontology

authors： Milgram NW,Head E,Zicker SC,Ikeda-Douglas C,Murphey H,Muggenberg BA,Siwak CT,Tapp PD,Lowry SR,Cotman CW

更新日期：2004-05-01 00:00:00

abstract：:Methionine restriction (MR) extends lifespan across different species. The main responses of rodent models to MR are well-documented in adipose tissue (AT) and liver, which have reduced mass and improved insulin sensitivity, respectively. Recently, molecular mechanisms that improve healthspan have been identified in b...

journal_title：Experimental gerontology

authors： Ables GP,Johnson JE

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND/OBJECTIVES:To explore the impact of diabetic peripheral neuropathy (DPN) on the recovery of older persons with diabetes mellitus (DM) after hip-fracture surgery. DESIGN, SETTING, PARTICIPANTS:Secondary data for this study came from a clinical trial on the effectiveness of a DM-specific care model for 176 ol...

journal_title：Experimental gerontology

authors： Tseng MY,Huang YF,Liang J,Wang JS,Yang CT,Wu CC,Cheng HS,Chen CY,Lin YE,Wang WS,Shyu YL

更新日期：2019-05-01 00:00:00

abstract：:The Senescence-Accelerated Mouse (SAM) strains are unique and appropriate models for genetic studies on aging because the SAMP strains have an "accelerated senescence" phenotype for which the SAMR strains are controls, and each SAMP strain has a strain-specific age-associated disorder. Furthermore, because they have g...

journal_title：Experimental gerontology

authors： Higuchi K

更新日期：1997-01-01 00:00:00

abstract：:Young and old C57BL/6 male mice were given a diet containing a high dose of vitamin E (VE treatment) and its effect on the immune system was examined before and after the exposure to restraint stress. The VE treatment per se gave rise to a slight increase of splenic T cells in percentage and a significant enhancement ...

journal_title：Experimental gerontology

authors： Wakikawa A,Utsuyama M,Wakabayashi A,Kitagawa M,Hirokawa K

更新日期：1999-11-01 00:00:00

abstract：:Aging is associated with changes in several metabolic pathways affecting liver function including the adaptive unfolded protein response (UPR). On the other hand, exercise training has been shown to exert beneficial effects on metabolism in the liver and exercise training has been reported to affect hepatic UPR. PGC-1...

journal_title：Experimental gerontology

authors： Kristensen CM,Brandt CT,Ringholm S,Pilegaard H

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Hyaline articular cartilage, which protects the bones of diarthrodial joints from forces associated with load bearing, frictions, and impacts has very limited capacities for self-repair. Over the years, the trend of treatments has shifted to regenerations and researchers have been on the quest for a lasting ...

journal_title：Experimental gerontology

authors： Ude CC,Shamsul BS,Ng MH,Chen HC,Ohnmar H,Amaramalar SN,Rizal AR,Johan A,Norhamdan MY,Azizi M,Aminuddin BS,Ruszymah BHI

更新日期：2018-04-01 00:00:00

abstract：:Reflective of age-associated decline in immune function among elderly individuals is a decrease in in vitro T cell proliferative ability. Impaired T cell proliferation in the elderly may result from disruption of the well-balanced network of regulatory cytokines produced during an immune response. The purpose of this ...

journal_title：Experimental gerontology

authors： Castle SC,Uyemura K,Crawford W,Wong W,Klaustermeyer WB,Makinodan T

更新日期：1999-04-01 00:00:00

abstract：:Progressive neuronal deterioration accompanied by sensory functions decline is typically observed during aging. On the other hand, structural or functional alterations of specific sensory neurons extend lifespan in the nematode Caenorhabditis elegans. Hormesis is a phenomenon by which the body benefits from moderate s...

journal_title：Experimental gerontology

authors： Maglioni S,Schiavi A,Runci A,Shaik A,Ventura N

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:The proportion of elderly individuals is growing and the prevalence of chronic kidney disease (CKD) among elderly people undergoing cardiac surgery is increasing constantly. The aim of this study was to determine the influence of different degrees of preoperative renal dysfunction on postoperative outcomes i...

journal_title：Experimental gerontology

authors： Shavit L,Lifschitz M,Slotki I,Oren A,Tauber R,Bitran D,Fink D

更新日期：2013-03-01 00:00:00

abstract：:A mathematical model of cellular metabolism is used to relate the rates of cell division and waste production to the concentrations of oxygen and glucose in the medium in which a normal diploid cell culture is grown. The metabolic model in tandem with an earlier waste-content model based on the waste-product theory of...

journal_title：Experimental gerontology

authors： Hirsch HR,Witten M

更新日期：1991-01-01 00:00:00

abstract：:Thiazolidine carboxylic acid (TCA) is a natural liver metabolite whose Mg-salt increased lifespan of flies and mice (Miquel and Economos, 1979, Exp. Geront. 14: 279). We studied the physiological and cellular fine structural effects of various concentrations of TCA in the food of male Drosophila. Flies on 0.3% TCA at ...

journal_title：Experimental gerontology

authors： Economos AC,Ballard RC,Miquel J,Binnard R,Philpott DE

更新日期：1982-01-01 00:00:00

abstract：:The dependent elderly are widely considered to be at higher risk of nutritional problems. Suboptimal micronutrient intake might put the elderly, especially those living in nursing homes, at high risk of morbidity. So far, no public authority, except for the Israel Ministry of Health, has issued particular recommendati...

journal_title：Experimental gerontology

authors： Tal S,Stern F,Polyak Z,Ichelzon I,Dror Y

更新日期：2016-11-01 00:00:00

abstract：:Since,D-galactose (D-gal) overload model has been used as a premature aging model, we hypothesized that it may also lead to accelerated aging in the inner ear. Furthermore, though the mitochondrial DNA (mtDNA) 4834 bp deletion mutation has been considered as the marker of aging, there is no information available in th...

journal_title：Experimental gerontology

authors： Kong WJ,Wang Y,Wang Q,Hu YJ,Han YC,Liu J

更新日期：2006-06-01 00:00:00

abstract：:Alterations in heparan sulfate, the principal glycosaminoglycan species in glomerular basement membrane, have been proposed as contributory to permeability changes in nephropathic disorders. In the present study, the extent of sulfation of glycosaminoglycans isolated from pronase digests of human glomerular basement m...

journal_title：Experimental gerontology

authors： Cohen MP,Ku L

更新日期：1983-01-01 00:00:00

abstract：:We have recently reported that activated mouse spleen mononuclear cells (MNCs) efficiently lyse autologous erythrocytes in vitro (Saxena and Chandrasekhar, 2000). In the present study, we have investigated erythrocyte-depleting ability (EDA) of spleen MNCs from young and old mice. Time kinetics of survival of erythroc...

journal_title：Experimental gerontology

authors： Saxena RK,Adler WH

更新日期：2000-05-01 00:00:00

abstract：OBJECTIVE:The contribution of the A3243G mutation in mitochondria DNA (mtDNA) to diabetes mellitus (DM) in Werner's syndrome (WS) was studied. PATIENTS AND METHOD:DNA samples from peripheral white blood cells (WBCs) originating from 24 Japanese WS patients aged 30-56 were used. For control, 239 subjects aged 15-95 wer...

journal_title：Experimental gerontology

authors： Takeuchi F,Harihara S,Nakamura K,Takubo K,Kanamori M,Goto M

更新日期：2003-03-01 00:00:00

abstract：:Engineering of fetal tissue has a high potential for the treatment of acute and chronic wounds of the skin in humans as these cells have high expansion capacity under simple culture conditions and one organ donation can produce Master Cell Banks which can fabricate over 900 million biological bandages (9 x 12cm). In a...

journal_title：Experimental gerontology

authors： Ramelet AA,Hirt-Burri N,Raffoul W,Scaletta C,Pioletti DP,Offord E,Mansourian R,Applegate LA

更新日期：2009-03-01 00:00:00

abstract：:We suggest that the processes that protect the turtle brain against anoxia and subsequent reoxygenation might also contribute to turtle longevity since many of them are linked to age related neurodegeneration. In the turtle the mechanisms for conserving ion channel function are particularly robust. The anoxic turtle b...

journal_title：Experimental gerontology

authors： Lutz PL,Prentice HM,Milton SL

更新日期：2003-07-01 00:00:00

abstract：:Aging is associated with impaired mitochondrial function, whereas exercise training enhances mitochondrial content and function in part through activation of PGC-1α. Mitochondria form dynamic networks regulated by fission and fusion with profound effects on mitochondrial functions, yet the effects of aging and exercis...

journal_title：Experimental gerontology

authors： Halling JF,Ringholm S,Olesen J,Prats C,Pilegaard H

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND/AIM:Age-related metabolic diseases are often associated with low-grade inflammation. The aim of the present study was to investigate the role of the transcriptional co-activator PGC-1α in the potential beneficial effects of exercise training and/or resveratrol in the prevention of age-associated low-grade in...

journal_title：Experimental gerontology

authors： Olesen J,Ringholm S,Nielsen MM,Brandt CT,Pedersen JT,Halling JF,Goodyear LJ,Pilegaard H

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Oxidative stress and inflammation may contribute to anabolic resistance in response to protein and exercise in older adults. We investigated whether consumption of montmorency cherry concentrate (MCC) increased anabolic sensitivity to protein ingestion and resistance exercise in healthy older men. METHODS:S...

journal_title：Experimental gerontology

authors： Jackman SR,Brook MS,Pulsford RM,Cockcroft EJ,Campbell MI,Rankin D,Atherton P,Smith K,Bowtell JL

更新日期：2018-09-01 00:00:00

abstract：:Several papers reported in recent years on a change in the age population distribution of the circulating erythrocytes in old mice, rats, rabbits, and humans. The results indicate the presence of a chronologically younger cell population in old animals and humans. The cells are typically lower in density and larger. I...

journal_title：Experimental gerontology

authors： Danon D,Bologna NB,Gavendo S

更新日期：1992-01-01 00:00:00

abstract：:Indigenous DNA adducts (I-compounds) are considered to be a biomarker of aging tissues. Thus far, few studies have been conducted to investigate the accumulation patterns of I-compounds in the brain during aging. Particularly, identities of age-dependent I-compounds have largely remained unknown. In the current study,...

journal_title：Experimental gerontology

authors： Cai Q,Tian L,Wei H

更新日期：1996-05-01 00:00:00

abstract：:Understanding telomere biology is of utmost importance for aging and cancer research. An essential tool is the determination of telomere length, which traditionally is done by telomere restriction fragment analysis, a laborious and time consuming method. Therefore, large efforts have been made to establish alternative...

journal_title：Experimental gerontology

authors： Wieser M,Stadler G,Böhm E,Borth N,Katinger H,Grillari J,Voglauer R

更新日期：2006-02-01 00:00:00

abstract：:Dietary restriction extends lifespan in a variety of organisms, but the key nutritional components driving this process and how they interact remain uncertain. In Drosophila, while a substantial body of research suggests that protein is the major dietary component affecting longevity, recent studies claim that carbohy...

journal_title：Experimental gerontology

authors： Bruce KD,Hoxha S,Carvalho GB,Yamada R,Wang HD,Karayan P,He S,Brummel T,Kapahi P,Ja WW

更新日期：2013-10-01 00:00:00

abstract：:A series of theoretical analyses of mortality were performed on recent data for Mediterranean fruit flies (Ceratitus capitata). Best fit computations were performed using the Marquardt-Levenburg technique on: 1) the classic Gompertz model, 2) the Johnson-Mehl-Avrami (JMA) model from chemical kinetics theory, which is ...

journal_title：Experimental gerontology

authors： Hirsh AG,Williams RJ,Mehl P

更新日期：1994-03-01 00:00:00

abstract：:Age-related behavioral declines are common manifestations of aging in animals. Negative geotaxis, an innate escape response during which flies ascend the wall of a cylinder after being tapped to its bottom, is one of the behaviors that senesces in Drosophila. Many laboratories, including ours, have used a variety of n...

journal_title：Experimental gerontology

authors： Gargano JW,Martin I,Bhandari P,Grotewiel MS

更新日期：2005-05-01 00:00:00

abstract：:Rats of Albino Oxford (AO) strain in our animal facility exhibit a longer average healthy life span than rats of Dark Agouit (DA) strain. Since chronic activation of macrophages contributes to chronic low level inflammation common in older age, elucidation of the changes in middle-aged rats could be useful in preventi...

journal_title：Experimental gerontology

authors： Stanojević S,Ćuruvija I,Blagojević V,Petrović R,Vujić V,Dimitrijević M

更新日期：2016-12-01 00:00:00

abstract：:Brain aging, Alzheimer disease and stroke share common elements of deficits in calcium regulation, declines in mitochondrial function, increases in generation of reactive oxygen species (ROS), accumulated damage from ROS and immune system dysfunction. The problem is to distinguish less significant side reactions, such...

journal_title：Experimental gerontology

authors： Brewer GJ

更新日期：2000-12-01 00:00:00