The relation between D-galactose injection and mitochondrial DNA 4834 bp deletion mutation.

Abstract:

:Since,D-galactose (D-gal) overload model has been used as a premature aging model, we hypothesized that it may also lead to accelerated aging in the inner ear. Furthermore, though the mitochondrial DNA (mtDNA) 4834 bp deletion mutation has been considered as the marker of aging, there is no information available in the literature concerning the mtDNA 4834 bp deletion mutation condition of the D-gal induced premature aging model. We investigate the changes in inner ear enzymatic activity, the occurring of mtDNA 4834 bp deletion in inner ear and other tissues and the relating hearing thresholds after the administration of high dosage (150 mg/kg per day) and low dosage (50 mg/kg per day) of D-gal to rats. Furthermore, the incidence of the mtDNA 4834 bp deletion in different tissues as well as in blood sample was compared. The results showed that daily subcutaneous injections of D-gal into rats for 8 weeks could lead to the biochemical defects and mtDNA 4834 bp deletion in the inner ear tissue and other tissues, which represent the typical aging animals, but the relating hearing threshold shifts (TS) were nearly identical in the three groups. This study also indicates that using of blood samples to detect mtDNA 4834 bp deletion in clinical research might lead to a 'false negative' result. A higher sensitive result could be gained using tissue biopsy to examine mtDNA 4834 bp deletion.

journal_name

Exp Gerontol

journal_title

Experimental gerontology

authors

Kong WJ,Wang Y,Wang Q,Hu YJ,Han YC,Liu J

doi

10.1016/j.exger.2006.04.008

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

628-34

issue

6

eissn

0531-5565

issn

1873-6815

pii

S0531-5565(06)00102-1

journal_volume

41

pub_type

杂志文章
  • Transcriptomic analysis of the life-extending effect exerted by black rice anthocyanin extract in D. melanogaster through regulation of aging pathways.

    abstract::This study examined the beneficial effects of black rice anthocyanin extract (BRAE), which provides as an excellent source of dietary antioxidants, on the lifespan of fruit flies and the underlying molecular mechanisms. Results showed that supplementation of BRAE extended the lifespan of fruit flies by 20% and retarde...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2019.01.015

    authors: Li X,Zhang Z,Zhang X,Cheng J,Liu D,Yan Y,Wang H

    更新日期:2019-05-01 00:00:00

  • Role of advanced glycation end products (AGEs) and receptor for AGEs (RAGE) in vascular damage in diabetes.

    abstract::A non-enzymatic reaction between ketones or aldehydes and the amino groups of proteins, lipids and nucleic acids contributes to the aging of macromolecules and to the development and progression of various age-related disorders such as vascular complications of diabetes, Alzheimer's disease, cancer growth and metastas...

    journal_title:Experimental gerontology

    pub_type: 杂志文章,评审

    doi:10.1016/j.exger.2010.11.007

    authors: Yamagishi S

    更新日期:2011-04-01 00:00:00

  • Aging of neurons in the mollusc Lymnaea stagnalis small parietal ganglion: a morpho-functional comparison in the same neuron.

    abstract::The aim of this study was to compare the functional and structural changes in similarly identified neurons of the small parietal ganglion in 56 molluscs (Lymnaea stagnalis) of two age groups: adult (10-12 months) and old (20-22 months). No age changes were found in the values of membrane potential, resistance of the n...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/0531-5565(95)00008-5

    authors: Frolkis VV,Kvitnitskaya-Ryzhova TYu,Martynenko OA

    更新日期:1995-09-01 00:00:00

  • Absence of association between SNPs in the promoter region of the insulin-like growth factor 1 (IGF-1) gene and longevity in the Han Chinese population.

    abstract::Previous studies have indicated that genetic variations in the factors of insulin/insulin-like growth factor 1 (IGF-1) signaling pathway could influence human life-span by affecting IGF-1 levels. The promoter region of the IGF-1 gene is an obvious candidate and has not been studied clearly. To explore the potential ro...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2008.08.004

    authors: Xie L,Gong YY,Lian SG,Yang J,Yang Y,Gao SJ,Xu LY,Zhang YP

    更新日期:2008-10-01 00:00:00

  • Urea synthesis in hepatocytes isolated from young and old rats.

    abstract::Effects of glucagon and epinephrine stimulation on urea synthesis from lactate, pyruvate, NH4Cl, and ornithine in isolated rat hepatocytes from young and old rats were compared. It was found that the production of urea from those substrates was almost the same in both age groups. The concentrations of hormones that ca...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/0531-5565(85)90052-x

    authors: Kmieć Z,Myśliwski A

    更新日期:1985-01-01 00:00:00

  • Aging membranes: Unexplored functions for lipids in the lifespan of the central nervous system.

    abstract::Lipids constitute a significant group of biological metabolites and the building blocks of all cell membranes. The abundance and stoichiometries of different lipid species are known to vary across the lifespan and metabolic state, yet the functional effects of these changes have been challenging to understand. Here we...

    journal_title:Experimental gerontology

    pub_type: 杂志文章,评审

    doi:10.1016/j.exger.2019.110817

    authors: Skowronska-Krawczyk D,Budin I

    更新日期:2020-03-01 00:00:00

  • Hesperidin reverses perivascular adipose-mediated aortic stiffness with aging.

    abstract::We tested the hypothesis that hesperidin would reverse age-related aortic stiffness, perivascular adipose (PVAT) mediated-arterial stiffening and PVAT advanced glycation end-products (AGE) accumulation. Aortic pulse wave velocity (aPWV) and intrinsic mechanical stiffness, two measures of arterial stiffness, were asses...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2017.08.003

    authors: Ouyang A,Garner TB,Fleenor BS

    更新日期:2017-10-15 00:00:00

  • Fetal and placental growth in young, primiparous and old, multiparous rats.

    abstract::Fetal and placental weights and peripheral blood progestagen concentrations were examined on days 13, 16 and 22 of gestation in young (3-5 month) nulliparous and old (9-12 month) multiparous, albino Wistar rats. There was no difference in fetal weights at any stage examined whereas placental weights were significantly...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/0531-5565(87)90004-0

    authors: Rahima A,Bruce NW

    更新日期:1987-01-01 00:00:00

  • Living longer but less healthy: The female disadvantage in health expectancy. Results from the KORA-Age study.

    abstract:OBJECTIVES:We explored the male-female health-survival paradox in the context of health expectancy (HE) at age 65 and thereafter, using three different morbidity measures and different severity cut-offs with and without adjustments for the share of nursing home residents. METHODS:HE at ages 65, 70, 75, 80, and 85 was ...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2020.111196

    authors: Stephan AJ,Schwettmann L,Meisinger C,Ladwig KH,Linkohr B,Thorand B,Schulz H,Peters A,Grill E

    更新日期:2021-03-01 00:00:00

  • Cluster-sets resistance training induce similar functional and strength improvements than the traditional method in postmenopausal and elderly women.

    abstract:OBJECTIVE:The aim of this study was to compare the effects of 12 weeks of traditional resistance training (TRT) or resistance training using Cluster-set (CS) on functional performance and physical fitness of postmenopausal and elderly women. METHODS:Participants (61.1 ± 4.9 years, body mass 64.5 ± 1.8 kg, height 155.7...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2020.111011

    authors: Dias RKN,Penna EM,Noronha ASN,de Azevedo ABC,Barbalho M,Gentil PV,Coswig VS

    更新日期:2020-09-01 00:00:00

  • Age-dependent response of lymphocytes in the induction of the linker histone variant, H1 degrees and histone H4 acetylation after treatment with the histone deacetylase inhibitor, trichostatin A.

    abstract::In the present study we investigated the age-related response of Phytohemaglutinin (PHA)-activated S phase human lymphocytes isolated from peripheral blood from donors of four different age groups, namely young (25-30 years), mid-aged (40-45 years), senior (60-65 years) and elderly (80-95 years) on the induction of th...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2003.12.014

    authors: Kypreou KP,Sourlingas TG,Sekeri-Pataryas KE

    更新日期:2004-04-01 00:00:00

  • Rate of power development of the knee extensors across the adult life span: A cross-sectional study in 1387 Flemish Caucasians.

    abstract::A growing body of research in elderly populations suggests that the early phase of an explosive muscle contraction (i.e., ≤200 ms) may be more functionally relevant than peak values. However, age-related variation in early phase explosive strength has never been investigated across the full-adult life span. This cross...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2018.06.021

    authors: Van Roie E,Van Driessche S,Inglis AJ,Thomis M,Delecluse C

    更新日期:2018-09-01 00:00:00

  • Effects of estrogen replacement therapy on the circadian rhythms of serum cortisol and body temperature in postmenopausal women.

    abstract::Estrogen replacement therapy (ERT) seems to enhance longevity in women. Both gender and aging have been shown to influence the regulation of circadian rhythms, yet little is known about the effect of ERT on circadian regulation. The aim of this study was to determine the effects of ERT (oral conjugated estrogen: Prema...

    journal_title:Experimental gerontology

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0531-5565(99)00044-3

    authors: Gudmundsson A,Goodman B,Lent S,Barczi S,Grace A,Boyle L,Ershler WB,Carnes M

    更新日期:1999-09-01 00:00:00

  • Proteomic analysis of age dependent nitration of rat cardiac proteins by solution isoelectric focusing coupled to nanoHPLC tandem mass spectrometry.

    abstract::Protein nitration occurs as a result of oxidative stress induced by reactive oxygen (ROS) and reactive nitrogen species (RNS). Therefore, protein nitration serves as a hallmark for protein oxidation in vivo. We have previously reported on age dependent protein nitration in cardiac tissue of Fisher 344 BN-F1 rats analy...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2007.03.005

    authors: Hong SJ,Gokulrangan G,Schöneich C

    更新日期:2007-07-01 00:00:00

  • Water-based aerobic training improves strength parameters and cardiorespiratory outcomes in elderly women.

    abstract::The aim of the present study was to compare the effects of water-based aerobic training and water-based resistance training on muscular strength and cardiorespiratory fitness in older women. Sixty-nine individuals were randomized into the following three groups: the water-based aerobic training (WA, n = 23) group, the...

    journal_title:Experimental gerontology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.exger.2018.04.022

    authors: Costa RR,Kanitz AC,Reichert T,Prado AKG,Coconcelli L,Buttelli ACK,Pereira LF,Masiero MPB,Meinerz AP,Conceição MO,Sbeghen IL,Kruel LFM

    更新日期:2018-07-15 00:00:00

  • Melatonin maintains calcium-binding calretinin-positive neurons in the dentate gyrus during aging of Balb/C mice.

    abstract::Melatonin, the main product synthesized by the pineal gland, modulates several brain functions through different mechanisms, some of them involving the activation or participation of calcium binding intracellular proteins, such as the alpha calcium dependent protein kinase C and calmodulin. Another calcium-binding pro...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2014.10.014

    authors: Ramírez-Rodríguez G,Gómez-Sánchez A,Ortíz-López L

    更新日期:2014-12-01 00:00:00

  • Lipofuscin pigment accumulation in the central nervous system of the mouse during aging.

    abstract::Histopathological and autofluorescence investigations were carried out to study lipofuscin pigment accumulation in various age groups of mice. Qualitative studies revealed an increase of lipofuscin pigment accumulation in old animals. Quantitative studies showed a significant increase in the percentage of pigmented ne...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/0531-5565(82)90041-9

    authors: Goyal VK

    更新日期:1982-01-01 00:00:00

  • Voluntary and forced exercise influence the survival and body composition of ageing male rats differently.

    abstract::The importance of maintaining physical fitness by engaging in exercise in a life-long perspective as well as the avoidance of obesity has been emphasised in recent years by epidemiological studies on human populations as well as studies on laboratory rodents. In laboratory studies, voluntary running in wheels and forc...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/s0531-5565(01)00145-0

    authors: Narath E,Skalicky M,Viidik A

    更新日期:2001-11-01 00:00:00

  • Intermittent bout exercise training down-regulates age-associated inflammation in skeletal muscles.

    abstract::Aging is characterized by the progressive decline in mass and function of the skeletal muscle along with increased susceptibility to inflammation, oxidative stress, and atrophy. In this study, we investigate the effect of intermittent bout and single bout exercise training on inflammatory molecules in young (3 months)...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2015.11.001

    authors: Kim JS,Yi HK

    更新日期:2015-12-01 00:00:00

  • Analysis of premature centromere division (PCD) of the X chromosome in Alzheimer patients through the cell cycle.

    abstract::Cytogenetic analysis of the X chromosome in phytohaemagglutinin stimulated peripheral blood lymphocytes was evaluated in 12 sporadic Alzheimer disease (AD) patients and in 11 healthy subjects. For chromosome analysis two methods were used: (1) standard analysis of G-banded metaphase chromosomes and; (2) fluorescent in...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2004.01.012

    authors: Spremo-Potparevic B,Zivkovic L,Djelic N,Bajic V

    更新日期:2004-05-01 00:00:00

  • Tuberculosis in aged gammadelta T cell gene disrupted mice.

    abstract::In young mice exposed to aerosol infection with Mycobacterium tuberculosis removal of the gammadelta T cell population by targeted gene disruption does not affect the expression of host resistance, but does influence the integrity of the early granulomatous response. The current study demonstrates that in aged gammade...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/s0531-5565(00)00199-6

    authors: Turner J,Frank AA,Brooks JV,Marietta PM,Vesosky B,Orme IM

    更新日期:2001-02-01 00:00:00

  • Age-related changes in the atrial muscarinic type 2 receptor and their effects on atrial fibrillation vulnerability in rabbits.

    abstract::Aging plays an important role in increased vulnerability to atrial fibrillation (AF). Mediated by activity at the muscarinic type 2 receptor (M2R), the parasympathetic nerve contributes to the onset of AF. The purpose of this study was to investigate whether aging changes the distribution of M2R in the atrial myocardi...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2009.06.002

    authors: Yang YH,Zheng QS,Li J,Shang FJ,Liu T,Wang HT,Liu XT,Liu L

    更新日期:2009-09-01 00:00:00

  • Age impairments in sleep, metabolic and immune functions.

    abstract::Age-related sleep impairments are chronic and common, occurring even in the absence of diagnosable disorders. Additional loss of sleep occurs with clinical sleep disorders, many of which can be ameliorated. This literature, reviewed below, raises the question of the possible biological consequences of age-related, chr...

    journal_title:Experimental gerontology

    pub_type: 杂志文章,评审

    doi:10.1016/j.exger.2004.06.023

    authors: Prinz PN

    更新日期:2004-11-01 00:00:00

  • Month of birth and survival to age 105+: evidence from the age validation study of German semi-supercentenarians.

    abstract::Using data from Germany, we examine if month of birth influences survival up to age 105. Since age reporting at the highest ages is notoriously unreliable we draw on age-validated information from a huge age validation project of 1487 alleged German semi-supercentenarians aged 105+. We use month of birth as an exogeno...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2005.07.012

    authors: Doblhammer G,Scholz R,Maier H

    更新日期:2005-10-01 00:00:00

  • Lifelong wheel running exercise and mild caloric restriction attenuate nuclear EndoG in the aging plantaris muscle.

    abstract::Apoptosis plays an important role in atrophy and sarcopenia in skeletal muscle. Recent evidence suggests that insufficient heat shock proteins (HSPs) may contribute to apoptosis and muscle wasting. In addition, long-term caloric restriction (CR) and lifelong wheel running exercise (WR) with CR provide significant prot...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2015.06.007

    authors: Kim JH,Lee Y,Kwak HB,Lawler JM

    更新日期:2015-09-01 00:00:00

  • The evolution of ovarian oocyte decline with aging and possible relationships to Down syndrome and Alzheimer disease.

    abstract::Evolutionary aspects of menopause are considered from several perspectives. First, the programmed exhaustion of ovarian oocytes appears to be a general trait of mammals that is not as widely found in other vertebrates. Second, studies on mice suggest that the maternal age effect that accelerates the incidence of Down ...

    journal_title:Experimental gerontology

    pub_type: 杂志文章,评审

    doi:10.1016/0531-5565(94)90009-4

    authors: Finch CE

    更新日期:1994-05-01 00:00:00

  • Genetic characterization of senescence-accelerated mouse (SAM).

    abstract::The Senescence-Accelerated Mouse (SAM) strains are unique and appropriate models for genetic studies on aging because the SAMP strains have an "accelerated senescence" phenotype for which the SAMR strains are controls, and each SAMP strain has a strain-specific age-associated disorder. Furthermore, because they have g...

    journal_title:Experimental gerontology

    pub_type: 杂志文章,评审

    doi:10.1016/s0531-5565(96)00060-5

    authors: Higuchi K

    更新日期:1997-01-01 00:00:00

  • Twenty-four hour growth hormone secretion in a patient with Werner's syndrome.

    abstract:OBJECTIVE:To assess the 24-h endogenous secretory growth hormone (GH) profile and serum insulin-like growth factor-I (IGF-I) response to exogenous recombinant human growth hormone (rhGH) in a patient with Werner's syndrome. DESIGN:Blood sampling every 20 min for 24 h followed by three daily injections of growth hormon...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/0531-5565(96)00031-9

    authors: Rubin CD,Reed B

    更新日期:1996-09-01 00:00:00

  • Metabolism in the Caenorhabditis elegans Mit mutants.

    abstract::In many eukaryotes oxidative phosphorylation via the mitochondrial electron transport chain provides the major means of ATP production. Complete removal of this capacity often results in premature death. Recent studies using the nematode Caenorhabditis elegans are surprising because they have revealed that disruption ...

    journal_title:Experimental gerontology

    pub_type: 杂志文章,评审

    doi:10.1016/j.exger.2005.06.015

    authors: Rea SL

    更新日期:2005-11-01 00:00:00

  • Tissue-specificity of reactivity to concanavalin-A of human cells in culture.

    abstract::Concanavalin-A (Con-A) reactivity was studied to identify the tissue-specificity of cells established from various normal human tissues. Cells were treated with Con-A-labelled human red blood cells (C-RBC). C-RBC was not absorbed on the cells derived from the bone marrow, skin and liver. Lung-derived fibroblast cells ...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/0531-5565(83)90040-2

    authors: Ban S,Iida S

    更新日期:1983-01-01 00:00:00