Vitamin E enhances the immune functions of young but not old mice under restraint stress.

Abstract:

:Young and old C57BL/6 male mice were given a diet containing a high dose of vitamin E (VE treatment) and its effect on the immune system was examined before and after the exposure to restraint stress. The VE treatment per se gave rise to a slight increase of splenic T cells in percentage and a significant enhancement of Con A response of spleen cells in young, but not in old mice. The VE treatment also resulted in the enhancement of production of IL-2 and IFNgamma in young, but not in old mice. Restraint stress led to thymic involution in both young and old mice. This thymic involution was not ameliorated by the VE treatment. Percentage of splenic T cells and their mitogenic response decreased just after the stress, but soon rebounded over the control level. The VE treatment further enhanced the recovery after the stress in young mice, but on the contrary suppressed the recovery in old mice. The results in the present study suggested that the VE treatment was effective in the prevention of immunological decline of young mice before and after the exposure to the stress. On the other hand, such a preventive effect was not observed in old mice that were already in the depressed state of immunological functions.

journal_name

Exp Gerontol

journal_title

Experimental gerontology

authors

Wakikawa A,Utsuyama M,Wakabayashi A,Kitagawa M,Hirokawa K

doi

10.1016/s0531-5565(99)00055-8

keywords:

subject

Has Abstract

pub_date

1999-11-01 00:00:00

pages

853-62

issue

7

eissn

0531-5565

issn

1873-6815

pii

S0531-5565(99)00055-8

journal_volume

34

pub_type

杂志文章
  • Inaccurate judgement of reach is associated with slow reaction time, poor balance, impaired executive function and predicts prospective falls in older people with cognitive impairment.

    abstract:BACKGROUND:Awareness of physical ability may impact fall risk during everyday tasks. Therefore, we investigated perceived reach (PR; estimation of furthest reach distance), maximal reach (MR) and reach judgement error (RJE), and their relationships with neuropsychological and physical performance, and falls in older pe...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2018.10.020

    authors: Taylor ME,Butler AA,Lord SR,Delbaere K,Kurrle SE,Mikolaizak AS,Close JCT

    更新日期:2018-12-01 00:00:00

  • Longevity and age-related pathology of LVG outbred golden Syrian hamsters (Mesocricetus auratus).

    abstract::A colony of male Lakeview Golden (LVG) Syrian hamsters has been maintained for the last nine years as a source of various tissues for cellular aging studies. Observations on this colony also yielded data on survival time and physical and pathological manifestations of aging in this strain. Based on 150 spontaneous dea...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/0531-5565(90)90032-w

    authors: Deamond SF,Portnoy LG,Strandberg JD,Bruce SA

    更新日期:1990-01-01 00:00:00

  • Altered transcriptional regulation of human interstitial collagenase in cultured skin fibroblasts from older donors.

    abstract::Primary human dermal fibroblasts isolated from the medial aspect of the proximal forearm of young and old donors were compared for the expression of interstitial collagenase, 72 kDa type IV collagenase, the tissue inhibitor of metalloproteinase type 1, and pro-alpha 2 (I) collagen mRNA at basal levels and after stimul...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/0531-5565(94)90061-2

    authors: Burke EM,Horton WE,Pearson JD,Crow MT,Martin GR

    更新日期:1994-01-01 00:00:00

  • Comparison of the level of mitochondrial DNA A3243G mutation in esophageal epithelium and myocardium from individuals of very advanced age.

    abstract::The A3243G mutation, one of the changes of human mitochondrial DNA (mtDNA) that accumulates in cells during aging, is a useful marker for investigating the aging of cells. We measured the mutation level of the mtDNA A3243G mutation using DNAs from two different tissues (esophageal epithelium and myocardium) from advan...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/s0531-5565(02)00020-7

    authors: Harihara S,Nakamura K,Takubo K,Takeuchi F

    更新日期:2002-07-01 00:00:00

  • Effect of DL-alpha-lipoic acid on the status of lipid peroxidation and antioxidant enzymes in various brain regions of aged rats.

    abstract::The effect of DL-alpha-lipoic acid on lipid peroxidation and antioxidant enzymes were evaluated in various brain regions of young and aged rats. Lipoate contents of discrete brain regions were also measured. In aged rats, the activities of superoxide dismutase, glutathione peroxidase, glutathione reductase and glucose...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/s0531-5565(02)00015-3

    authors: Arivazhagan P,Shila S,Kumaran S,Panneerselvam C

    更新日期:2002-06-01 00:00:00

  • Basal cells have longest telomeres measured by tissue Q-FISH method in lingual epithelium.

    abstract::We investigated the telomere lengths of individual cell types in lingual mucosa using an improved tissue quantitative fluorescence in situ hybridization (Q-FISH) method. Our tissue Q-FISH method compensates for partially cut nuclei in a tissue section by using the telomere:centromere ratio (TCR). We normalized our TCR...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2008.06.001

    authors: Aida J,Izumiyama-Shimomura N,Nakamura K,Ishikawa N,Poon SS,Kammori M,Sawabe M,Arai T,Matsuura M,Fujiwara M,Kishimoto H,Takubo K

    更新日期:2008-09-01 00:00:00

  • Life long calorie restriction increases heat shock proteins and proteasome activity in soleus muscles of Fisher 344 rats.

    abstract::Heat shock proteins (HSP's) closely interact with 20S proteasome and have been shown to maintain catalytic activity, responsible for the prevention of protein aggregation. A decrease in both proteasome activity and heat shock proteins (HSP's) has been observed with age. We investigated whether life-long calorie restri...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2004.08.012

    authors: Selsby JT,Judge AR,Yimlamai T,Leeuwenburgh C,Dodd SL

    更新日期:2005-01-01 00:00:00

  • Extension of life span and stress resistance of Drosophila melanogaster by long-term supplementation with melatonin.

    abstract::According to the free radical theory of aging, free radicals are involved in the production of changes in cellular metabolism that lead to a time-dependent functional decline in all living beings. Consequently, antioxidant and/or free radicals scavengers may retard the aging process. We explored the effect of melatoni...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/s0531-5565(01)00229-7

    authors: Bonilla E,Medina-Leendertz S,Díaz S

    更新日期:2002-05-01 00:00:00

  • Association of telomere length and mitochondrial DNA copy number in a community sample of healthy adults.

    abstract::Cellular aging plays a role in longevity and senescence, and has been implicated in medical and psychiatric conditions, including heart disease, cancer, major depression and posttraumatic stress disorder. Telomere shortening and mitochondrial dysfunction are thought to be central to the cellular aging process. The pre...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2015.04.002

    authors: Tyrka AR,Carpenter LL,Kao HT,Porton B,Philip NS,Ridout SJ,Ridout KK,Price LH

    更新日期:2015-06-01 00:00:00

  • A combination of Korean mistletoe extract and resistance exercise retarded the decline in muscle mass and strength in the elderly: A randomized controlled trial.

    abstract::Given the increased concerns about the degenerative decline in the physical performance of the elderly, there is a need for developing effective strategies to suppress the age-related loss of skeletal muscle mass and functional capacity through a lifestyle intervention. This randomized controlled trial examined whethe...

    journal_title:Experimental gerontology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.exger.2016.11.003

    authors: Lim NJ,Shin JH,Kim HJ,Lim Y,Kim JY,Lee WJ,Han SJ,Kwon O

    更新日期:2017-01-01 00:00:00

  • Exercise training protects against aging-induced mitochondrial fragmentation in mouse skeletal muscle in a PGC-1α dependent manner.

    abstract::Aging is associated with impaired mitochondrial function, whereas exercise training enhances mitochondrial content and function in part through activation of PGC-1α. Mitochondria form dynamic networks regulated by fission and fusion with profound effects on mitochondrial functions, yet the effects of aging and exercis...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2017.05.020

    authors: Halling JF,Ringholm S,Olesen J,Prats C,Pilegaard H

    更新日期:2017-10-01 00:00:00

  • Phenotype, antigen-presenting capacity, and migration of antigen-presenting cells in young and old age.

    abstract::In the present paper, we investigated whether the phenotype, the antigen-presenting capacity, and the migration of antigen-presenting cells (APCs), are affected by the aging process. APCs were obtained incubating peritoneal monocyte-macrophage cells with granulocyte-macrophage colony-stimulating factor (GM-CSF) (immat...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/s0531-5565(02)00087-6

    authors: Donnini A,Argentati K,Mancini R,Smorlesi A,Bartozzi B,Bernardini G,Provinciali M

    更新日期:2002-08-01 00:00:00

  • Neuronal and glial region dependent changes in female mice from a model of premature aging.

    abstract::Adult Premature Aging Mice (PAM) show premature immunosenescence, oxidative and inflammatory stress and consequently a shorter lifespan than Exceptional Non-Prematurely Aging Mice (E-NPAM) at the same age. Indeed, adult female PAM exhibit behavioral age-related declines and abnormalities in its brain neurochemistry. N...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2020.111224

    authors: Garrido A,De La Serna M,De La Fuente M,Marco EM,López-Gallardo M

    更新日期:2020-12-31 00:00:00

  • Late life maintenance and enhancement of functional exercise capacity in low and high responding rats after low intensity treadmill training.

    abstract::Intrinsic exercise capacity is predictive of both lifespan and healthspan but whether adaptive exercise capacity influences the benefits achieved from aerobic training implemented later in life is not known. AIM:To determine if exercise late in life provides any functional improvements or underlying beneficial bioche...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2019.110657

    authors: Brown LA,Macpherson PC,Koch LG,Qi NR,Britton SL,Brooks SV

    更新日期:2019-10-01 00:00:00

  • Sex-dependent and sex-independent muscle activation patterns in adult gait as a function of age.

    abstract:INTRODUCTION:Aging leads to poorer neuromuscular control that may impact mobility. However, the specific decades when these changes occur, and whether these time-based changes are sex-specific, are unclear. METHODS:Adults aged 20-82 years (N = 93, 51 females) walked six gait trials at their preferred speed over a 10-m...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2018.05.005

    authors: Bailey CA,Corona F,Pilloni G,Porta M,Fastame MC,Hitchcott PK,Penna MP,Pau M,Côté JN

    更新日期:2018-09-01 00:00:00

  • Rapamycin reverses age-related increases in mitochondrial ROS production at complex I, oxidative stress, accumulation of mtDNA fragments inside nuclear DNA, and lipofuscin level, and increases autophagy, in the liver of middle-aged mice.

    abstract::Rapamycin consistently increases longevity in mice although the mechanism of action of this drug is unknown. In the present investigation we studied the effect of rapamycin on mitochondrial oxidative stress at the same dose that is known to increase longevity in mice (14mgofrapamycin/kg of diet). Middle aged mice (16m...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2016.08.002

    authors: Martínez-Cisuelo V,Gómez J,García-Junceda I,Naudí A,Cabré R,Mota-Martorell N,López-Torres M,González-Sánchez M,Pamplona R,Barja G

    更新日期:2016-10-01 00:00:00

  • CSF protein changes associated with hippocampal sclerosis risk gene variants highlight impact of GRN/PGRN.

    abstract:OBJECTIVE:Hippocampal sclerosis of aging (HS-Aging) is a common cause of dementia in older adults. We tested the variability in cerebrospinal fluid (CSF) proteins associated with previously identified HS-Aging risk single nucleotide polymorphisms (SNPs). METHODS:Alzheimer's Disease Neuroimaging Initiative cohort (ADNI...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2017.01.025

    authors: Fardo DW,Katsumata Y,Kauwe JSK,Deming Y,Harari O,Cruchaga C,Alzheimer's Disease Neuroimaging Initiative.,Nelson PT

    更新日期:2017-04-01 00:00:00

  • Primary mouse brain pericytes isolated from transgenic Alzheimer mice spontaneously differentiate into a CD11b+ microglial-like cell type in vitro.

    abstract::Alzheimer's disease (AD) is characterized by amyloid-β plaques, tau pathology and vascular impairment including pericyte damage. Pericytes are perivascular cells of the blood-brain barrier and can differentiate into different cell types in vitro including microglia. The aim of the present study is to explore if primar...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2018.08.003

    authors: Hutter-Schmid B,Humpel C

    更新日期:2018-10-02 00:00:00

  • Gene-diet interactions and aging in C. elegans.

    abstract::Diet is the most variable aspect of life history, as most individuals have a large diversity of food choices, varying in the type and amount that they ingest. In the short-term, diet can affect metabolism and energy levels. However, in the long run, the net deficiency or excess of calories from diet can influence the ...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2016.02.012

    authors: Yen CA,Curran SP

    更新日期:2016-12-15 00:00:00

  • Divergent effects of resistance training and anabolic steroid on the postsynaptic region of different skeletal muscles of aged rats.

    abstract::This study aimed to analyze the effects of resistance training associated with testosterone administration in the neuromuscular junction (NMJ) postsynaptic region of different skeletal muscle types of aged rats. Wistar rats were divided into: SEI - 20-months-old control, SEF - 24-months-old control, T - 20-months-old ...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2017.08.018

    authors: Krause Neto W,de Assis Silva W,Ciena AP,Anaruma CA,Gama EF

    更新日期:2017-11-01 00:00:00

  • Orally supplemented catechin increases heme amounts and catalase activities in rat heart blood mitochondria: a comparison between middle-aged and young rats.

    abstract::Orally-administered catechin has long been known to have several beneficial effects on the mammalian host, however, the effects of orally supplemented catechin on the host through gingival tissues have not yet been established. Here, we elucidated the effects of orally supplemented catechin in the rat heart blood mito...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2013.08.014

    authors: Cueno ME,Tamura M,Imai K,Ochiai K

    更新日期:2013-11-01 00:00:00

  • Changes in the insulin-like growth factor-system may contribute to in vitro age-related impaired osteoblast functions.

    abstract::Age-related bone loss is thought to be due to impaired osteoblast functions. Insulin-like growth factors (IGFs) have been shown to be important stimulators of bone formation and osteoblast activities in vitro and in vivo. We tested the hypothesis that in vitro osteoblast senescence is associated with changes in compon...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/s0531-5565(00)00125-x

    authors: Kveiborg M,Flyvbjerg A,Rattan SI,Kassem M

    更新日期:2000-10-01 00:00:00

  • Analysis of premature centromere division (PCD) of the X chromosome in Alzheimer patients through the cell cycle.

    abstract::Cytogenetic analysis of the X chromosome in phytohaemagglutinin stimulated peripheral blood lymphocytes was evaluated in 12 sporadic Alzheimer disease (AD) patients and in 11 healthy subjects. For chromosome analysis two methods were used: (1) standard analysis of G-banded metaphase chromosomes and; (2) fluorescent in...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2004.01.012

    authors: Spremo-Potparevic B,Zivkovic L,Djelic N,Bajic V

    更新日期:2004-05-01 00:00:00

  • Age-dependent increase of indigenous DNA adducts in rat brain is associated with a lipid peroxidation product.

    abstract::Indigenous DNA adducts (I-compounds) are considered to be a biomarker of aging tissues. Thus far, few studies have been conducted to investigate the accumulation patterns of I-compounds in the brain during aging. Particularly, identities of age-dependent I-compounds have largely remained unknown. In the current study,...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/0531-5565(95)02027-6

    authors: Cai Q,Tian L,Wei H

    更新日期:1996-05-01 00:00:00

  • Living longer but less healthy: The female disadvantage in health expectancy. Results from the KORA-Age study.

    abstract:OBJECTIVES:We explored the male-female health-survival paradox in the context of health expectancy (HE) at age 65 and thereafter, using three different morbidity measures and different severity cut-offs with and without adjustments for the share of nursing home residents. METHODS:HE at ages 65, 70, 75, 80, and 85 was ...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2020.111196

    authors: Stephan AJ,Schwettmann L,Meisinger C,Ladwig KH,Linkohr B,Thorand B,Schulz H,Peters A,Grill E

    更新日期:2021-03-01 00:00:00

  • A busy day has minimal effect on factors associated with falls in older people: An ecological randomised crossover trial.

    abstract::Fatigue is a common complaint in older people. Laboratory-induced muscle fatigue has been found to affect physical functions in older populations but these protocols are rigorous and are unlikely to accurately reflect daily activities. This study used an ecological approach to determine the effects of a busy day on se...

    journal_title:Experimental gerontology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.exger.2018.03.009

    authors: Sturnieks DL,Yak SL,Ratanapongleka M,Lord SR,Menant JC

    更新日期:2018-06-01 00:00:00

  • High carbohydrate-low protein consumption maximizes Drosophila lifespan.

    abstract::Dietary restriction extends lifespan in a variety of organisms, but the key nutritional components driving this process and how they interact remain uncertain. In Drosophila, while a substantial body of research suggests that protein is the major dietary component affecting longevity, recent studies claim that carbohy...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2013.02.003

    authors: Bruce KD,Hoxha S,Carvalho GB,Yamada R,Wang HD,Karayan P,He S,Brummel T,Kapahi P,Ja WW

    更新日期:2013-10-01 00:00:00

  • Neuron-specific overexpression of core clock genes improves stress-resistance and extends lifespan of Drosophila melanogaster.

    abstract::Gene expression is much altered in aging. We observed age-dependent decline of core clock genes' expression in the whole body of the fruit fly. We hypothesized that inducible overexpression of clock genes (cry, per, tim, cyc and Clk) in the nervous system can improve healthspan of D. melanogaster. We studied the lifes...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2018.11.005

    authors: Solovev I,Dobrovolskaya E,Shaposhnikov M,Sheptyakov M,Moskalev A

    更新日期:2019-03-01 00:00:00

  • Why is the dog an ideal model for aging research?

    abstract::With many caveats to the traditional vertebrate species pertaining to biogerontology investigations, it has been suggested that a most informative model is the one which: 1) examines closely related species, or various members of the same species with naturally occurring lifespan variation, 2) already has adequate med...

    journal_title:Experimental gerontology

    pub_type: 杂志文章,评审

    doi:10.1016/j.exger.2015.08.008

    authors: Gilmore KM,Greer KA

    更新日期:2015-11-01 00:00:00

  • A polymorphic marker in the first intron of the Werner gene associates with cognitive function in aged Danish twins.

    abstract::Werner's syndrome is a premature aging syndrome with many features common to normal aging. The possible association between phenotypic markers for normal aging and SNP's in the WRN gene was investigated in 426 dizygotic, Danish twins age 70-90 years. All participants were scored every second year using a number of phy...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2004.03.036

    authors: Bendixen MH,Nexø BA,Bohr VA,Frederiksen H,McGue M,Kølvraa S,Christensen K

    更新日期:2004-07-01 00:00:00