Abstract：
:Aging is associated with impaired mitochondrial function, whereas exercise training enhances mitochondrial content and function in part through activation of PGC-1α. Mitochondria form dynamic networks regulated by fission and fusion with profound effects on mitochondrial functions, yet the effects of aging and exercise training on mitochondrial network structure remain unclear. This study examined the effects of aging and exercise training on mitochondrial network structure using confocal microscopy on mitochondria-specific stains in single muscle fibers from PGC-1α KO and WT mice. Hyperfragmentation of mitochondrial networks was observed in aged relative to young animals while exercise training normalized mitochondrial network structure in WT, but not in PGC-1α KO. Mitochondrial fission protein content (FIS1 and DRP1) relative to mitochondrial content was increased with aging in both WT and PGC-1α KO mice, while exercise training lowered mitochondrial fission protein content relative to mitochondrial content only in WT. Mitochondrial fusion protein content (MFN1/2 and OPA1) was unaffected by aging and lifelong exercise training in both PGC-1α KO and WT mice. The present results provide evidence that exercise training rescues aging-induced mitochondrial fragmentation in skeletal muscle by suppressing mitochondrial fission protein expression in a PGC-1α dependent manner.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Halling JF,Ringholm S,Olesen J,Prats C,Pilegaard Hdoi
10.1016/j.exger.2017.05.020subject
Has Abstractpub_date
2017-10-01 00:00:00pages
1-6eissn
0531-5565issn
1873-6815pii
S0531-5565(16)30626-Xjournal_volume
96pub_type
杂志文章abstract：:Mechanical loading is considered to be a major parameter of the periodontal ligament (PDL) remodeling and differentiation. However, the molecular mechanisms that translate these forces to cellular responses are not fully elucidated. Especially, although aging affects PDL homeostasis, the role of cellular senescence on...
journal_title：Experimental gerontology
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pub_type： 杂志文章
doi：10.1016/j.exger.2016.03.021
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journal_title：Experimental gerontology
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pub_type： 杂志文章
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更新日期：2020-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
doi：10.1016/j.exger.2019.110817
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pub_type： 杂志文章
doi：10.1016/j.exger.2015.02.016
更新日期：2015-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.exger.2006.04.006
更新日期：2006-08-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2017.12.010
更新日期：2018-02-01 00:00:00
abstract：:Previous studies have indicated that genetic variations in the factors of insulin/insulin-like growth factor 1 (IGF-1) signaling pathway could influence human life-span by affecting IGF-1 levels. The promoter region of the IGF-1 gene is an obvious candidate and has not been studied clearly. To explore the potential ro...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2008.08.004
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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journal_title：Experimental gerontology
pub_type： 杂志文章
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更新日期：2000-12-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
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更新日期：2007-03-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(87)90048-9
更新日期：1987-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
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更新日期：2011-04-01 00:00:00
abstract：:In order to clarify immunogenetic markers contributing to successful aging, HLA and cytokine gene profiles were analyzed in healthy elderly Bulgarians. Family segregation analysis was performed to define combined effect of haplotypes and immunophenotype profiles. The results of this study did not reveal any statistica...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2003.08.014
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2006.07.006
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journal_title：Experimental gerontology
pub_type： 杂志文章,多中心研究
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更新日期：2015-10-01 00:00:00
abstract：:Reproductive senescence occurs in all female mammals with resultant changes in numerous body functional systems and several important features may be species-specific. Those features that appear to parallel human menopause and aging include general similarity of hormone profiles across the menopausal transition, progr...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
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更新日期：2006-02-01 00:00:00
