Abstract：
:Previous studies have indicated that genetic variations in the factors of insulin/insulin-like growth factor 1 (IGF-1) signaling pathway could influence human life-span by affecting IGF-1 levels. The promoter region of the IGF-1 gene is an obvious candidate and has not been studied clearly. To explore the potential role of the promoter region variation of IGF-1 gene in longevity, we investigated 485 longevity subjects and 392 younger individuals from Dujiangyan, China. By sequencing about 2.5 kb (kilo base pairs) upstream the transcription start site of exon 1 of the IGF-1 gene in 30 individuals from both groups respectively, we acquired three previously described SNPs (-439T/A (rs2288377), -541T/C (rs5742612) and -1246C/T (rs35767)). We examined the association between these three SNPs and longevity by comparing the distribution of genotypes, alleles, and haplotypes in both the longevity and control groups. None of these variants were found to be associated with longevity. Our results suggest that there is no association between SNPs in the promoter region of IGF-1 gene and longevity in the Han Chinese population.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Xie L,Gong YY,Lian SG,Yang J,Yang Y,Gao SJ,Xu LY,Zhang YPdoi
10.1016/j.exger.2008.08.004subject
Has Abstractpub_date
2008-10-01 00:00:00pages
962-5issue
10eissn
0531-5565issn
1873-6815pii
S0531-5565(08)00223-4journal_volume
43pub_type
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pub_type： 杂志文章
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pub_type： 杂志文章
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abstract：:The Tokyo Metropolitan Institute of Gerontology (TMIG) celebrates its 30th anniversary in 2002. Since its establishment, TMIG has been carrying out inter-disciplinary research on aging as a core institute in Japan and functions as a knowledge bank and a source for capable researchers of gerontology. The proportion of ...
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,meta分析,评审
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