Abstract：
:Type 2 diabetes is associated with progressive beta-cell failure manifest as a decline in insulin secretion and increasing hyperglycemia. A growing body of evidence suggests that beta-cell failure in type 2 diabetes correlates with the formation of pancreatic islet amyloid deposits, indicating that islet amyloid may have an important role in beta-cell loss in this disease. Islet amyloid polypeptide (IAPP; amylin), the major component of islet amyloid, is co-secreted with insulin from beta-cells. In type 2 diabetes, this peptide aggregates to form amyloid fibrils that are toxic to beta-cells. The mechanism(s) responsible for islet amyloid formation in type 2 diabetes is still unclear but it appears that an increase in the secretion of IAPP, per se, is not sufficient. Other factors, such as impairment in the processing of proIAPP, the IAPP precursor, have been proposed to contribute to the development of islet amyloid deposits. Inhibitors of islet amyloid fibril formation might prevent the progression to beta-cell failure in type 2 diabetes and should therefore be considered as a therapeutic approach to treat this disease.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Marzban L,Park K,Verchere CBdoi
10.1016/s0531-5565(03)00004-4keywords:
subject
Has Abstractpub_date
2003-04-01 00:00:00pages
347-51issue
4eissn
0531-5565issn
1873-6815pii
S0531556503000044journal_volume
38pub_type
杂志文章,评审abstract：:For more than 60 years the only dietary manipulation known to retard aging was caloric restriction, in which a variety of species respond to a reduction in energy intake by demonstrating extended median and maximum life span. More recently, two alternative dietary manipulations have been reported to also extend surviv...
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
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doi：10.1016/s0531-5565(00)00101-7
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pub_type： 杂志文章
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更新日期：1982-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：1992-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2020.110984
更新日期：2020-09-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
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更新日期：2015-09-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2004.01.012
更新日期：2004-05-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/0531-5565(94)90009-4
更新日期：1994-05-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2008.05.003
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journal_title：Experimental gerontology
pub_type： 杂志文章,随机对照试验
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
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journal_title：Experimental gerontology
pub_type： 杂志文章,随机对照试验
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更新日期：2018-09-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
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更新日期：1988-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2012.06.015
更新日期：2012-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0531-5565(85)90038-5
更新日期：1985-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2003.12.007
更新日期：2004-03-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(00)00199-6
更新日期：2001-02-01 00:00:00
abstract：:Aging-related changes to biological structures such as cardiovascular and musculoskeletal systems contribute to the development of comorbid conditions including cardiovascular disease and frailty, and ultimately lead to premature death. Although, frail older adults often demonstrate both cardiovascular and musculoskel...
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