Abstract:
:Advances in our understanding of tau-mediated neurodegeneration in Alzheimer's disease (AD) are moving this disease pathway to center stage for the development of biomarkers and disease modifying drug discovery efforts. Immunoassays were developed detecting total (t-tau) and tau phosphorylated at specific epitopes (p-tauX) in cerebrospinal fluid (CSF), methods to analyse tau in blood are at the experimental beginning. Clinical research consistently demonstrated CSF t- and p-tau increased in AD compared to controls. Measuring these tau species proved informative for classifying AD from relevant differential diagnoses. Tau phosphorylated at threonine 231 (p-tau231) differentiated between AD and frontotemporal dementia, tau phosphorylated at serine 181 (p-tau181) enhanced classification between AD and dementia with Lewy bodies. T- and p-tau are considered "core" AD biomarkers that have been successfully validated by controlled large-scale multi-center studies. Tau biomarkers are implemented in clinical trials to reflect biological activity, mechanisms of action of compounds, support enrichment of target populations, provide endpoints for proof-of-concept and confirmatory trials on disease modification. World-wide quality control initiatives are underway to set required methodological and protocol standards. Discussions with regulatory authorities gain momentum defining the role of tau biomarkers for trial designs and how they may be further qualified for surrogate marker status.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Hampel H,Blennow K,Shaw LM,Hoessler YC,Zetterberg H,Trojanowski JQdoi
10.1016/j.exger.2009.10.010subject
Has Abstractpub_date
2010-01-01 00:00:00pages
30-40issue
1eissn
0531-5565issn
1873-6815pii
S0531-5565(09)00207-1journal_volume
45pub_type
杂志文章,评审abstract:BACKGROUND:Geriatric depression is common due to the high rate of chronic diseases suffered by the older population. There is a well-established effect of exercise on one's wellbeing, however, for the elderly females there is dearth in research addressing exercise and its effect on their neurotransmitters and depressio...
journal_title:Experimental gerontology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.exger.2018.11.009
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:To assess the 24-h endogenous secretory growth hormone (GH) profile and serum insulin-like growth factor-I (IGF-I) response to exogenous recombinant human growth hormone (rhGH) in a patient with Werner's syndrome. DESIGN:Blood sampling every 20 min for 24 h followed by three daily injections of growth hormon...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(96)00031-9
更新日期:1996-09-01 00:00:00
abstract::Despite general belief that the mechanical properties of bone material contribute to whole bone strength, it is still obscure what the age effects are on mechanical behavior of the bone material, particularly in the case of the femoral neck trabeculae. In this study, atomic force microscopy was used for imaging and me...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2011.11.011
更新日期:2012-02-01 00:00:00
abstract::Male F344 rats, 3, 12, and 24 months of age, were acclimated to either 5 degrees C (CA) or 23 degrees C (non-CA). At the end of acclimation, all CA rats exhibited higher basal oxygen uptake than the non-CA when measured at 28 degrees C. When challenged by a 3-hour exposure to -10 degrees C, significant difference in t...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(85)90038-5
更新日期:1985-01-01 00:00:00
abstract::We have analyzed birth records from the International Species Inventory System database of zoo animals to describe patterns of fertility as a function of age in birds and mammals. Unlike age at death, fertility in captive populations is partly controlled by animal keepers depending on availability of space and potenti...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(03)00101-3
更新日期:2003-07-01 00:00:00
abstract::Progressive neuronal deterioration accompanied by sensory functions decline is typically observed during aging. On the other hand, structural or functional alterations of specific sensory neurons extend lifespan in the nematode Caenorhabditis elegans. Hormesis is a phenomenon by which the body benefits from moderate s...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2014.03.026
更新日期:2014-08-01 00:00:00
abstract:PURPOSE:The elderly lose skeletal muscle mass with age, which may be detrimental for function and quality of life. Both inactivity and heavy resistance exercise are known to have marked but opposite effects upon muscle mass. However, the potential effects of daily physical activity upon muscle protein synthesis (MPS) a...
journal_title:Experimental gerontology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.exger.2016.03.008
更新日期:2016-06-15 00:00:00
abstract:BACKGROUND:The World Health Organization (WHO) recently proposed an innovative model of care focusing on functional rather than disease-based perspectives, based on a construct of intrinsic capacity (IC). OBJECTIVE:This study aimed to analyze if low-grade inflammation (LGI) (chronically raised C-reactive protein - CRP...
journal_title:Experimental gerontology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.exger.2019.110716
更新日期:2019-11-01 00:00:00
abstract::Ascorbic acid decreases from age-group I to II in Kidney, skeletal muscle, and increases in the Pancreas of female. There is no significant change in the Pancreas of male toad. There is an increase in the ascorbic acid content from age group II to III except in the Pancreas of females, where there is a decline of the ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(84)90011-1
更新日期:1984-01-01 00:00:00
abstract::Intrinsic exercise capacity is predictive of both lifespan and healthspan but whether adaptive exercise capacity influences the benefits achieved from aerobic training implemented later in life is not known. AIM:To determine if exercise late in life provides any functional improvements or underlying beneficial bioche...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2019.110657
更新日期:2019-10-01 00:00:00
abstract::One of the most remarkable life history traits of many species of eusocial insects is the extraordinary longevity of their queens, with the recorded life span of some individuals exceeding 30 years. Surprisingly, little research has been conducted on either the proximate or ultimate questions concerning what factors f...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/s0531-5565(00)00237-0
更新日期:2001-04-01 00:00:00
abstract::Accumulation of oxidative stress-induced damage in brain tissue plays an important role in the pathogenesis of normal aging and neurodegenerative diseases. Neuronal oxidative damage typically increases with age in humans, and also in the invertebrate and vertebrate model species most commonly used in aging research. B...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2006.08.004
更新日期:2006-11-01 00:00:00
abstract::The age-related decrease in neuromuscular performance is usually accentuated in very old age (>80 yr) as evidenced by a marked reduction in maximal force production. However, little is known about the ability to rapidly produce force, which limits daily activities and increase the risk of falling. We aimed to assess r...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2019.110640
更新日期:2019-09-01 00:00:00
abstract::There is currently no test to directly and easily measure dynamic balance during walking in old adults. We examined the idea that distance of beam walking with and without cognitive dual-tasking could detect age differences in dynamic balance. Healthy old (n = 16, 71.2 y) and young (n = 20, 22.0 y) volunteers walked 3...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2018.10.016
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Epidemiological and objective studies report an association between sedentary time and lower risk of the metabolic syndrome (MetS) and its risk factors in young and middle-age adults. To date, there is a lack of objective data on the association between sedentary time and MetS among older adults. METHODS:Th...
journal_title:Experimental gerontology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.exger.2015.06.018
更新日期:2015-10-01 00:00:00
abstract::Aging is associated with altered immune responses, particularly with a diminished CD8 T cell response. Although both intrinsic and extrinsic factors are hypothesized to impact this decreased T cell response, the direct evidence of an intrinsic deficiency in virus-specific CD8 T cells is limited. In this study, a TCR t...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2013.02.027
更新日期:2013-06-01 00:00:00
abstract::Aberrant mineralization of soft connective tissues (ectopic calcification) may occur as a frequent age-related complication. Still, it remains unclear the role of mesenchymal cell donor's age and of replicative senescence on ectopic calcification. Therefore, the ability of cells to deposit in-vitro hydroxyapatite crys...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2015.10.009
更新日期:2015-12-01 00:00:00
abstract::Accumulation of altered proteins is the most common molecular symptom of ageing. Altered proteins are also associated with many age-related pathologies. Altered proteins are continuously produced but are normally selectively degraded by cellular proteases; their accumulation during ageing may be explained by either or...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2006.03.004
更新日期:2006-05-01 00:00:00
abstract::The study examined the influence of sex on the alterations occurring with ageing in rat lymph node (LN) T cell compartment. In female and male rats the decrease in LN T cell counts was followed by a shift in CD4+/CD8+ T cell ratio towards CD8+ T cells, which was more prominent in males than in females. With ageing, in...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2020.111140
更新日期:2020-12-01 00:00:00
abstract::Age-related sleep impairments are chronic and common, occurring even in the absence of diagnosable disorders. Additional loss of sleep occurs with clinical sleep disorders, many of which can be ameliorated. This literature, reviewed below, raises the question of the possible biological consequences of age-related, chr...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2004.06.023
更新日期:2004-11-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to compare the effects of 12 weeks of traditional resistance training (TRT) or resistance training using Cluster-set (CS) on functional performance and physical fitness of postmenopausal and elderly women. METHODS:Participants (61.1 ± 4.9 years, body mass 64.5 ± 1.8 kg, height 155.7...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2020.111011
更新日期:2020-09-01 00:00:00
abstract::Vascular endothelial growth factor (VEGF) has been identified as a potential treatment for effectively improving cognitive function in several neuropathological conditions. However, the underlying mechanism and the relevant downstream protective pathways that are activated in neurons by VEGF remain elusive, especially...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2017.12.010
更新日期:2018-02-01 00:00:00
abstract::According to the free radical theory of aging, free radicals are involved in the production of changes in cellular metabolism that lead to a time-dependent functional decline in all living beings. Consequently, antioxidant and/or free radicals scavengers may retard the aging process. We explored the effect of melatoni...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(01)00229-7
更新日期:2002-05-01 00:00:00
abstract::Serum lipid peroxide (LPO) in 72 healthy male subjects was studied using a newly developed assay method based on the reaction of LPO with methylene blue derivative (MCDP; 10-N-Methylcarbamoyl-3,7-dimethylamino-10 H-phenothiazine). This method is specific for lipid hydroperoxide and the relation is equimolar. The value...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(87)90045-3
更新日期:1987-01-01 00:00:00
abstract::The aging process is known to be regulated by specific genes in various organisms, including yeast, the nematode C. elegans, fruitflies and mice. To explore the novel genes involved in aging process, we applied cDNA microarray technology to a replicative senescence model of human dermal fibroblasts (HDF). Eighty-four ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2004.07.002
更新日期:2004-09-01 00:00:00
abstract::Motor performance of rats of different ages was determined in a cross sectional study. The design includes a test battery of seven motor tasks of graduated complexity. The results show a hierarchical order of impairments of motor functions in aging rats; that is, the more complex the task requirement, the earlier and ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(83)90018-9
更新日期:1983-01-01 00:00:00
abstract::The results of life table experiments to determine the effects of artificial impairment (leg amputation) in 7500 Drosophila melanogaster adults revealed that the extent to which life expectancy was reduced in impaired individuals was conditional on: (1) leg location and number amputated--front leg had greatest impact ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2006.10.002
更新日期:2007-03-01 00:00:00
abstract::The age-associated decline in the regenerative abilities of mesenchymal stem cells (MSCs) may be due to age-related changes in reduction in number, intrinsic properties of MSCs and extrinsic factors of the extracellular environment (the stem cell niche). The effect of age on the efficacy of MSC transplantation on rege...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2014.01.020
更新日期:2014-04-01 00:00:00
abstract::Aging in Brown Norway rats is accompanied by the reduced production of testosterone by the Leydig cells, the testicular cells responsible for synthesizing and secreting this essential steroid. As yet, the mechanism by which Leydig cell steroidogenesis is reduced is unknown. Herein we assess the production of mitochond...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(01)00118-8
更新日期:2001-08-01 00:00:00
abstract::The cold-induced enhancement of non-shivering thermogenesis (NST), involving brown-adipose tissue (BAT) metabolism, could participate to impair energy balance in the aged gray mouse lemur (Microcebus murinus). We first investigated the age-related modulations of cold-stimulated BAT cell morphology and contents. Then, ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2010.03.013
更新日期:2010-06-01 00:00:00