Abstract：
:Age-related changes of immune functions have been extensively investigated in both humans and animal models; nevertheless, the literature on potential alterations of dendritic cells, potent antigen presenting cells responsible for initiating immune responses, with aging is very scarce. We studied the immuno-phenotype of peripheral blood dendritic cells of elderly and young subjects by three-color flow cytometry. In addition, the capacity of transendothelial migration, an important step in inflammatory reactions, of peripheral blood dendritic cells of elderly subjects was investigated in an in vitro model. The expression of HLA-DR in the peripheral blood dendritic cells of the elderly subjects was significantly decreased when compared to the young control subjects. The expression of various other surface markers was similar in the young and elderly subjects. The ability of transendothelial migration of dendritic cells was found to be unimpaired in the elderly subjects. Both in the young and elderly subjects a significantly higher expression of CD29, CD86, HLA-DR, and HLA-DQ in the dendritic cells that had migrated through the endothelium in comparison to nonadherent, nonmigrating cells was found. In the migrating dendritic cells of the elderly subjects a significantly increased expression of CD11c was observed, whereas the expression of CD54 was significantly enhanced in the migrating dendritic cells of the young subjects only. In conclusion, our results demonstrate intact functions and a normal immunophenotype of dendritic cells derived from elderly subjects. Dendritic cells thus seem to be functional and therefore are not responsible for the well-known decline of T cell functions with aging.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Pietschmann P,Hahn P,Kudlacek S,Thomas R,Peterlik Mdoi
10.1016/s0531-5565(99)00089-3keywords:
subject
Has Abstractpub_date
2000-03-01 00:00:00pages
213-24issue
2eissn
0531-5565issn
1873-6815pii
S0531-5565(99)00089-3journal_volume
35pub_type
杂志文章abstract：INTRODUCTION:The actual mechanisms leading to a reduced muscle power and functional ability in older adults are poorly understood. We investigated the association between different force-velocity (F-V) profiles and impaired muscle power, physical and cognitive function, frailty, and health-related quality of life (HRQo...
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abstract：AIM:The present study investigated whether hypertension, blood pressure, and antihypertensive therapy were associated with frailty status in community-dwelling older adults. In addition, we tested whether such associations were consistent across different frailty instruments. MATERIAL AND METHODS:Two-hundred older adu...
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pub_type： 杂志文章,评审
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更新日期：2001-07-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2013-08-01 00:00:00
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journal_title：Experimental gerontology
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journal_title：Experimental gerontology
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journal_title：Experimental gerontology
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doi：10.1016/j.exger.2015.03.011
更新日期：2015-06-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2019.110721
更新日期：2019-11-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2003.10.011
更新日期：2004-02-01 00:00:00
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journal_title：Experimental gerontology
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doi：10.1016/j.exger.2018.10.020
更新日期：2018-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.exger.2020.111173
更新日期：2021-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2015.12.002
更新日期：2016-02-01 00:00:00
abstract：:Stem cells are located throughout the adult body of higher organisms, supporting a continuous renewal and repair of tissues. Unique abilities of stem cells are self-renewal and multipotential differentiation. It is, therefore, of critical importance for an organism to maintain and control quantity and quality of stem ...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2005.07.006
更新日期：2005-12-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
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pub_type： 杂志文章
doi：10.1016/s0531-5565(00)00157-1
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2010.05.004
更新日期：2010-09-01 00:00:00
abstract：OBJECTIVES:1) To determine if there was a practice effect associated with walk tests performed by frail older adults with and without dementia, 2) to examine the role of systematic cueing in the walk tests for those with dementia, and 3) to make recommendations to testing protocols of the walk tests for frail older adu...
journal_title：Experimental gerontology
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更新日期：2019-09-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2016.10.003
更新日期：2017-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(85)90052-x
更新日期：1985-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2004.04.003
更新日期：2004-08-01 00:00:00
abstract：:The loss of bone mineral with aging and subsequent development of osteoporosis is a common problem in elderly women, and as life expectancy increases, in elderly men as well. Space flight also causes bone loss and could be a limiting factor for long duration missions, such as, a Mars expedition or extended occupation ...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/0531-5565(91)90011-a
更新日期：1991-01-01 00:00:00
abstract：:Currently, there is little doubt that the immune system plays a role in the neurodegenerative process in Alzheimer's disease (AD). Inflammatory proteins such as complement components, enzymes, eicosanoids, and cytokines are found in association with cerebral amyloid plaques and may exacerbate the fundamental pathology...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(98)00028-x
更新日期：1998-11-01 00:00:00
abstract：:Evolutionary aspects of menopause are considered from several perspectives. First, the programmed exhaustion of ovarian oocytes appears to be a general trait of mammals that is not as widely found in other vertebrates. Second, studies on mice suggest that the maternal age effect that accelerates the incidence of Down ...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/0531-5565(94)90009-4
更新日期：1994-05-01 00:00:00
