Stress, DNA damage and ageing -- an integrative approach.

abstract：BACKGROUNDS:Elucidating the causal effects of common intermediate risk factors on the onset of age-related diseases is indispensable for developing prevention and intervention procedures. METHODS:We conducted two-stage time-to-event Mendelian randomization meta-analyses combining five large-scale longitudinal cohorts ...

journal_title：Experimental gerontology

authors： He L,Culminskaya I,Loika Y,Arbeev KG,Bagley O,Duan M,Yashin AI,Kulminski AM

更新日期：2018-07-01 00:00:00

abstract：:Aging is associated with an increased incidence of heart failure, but the existence of an age-related cardiomyopathy remains controversial. Differences in strain, age and technique of measuring cardiac function differ between experiments, confounding the interpretation of these studies. Additionally, the structural an...

journal_title：Experimental gerontology

authors： Boyle AJ,Shih H,Hwang J,Ye J,Lee B,Zhang Y,Kwon D,Jun K,Zheng D,Sievers R,Angeli F,Yeghiazarians Y,Lee R

更新日期：2011-07-01 00:00:00

abstract：:A micromethod was used to study myelin from individual rat optic nerves as a function of age. Protein and galactolipid content as well as 2',3'-cyclic nucleotide phosphohydrolase (CNPase) activity at ages 2, 4, 22, and 28 months were determined. Protein content increased significantly at 22 months and decreased at adv...

journal_title：Experimental gerontology

authors： Jacks AS,Richardson AR,Jones MA

更新日期：1989-01-01 00:00:00

abstract：:This study was aimed at determining the effect of exercise and vitamin E on age-associated changes in the superoxide dismutase (SOD), lipid (LPO) and protein oxidations (PO) in the cerebral cortex (CC), cerebellum (CB) and hippocampus (HC) of rat brain. For this, male Wistar albino rats of 4- (adult), 12- (middle-age)...

journal_title：Experimental gerontology

authors： Jolitha AB,Subramanyam MV,Asha Devi S

更新日期：2006-08-01 00:00:00

abstract：:The present study investigated the time-course for aging-associated effects on contractile and relaxing vascular responses and nitric oxide (NO) production in the aorta from female senescence-accelerated resistant (SAMR1) and prone (SAMP8) mice. Both SAMR1 and SAMP8 were studied at three different ages: 3 (young), 6 (...

journal_title：Experimental gerontology

authors： Novella S,Dantas AP,Segarra G,Vidal-Gómez X,Mompeón A,Garabito M,Hermenegildo C,Medina P

更新日期：2013-11-01 00:00:00

abstract：:During the course of life, cyclic females face a state of midlife transition that occurs in a fully functioning neurological system, and results in reproductive senescence. The authors' hypothesis was that changes in the activity noradrenergic neurons may be one of the factors involved in this phenomenon. The aim of t...

journal_title：Experimental gerontology

authors： Nicola AC,Leite CM,Nishikava MM,de Castro JC,Anselmo-Franci JA,Dornelles RC

更新日期：2016-08-01 00:00:00

abstract：:Aging is associated with a decline in muscle force that exceeds loss of muscle mass, suggesting that factors other than sarcopenia affect age-related muscle weakness. Here, we investigate in situ muscle force and sarcoplasmic reticulum (SR) properties in gastrocnemius muscles of adult (6-8 months) and aged (24 months)...

journal_title：Experimental gerontology

authors： Russ DW,Wills AM,Boyd IM,Krause J

更新日期：2014-02-01 00:00:00

abstract：:The study examined the influence of sex on the alterations occurring with ageing in rat lymph node (LN) T cell compartment. In female and male rats the decrease in LN T cell counts was followed by a shift in CD4+/CD8+ T cell ratio towards CD8+ T cells, which was more prominent in males than in females. With ageing, in...

journal_title：Experimental gerontology

authors： Nacka-Aleksić M,Stojić-Vukanić Z,Pilipović I,Blagojević V,Kotur-Stevuljević J,Leposavić G

更新日期：2020-12-01 00:00:00

abstract：:Aging plays an important role in increased vulnerability to atrial fibrillation (AF). Mediated by activity at the muscarinic type 2 receptor (M2R), the parasympathetic nerve contributes to the onset of AF. The purpose of this study was to investigate whether aging changes the distribution of M2R in the atrial myocardi...

journal_title：Experimental gerontology

authors： Yang YH,Zheng QS,Li J,Shang FJ,Liu T,Wang HT,Liu XT,Liu L

更新日期：2009-09-01 00:00:00

abstract：:The dependent elderly are widely considered to be at higher risk of nutritional problems. Suboptimal micronutrient intake might put the elderly, especially those living in nursing homes, at high risk of morbidity. So far, no public authority, except for the Israel Ministry of Health, has issued particular recommendati...

journal_title：Experimental gerontology

authors： Tal S,Stern F,Polyak Z,Ichelzon I,Dror Y

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:Hippocampal sclerosis of aging (HS-Aging) is a common cause of dementia in older adults. We tested the variability in cerebrospinal fluid (CSF) proteins associated with previously identified HS-Aging risk single nucleotide polymorphisms (SNPs). METHODS:Alzheimer's Disease Neuroimaging Initiative cohort (ADNI...

journal_title：Experimental gerontology

authors： Fardo DW,Katsumata Y,Kauwe JSK,Deming Y,Harari O,Cruchaga C,Alzheimer's Disease Neuroimaging Initiative.,Nelson PT

更新日期：2017-04-01 00:00:00

abstract：:Pioglitazone (Piog) activates peroxisome proliferator activated receptor-γ (PPARγ) and is widely used in clinic for the treatment of diabetes mellitus. PPARγ in various tissues has the essential regulatory role of multiple metabolic function, suggest that PPARγ signaling may contribute to aging processes. However, lit...

journal_title：Experimental gerontology

authors： Shen D,Li H,Zhou R,Liu MJ,Yu H,Wu DF

更新日期：2018-02-01 00:00:00

abstract：:It is well established that during early life the thymus gland and the neuroendocrine system influence each other's maturation. Furthermore, there is a growing body of evidence indicating that the immune and neuroendocrine systems also function as a bidirectional network during adult life. In order to assess possible ...

journal_title：Experimental gerontology

authors： Goya RG,Naylor PH,Goldstein AL,Meites J

更新日期：1990-01-01 00:00:00

abstract：:Aberrant mineralization of soft connective tissues (ectopic calcification) may occur as a frequent age-related complication. Still, it remains unclear the role of mesenchymal cell donor's age and of replicative senescence on ectopic calcification. Therefore, the ability of cells to deposit in-vitro hydroxyapatite crys...

journal_title：Experimental gerontology

authors： Boraldi F,Bartolomeo A,Di Bari C,Cocconi A,Quaglino D

更新日期：2015-12-01 00:00:00

abstract：:Lipids constitute a significant group of biological metabolites and the building blocks of all cell membranes. The abundance and stoichiometries of different lipid species are known to vary across the lifespan and metabolic state, yet the functional effects of these changes have been challenging to understand. Here we...

journal_title：Experimental gerontology

authors： Skowronska-Krawczyk D,Budin I

更新日期：2020-03-01 00:00:00

abstract：:Plasma and pituitary concentrations of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and prolactin (Prl) were determined by radioimmunoassay in young (2-4 months-old) and aged CD-1 (14-18 months-old) and C57BL/6 (16-22 months-old) mice one month after ovariectomy. In young, ovariectomized mice, plasma ...

journal_title：Experimental gerontology

authors： Parkening TA,Collins TJ,Smith ER

更新日期：1982-01-01 00:00:00

abstract：:Ageing is a complex process that in muscle in usually associated with a decrease in mass, strength, and velocity of contraction. One of the most striking effects of ageing on muscle is known as sarcopenia, a process that is the result of many cellular changes, such as a reduction in the number of motor units coupled w...

journal_title：Experimental gerontology

authors： Fulle S,Protasi F,Di Tano G,Pietrangelo T,Beltramin A,Boncompagni S,Vecchiet L,Fanò G

更新日期：2004-01-01 00:00:00

abstract：:Measuring physiological dysregulation during aging could be a key tool both to understand underlying aging mechanisms and to predict clinical outcomes in patients. However, most existing indices are either circular or hard to interpret biologically. Recently, we showed that statistical distance of 14 common blood biom...

journal_title：Experimental gerontology

authors： Cohen AA,Milot E,Li Q,Legault V,Fried LP,Ferrucci L

更新日期：2014-09-01 00:00:00

abstract：:Long-lived recombinant inbred lines, some of which have mean and maximum life spans up to 70% longer than wild type, were used in these analyses. Longer life results from a slower exponential rate of increase in mortality. General motor activity decreases with chronological age in all genotypes; this decay in general ...

journal_title：Experimental gerontology

authors： Johnson TE,Conley WL,Keller ML

更新日期：1988-01-01 00:00:00

abstract：:Reflective of age-associated decline in immune function among elderly individuals is a decrease in in vitro T cell proliferative ability. Impaired T cell proliferation in the elderly may result from disruption of the well-balanced network of regulatory cytokines produced during an immune response. The purpose of this ...

journal_title：Experimental gerontology

authors： Castle SC,Uyemura K,Crawford W,Wong W,Klaustermeyer WB,Makinodan T

更新日期：1999-04-01 00:00:00

abstract：:Accumulation of myeloid-derived suppressor cells (MDSCs) in aged hosts contribute to the age-related increase of susceptibility to murine breast adenocarcinoma and co-stimulatory molecules expressed in MDSCs are essential for MDSCs-mediated immune suppression. However, the co-stimulatory molecules that exert a direct ...

journal_title：Experimental gerontology

authors： Chen S,Liu H,Su N,Zhang G,Wang L

更新日期：2015-01-01 00:00:00

abstract：:Perimenopause is a period in a woman's life that precedes menopause and is characterized by hormonal changes that result in increased oxidative stress. Since oxidative stress is associated with age-related diseases and perimenopausal symptoms including somato-vegetative manifestations, nutritional antioxidant suppleme...

journal_title：Experimental gerontology

authors： Pereira AAF,Tirapeli KG,Chaves-Neto AH,da Silva Brasilino M,da Rocha CQ,Belló-Klein A,Llesuy SF,Dornelles RCM,Nakamune ACMS

更新日期：2017-04-01 00:00:00

abstract：AIM:The present study investigated whether hypertension, blood pressure, and antihypertensive therapy were associated with frailty status in community-dwelling older adults. In addition, we tested whether such associations were consistent across different frailty instruments. MATERIAL AND METHODS:Two-hundred older adu...

journal_title：Experimental gerontology

authors： Coelho-Junior HJ,Uchida MC,Picca A,Calvani R,Landi F,de Oliveira Gonçalves I,Rodrigues B,Bernabei R,Marzetti E

更新日期：2021-01-19 00:00:00

abstract：:The purpose of this study was to examine the combined cardiorespiratory and cerebrovascular responses to head-up tilt (HUT) in young and older trained and untrained humans following moderate-duration exercise. Middle cerebral artery blood flow velocity (MCAv; transcranial Doppler ultrasound), blood pressure (BP; Finom...

journal_title：Experimental gerontology

authors： Murrell CJ,Cotter JD,George K,Shave R,Wilson L,Thomas K,Williams MJ,Ainslie PN

更新日期：2011-01-01 00:00:00

abstract：:Age-related behavioral declines are common manifestations of aging in animals. Negative geotaxis, an innate escape response during which flies ascend the wall of a cylinder after being tapped to its bottom, is one of the behaviors that senesces in Drosophila. Many laboratories, including ours, have used a variety of n...

journal_title：Experimental gerontology

authors： Gargano JW,Martin I,Bhandari P,Grotewiel MS

更新日期：2005-05-01 00:00:00

abstract：:Coenzyme Q10 supplementation increases life-span of rats fed on a diet enriched with polyunsaturated fatty acids (Quiles, J.L., Ochoa, J.J., Huertas, J.R., Mataix, J., 2004b. Coenzyme Q supplementation protects from age-related DNA double-strand breaks and increased lifespan in rats fed on a PUFA-rich diet. Exp. Geron...

journal_title：Experimental gerontology

authors： Bello RI,Gómez-Díaz C,Burón MI,Alcaín FJ,Navas P,Villalba JM

更新日期：2005-08-01 00:00:00

abstract：:The immune response declines with age. This decline correlates with thymic involution and involves primarily a loss in T-cell function, whereas humoral immunity is more variably affected. In the current experiments we have measured immunoglobulin synthesis in vitro after mitogen stimulation, and specific antibody resp...

journal_title：Experimental gerontology

authors： Ershler WB,Robbins DL,Moore AL,Hebert JC

更新日期：1986-01-01 00:00:00

abstract：:Physical activity may help to prevent or delay brain atrophy. Numerous studies have shown associations between physical activity and age-related changes in the brain. However, most of these studies involved self-reported physical activity, not objectively measured physical activity. Therefore, the aim of this study wa...

journal_title：Experimental gerontology

authors： Doi T,Makizako H,Shimada H,Tsutsumimoto K,Hotta R,Nakakubo S,Park H,Suzuki T

更新日期：2015-02-01 00:00:00

abstract：:The aim of this study was to compare the functional and structural changes in similarly identified neurons of the small parietal ganglion in 56 molluscs (Lymnaea stagnalis) of two age groups: adult (10-12 months) and old (20-22 months). No age changes were found in the values of membrane potential, resistance of the n...

journal_title：Experimental gerontology

authors： Frolkis VV,Kvitnitskaya-Ryzhova TYu,Martynenko OA

更新日期：1995-09-01 00:00:00

abstract：:Homeostenosis (i.e. decline in stress resistance and resilience with age) is a fundamental notion of the biogerontology and physiology of aging. Stressful situations typically challenge metabolic homeostasis and the capacity to recover from a stress-induced metabolic disorder might be particularly compromised in senes...

journal_title：Experimental gerontology

authors： Colinet H,Renault D

更新日期：2018-02-01 00:00:00