Abstract：
:Aging is associated with a decline in muscle force that exceeds loss of muscle mass, suggesting that factors other than sarcopenia affect age-related muscle weakness. Here, we investigate in situ muscle force and sarcoplasmic reticulum (SR) properties in gastrocnemius muscles of adult (6-8 months) and aged (24 months) rats. Despite minimal loss of muscle mass, peak tetanic force was significantly reduced (-28%) in aged muscles. Adjusting for differences in muscle cross-sectional area mitigated the age difference (-23%), but it remained significant. The SR calcium release function was also impaired (-17%) with aging, although calcium uptake was not, and SR-associated glycogen increased (+30%) with aging. Western blotting revealed age related increases in Grp78, serinepalmitoyltransferase and neutral sphingomyelinase, suggesting that age increased the stress response and ceramide metabolism in the SR. In contrast Parkin, a protein associated with autophagic signaling, was reduced in the aged SR. These findings are consistent with a hypothesis that age-related impairments of the SR, possibly due to impaired autophagy and/or altered membrane metabolism, contribute to age-related muscle weakness, independent of changes in muscle mass.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Russ DW,Wills AM,Boyd IM,Krause Jdoi
10.1016/j.exger.2013.11.018subject
Has Abstractpub_date
2014-02-01 00:00:00pages
40-4eissn
0531-5565issn
1873-6815pii
S0531-5565(13)00347-1journal_volume
50pub_type
杂志文章abstract：:Stem cells are located throughout the adult body of higher organisms, supporting a continuous renewal and repair of tissues. Unique abilities of stem cells are self-renewal and multipotential differentiation. It is, therefore, of critical importance for an organism to maintain and control quantity and quality of stem ...
journal_title：Experimental gerontology
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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journal_title：Experimental gerontology
pub_type： 杂志文章
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journal_title：Experimental gerontology
pub_type： 临床试验,杂志文章
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2011.08.007
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journal_title：Experimental gerontology
pub_type： 杂志文章
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journal_title：Experimental gerontology
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doi：10.1016/j.exger.2005.01.004
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2020.111123
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pub_type： 杂志文章
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journal_title：Experimental gerontology
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doi：10.1016/j.exger.2009.12.001
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(83)90047-5
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(00)00121-2
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journal_title：Experimental gerontology
pub_type： 杂志文章
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journal_title：Experimental gerontology
pub_type： 杂志文章
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journal_title：Experimental gerontology
pub_type： 杂志文章
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journal_title：Experimental gerontology
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更新日期：2016-08-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2004.04.003
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2010.08.023
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2006.09.003
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pub_type： 杂志文章
doi：10.1016/0531-5565(92)90056-6
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journal_title：Experimental gerontology
pub_type： 杂志文章
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2015.08.008
更新日期：2015-11-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2017.01.012
更新日期：2017-08-01 00:00:00
abstract：:Mitochondria play a critical role in the life of the cell as they control their metabolic rate, energy production and cell death. Mitochondria have long been appreciated as causative to aging. The age-associated respiratory chain deficiency is typically unevenly distributed and affects only a subset of cells in variou...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
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更新日期：2009-01-01 00:00:00
