Abstract：
:Age-related hearing loss (AHL) is a progressive neurodegenerative disease that is largely silent in its initial stages. There is no sensitive blood biomarker for diagnosis or early detection of AHL. MicroRNAs (miRNAs or miRs) are abundant and highly stable in blood, and have been recently described as powerful circulating biomarkers in a wide range of diseases. In the present study, we identified concordant increases in miR-34a levels in the cochlea, auditory cortex, and plasma of C57BL/6 mice during aging. These increases were accompanied by elevated hearing thresholds and greater loss of hair cells. Levels of miR-34a targets, silent information regulator 1 (SIRT1), B-cell lymphoma-2 (Bcl-2), and E2F transcription factor 3 (E2F3), in the cochlea, auditory cortex, and plasma decreased with aging inversely to miR-34a. Moreover, plasma miR-34a levels were significantly higher in patients with AHL compared with controls who had normal hearing and had a receiver-operating characteristic curve that distinguished AHL patients from controls. However, SIRT1, Bcl-2, and E2F3 showed no correlation with AHL in humans. In summary, circulating miR-34a level may potentially serve as a useful biomarker for early detection of AHL.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Pang J,Xiong H,Yang H,Ou Y,Xu Y,Huang Q,Lai L,Chen S,Zhang Z,Cai Y,Zheng Ydoi
10.1016/j.exger.2016.01.009subject
Has Abstractpub_date
2016-04-01 00:00:00pages
58-67eissn
0531-5565issn
1873-6815pii
S0531-5565(16)30009-2journal_volume
76pub_type
杂志文章abstract：:Senescence, a deteriorative process that increases the probability of death of an organism with increasing chronological age, has been found in all metazoans where careful studies have been carried out. There has been much controversy, however, about the potential immortality of hydra, a solitary freshwater member of ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(97)00113-7
更新日期：1998-05-01 00:00:00
abstract：BACKGROUND:Inflammation plays a pivotal role in amyloid plaque progression thereby contributing to Alzheimer's disease-related neurodegeneration. We hypothesized that patients with Alzheimer's disease have an innate pro-inflammatory phenotype, as compared to control subjects without dementia. METHODS:Patients with a d...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(00)00176-5
更新日期：2001-01-01 00:00:00
abstract：:In many eukaryotes oxidative phosphorylation via the mitochondrial electron transport chain provides the major means of ATP production. Complete removal of this capacity often results in premature death. Recent studies using the nematode Caenorhabditis elegans are surprising because they have revealed that disruption ...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2005.06.015
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abstract：:The role of the glucocorticoid receptor (GR) in senescence was studied in rats of increasing age. Statistically significant changes in the number of GRs from rat liver were detected, whereas the affinity for the ligand triamcinolone acetonide (TA) did not change with increasing age, and was in the range of 1-2 nM. In ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(99)00067-4
更新日期：1999-12-01 00:00:00
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journal_title：Experimental gerontology
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doi：10.1016/s0531-5565(02)00202-4
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2006.04.008
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2012.08.008
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abstract：:Coronary heart disease is less prevalent in pre-menopausal women than in men, but increases at the onset of menopause. This delay is due to estrogen protective effects. The rise of cholesterolemia is one of the main risk factors for coronary disease. Since 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) is the ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2009.10.014
更新日期：2010-02-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2010.01.009
更新日期：2010-03-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2005.07.014
更新日期：2005-10-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(00)00157-1
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2017.03.002
更新日期：2017-06-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2019.110657
更新日期：2019-10-01 00:00:00
abstract：OBJECTIVES:To examine the individual association between BMI and level of serum uric acid (SUA) among the very elderly Chinese population. METHODS:A survey was conducted on 870 long-lived subjects (aged ≥90years). Subjects were divided into four groups according to quartile of BMI (<16.6, 16.6-18.9, 18.9-21.1, ≥21.1kg...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2012.05.008
更新日期：2012-08-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2011.02.004
更新日期：2011-06-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2010.03.013
更新日期：2010-06-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2016.04.015
更新日期：2016-08-01 00:00:00
abstract：:The aging process is known to be regulated by specific genes in various organisms, including yeast, the nematode C. elegans, fruitflies and mice. To explore the novel genes involved in aging process, we applied cDNA microarray technology to a replicative senescence model of human dermal fibroblasts (HDF). Eighty-four ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2004.07.002
更新日期：2004-09-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(83)90023-2
更新日期：1983-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.exger.2015.06.018
更新日期：2015-10-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 社论
doi：10.1016/j.exger.2013.01.003
更新日期：2013-07-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2014.11.013
更新日期：2015-01-01 00:00:00
abstract：:Reflective of age-associated decline in immune function among elderly individuals is a decrease in in vitro T cell proliferative ability. Impaired T cell proliferation in the elderly may result from disruption of the well-balanced network of regulatory cytokines produced during an immune response. The purpose of this ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(98)00064-3
更新日期：1999-04-01 00:00:00
abstract：:The dependent elderly are widely considered to be at higher risk of nutritional problems. Suboptimal micronutrient intake might put the elderly, especially those living in nursing homes, at high risk of morbidity. So far, no public authority, except for the Israel Ministry of Health, has issued particular recommendati...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2016.09.009
更新日期：2016-11-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2017.12.022
更新日期：2018-05-01 00:00:00
abstract：:Prior to three months of age there is little melatonin (MLT) secretion in humans. MLT production then commences, becomes circadian, and reaches its highest nocturnal blood levels between the ages of one to three years. During the remainder of childhood, nocturnal peak levels drop progressively by 80%. In adults, these...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(98)00054-0
更新日期：1998-11-01 00:00:00
abstract：:Centenarians are people who escaped from major common diseases, including cancer, and reached the extreme limits of human life-span. The analysis of demographic data indicates that cancer incidence and mortality show a levelling off around the age of 85-90 years, and suggests that oldest old people and centenarians ar...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(02)00137-7
更新日期：2002-10-01 00:00:00
abstract：:A growing body of research in elderly populations suggests that the early phase of an explosive muscle contraction (i.e., ≤200 ms) may be more functionally relevant than peak values. However, age-related variation in early phase explosive strength has never been investigated across the full-adult life span. This cross...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2018.06.021
更新日期：2018-09-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(98)00058-8
更新日期：1999-01-01 00:00:00
abstract：:Several factors involved in regulation of bone mineral metabolism were compared in male and female Fischer 344 rats of different ages (1, 2.5, 6, and 18 months). Plasma 1,25-(OH)2D3 concentrations decreased with age in rats of both genders. Abundance of calbindin-D28K and its mRNA in kidney and calbindin-D9K and its m...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(95)00014-3
更新日期：1995-11-01 00:00:00
