Abstract：
:Aging is one of the most basic properties of living organisms. Abundant evidence supports the idea that cell senescence underlies organismal aging in higher mammals. Therefore, examining the molecular mechanisms that control cell and replicative senescence is of great interest for biology and medicine. Several discoveries strongly support telomere shortening as the main molecular mechanism that limits the growth of normal cells. Although cultures gradually approach their growth limit, appearance of individual senescent cells is sudden and stochastic. A theoretical model of abrupt telomere shortening has been proposed in order to explain this phenomenon, but until now there was no reliable experimental evidence supporting this idea. Here, we have employed novel methodology to provide evidence for the generation of extrachromosomal circular telomeric DNA as a result of abrupt telomere shortening in normal human fibroblasts. This mechanism ensures heterogeneity in growth potential among individual cells, which is crucial for gradual progression of the aging process.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Vidacek NS,Cukusić A,Ivanković M,Fulgosi H,Huzak M,Smith JR,Rubelj Idoi
10.1016/j.exger.2010.01.009subject
Has Abstractpub_date
2010-03-01 00:00:00pages
235-42issue
3eissn
0531-5565issn
1873-6815pii
S0531-5565(10)00043-4journal_volume
45pub_type
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1992-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,多中心研究
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更新日期：2019-11-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2018-05-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2015.05.003
更新日期：2015-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0531-5565(01)00118-8
更新日期：2001-08-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(87)90031-3
更新日期：1987-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.08.003
更新日期：2013-11-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
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更新日期：2001-09-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
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doi：10.1016/s0531-5565(01)00145-0
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journal_title：Experimental gerontology
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(99)00026-1
更新日期：1999-08-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,随机对照试验
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更新日期：2018-09-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2017.08.006
更新日期：2017-11-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2003.08.003
更新日期：2003-10-01 00:00:00
abstract：:Senescence accelerated mice (SAM) are susceptible to developing vascular dysfunction and remodeling. Food intake and type of diet have also been identified as determining factors in vascular remodeling. However, the interplay between senescence and diet in vascular remodeling is largely unknown. We aimed to analyze st...
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doi：10.1016/j.exger.2014.03.004
更新日期：2014-07-01 00:00:00
