Glucocorticoid receptors in ageing rats.

abstract：:In the present study, using RNA gel-blot analysis, we characterized the developmental changes in the prevalence of mRNA coding for fibronectin (FN), glial fibrillary acidic protein (GFAP), neurotrophic protein S100 beta, and beta-actin mRNA in rat hippocampus and forebrain from 1 to 720 days of age. We found that the ...

journal_title：Experimental gerontology

authors： Wagner AP,Reck G,Platt D

更新日期：1993-03-01 00:00:00

abstract：:Several factors involved in regulation of bone mineral metabolism were compared in male and female Fischer 344 rats of different ages (1, 2.5, 6, and 18 months). Plasma 1,25-(OH)2D3 concentrations decreased with age in rats of both genders. Abundance of calbindin-D28K and its mRNA in kidney and calbindin-D9K and its m...

journal_title：Experimental gerontology

authors： Johnson JA,Beckman MJ,Pansini-Porta A,Christakos S,Bruns ME,Beitz DC,Horst RL,Reinhardt TA

更新日期：1995-11-01 00:00:00

abstract：:Centenarians are people who escaped from major common diseases, including cancer, and reached the extreme limits of human life-span. The analysis of demographic data indicates that cancer incidence and mortality show a levelling off around the age of 85-90 years, and suggests that oldest old people and centenarians ar...

journal_title：Experimental gerontology

authors： Bonafè M,Barbi C,Storci G,Salvioli S,Capri M,Olivieri F,Valensin S,Monti D,Gonos ES,De Benedictis G,Franceschi C

更新日期：2002-10-01 00:00:00

abstract：:It is well established that the proliferative potential of the liver declines with aging. Epidermal growth factor (EGF)-stimulated DNA synthesis is reduced in hepatocytes from aged rats relative to young rats, and this reduction correlates with diminished activation of the extracellular signal-regulated kinase (ERK) p...

journal_title：Experimental gerontology

authors： Ikeyama S,Kokkonen G,Martindale JL,Wang XT,Gorospe M,Holbrook NJ

更新日期：2003-04-01 00:00:00

abstract：:Aging is associated with impaired mitochondrial function, whereas exercise training enhances mitochondrial content and function in part through activation of PGC-1α. Mitochondria form dynamic networks regulated by fission and fusion with profound effects on mitochondrial functions, yet the effects of aging and exercis...

journal_title：Experimental gerontology

authors： Halling JF,Ringholm S,Olesen J,Prats C,Pilegaard H

更新日期：2017-10-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) has been identified as a potential treatment for effectively improving cognitive function in several neuropathological conditions. However, the underlying mechanism and the relevant downstream protective pathways that are activated in neurons by VEGF remain elusive, especially...

journal_title：Experimental gerontology

authors： Wang L,Wang F,Liu S,Yang X,Yang J,Ming D

更新日期：2018-02-01 00:00:00

abstract：:Telomeres serve as a mitotic clock and biological marker of senescence. Diabetes mellitus (DM) is associated with damage to target organs and premature aging. We assessed the effect of glycemic control on telomere dynamics in arterial cells of 58 patients undergoing coronary artery bypass and in mononuclear blood cell...

journal_title：Experimental gerontology

authors： Uziel O,Singer JA,Danicek V,Sahar G,Berkov E,Luchansky M,Fraser A,Ram R,Lahav M

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVES:To investigate whether the implementation of a multifactorial falls intervention in nursing homes is cost-beneficial and alleviates the professional workload. DESIGN:A comprehensive quantitative model was developed to calculate the impact of investments in multifactorial falls prevention in nursing homes in...

journal_title：Experimental gerontology

authors： Panneman MJM,Sterke CS,Eilering MJ,Blatter BM,Polinder S,Van Beeck EF

更新日期：2021-01-01 00:00:00

abstract：:A series of theoretical analyses of mortality were performed on recent data for Mediterranean fruit flies (Ceratitus capitata). Best fit computations were performed using the Marquardt-Levenburg technique on: 1) the classic Gompertz model, 2) the Johnson-Mehl-Avrami (JMA) model from chemical kinetics theory, which is ...

journal_title：Experimental gerontology

authors： Hirsh AG,Williams RJ,Mehl P

更新日期：1994-03-01 00:00:00

abstract：:The ascorbic acid content of Drosophila melanogaster was found to be high in the absence of a dietary source. The amount of ascorbic acid per fly declined with aging in both the Oregon R and Swedish C strains. The median life span at 25 degrees C was 45 days for Swedish C and 59 days for Oregon R. The amount of ascorb...

journal_title：Experimental gerontology

authors： Massie HR,Shumway ME,Whitney SJ,Sternick SM,Aiello VR

更新日期：1991-01-01 00:00:00

abstract：:It has been suggested that alterations in Na(+),K(+)-ATPase mediate the development of several aging-related pathologies, such as hypertension and diabetes. Thus, we evaluated Na(+),K(+)-ATPase function and H(2)O(2) production in the renal cortex and medulla of Wistar Kyoto (WKY) rats at 13, 52 and 91 weeks of age. Cr...

journal_title：Experimental gerontology

authors： Silva E,Pinto V,Simão S,Serrão MP,Afonso J,Amaral J,Pinho MJ,Gomes P,Soares-da-Silva P

更新日期：2010-12-01 00:00:00

abstract：:Whereas biological rhythms are now fairly well documented in young healthy adults, reports in elderly are relatively few for obvious reasons, including the difficulty of setting groups matched in age, sociological and professional background, medical history, and not in need of specific medication. Aging may modify on...

journal_title：Experimental gerontology

authors： Touitou Y,Bogdan A,Haus E,Touitou C

更新日期：1997-07-01 00:00:00

abstract：:Neural correlates of placebo analgesia (PA) in patients with neurocognitive disorders have not yet been elucidated. The present study aimed to evaluate how and to what extent executive (dys)functions of the medial prefrontal cortex (MPFC) may be related to PA. To this end, twenty-three subjects complaining of differen...

journal_title：Experimental gerontology

authors： Palermo S,Rainero I,Stanziano M,Vase L,D'Agata F,Rubino E,Fonio P,Sardanelli F,Amanzio M

更新日期：2019-04-01 00:00:00

abstract：:Fish provide enormous spectrum of longevity and thus present the possibility of multiple mechanisms of senescence. Oxidative stress as a causative agent of senescence and the protective role of antioxidant enzymes were tested in the teleost, Channa punctatus taking peroxidase (POD) (EC 1.1 1.1.7) as the representative...

journal_title：Experimental gerontology

authors： Nayak SB,Jena BS,Patnaik BK

更新日期：1999-06-01 00:00:00

abstract：:The objective of this study was to determine whether and to what extent age-related changes occur in atrioventricular (AV) heart valve innervation. The AV valves from three young adult (3 months) and three older (> 24 months) female guinea pigs were studied. An acetylcholinesterase (AChE) localization method was used ...

journal_title：Experimental gerontology

authors： Folan-Curran J,Wang YF,Jew JY,Williams TH

更新日期：1994-09-01 00:00:00

abstract：:The importance of maintaining physical fitness by engaging in exercise in a life-long perspective as well as the avoidance of obesity has been emphasised in recent years by epidemiological studies on human populations as well as studies on laboratory rodents. In laboratory studies, voluntary running in wheels and forc...

journal_title：Experimental gerontology

authors： Narath E,Skalicky M,Viidik A

更新日期：2001-11-01 00:00:00

abstract：:Spectrins are a part of cytoskeletal platform that lines the intracellular side of plasma membrane, which can be proteolyzed by calcium-sensitive enzymes including calpains and caspases. Caspase-3 mediated αII-spectrin proteolysis results in the release of a 120kDa spectrin breakdown product (SBDP120), known to occur ...

journal_title：Experimental gerontology

authors： Zhu HX,Xue ZQ,Qiu WY,Zeng ZJ,Dai JP,Ma C,Luo XG,Yan XX

更新日期：2015-09-01 00:00:00

abstract：:Exercise training has been associated with the attenuation of cardiovascular impairment after menopause. This study aimed to compare central and peripheral blood pressure and aortic pulse wave reflection in sedentary and trained (aerobic exercise in the water) hypertensive postmenopausal women. Hypertensive postmenopa...

journal_title：Experimental gerontology

authors： de Andrade Barboza C,Moura EG,Ministro G,Castaño JB,Silva Santos GC,Dias Junior G,Moreno Junior H,Rodrigues B

更新日期：2021-01-01 00:00:00

abstract：:Studies have suggested that older individuals are more fatigable than young adults when power loss, measured during single-joint contractions, is considered the fatigue index; however, age-related differences in fatigue considering power measurements during multi-joint movements (e.g., cycling) have not been fully elu...

journal_title：Experimental gerontology

authors： Krüger RL,Aboodarda SJ,Jaimes LM,Vaz MA,Samozino P,Millet GY

更新日期：2020-05-01 00:00:00

abstract：:Primary human dermal fibroblasts isolated from the medial aspect of the proximal forearm of young and old donors were compared for the expression of interstitial collagenase, 72 kDa type IV collagenase, the tissue inhibitor of metalloproteinase type 1, and pro-alpha 2 (I) collagen mRNA at basal levels and after stimul...

journal_title：Experimental gerontology

authors： Burke EM,Horton WE,Pearson JD,Crow MT,Martin GR

更新日期：1994-01-01 00:00:00

abstract：:Acute illness requiring hospitalization is a sentinel event leading to functional decline and frequently, long-term disability in older adults. Although functional decline has become a key outcome during and after hospitalization, there is currently no gold standard for measuring functional impairment. The purpose of ...

journal_title：Experimental gerontology

authors： Sáez de Asteasu ML,Martínez-Velilla N,Zambom-Ferraresi F,Casas-Herrero Á,Ramirez-Vélez R,Izquierdo M

更新日期：2019-09-01 00:00:00

abstract：:In the present paper, we investigated whether the phenotype, the antigen-presenting capacity, and the migration of antigen-presenting cells (APCs), are affected by the aging process. APCs were obtained incubating peritoneal monocyte-macrophage cells with granulocyte-macrophage colony-stimulating factor (GM-CSF) (immat...

journal_title：Experimental gerontology

authors： Donnini A,Argentati K,Mancini R,Smorlesi A,Bartozzi B,Bernardini G,Provinciali M

更新日期：2002-08-01 00:00:00

abstract：:The immune response declines with age. This decline correlates with thymic involution and involves primarily a loss in T-cell function, whereas humoral immunity is more variably affected. In the current experiments we have measured immunoglobulin synthesis in vitro after mitogen stimulation, and specific antibody resp...

journal_title：Experimental gerontology

authors： Ershler WB,Robbins DL,Moore AL,Hebert JC

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Self-report questionnaires are widely used to assess physical function in older adults. However, they often lack a clear frame of reference and hence interpreting and rating task difficulty levels can be problematic for the responder. Consequently, the usefulness of traditional self-report questionnaires for...

journal_title：Experimental gerontology

authors： Balachandran A,N Verduin C,Potiaumpai M,Ni M,Signorile JF

更新日期：2016-08-01 00:00:00

abstract：:Pioglitazone (Piog) activates peroxisome proliferator activated receptor-γ (PPARγ) and is widely used in clinic for the treatment of diabetes mellitus. PPARγ in various tissues has the essential regulatory role of multiple metabolic function, suggest that PPARγ signaling may contribute to aging processes. However, lit...

journal_title：Experimental gerontology

authors： Shen D,Li H,Zhou R,Liu MJ,Yu H,Wu DF

更新日期：2018-02-01 00:00:00

abstract：:Mitochondria play a critical role in the life of the cell as they control their metabolic rate, energy production and cell death. Mitochondria have long been appreciated as causative to aging. The age-associated respiratory chain deficiency is typically unevenly distributed and affects only a subset of cells in variou...

journal_title：Experimental gerontology

authors： Kukat A,Trifunovic A

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:This study aimed to evaluate the effect of vitamin D3 megadose supplementation and influence of BsmI polymorphism in the VDR gene on the inflammatory profile and oxidative stress in elderly women with vitamin D deficiency. METHODS:A double blind, randomized, placebo-controlled trial was conducted with 40 eld...

journal_title：Experimental gerontology

authors： de Medeiros Cavalcante IG,Silva AS,Costa MJ,Persuhn DC,Issa CT,de Luna Freire TL,da Conceição Rodrigues Gonçalves M

更新日期：2015-06-01 00:00:00

abstract：:In order to clarify immunogenetic markers contributing to successful aging, HLA and cytokine gene profiles were analyzed in healthy elderly Bulgarians. Family segregation analysis was performed to define combined effect of haplotypes and immunophenotype profiles. The results of this study did not reveal any statistica...

journal_title：Experimental gerontology

authors： Naumova E,Mihaylova A,Ivanova M,Michailova S,Penkova K,Baltadjieva D

更新日期：2004-04-01 00:00:00

abstract：:Currently, there is little doubt that the immune system plays a role in the neurodegenerative process in Alzheimer's disease (AD). Inflammatory proteins such as complement components, enzymes, eicosanoids, and cytokines are found in association with cerebral amyloid plaques and may exacerbate the fundamental pathology...

journal_title：Experimental gerontology

authors： Marx F,Blasko I,Pavelka M,Grubeck-Loebenstein B

更新日期：1998-11-01 00:00:00

abstract：:Calorie restriction (CR) may affect glucose tolerance via modulation of the insulin action in skeletal muscle. The present study investigated the effect of CR initiated at middle age in rats bearing glucose intolerance, in comparison with CR at a younger age. Male F344 rats at 2.5 and 18months (mo) of age were fed ad ...

journal_title：Experimental gerontology

authors： Park S,Komatsu T,Hayashi H,Yamaza H,Chiba T,Higami Y,Kuramoto K,Shimokawa I

更新日期：2006-09-01 00:00:00