Altered transcriptional regulation of human interstitial collagenase in cultured skin fibroblasts from older donors.

abstract：:Despite well-documented evidence for lifespan extension by methionine restriction (MR), underlying mechanisms remain unknown. As methionine can alter S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH), the substrate and product of DNA methyltransferase-1 (DNMT1), we hypothesized that MR diet alters DNA methyl...

journal_title：Experimental gerontology

authors： Mattocks DA,Mentch SJ,Shneyder J,Ables GP,Sun D,Richie JP Jr,Locasale JW,Nichenametla SN

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:The proportion of elderly individuals is growing and the prevalence of chronic kidney disease (CKD) among elderly people undergoing cardiac surgery is increasing constantly. The aim of this study was to determine the influence of different degrees of preoperative renal dysfunction on postoperative outcomes i...

journal_title：Experimental gerontology

authors： Shavit L,Lifschitz M,Slotki I,Oren A,Tauber R,Bitran D,Fink D

更新日期：2013-03-01 00:00:00

abstract：:The present study investigated the time-course for aging-associated effects on contractile and relaxing vascular responses and nitric oxide (NO) production in the aorta from female senescence-accelerated resistant (SAMR1) and prone (SAMP8) mice. Both SAMR1 and SAMP8 were studied at three different ages: 3 (young), 6 (...

journal_title：Experimental gerontology

authors： Novella S,Dantas AP,Segarra G,Vidal-Gómez X,Mompeón A,Garabito M,Hermenegildo C,Medina P

更新日期：2013-11-01 00:00:00

abstract：:The objective of this study was to determine whether and to what extent age-related changes occur in atrioventricular (AV) heart valve innervation. The AV valves from three young adult (3 months) and three older (> 24 months) female guinea pigs were studied. An acetylcholinesterase (AChE) localization method was used ...

journal_title：Experimental gerontology

authors： Folan-Curran J,Wang YF,Jew JY,Williams TH

更新日期：1994-09-01 00:00:00

abstract：:Young and old C57BL/6 male mice were given a diet containing a high dose of vitamin E (VE treatment) and its effect on the immune system was examined before and after the exposure to restraint stress. The VE treatment per se gave rise to a slight increase of splenic T cells in percentage and a significant enhancement ...

journal_title：Experimental gerontology

authors： Wakikawa A,Utsuyama M,Wakabayashi A,Kitagawa M,Hirokawa K

更新日期：1999-11-01 00:00:00

abstract：:An age-related increase of DNA damage/mutation has been previously reported in human lymphocytes. The high copy number and mutation rate make the mtDNA genome an ideal candidate for assessing damage and to act as a potential biomarker of ageing. In the present study, two assays were developed to evaluate the level of ...

journal_title：Experimental gerontology

authors： Ross OA,Hyland P,Curran MD,McIlhatton BP,Wikby A,Johansson B,Tompa A,Pawelec G,Barnett CR,Middleton D,Barnett YA

更新日期：2002-01-01 00:00:00

abstract：:In this study, spontaneous multiple unit activity (MUA, action potentials derived simultaneously from a number of neurons in a given brain region) was recorded through electrodes chronically implanted in the parietal cerebral cortex of the rats of 1, 3, 6, 9, 12, and 26 months of age (cross-sectional study). Electroph...

journal_title：Experimental gerontology

authors： Roy D,Singh R

更新日期：1988-01-01 00:00:00

abstract：:Mitochondrial proton leak may modulate reactive oxygen species (ROS) production and play a role in aging. The purpose of this study was to determine proton leak across the life span in skeletal mitochondria from calorie-restricted and UCP2/3 overexpressing mice. Proton leak in isolated mitochondria and markers of oxid...

journal_title：Experimental gerontology

authors： Asami DK,McDonald RB,Hagopian K,Horwitz BA,Warman D,Hsiao A,Warden C,Ramsey JJ

更新日期：2008-12-01 00:00:00

abstract：:Advances in our understanding of tau-mediated neurodegeneration in Alzheimer's disease (AD) are moving this disease pathway to center stage for the development of biomarkers and disease modifying drug discovery efforts. Immunoassays were developed detecting total (t-tau) and tau phosphorylated at specific epitopes (p-...

journal_title：Experimental gerontology

authors： Hampel H,Blennow K,Shaw LM,Hoessler YC,Zetterberg H,Trojanowski JQ

更新日期：2010-01-01 00:00:00

abstract：:Reductive stress, which is due to a paradoxical excess of antioxidants such as reduced glutathione (GSH) and GSH-related enzymes associated with decreased oxidant levels, has emerged as a pathogenetic mechanism of myocardial damage in pathological conditions such as protein aggregation cardiomyopathy. Notably, in the ...

journal_title：Experimental gerontology

authors： Lapenna D,Ciofani G,Lelli Chiesa P,Porreca E

更新日期：2020-02-06 00:00:00

abstract：:DNA binding of the ku protein was investigated in peripheral blood mononuclear cells (PBMC) from 24 subjects of different ages (20-89 years old) displaying age-related changes in DNA repair, mitotic responsiveness, and cytokine production. Ku is an heterodimeric protein composed of two subunits of 70 and 80 kDa, which...

journal_title：Experimental gerontology

authors： Frasca D,Barattini P,Tirindelli D,Guidi L,Bartoloni C,Errani A,Costanzo M,Tricerri A,Pierelli L,Doria G

更新日期：1999-08-01 00:00:00

abstract：:The Senescence-Accelerated Mouse (SAM) strains are unique and appropriate models for genetic studies on aging because the SAMP strains have an "accelerated senescence" phenotype for which the SAMR strains are controls, and each SAMP strain has a strain-specific age-associated disorder. Furthermore, because they have g...

journal_title：Experimental gerontology

authors： Higuchi K

更新日期：1997-01-01 00:00:00

abstract：:The field of toxicology adopted the threshold dose response in the early decades of the 20th century. The model was rapidly incorporated into governmental regulatory assessment procedures and became a central feature of chemical evaluation and assessment. The toxicological community never validated the capacity of thi...

journal_title：Experimental gerontology

authors： Calabrese EJ

更新日期：2013-01-01 00:00:00

abstract：:During aging declining maximum force capacity with more or less unchanged fatigability is observed with the underlying mechanisms still not fully understood. Therefore, we compared morphology and function of skeletal muscles between different age groups. Changes in high-energy phosphate turnover (PCr, Pi and pH) and m...

journal_title：Experimental gerontology

authors： Hiepe P,Gussew A,Rzanny R,Kurz E,Anders C,Walther M,Scholle HC,Reichenbach JR

更新日期：2015-05-01 00:00:00

abstract：:Declines in mobility with advancing age are often associated with a reduction in the use of lower leg muscles. We examined the influence of two interventions that involved neuromuscular electrical stimulation (NMES) applied to the triceps surae muscles on the mobility and muscle function of older adults. Thirty health...

journal_title：Experimental gerontology

authors： Mani D,Almuklass AM,Amiridis IG,Enoka RM

更新日期：2018-07-15 00:00:00

abstract：:For more than 60 years the only dietary manipulation known to retard aging was caloric restriction, in which a variety of species respond to a reduction in energy intake by demonstrating extended median and maximum life span. More recently, two alternative dietary manipulations have been reported to also extend surviv...

journal_title：Experimental gerontology

authors： Zimmerman JA,Malloy V,Krajcik R,Orentreich N

更新日期：2003-01-01 00:00:00

abstract：:Understanding telomere biology is of utmost importance for aging and cancer research. An essential tool is the determination of telomere length, which traditionally is done by telomere restriction fragment analysis, a laborious and time consuming method. Therefore, large efforts have been made to establish alternative...

journal_title：Experimental gerontology

authors： Wieser M,Stadler G,Böhm E,Borth N,Katinger H,Grillari J,Voglauer R

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:Sarcopenic obesity is a combination of both sarcopenia and obesity, which potentiate each other and maximize the negative influences of each, such as physical disability, morbidity, or even mortality. OBJECTIVES:To describe the criteria used to identify people with sarcopenic obesity and the components of t...

journal_title：Experimental gerontology

authors： Yin YH,Liu JYW,Välimäki M

更新日期：2020-07-01 00:00:00

abstract：:Post-viral pneumococcal pneumonia is a leading morbidity and mortality in older patients (≥65years of age). The goal of our current study is to understand the impact of chronological aging on innate immune responses to a secondary, post viral infection with Streptococcus pneumoniae, a causative agent of bacterial pneu...

journal_title：Experimental gerontology

authors： Cho SJ,Plataki M,Mitzel D,Lowry G,Rooney K,Stout-Delgado H

更新日期：2018-05-01 00:00:00

abstract：:Age-related behavioral declines are common manifestations of aging in animals. Negative geotaxis, an innate escape response during which flies ascend the wall of a cylinder after being tapped to its bottom, is one of the behaviors that senesces in Drosophila. Many laboratories, including ours, have used a variety of n...

journal_title：Experimental gerontology

authors： Gargano JW,Martin I,Bhandari P,Grotewiel MS

更新日期：2005-05-01 00:00:00

abstract：:Ageing is defined as the loss of ability to maintain cellular homeostasis of an organism associated with the free radical-elicited oxidative damage to cellular macromolecules. The aim of this study was to evaluate the efficacy of epigallocatechin-3-gallate (EGCG), the key component of green tea catechins on attenuatin...

journal_title：Experimental gerontology

authors： Senthil Kumaran V,Arulmathi K,Srividhya R,Kalaiselvi P

更新日期：2008-03-01 00:00:00

abstract：:The CG9940 gene, which encodes the NAD(+) synthase protein in Drosophila, is conserved in human, zebra fish, and mosquito. NAD(+) synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD(+)) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic a...

journal_title：Experimental gerontology

authors： Wen DT,Zheng L,Ni L,Wang H,Feng Y,Zhang M

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVE:Senescent patients exhibit an elevated perioperative risk for cardiac dysfunction, hemodynamic depression and subsequent cardiac death compared to young patients. Despite the fact that a growing proportion of cardiac surgery patients are octogenarians, cardioplegic regimes remain comparable across patients of...

journal_title：Experimental gerontology

authors： Böning A,Rohrbach S,Kohlhepp L,Heep M,Hagmüller S,Niemann B,Mühlfeld C

更新日期：2015-07-01 00:00:00

abstract：:Aging is associated with changes in several metabolic pathways affecting liver function including the adaptive unfolded protein response (UPR). On the other hand, exercise training has been shown to exert beneficial effects on metabolism in the liver and exercise training has been reported to affect hepatic UPR. PGC-1...

journal_title：Experimental gerontology

authors： Kristensen CM,Brandt CT,Ringholm S,Pilegaard H

更新日期：2017-11-01 00:00:00

abstract：:We studied the contractile, histological and biochemical characteristics of regenerating slow (soleus) muscles of aged rats and the effect of IGF-1 treatment on these parameters. Regenerating soleus muscles were studied 21 days after myotoxic injury. In senescent rats (24 month old), the in situ isometric maximal teta...

journal_title：Experimental gerontology

authors： Vignaud A,Noirez P,Besse S,Rieu M,Barritault D,Ferry A

更新日期：2003-05-01 00:00:00

abstract：:In young mice exposed to aerosol infection with Mycobacterium tuberculosis removal of the gammadelta T cell population by targeted gene disruption does not affect the expression of host resistance, but does influence the integrity of the early granulomatous response. The current study demonstrates that in aged gammade...

journal_title：Experimental gerontology

authors： Turner J,Frank AA,Brooks JV,Marietta PM,Vesosky B,Orme IM

更新日期：2001-02-01 00:00:00

abstract：:Numerous trials have shown that physical activity and exercise training have beneficial effects in general older populations. However, few have studied its effectiveness among people with dementia. The aim of this systematic review is to examine the efficacy of trials using a rigorous randomised, controlled design and...

journal_title：Experimental gerontology

authors： Pitkälä K,Savikko N,Poysti M,Strandberg T,Laakkonen ML

更新日期：2013-01-01 00:00:00

abstract：:To study the several elements and causes of ageing, diverse model organisms and methodologies are required. The most frequently used models are Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster and rodents. All have their advantages and disadvantages and allow studying particular aspects of the...

journal_title：Experimental gerontology

authors： Mouton S,Willems M,Braeckman BP,Egger B,Ladurner P,Schärer L,Borgonie G

更新日期：2009-04-01 00:00:00

abstract：:Calorie restriction (CR) may affect glucose tolerance via modulation of the insulin action in skeletal muscle. The present study investigated the effect of CR initiated at middle age in rats bearing glucose intolerance, in comparison with CR at a younger age. Male F344 rats at 2.5 and 18months (mo) of age were fed ad ...

journal_title：Experimental gerontology

authors： Park S,Komatsu T,Hayashi H,Yamaza H,Chiba T,Higami Y,Kuramoto K,Shimokawa I

更新日期：2006-09-01 00:00:00

abstract：:A correct clinical diagnosis in the early stage of Alzheimer Disease (AD) is mandatory given the current available treatment with acetylcholine esterase inhibitors. Moreover, a early to preclinical diagnosis would allow to identify patients eligible for future disease-modifying therapies. In the last ten years, we hav...

journal_title：Experimental gerontology

authors： Borroni B,Agosti C,Marcello E,Di Luca M,Padovani A

更新日期：2010-01-01 00:00:00