Abstract:
:In young mice exposed to aerosol infection with Mycobacterium tuberculosis removal of the gammadelta T cell population by targeted gene disruption does not affect the expression of host resistance, but does influence the integrity of the early granulomatous response. The current study demonstrates that in aged gammadelta T cell gene disrupted mice similar immunopathologic changes ensued in both gene knockout and wild type control mice. Changes in cell surface marker expression, evident in other gene knockout models, was not observed in the aged gammadelta T cell knockout mice. These data imply that gammadelta T cell functions previously observed in young mice become much less important as the animal ages.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Turner J,Frank AA,Brooks JV,Marietta PM,Vesosky B,Orme IMdoi
10.1016/s0531-5565(00)00199-6keywords:
subject
Has Abstractpub_date
2001-02-01 00:00:00pages
245-54issue
2eissn
0531-5565issn
1873-6815pii
S0531-5565(00)00199-6journal_volume
36pub_type
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journal_title:Experimental gerontology
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更新日期:2014-03-01 00:00:00
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