Repletion of antioxidant status by EGCG and retardation of oxidative damage induced macromolecular anomalies in aged rats.

abstract：:Stem cells are located throughout the adult body of higher organisms, supporting a continuous renewal and repair of tissues. Unique abilities of stem cells are self-renewal and multipotential differentiation. It is, therefore, of critical importance for an organism to maintain and control quantity and quality of stem ...

journal_title：Experimental gerontology

authors： Fehrer C,Lepperdinger G

更新日期：2005-12-01 00:00:00

abstract：:We suggest that the processes that protect the turtle brain against anoxia and subsequent reoxygenation might also contribute to turtle longevity since many of them are linked to age related neurodegeneration. In the turtle the mechanisms for conserving ion channel function are particularly robust. The anoxic turtle b...

journal_title：Experimental gerontology

authors： Lutz PL,Prentice HM,Milton SL

更新日期：2003-07-01 00:00:00

abstract：:The ascorbic acid content of Drosophila melanogaster was found to be high in the absence of a dietary source. The amount of ascorbic acid per fly declined with aging in both the Oregon R and Swedish C strains. The median life span at 25 degrees C was 45 days for Swedish C and 59 days for Oregon R. The amount of ascorb...

journal_title：Experimental gerontology

authors： Massie HR,Shumway ME,Whitney SJ,Sternick SM,Aiello VR

更新日期：1991-01-01 00:00:00

abstract：:Sex hormones are known to help maintaining the cognitive ability in male and female rats. Hypogonadism results in the reduction of the dendritic spines of central neurons which is believed to undermine memory and cognition and cause fatigue and poor concentration. In our previous studies, we have reported age-related ...

journal_title：Experimental gerontology

authors： Chen JR,Tseng GF,Wang YJ,Wang TJ

更新日期：2014-09-01 00:00:00

abstract：:Primary cultures of hepatocytes are widely used to investigate liver function, but this technology has not been exploited fully in the study of ageing and caloric restriction (CR). Hepatocytes were isolated from adult and aged, fully fed, and calorie restricted male Sprague-Dawley rats and their viability and biochemi...

journal_title：Experimental gerontology

authors： Lambert AJ,Merry BJ

更新日期：2000-08-01 00:00:00

abstract：:Average life expectancy at birth is a rough measure of the span of healthy, productive life--the functional life span. In the developed countries average life expectancies at birth now range from 76-79 years, six to nine years less than the limit of about 85 years imposed by aging. Aging is the accumulation of changes...

journal_title：Experimental gerontology

authors： Harman D

更新日期：1998-01-01 00:00:00

abstract：:Previous studies have shown that adult mice increase cold-induced heat production as a result of repeated exposures to cold, but that aged mice do not. The objective of the present study was to investigate changes in heat loss during repeated cold exposures in adult and aged C57BL/6J mice. Mice were partially restrain...

journal_title：Experimental gerontology

authors： Shefer VI,Talan MI

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND:Low muscle strength (dynapenia) is a primary characteristic of sarcopenia, the age-related loss of muscle mass and strength or low walking speed. New evidence suggests that muscle strength positively affects blood pressure (BP) responses to exercise. As older adults with lowest handgrip strength also have lo...

journal_title：Experimental gerontology

authors： Wong A,Jaime SJ,Grubbs B,Panton LB,Fischer SM,Figueroa A

更新日期：2020-09-01 00:00:00

abstract：:The effect of DL-alpha-lipoic acid on lipid peroxidation and antioxidant enzymes were evaluated in various brain regions of young and aged rats. Lipoate contents of discrete brain regions were also measured. In aged rats, the activities of superoxide dismutase, glutathione peroxidase, glutathione reductase and glucose...

journal_title：Experimental gerontology

authors： Arivazhagan P,Shila S,Kumaran S,Panneerselvam C

更新日期：2002-06-01 00:00:00

abstract：:Aging is associated with changes in lymphocyte subsets and unexplained HLA-DR upregulation on T-lymphocytes. We further investigated this activation, by measuring early (CD69), middle (CD25), and late (HLA-DR) T-lymphocyte activation markers on CD3+ lymphocytes, across subjects (20-100 years) together with serum tumor...

journal_title：Experimental gerontology

authors： Rea IM,McNerlan SE,Alexander HD

更新日期：1999-01-01 00:00:00

abstract：:Perimenopause is a period in a woman's life that precedes menopause and is characterized by hormonal changes that result in increased oxidative stress. Since oxidative stress is associated with age-related diseases and perimenopausal symptoms including somato-vegetative manifestations, nutritional antioxidant suppleme...

journal_title：Experimental gerontology

authors： Pereira AAF,Tirapeli KG,Chaves-Neto AH,da Silva Brasilino M,da Rocha CQ,Belló-Klein A,Llesuy SF,Dornelles RCM,Nakamune ACMS

更新日期：2017-04-01 00:00:00

abstract：:Rodent animal models take at least 18months to develop aging phenotypes for researchers to investigate the mechanism of age-related metabolic complications. Senescence-accelerated mouse prone 8 (SAMP8) shortens the process of aging and may facilitate an alternative model for studying age-related insulin resistance. Th...

journal_title：Experimental gerontology

authors： Liu HW,Chan YC,Wei CC,Chen YA,Wang MF,Chang SJ

更新日期：2017-12-01 00:00:00

abstract：:Aging is the primary risk factor for functional decline; thus, understanding and preventing disability among older adults has emerged as an important public health challenge of the 21st century. The science of gerontology - or geroscience - has the practical purpose of "adding life to the years." The overall goal of g...

journal_title：Experimental gerontology

authors： Anton SD,Cruz-Almeida Y,Singh A,Alpert J,Bensadon B,Cabrera M,Clark DJ,Ebner NC,Esser KA,Fillingim RB,Goicolea SM,Han SM,Kallas H,Johnson A,Leeuwenburgh C,Liu AC,Manini TM,Marsiske M,Moore F,Qiu P,Mankowski RT,M

更新日期：2020-12-01 00:00:00

abstract：:Alzheimer's disease is one of the most devastating neurodegenerative diseases. The exact cause of the disease is still not known although many scientists believe in the beta amyloid hypothesis which states that the accumulation of the amyloid peptide beta (Aβ) in brain is the initial cause which consequently leads to ...

journal_title：Experimental gerontology

authors： Le Page A,Dupuis G,Frost EH,Larbi A,Pawelec G,Witkowski JM,Fulop T

更新日期：2018-07-01 00:00:00

abstract：:Aging plays an important role in increased vulnerability to atrial fibrillation (AF). Mediated by activity at the muscarinic type 2 receptor (M2R), the parasympathetic nerve contributes to the onset of AF. The purpose of this study was to investigate whether aging changes the distribution of M2R in the atrial myocardi...

journal_title：Experimental gerontology

authors： Yang YH,Zheng QS,Li J,Shang FJ,Liu T,Wang HT,Liu XT,Liu L

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to compare the effects of 12 weeks of traditional resistance training (TRT) or resistance training using Cluster-set (CS) on functional performance and physical fitness of postmenopausal and elderly women. METHODS:Participants (61.1 ± 4.9 years, body mass 64.5 ± 1.8 kg, height 155.7...

journal_title：Experimental gerontology

authors： Dias RKN,Penna EM,Noronha ASN,de Azevedo ABC,Barbalho M,Gentil PV,Coswig VS

更新日期：2020-09-01 00:00:00

abstract：:The interrelationship between muscle strength, motor unit (MU) number, and age is poorly understood, and in this study we sought to determine whether age-related differences in muscle strength are moderated by estimates of functioning MU number and size. Eighteen older adults (OA; 67 ± 1.20 years) and 24 young adults ...

journal_title：Experimental gerontology

authors： Kaya RD,Nakazawa M,Hoffman RL,Clark BC

更新日期：2013-09-01 00:00:00

abstract：:Studying the changes of serum N-glycome during mouse aging is beneficial to explore the molecular basis behind the alterations reported in human. However, such studies remainscarce and lack some information such as sialylation due to the method limitation. Here, we introduced Bionic Glycome method to quantify the seru...

journal_title：Experimental gerontology

authors： Han J,Pan Y,Qin W,Gu Y,Xu X,Zhao R,Sha J,Zhang R,Gu J,Ren S

更新日期：2020-11-01 00:00:00

abstract：:Mitochondrial proton leak may modulate reactive oxygen species (ROS) production and play a role in aging. The purpose of this study was to determine proton leak across the life span in skeletal mitochondria from calorie-restricted and UCP2/3 overexpressing mice. Proton leak in isolated mitochondria and markers of oxid...

journal_title：Experimental gerontology

authors： Asami DK,McDonald RB,Hagopian K,Horwitz BA,Warman D,Hsiao A,Warden C,Ramsey JJ

更新日期：2008-12-01 00:00:00

abstract：:The results of life table experiments to determine the effects of artificial impairment (leg amputation) in 7500 Drosophila melanogaster adults revealed that the extent to which life expectancy was reduced in impaired individuals was conditional on: (1) leg location and number amputated--front leg had greatest impact ...

journal_title：Experimental gerontology

authors： Carey JR,Pinter-Wollman N,Wyman M,Müller HG,Molleman F,Zhang N

更新日期：2007-03-01 00:00:00

abstract：:Intrinsic exercise capacity is predictive of both lifespan and healthspan but whether adaptive exercise capacity influences the benefits achieved from aerobic training implemented later in life is not known. AIM:To determine if exercise late in life provides any functional improvements or underlying beneficial bioche...

journal_title：Experimental gerontology

authors： Brown LA,Macpherson PC,Koch LG,Qi NR,Britton SL,Brooks SV

更新日期：2019-10-01 00:00:00

abstract：:Reflective of age-associated decline in immune function among elderly individuals is a decrease in in vitro T cell proliferative ability. Impaired T cell proliferation in the elderly may result from disruption of the well-balanced network of regulatory cytokines produced during an immune response. The purpose of this ...

journal_title：Experimental gerontology

authors： Castle SC,Uyemura K,Crawford W,Wong W,Klaustermeyer WB,Makinodan T

更新日期：1999-04-01 00:00:00

abstract：:Plantar-flexor muscles are key muscles in the control of postural sway. Older fallers present lower maximal plantar-flexor performance than older non-fallers; however, the mechanisms underlying this motor impairment remain to be elucidated. This study aimed to determine whether muscular and neural factors are both inv...

journal_title：Experimental gerontology

authors： Cattagni T,Harnie J,Jubeau M,Hucteau E,Couturier C,Mignardot JB,Deschamps T,Berrut G,Cornu C

更新日期：2018-10-02 00:00:00

abstract：:Physical activity may help to prevent or delay brain atrophy. Numerous studies have shown associations between physical activity and age-related changes in the brain. However, most of these studies involved self-reported physical activity, not objectively measured physical activity. Therefore, the aim of this study wa...

journal_title：Experimental gerontology

authors： Doi T,Makizako H,Shimada H,Tsutsumimoto K,Hotta R,Nakakubo S,Park H,Suzuki T

更新日期：2015-02-01 00:00:00

abstract：:With many caveats to the traditional vertebrate species pertaining to biogerontology investigations, it has been suggested that a most informative model is the one which: 1) examines closely related species, or various members of the same species with naturally occurring lifespan variation, 2) already has adequate med...

journal_title：Experimental gerontology

authors： Gilmore KM,Greer KA

更新日期：2015-11-01 00:00:00

abstract：:Advances in our understanding of tau-mediated neurodegeneration in Alzheimer's disease (AD) are moving this disease pathway to center stage for the development of biomarkers and disease modifying drug discovery efforts. Immunoassays were developed detecting total (t-tau) and tau phosphorylated at specific epitopes (p-...

journal_title：Experimental gerontology

authors： Hampel H,Blennow K,Shaw LM,Hoessler YC,Zetterberg H,Trojanowski JQ

更新日期：2010-01-01 00:00:00

abstract：:It is now widely recognized that in order to optimize bone health in the later years, bone healthy behaviors should begin at a young age and continue throughout life. Prescribed orally to lower lipid levels in adults of all ages, statins have also been shown to stimulate bone formation in vitro by promoting bone morph...

journal_title：Experimental gerontology

authors： Starnes JW,Neidre DB,Nyman JS,Roy A,Nelson MJ,Gutierrez G,Wang X

更新日期：2013-08-01 00:00:00

abstract：:Senescence accelerated mice (SAM) are susceptible to developing vascular dysfunction and remodeling. Food intake and type of diet have also been identified as determining factors in vascular remodeling. However, the interplay between senescence and diet in vascular remodeling is largely unknown. We aimed to analyze st...

journal_title：Experimental gerontology

authors： Dantas AP,Onetti Y,Oliveira MA,Carvalho MH,Heras M,Vila E,Jiménez-Altayó F

更新日期：2014-07-01 00:00:00

abstract：:Declines in mobility with advancing age are often associated with a reduction in the use of lower leg muscles. We examined the influence of two interventions that involved neuromuscular electrical stimulation (NMES) applied to the triceps surae muscles on the mobility and muscle function of older adults. Thirty health...

journal_title：Experimental gerontology

authors： Mani D,Almuklass AM,Amiridis IG,Enoka RM

更新日期：2018-07-15 00:00:00

abstract：:Aging in Brown Norway rats is accompanied by the reduced production of testosterone by the Leydig cells, the testicular cells responsible for synthesizing and secreting this essential steroid. As yet, the mechanism by which Leydig cell steroidogenesis is reduced is unknown. Herein we assess the production of mitochond...

journal_title：Experimental gerontology

authors： Chen H,Cangello D,Benson S,Folmer J,Zhu H,Trush MA,Zirkin BR

更新日期：2001-08-01 00:00:00