Abstract：
:The ascorbic acid content of Drosophila melanogaster was found to be high in the absence of a dietary source. The amount of ascorbic acid per fly declined with aging in both the Oregon R and Swedish C strains. The median life span at 25 degrees C was 45 days for Swedish C and 59 days for Oregon R. The amount of ascorbic acid in Swedish C flies (0.078 micrograms/fly) was higher than that for Oregon R (0.058 micrograms/fly) for newly emerged flies but the rate of decline with aging was greater for Swedish C than Oregon R. The decline in ascorbic acid content with aging was 70.4% for Swedish C versus 19.9% for Oregon R. A brief cold shock was found to significantly increase the amount of ascorbic acid in Oregon R flies. Feeding the precursor of ascorbic acid synthesis, L-gulonolactone, did not improve the life span. Life-time feeding of ascorbic acid did not improve the life span of either Swedish C or Oregon R flies.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Massie HR,Shumway ME,Whitney SJ,Sternick SM,Aiello VRdoi
10.1016/0531-5565(91)90037-msubject
Has Abstractpub_date
1991-01-01 00:00:00pages
487-94issue
5eissn
0531-5565issn
1873-6815journal_volume
26pub_type
杂志文章abstract：:In young mice exposed to aerosol infection with Mycobacterium tuberculosis removal of the gammadelta T cell population by targeted gene disruption does not affect the expression of host resistance, but does influence the integrity of the early granulomatous response. The current study demonstrates that in aged gammade...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(00)00199-6
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abstract：:The visual appearance of humans derives predominantly from their skin and hair color. The phylogenetically ancient biochemical [corrected] pathway underling this phenomenon is called melanogenesis and results in the production of melanin pigments in neural crest-derived melanocytes, followed by its transfer to epithel...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
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abstract：:Fish provide enormous spectrum of longevity and thus present the possibility of multiple mechanisms of senescence. Oxidative stress as a causative agent of senescence and the protective role of antioxidant enzymes were tested in the teleost, Channa punctatus taking peroxidase (POD) (EC 1.1 1.1.7) as the representative...
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journal_title：Experimental gerontology
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abstract：:The elderly exhibit reduced responses to vaccinations, leaving them more susceptible to preventable infectious diseases such as influenza and pneumonia. It has been unclear as to the specific changes in the aging immune system that contribute to this decline, thus we have developed a mouse model to examine this phenom...
journal_title：Experimental gerontology
pub_type： 杂志文章
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abstract：:Aging is associated with a decline in immune functions. Among them, T-cell activation is altered at several points of the signaling cascade following TCR engagement. Recent findings suggest that lipid rafts act as a platform in the initiation of T-cell activation. We have previously demonstrated that cholesterol conte...
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2009.07.002
更新日期：2009-10-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2016.07.013
更新日期：2016-10-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(87)90045-3
更新日期：1987-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2016.10.002
更新日期：2016-12-01 00:00:00
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journal_title：Experimental gerontology
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doi：10.1016/j.exger.2010.10.004
更新日期：2011-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(95)00008-5
更新日期：1995-09-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2017.12.007
更新日期：2018-02-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2018.10.020
更新日期：2018-12-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2014.10.005
更新日期：2014-12-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2009.10.010
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journal_title：Experimental gerontology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.exger.2015.06.018
更新日期：2015-10-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2018.03.015
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journal_title：Experimental gerontology
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2014.01.020
更新日期：2014-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2014-12-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
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更新日期：2005-12-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.05.055
更新日期：2013-08-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
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更新日期：1982-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
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更新日期：2003-08-01 00:00:00
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journal_title：Experimental gerontology
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doi：10.1016/j.exger.2011.11.011
更新日期：2012-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2003-10-01 00:00:00
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journal_title：Experimental gerontology
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abstract：BACKGROUND:The World Health Organization (WHO) recently proposed an innovative model of care focusing on functional rather than disease-based perspectives, based on a construct of intrinsic capacity (IC). OBJECTIVE:This study aimed to analyze if low-grade inflammation (LGI) (chronically raised C-reactive protein - CRP...
journal_title：Experimental gerontology
pub_type： 杂志文章,多中心研究
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