Abstract：
:Mitochondrial proton leak may modulate reactive oxygen species (ROS) production and play a role in aging. The purpose of this study was to determine proton leak across the life span in skeletal mitochondria from calorie-restricted and UCP2/3 overexpressing mice. Proton leak in isolated mitochondria and markers of oxidative stress in whole tissue were measured in female C57BL/6J mice fed ad-libitum (WT-Control) or a 30% calorie-restricted (WT-CR) diet, and in mice overexpressing UCP2 and UCP3 (Positive-TG), their non-overexpressing littermates (Negative-TG) and UCP3 knockout mice (UCP3KO). Proton leak in WT-CR mice was lower than that of control mice at 8 and 26 months of age. The Positive-TG mice had greater proton leak than the Negative-TG and UCP3KO mice at 8 months of age, but this difference disappeared by 19 and 26 months. Lipid peroxidation was generally lower in WT-CR vs. WT-Control mice and UCP3KO mice had greater concentrations of T-BARS (thiobarbituric acid reactive substances, a measure of lipid peroxidation) than did Positive-TG and Negative-TG. The results of this study indicate that sustained increases in muscle mitochondrial proton leak are not responsible for alterations in life span with calorie restriction or UCP3 overexpression in mice. However, UCP3 may contribute to the actions of CR through mechanisms distinct from increasing basal proton leak.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Asami DK,McDonald RB,Hagopian K,Horwitz BA,Warman D,Hsiao A,Warden C,Ramsey JJdoi
10.1016/j.exger.2008.09.010subject
Has Abstractpub_date
2008-12-01 00:00:00pages
1069-76issue
12eissn
0531-5565issn
1873-6815pii
S0531-5565(08)00317-3journal_volume
43pub_type
杂志文章abstract：BACKGROUND:Awareness of physical ability may impact fall risk during everyday tasks. Therefore, we investigated perceived reach (PR; estimation of furthest reach distance), maximal reach (MR) and reach judgement error (RJE), and their relationships with neuropsychological and physical performance, and falls in older pe...
journal_title：Experimental gerontology
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doi：10.1016/j.exger.2018.10.020
更新日期：2018-12-01 00:00:00
abstract：:A decline in instrumental activities of daily living has been described as the earliest functional deficit in patients with neurodegenerative disease. It embraces specific competencies such as: "recalling the date and telephone calls, orienting to new places, remembering the location of objects at home, understanding ...
journal_title：Experimental gerontology
pub_type： 评论,杂志文章
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2008.10.007
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(02)00087-6
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(01)00145-0
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pub_type： 杂志文章
doi：10.1016/j.exger.2019.01.019
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2012.05.005
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(96)00031-9
更新日期：1996-09-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
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journal_title：Experimental gerontology
pub_type： 杂志文章
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更新日期：2020-03-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
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journal_title：Experimental gerontology
pub_type： 杂志文章
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更新日期：1986-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.10.003
更新日期：2013-12-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2014.12.001
更新日期：2015-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2006.09.014
更新日期：2007-03-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/0531-5565(92)90012-o
更新日期：1992-09-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2006.06.055
更新日期：2006-09-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2018.01.009
更新日期：2018-03-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2010.05.004
更新日期：2010-09-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2003.08.014
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journal_title：Experimental gerontology
pub_type： 杂志文章
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更新日期：2018-05-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2012.04.009
更新日期：2012-07-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
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更新日期：2018-02-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,多中心研究
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更新日期：2014-09-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
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更新日期：1996-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2012.07.010
更新日期：2013-07-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
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更新日期：2017-07-01 00:00:00
