当前位置： SCI文献检索 > EXPERIMENTAL GERONTOLOGY期刊下所有文献 > Phenotype, antigen-presenting capacity, and migration of antigen-presenting cells in young and old age.

Phenotype, antigen-presenting capacity, and migration of antigen-presenting cells in young and old age.

Abstract：

:In the present paper, we investigated whether the phenotype, the antigen-presenting capacity, and the migration of antigen-presenting cells (APCs), are affected by the aging process. APCs were obtained incubating peritoneal monocyte-macrophage cells with granulocyte-macrophage colony-stimulating factor (GM-CSF) (immature APCs) or GM-CSF and IFNgamma (mature APCs). Phenotypically, after 8 days incubation, APCs cultures were composed of CD11c and Mac-3 cells, with a similar representation, both in young and old mice. The absolute number and the expression of MHC I and II, CD80, and CD86 both on immature and mature APCs were not significantly different in young and old mice. APCs from old mice induced similar lymphocyte proliferative responses but lower lymphocyte cytotoxicity and a reduced number of CD8(+) T cells producing IFNgamma in comparison with APCs from young animals. Lymphocyte responses were antigen-specific, since TS/A pulsed APCs induced lymphocyte cytotoxicity against TS/A but not against syngeneic TUBO tumor cells. The low expression of the mRNA for the migratory CCR7 chemokine receptor present in immature APCs from old mice was greatly increased in mature APCs up to the levels found in APCs from young animals. The in vivo migration of APCs was higher in old than in young mice. These results demonstrate that some alterations in APCs function are present in aging, suggesting that an increased migratory capacity of old APCs may be required to balance their reduced antigen presentation to cytotoxic lymphocytes.

journal_name

Exp Gerontol

journal_title

Experimental gerontology

authors

Donnini A,Argentati K,Mancini R,Smorlesi A,Bartozzi B,Bernardini G,Provinciali M

doi

10.1016/s0531-5565(02)00087-6

keywords:

subject

Has Abstract

pub_date

2002-08-01 00:00:00

pages

1097-112

issue

8-9

eissn

0531-5565

issn

1873-6815

pii

S0531556502000876

journal_volume

37

pub_type

杂志文章

相关文献

EXPERIMENTAL GERONTOLOGY文献大全
  • Longevity-associated mitochondrial DNA 5178 A/C polymorphism modulates effects of daily drinking and cigarette consumption on serum triglyceride levels in middle-aged Japanese men.

    abstract：:Mitochondrial DNA 5178 adenine/cytosine (mt5178 A/C) polymorphism is one of the longevity-associated mitochondrial DNA polymorphisms. The frequency of the mt5178A genotype is significantly higher in Japanese centenarians than in the general population. We previously reported that serum high-density lipoprotein cholest...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/s0531-5565(03)00211-0

    authors： Kokaze A,Ishikawa M,Matsunaga N,Yoshida M,Sekine Y,Sekiguchi K,Satoh M,Harada M,Teruya K,Takeda N,Uchida Y,Tsunoda T,Takashima Y

    更新日期：2003-10-01 00:00:00

  • Age-related differences in the adaptive potential of type I skeletal muscle fibers.

    abstract：:This study was designed to investigate whether the relationship of fiber size and force is maintained with aging and inactivity. We hypothesized that fiber size and fiber force-generating capacity would decrease in parallel, thus resulting in no change in specific force with either age or inactivity. Thirty male Fisch...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2004.12.002

    authors： Husom AD,Ferrington DA,Thompson LV

    更新日期：2005-03-01 00:00:00

  • Soluble cell adhesion molecules in monocytes of Alzheimer's disease and mild cognitive impairment.

    abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disorder with characteristic neuropathological features that are accompanied by inflammatory processes and release of pro-inflammatory cytokines. There is evidence that microglial cells are a key mediator of damage in AD. The microglial compartment may arise ...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2009.10.005

    authors： Hochstrasser T,Weiss E,Marksteiner J,Humpel C

    更新日期：2010-01-01 00:00:00

  • Aging-related changes in myocardial purine metabolism and ischemic tolerance.

    abstract：:Impaired tolerance to ischemia-reperfusion in older hearts may stem in part from alterations in purine catabolism, impacting on maintenance of energy state and protective signaling via extracellular adenosine. We characterized effects of aging on normoxic and post-ischemic purine metabolism in hearts from young (2-4 m...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2003.08.003

    authors： Willems L,Garnham B,Headrick JP

    更新日期：2003-10-01 00:00:00

  • Motor performance achievements in rats of different ages.

    abstract：:Motor performance of rats of different ages was determined in a cross sectional study. The design includes a test battery of seven motor tasks of graduated complexity. The results show a hierarchical order of impairments of motor functions in aging rats; that is, the more complex the task requirement, the earlier and ...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/0531-5565(83)90018-9

    authors： Jänicke B,Schulze G,Coper H

    更新日期：1983-01-01 00:00:00

  • Frailty is not associated with hypertension, blood pressure or antihypertensive medication in community-dwelling older adults: A cross-sectional comparison across 3 frailty instruments.

    abstract：AIM:The present study investigated whether hypertension, blood pressure, and antihypertensive therapy were associated with frailty status in community-dwelling older adults. In addition, we tested whether such associations were consistent across different frailty instruments. MATERIAL AND METHODS:Two-hundred older adu...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2021.111245

    authors： Coelho-Junior HJ,Uchida MC,Picca A,Calvani R,Landi F,de Oliveira Gonçalves I,Rodrigues B,Bernabei R,Marzetti E

    更新日期：2021-01-19 00:00:00

  • Aging and cancer mortality: dynamics of change and sex differences.

    abstract：:Age-related changes in cancer mortality risk are important for understanding the processes of disease and aging interaction. The extent to which these age changes differ by sex further contributes to this understanding but has not been well studied to date. We conducted a systematic examination of dynamics and heterog...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2012.06.009

    authors： Yang Y,Li T,Nielsen ME

    更新日期：2012-09-01 00:00:00

  • Role of mineralocorticoid receptors in arterial stiffness in human aging.

    abstract：:Arterial stiffness, an independent predictor of cardiovascular disease, is increased in aging, but the underlying mechanisms are not completely understood. Mineralocorticoid receptors (MR) may contribute to oxidative stress and arterial stiffness in healthy older adults. To test the hypothesis that short-term MR block...

    journal_title：Experimental gerontology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.exger.2013.05.058

    authors： Hwang MH,Yoo JK,Luttrell M,Kim HK,Meade TH,English M,Nichols WW,Christou DD

    更新日期：2013-08-01 00:00:00

  • Role of the peripheral innate immune system in the development of Alzheimer's disease.

    abstract：:Alzheimer's disease is one of the most devastating neurodegenerative diseases. The exact cause of the disease is still not known although many scientists believe in the beta amyloid hypothesis which states that the accumulation of the amyloid peptide beta (Aβ) in brain is the initial cause which consequently leads to ...

    journal_title：Experimental gerontology

    pub_type： 杂志文章,评审

    doi：10.1016/j.exger.2017.12.019

    authors： Le Page A,Dupuis G,Frost EH,Larbi A,Pawelec G,Witkowski JM,Fulop T

    更新日期：2018-07-01 00:00:00

  • Effect of genetic and non-genetic factors, including aging, on waist circumference and BMI, and inter-indicator differences in risk assessment.

    abstract：OBJECTIVE:To assess the effect of genetic and non-genetic factors on indicators derived from waist circumference (WC) and body mass index (BMI) as well as inter-indicator differences in risk assessment age-related diseases including diabetes mellitus, coronary heart disease and liver cancer. METHODS:Height, weight and...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2014.10.005

    authors： Xin G,Shong L,Hui L

    更新日期：2014-12-01 00:00:00

  • Decreased accuracy of protein synthesis in extracts from aging human diploid fibroblasts.

    abstract：:The accuracy of protein synthesis has been measured in extracts from human diploid fibroblasts of different ages. Extracts were supplied with purified mRNA for the coat protein of the cowpea variant of tobacco mosaic virus (CcTMV), which lacks codons for cysteine and methionine. The presence of 35S-cysteine in CcTMV c...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/0531-5565(89)90022-3

    authors： Luce MC,Bunn CL

    更新日期：1989-01-01 00:00:00

  • CSF protein changes associated with hippocampal sclerosis risk gene variants highlight impact of GRN/PGRN.

    abstract：OBJECTIVE:Hippocampal sclerosis of aging (HS-Aging) is a common cause of dementia in older adults. We tested the variability in cerebrospinal fluid (CSF) proteins associated with previously identified HS-Aging risk single nucleotide polymorphisms (SNPs). METHODS:Alzheimer's Disease Neuroimaging Initiative cohort (ADNI...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2017.01.025

    authors： Fardo DW,Katsumata Y,Kauwe JSK,Deming Y,Harari O,Cruchaga C,Alzheimer's Disease Neuroimaging Initiative.,Nelson PT

    更新日期：2017-04-01 00:00:00

  • Grape seed proanthocyanidin lowers brain oxidative stress in adult and middle-aged rats.

    abstract：:There is growing concern over the increasing instances of decline in cognitive abilities with aging in humans. The present study evaluated the benefits of the natural antioxidant, grape seed proanthocyanidin extract (GSPE) in treating the effects of age-related oxidative stress (OS) and accumulation of lipofuscin (LF)...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2011.08.006

    authors： Asha Devi S,Sagar Chandrasekar BK,Manjula KR,Ishii N

    更新日期：2011-11-01 00:00:00

  • Evidence for oxidative and not reductive stress in the aged rabbit heart.

    abstract：:Reductive stress, which is due to a paradoxical excess of antioxidants such as reduced glutathione (GSH) and GSH-related enzymes associated with decreased oxidant levels, has emerged as a pathogenetic mechanism of myocardial damage in pathological conditions such as protein aggregation cardiomyopathy. Notably, in the ...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2020.110871

    authors： Lapenna D,Ciofani G,Lelli Chiesa P,Porreca E

    更新日期：2020-02-06 00:00:00

  • Effect of inhibitors and stimulators on isolated liver cell mitochondrial protein synthesis from young and old rats.

    abstract：:Mitochondria isolated from the livers of old rats (26-30 months) were found to incorporate 41% less leucine into mitochondrial proteins as compared to those from young rats (2-3 months). The initial rates of incorporation of label were 145 cpm/mg/min for the "old" animals, and 320 cpm/mg/min for the young animal. No d...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/s0531-5565(82)80004-1

    authors： Marcus DL,Lew G,Gruenspecht-Faham N,Freedman ML

    更新日期：1982-01-01 00:00:00

  • A novel neurocognitive approach for placebo analgesia in neurocognitive disorders.

    abstract：:Neural correlates of placebo analgesia (PA) in patients with neurocognitive disorders have not yet been elucidated. The present study aimed to evaluate how and to what extent executive (dys)functions of the medial prefrontal cortex (MPFC) may be related to PA. To this end, twenty-three subjects complaining of differen...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2019.01.011

    authors： Palermo S,Rainero I,Stanziano M,Vase L,D'Agata F,Rubino E,Fonio P,Sardanelli F,Amanzio M

    更新日期：2019-04-01 00:00:00

  • In vitro model of chronological aging of adipocytes: Interrelationships with hypoxia and oxidation.

    abstract：:Aging is a physiological process characterized by an age-progressive decline in intrinsic physiological functions, with an increased risk of developing chronic metabolic conditions, such as insulin resistance and diabetes. Furthermore, from a physiopathological point of view, several authors describe an association be...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2019.03.011

    authors： Zoico E,Rizzatti V,Policastro G,Tebon M,Darra E,Rossi AP,Mazzali G,Fantin F,Zamboni M

    更新日期：2019-07-01 00:00:00

  • A prospective study on the association of sleep duration with grip strength among middle-aged and older Chinese.

    abstract：BACKGROUND:Longitudinal studies on sleep duration and grip strength decline are limited. This study aimed to evaluate the associations of baseline sleep duration with follow-up grip strength and grip strength changeover time among a large sample of middle-aged and older Chinese. METHODS:Data from China Health and Reti...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2018.01.009

    authors： Wang TY,Wu Y,Wang T,Li Y,Zhang D

    更新日期：2018-03-01 00:00:00

  • Physical training promotes similar effects to the blockade of angiotensin-converting enzyme on the cardiac morphology and function in old female rats subjected to premature ovarian failure.

    abstract：:We investigated the effects of angiotensin-converting enzyme (ACE) inhibition and aerobic physical training on the heart of old female rats (82-wk-old) submitted to premature ovarian failure (10-wk.-old). We used different approaches: morphology and function by echocardiography, reactivity of the coronary bed and left...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2017.04.003

    authors： Felix ACS,Dutra SGV,Gastaldi AC,Bonfim PC,Vieira S,de Souza HCD

    更新日期：2018-08-01 00:00:00

  • In vitro models of age-related neurodegenerative disorders.

    abstract：:Aging is the major risk factor for numerous brain diseases. This is especially true for Alzheimer's disease (AD), a peculiar neurodegenerative disorder in that it results from the synergy of two simultaneous but distinct degenerating processes: A beta and tau pathologies. For AD, and for most neurodegenerative disorde...

    journal_title：Experimental gerontology

    pub_type： 杂志文章,评审

    doi：10.1016/j.exger.2003.09.010

    authors： Delacourte A,Sergeant N,Buée L

    更新日期：2003-11-01 00:00:00

  • Why is the dog an ideal model for aging research?

    abstract：:With many caveats to the traditional vertebrate species pertaining to biogerontology investigations, it has been suggested that a most informative model is the one which: 1) examines closely related species, or various members of the same species with naturally occurring lifespan variation, 2) already has adequate med...

    journal_title：Experimental gerontology

    pub_type： 杂志文章,评审

    doi：10.1016/j.exger.2015.08.008

    authors： Gilmore KM,Greer KA

    更新日期：2015-11-01 00:00:00

  • Analysis of the effect of membrane arachidonic acid concentration on modulation of glutamate release by interleukin-1: an age-related study.

    abstract：:Aging is associated with a change in membrane composition that includes a decrease in membrane polyunsaturated fatty acids, including arachidonic acid, and an increase in membrane cholesterol. Alterations in membrane structure are likely to impact on transmitter release, which relies on the fusion of synaptic plasma a...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/s0531-5565(97)00130-7

    authors： McGahon B,Murray CA,Clements MP,Lynch MA

    更新日期：1998-06-01 00:00:00

  • Abrupt telomere shortening in normal human fibroblasts.

    abstract：:Aging is one of the most basic properties of living organisms. Abundant evidence supports the idea that cell senescence underlies organismal aging in higher mammals. Therefore, examining the molecular mechanisms that control cell and replicative senescence is of great interest for biology and medicine. Several discove...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2010.01.009

    authors： Vidacek NS,Cukusić A,Ivanković M,Fulgosi H,Huzak M,Smith JR,Rubelj I

    更新日期：2010-03-01 00:00:00

  • The impact of 2 weeks of detraining on phase angle, BIVA patterns, and muscle strength in trained older adults.

    abstract：BACKGROUND:An intermission in the training routine, in which older adults refrain from regular structured exercise, may have deleterious effects on muscle performance and bioelectric phase angle (PhA), which is a predictive marker for cellular integrity. PURPOSE:To determine the effects of a 2-week detraining period o...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2020.111175

    authors： Freitas SP,Júdice PB,Hetherington-Rauth M,Magalhães JP,Correia IR,Lopes JM,Strong C,Matos D,Sardinha LB

    更新日期：2021-02-01 00:00:00

  • Expression and production of two selected beta-chemokines in peripheral blood mononuclear cells from patients with Alzheimer's disease.

    abstract：:MCP-1 and RANTES are molecules that regulate monocyte and T-lymphocyte recruitment towards sites of inflammation. We sought to evaluate the role of these chemokines in Alzheimer's disease (AD), and the effect of acetylcholinesterase inhibitor (AchEI) therapy on their release from peripheral blood mononuclear cells (PB...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2005.04.007

    authors： Iarlori C,Gambi D,Gambi F,Lucci I,Feliciani C,Salvatore M,Reale M

    更新日期：2005-07-01 00:00:00

  • Stress, DNA damage and ageing -- an integrative approach.

    abstract：:Ageing is highly complex, involving multiple mechanisms at different levels. Nevertheless, recent evidence suggests that several of the most important mechanisms are linked via endogenous stress-induced DNA damage caused by reactive oxygen species (ROS). Understanding how such damage contributes to age-related changes...

    journal_title：Experimental gerontology

    pub_type： 杂志文章,评审

    doi：10.1016/s0531-5565(01)00111-5

    authors： von Zglinicki T,Bürkle A,Kirkwood TB

    更新日期：2001-07-01 00:00:00

  • Effects of elastic band resistance training and nutritional supplementation on physical performance of institutionalised elderly--A randomized controlled trial.

    abstract：OBJECTIVES:To evaluate the effects of elastic band resistance training in combination with nutrient supplementation on muscular strength and the ability to perform mobility-related activities of daily living in older adults living in retirement care facilities. DESIGN:Randomized controlled trial, with a 6-month interv...

    journal_title：Experimental gerontology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.exger.2015.08.013

    authors： Oesen S,Halper B,Hofmann M,Jandrasits W,Franzke B,Strasser EM,Graf A,Tschan H,Bachl N,Quittan M,Wagner KH,Wessner B

    更新日期：2015-12-01 00:00:00

  • The crosstalk between cellular reprogramming and senescence in aging and regeneration.

    abstract：:Aging is associated with diminished regenerative capacity and increased risk of chronic diseases. There is now compelling evidence suggests that aging process is reversible. Besides metabolic modification and systematic factors, both senescence elimination and cellular reprogramming showed beneficial effects on tissue...

    journal_title：Experimental gerontology

    pub_type： 杂志文章,评审

    doi：10.1016/j.exger.2020.111005

    authors： Chiche A,Chen C,Li H

    更新日期：2020-09-01 00:00:00

  • Twenty-four hour growth hormone secretion in a patient with Werner's syndrome.

    abstract：OBJECTIVE:To assess the 24-h endogenous secretory growth hormone (GH) profile and serum insulin-like growth factor-I (IGF-I) response to exogenous recombinant human growth hormone (rhGH) in a patient with Werner's syndrome. DESIGN:Blood sampling every 20 min for 24 h followed by three daily injections of growth hormon...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/0531-5565(96)00031-9

    authors： Rubin CD,Reed B

    更新日期：1996-09-01 00:00:00

  • A search for principles of disability using experimental impairment of Drosophila melanogaster.

    abstract：:The results of life table experiments to determine the effects of artificial impairment (leg amputation) in 7500 Drosophila melanogaster adults revealed that the extent to which life expectancy was reduced in impaired individuals was conditional on: (1) leg location and number amputated--front leg had greatest impact ...

    journal_title：Experimental gerontology

    pub_type： 杂志文章

    doi：10.1016/j.exger.2006.10.002

    authors： Carey JR,Pinter-Wollman N,Wyman M,Müller HG,Molleman F,Zhang N

    更新日期：2007-03-01 00:00:00