Abstract:
:There is growing concern over the increasing instances of decline in cognitive abilities with aging in humans. The present study evaluated the benefits of the natural antioxidant, grape seed proanthocyanidin extract (GSPE) in treating the effects of age-related oxidative stress (OS) and accumulation of lipofuscin (LF) on the cognitive ability in rats. Female Wistar rats of 3- and 12-months of age received a daily oral supplement of GSPE until they attained 6- and 15-months of age. During this period, rats were tested for their cognitive ability. At the end of this period, blood glucose and markers of OS were assessed in the hippocampus. GSPE lowered blood glucose, lipid peroxidation, hydrogen peroxide level, and increased protein sulphydryl (P-SH) content in the hippocampus. In addition, GSPE significantly improved cognitive performance in the two age groups. These results demonstrate that the extent of OS-related LF accumulation is reducible by GSPE. They also suggest a critical role for GSPE as a neuroprotectant in the hippocampus and in preventing cognitive loss with aging.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Asha Devi S,Sagar Chandrasekar BK,Manjula KR,Ishii Ndoi
10.1016/j.exger.2011.08.006subject
Has Abstractpub_date
2011-11-01 00:00:00pages
958-64issue
11eissn
0531-5565issn
1873-6815pii
S0531-5565(11)00205-1journal_volume
46pub_type
杂志文章abstract::According to the free radical theory of aging, free radicals are involved in the production of changes in cellular metabolism that lead to a time-dependent functional decline in all living beings. Consequently, antioxidant and/or free radicals scavengers may retard the aging process. We explored the effect of melatoni...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(01)00229-7
更新日期:2002-05-01 00:00:00
abstract::We investigated the effects of angiotensin-converting enzyme (ACE) inhibition and aerobic physical training on the heart of old female rats (82-wk-old) submitted to premature ovarian failure (10-wk.-old). We used different approaches: morphology and function by echocardiography, reactivity of the coronary bed and left...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2017.04.003
更新日期:2018-08-01 00:00:00
abstract::Exercise training has been associated with the attenuation of cardiovascular impairment after menopause. This study aimed to compare central and peripheral blood pressure and aortic pulse wave reflection in sedentary and trained (aerobic exercise in the water) hypertensive postmenopausal women. Hypertensive postmenopa...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2020.111146
更新日期:2021-01-01 00:00:00
abstract::A revolution has occurred in the attitude of biologists toward their intellectual property rights. What today is patentable and highly profitable was, 20 years ago, unpatentable and given away for nothing. The history of this revolution began in the early 1960s when we made the first effort to have self-duplicating ce...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/s0531-5565(97)00115-0
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVES:There is a scarcity of data on the association between mild cognitive impairment (MCI) and falls, especially from low- and middle-income countries (LMICs) where 70% of all older adults reside. Thus, we investigated the association between MCI and fall-related injury among older adults residing in six LMICs (...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2020.111222
更新日期:2020-12-29 00:00:00
abstract::Working from the hypothesis that modest deviations from physiological oxygen tension will influence cell characteristics important for infections/immunity and tumor development, cells were studied at three oxygen tensions during in vitro aging. Primary mouse embryo fibroblasts were established and subsequently passage...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(93)90046-g
更新日期:1993-11-01 00:00:00
abstract::Coenzyme Q10 supplementation increases life-span of rats fed on a diet enriched with polyunsaturated fatty acids (Quiles, J.L., Ochoa, J.J., Huertas, J.R., Mataix, J., 2004b. Coenzyme Q supplementation protects from age-related DNA double-strand breaks and increased lifespan in rats fed on a PUFA-rich diet. Exp. Geron...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2005.07.003
更新日期:2005-08-01 00:00:00
abstract::Ethanol ingestion has been implicated in accidental hypothermia of the elderly, but there is no prior data on the relative sensitivity to alcohol of aged homeotherms that might account for disproportionate dysthermia in this age group. To assess their sensitivity, ethanol (0.5-2.0 g/kg) or H20 was given by gavage to s...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(83)90047-5
更新日期:1983-01-01 00:00:00
abstract::Alpha-synuclein (α-Syn) accumulation is significantly correlated with motor deficits and mitochondrial dysfunction in Parkinson's disease (PD), but the molecular mechanism underlying its pathogenesis is unclear. In this study, we investigated the effects of treadmill exercise on motor deficits and mitochondrial dysfun...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2017.01.001
更新日期:2017-03-01 00:00:00
abstract::Alzheimer's disease (AD) is a neurodegenerative disorder characterized by accumulation of aggregated forms of the 40- and 42-amino acid Abeta peptides (Abeta40 and Abeta42). Estrogen replacement therapy (ERT) in postmenopausal women is associated with decreased risk for AD and/or delay in disease onset. The mechanism ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(00)00157-1
更新日期:2000-12-01 00:00:00
abstract::Lipid hydroperoxides are formed in vivo through free radical pathways from the action of reactive oxygen species on polyunsaturated fatty acids. They are also formed as specific products of lipoxygenases and cyclooxygenases. Homolytic decomposition of lipid hydroperoxides to the alpha,beta-unsaturated aldehyde genotox...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/s0531-5565(01)00133-4
更新日期:2001-09-01 00:00:00
abstract::The concept that lifespan is a function of the capacity to withstand extrinsic stress is very old. In concordance with this, long-lived individuals often have increased resistance against a variety of stresses throughout life. Genes underlying the stress response may therefore have the ability to affect lifespan. The ...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2006.09.014
更新日期:2007-03-01 00:00:00
abstract::Cardiovascular function during sleep was studied in 14 (6 males, 8 females) healthy, active, older adults (57-70) years). Noninvasive measures of stroke volume (SV), heart rate (HR), cardiac output (CO), pre-ejection period (PEP), and left ventricular ejection time (LVET) were taken using impedance cardiography and co...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(87)90031-3
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:Homocysteine (Hcy) high levels are associated with fractures, bone resorption and an early onset of osteoporosis in elderly persons; a relationship between Hcy and bone formation has also been suggested but is still controversial. Frailty, an independent predictor of fractures and decreased bone mineral dens...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2018.04.019
更新日期:2018-07-15 00:00:00
abstract::Natural killer (NK) cells play an important role in controlling several viral diseases. Our previous studies demonstrated an age-dependent susceptibility to mousepox due to defective NK cell responses and trafficking. However, the mechanisms that underlie the age-related impairment in NK cell migration have yet to be ...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2017.06.021
更新日期:2017-10-01 00:00:00
abstract::In muscles, sarcopenia, the loss of muscle mass, is the major cause of aging-related functional decline and frailty. Several factors are correlated with sarcopenia during aging, including contraction-related cellular injury, oxidative stress, endocrine changes and reduced regenerative potential. However the involvemen...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2005.12.004
更新日期:2006-03-01 00:00:00
abstract::Age-related behavioral declines are common manifestations of aging in animals. Negative geotaxis, an innate escape response during which flies ascend the wall of a cylinder after being tapped to its bottom, is one of the behaviors that senesces in Drosophila. Many laboratories, including ours, have used a variety of n...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2005.02.005
更新日期:2005-05-01 00:00:00
abstract::Aging is associated with an increased incidence of heart failure, but the existence of an age-related cardiomyopathy remains controversial. Differences in strain, age and technique of measuring cardiac function differ between experiments, confounding the interpretation of these studies. Additionally, the structural an...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2011.02.010
更新日期:2011-07-01 00:00:00
abstract::Muscle wasting diseases are gradually increasing with the increase in global life expectancy. This study was designed to evaluate the efficacy of HIM-CHX, a herbal combination of Boswellia serrata, Cissus quadrangularis, and Withania somnifera, on Sarcopenia. The effects of HIM-CHX on parameters such as muscle mass, g...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2019.110663
更新日期:2019-10-01 00:00:00
abstract::In order to clarify immunogenetic markers contributing to successful aging, HLA and cytokine gene profiles were analyzed in healthy elderly Bulgarians. Family segregation analysis was performed to define combined effect of haplotypes and immunophenotype profiles. The results of this study did not reveal any statistica...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2003.08.014
更新日期:2004-04-01 00:00:00
abstract::Accumulation of CD28(-)CD8 T cells that are defective in response to antigenic stimulation is a hallmark of age-associated decline in T cell function. However, the underlying mechanism of this age-associated change is not fully understood. We recently analyzed the global gene expression profiles of CD8 T cell subsets ...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2006.11.015
更新日期:2007-05-01 00:00:00
abstract::Light and electron microscope comparisons were made of parotid and submandibular glands from male Swiss-Webster white mice 3, 13, and 18 months old. The glands from the 13- and 18-month-old mice were less organized and the parenchyma was not as dense. Fibrous connective tissue, intracellular lipofuscin granules, and r...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(88)90007-1
更新日期:1988-01-01 00:00:00
abstract::Adult Premature Aging Mice (PAM) show premature immunosenescence, oxidative and inflammatory stress and consequently a shorter lifespan than Exceptional Non-Prematurely Aging Mice (E-NPAM) at the same age. Indeed, adult female PAM exhibit behavioral age-related declines and abnormalities in its brain neurochemistry. N...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2020.111224
更新日期:2020-12-31 00:00:00
abstract::Understanding telomere biology is of utmost importance for aging and cancer research. An essential tool is the determination of telomere length, which traditionally is done by telomere restriction fragment analysis, a laborious and time consuming method. Therefore, large efforts have been made to establish alternative...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2005.09.013
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVE:To assess the 24-h endogenous secretory growth hormone (GH) profile and serum insulin-like growth factor-I (IGF-I) response to exogenous recombinant human growth hormone (rhGH) in a patient with Werner's syndrome. DESIGN:Blood sampling every 20 min for 24 h followed by three daily injections of growth hormon...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(96)00031-9
更新日期:1996-09-01 00:00:00
abstract::Aging is associated with a progressive decline of muscle mass, strength, and quality, a condition described as sarcopenia of aging. Despite the significance of skeletal muscle atrophy, the mechanisms responsible for the deterioration of muscle performance are only partially understood. The purpose of this review is to...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2008.05.003
更新日期:2009-01-01 00:00:00
abstract::Recently, it has been suggested that oxytocin (OT) might play a role in the control of bone remodeling and in bone health of young and adult females. The purpose of this study was to evaluate the effect of osteogenic medium (OM) plus OT (OM + OT; 100 nmol/L) on osteoblastic differentiation of bone marrow mesenchymal s...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2018.09.023
更新日期:2018-11-01 00:00:00
abstract::Delirium is an acute-onset syndrome that exacerbates patients' condition and significantly increases consequential morbidity and mortality. There is no comprehensive, cellular and tissue-level, pathophysiological theory. The melatonin hormone imbalance has been shown to be linked to circadian rhythms, sleep-wake cycle...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2015.09.007
更新日期:2015-12-01 00:00:00
abstract::Evolutionary aspects of menopause are considered from several perspectives. First, the programmed exhaustion of ovarian oocytes appears to be a general trait of mammals that is not as widely found in other vertebrates. Second, studies on mice suggest that the maternal age effect that accelerates the incidence of Down ...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/0531-5565(94)90009-4
更新日期:1994-05-01 00:00:00
abstract::Although galanin has been shown to increase GLUT4 expression in the cardiac muscle of rats, there is no literature available about the effect of GalR1 on GLUT4 expression in the cardiac muscle of type 2 diabetic rats. The aim of this study was to determine whether intracerebroventricular injection of GalR1 agonist M61...
journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2014.11.009
更新日期:2015-05-01 00:00:00