Oxytocin effects on osteoblastic differentiation of Bone Marrow Mesenchymal Stem Cells from adult and aging female Wistar rats.

abstract：:Type 2 diabetes is associated with progressive beta-cell failure manifest as a decline in insulin secretion and increasing hyperglycemia. A growing body of evidence suggests that beta-cell failure in type 2 diabetes correlates with the formation of pancreatic islet amyloid deposits, indicating that islet amyloid may h...

journal_title：Experimental gerontology

authors： Marzban L,Park K,Verchere CB

更新日期：2003-04-01 00:00:00

abstract：:Telomere length is considered as a biological marker for aging. It is expected that telomeres shorten with age and with conditions associated with oxidative stress and inflammation. Both are present in patients with chronic kidney disease (CKD) who have a very high cardiovascular risk. We investigated whether CKD dura...

journal_title：Experimental gerontology

authors： Raschenberger J,Kollerits B,Titze S,Köttgen A,Bärthlein B,Ekici AB,Forer L,Schönherr S,Weissensteiner H,Haun M,Wanner C,Eckardt KU,Kronenberg F,GCKD study Investigators.

更新日期：2015-12-01 00:00:00

abstract：:Several studies have shown that centenarians have better cardiovascular risk profiles compared to younger old people. Some reports have revealed that cardiovascular diseases (i.e. hypertension, diabetes, angina and/or myocardial infarction) are less common in centenarians respect to 70 and 80 years old persons. In ord...

journal_title：Experimental gerontology

authors： Galioto A,Dominguez LJ,Pineo A,Ferlisi A,Putignano E,Belvedere M,Costanza G,Barbagallo M

更新日期：2008-02-01 00:00:00

abstract：PURPOSE:The elderly lose skeletal muscle mass with age, which may be detrimental for function and quality of life. Both inactivity and heavy resistance exercise are known to have marked but opposite effects upon muscle mass. However, the potential effects of daily physical activity upon muscle protein synthesis (MPS) a...

journal_title：Experimental gerontology

authors： Bülow J,Agergaard J,Kjaer M,Holm L,Reitelseder S

更新日期：2016-06-15 00:00:00

abstract：:Reductions in physical performance, cognitive impairment (CI) and decline (CD), are common in older age, but few prospective cohort studies have considered the relationship between these domains. In this study we investigated whether reduced physical performance and low handgrip/lower limbs strength, could predict a h...

journal_title：Experimental gerontology

authors： Veronese N,Stubbs B,Trevisan C,Bolzetta F,De Rui M,Solmi M,Sartori L,Musacchio E,Zambon S,Perissinotto E,Crepaldi G,Manzato E,Sergi G

更新日期：2016-08-01 00:00:00

abstract：:The A3243G mutation, one of the changes of human mitochondrial DNA (mtDNA) that accumulates in cells during aging, is a useful marker for investigating the aging of cells. We measured the mutation level of the mtDNA A3243G mutation using DNAs from two different tissues (esophageal epithelium and myocardium) from advan...

journal_title：Experimental gerontology

authors： Harihara S,Nakamura K,Takubo K,Takeuchi F

更新日期：2002-07-01 00:00:00

abstract：:Stem cells are located throughout the adult body of higher organisms, supporting a continuous renewal and repair of tissues. Unique abilities of stem cells are self-renewal and multipotential differentiation. It is, therefore, of critical importance for an organism to maintain and control quantity and quality of stem ...

journal_title：Experimental gerontology

authors： Fehrer C,Lepperdinger G

更新日期：2005-12-01 00:00:00

abstract：:Dietary restriction (DR) has multiple and essential effects in protecting against DNA damage in model organisms. Persistent DNA damage plays a central role in the process of aging. Senescence-associated secretory phenotype (SASP), as a product of cellular aging, can accelerate the process of cellular senescence as a f...

journal_title：Experimental gerontology

authors： Wang W,Cai G,Chen X

更新日期：2018-07-01 00:00:00

abstract：:Light and electron microscope comparisons were made of parotid and submandibular glands from male Swiss-Webster white mice 3, 13, and 18 months old. The glands from the 13- and 18-month-old mice were less organized and the parenchyma was not as dense. Fibrous connective tissue, intracellular lipofuscin granules, and r...

journal_title：Experimental gerontology

authors： Meisel DL,Skobe Z,Prostak KS,Shklar G

更新日期：1988-01-01 00:00:00

abstract：:Studies have suggested that older individuals are more fatigable than young adults when power loss, measured during single-joint contractions, is considered the fatigue index; however, age-related differences in fatigue considering power measurements during multi-joint movements (e.g., cycling) have not been fully elu...

journal_title：Experimental gerontology

authors： Krüger RL,Aboodarda SJ,Jaimes LM,Vaz MA,Samozino P,Millet GY

更新日期：2020-05-01 00:00:00

abstract：:Age-related changes of gene expression contribute to the physiological alteration observed with human ageing. Herein, the abundance of a selection of 148 transcripts involved in immunosenescence and stress response was compared in total RNA of PBMC of healthy young to middle-age probands (35.0 +/- 6.5 year old) and he...

journal_title：Experimental gerontology

authors： Vo TK,Godard P,de Saint-Hubert M,Morrhaye G,Bauwens E,Debacq-Chainiaux F,Glupczynski Y,Swine C,Geenen V,Martens HJ,Toussaint O

更新日期：2010-03-01 00:00:00

abstract：:Given the increased concerns about the degenerative decline in the physical performance of the elderly, there is a need for developing effective strategies to suppress the age-related loss of skeletal muscle mass and functional capacity through a lifestyle intervention. This randomized controlled trial examined whethe...

journal_title：Experimental gerontology

authors： Lim NJ,Shin JH,Kim HJ,Lim Y,Kim JY,Lee WJ,Han SJ,Kwon O

更新日期：2017-01-01 00:00:00

abstract：:Several papers reported in recent years on a change in the age population distribution of the circulating erythrocytes in old mice, rats, rabbits, and humans. The results indicate the presence of a chronologically younger cell population in old animals and humans. The cells are typically lower in density and larger. I...

journal_title：Experimental gerontology

authors： Danon D,Bologna NB,Gavendo S

更新日期：1992-01-01 00:00:00

abstract：:Gene expression is much altered in aging. We observed age-dependent decline of core clock genes' expression in the whole body of the fruit fly. We hypothesized that inducible overexpression of clock genes (cry, per, tim, cyc and Clk) in the nervous system can improve healthspan of D. melanogaster. We studied the lifes...

journal_title：Experimental gerontology

authors： Solovev I,Dobrovolskaya E,Shaposhnikov M,Sheptyakov M,Moskalev A

更新日期：2019-03-01 00:00:00

abstract：:Despite well-documented evidence for lifespan extension by methionine restriction (MR), underlying mechanisms remain unknown. As methionine can alter S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH), the substrate and product of DNA methyltransferase-1 (DNMT1), we hypothesized that MR diet alters DNA methyl...

journal_title：Experimental gerontology

authors： Mattocks DA,Mentch SJ,Shneyder J,Ables GP,Sun D,Richie JP Jr,Locasale JW,Nichenametla SN

更新日期：2017-02-01 00:00:00

abstract：:Serum lipid peroxide (LPO) in 72 healthy male subjects was studied using a newly developed assay method based on the reaction of LPO with methylene blue derivative (MCDP; 10-N-Methylcarbamoyl-3,7-dimethylamino-10 H-phenothiazine). This method is specific for lipid hydroperoxide and the relation is equimolar. The value...

journal_title：Experimental gerontology

authors： Tateishi T,Yoshimine N,Kuzuya F

更新日期：1987-01-01 00:00:00

abstract：:Estrogen replacement therapy (ERT) seems to enhance longevity in women. Both gender and aging have been shown to influence the regulation of circadian rhythms, yet little is known about the effect of ERT on circadian regulation. The aim of this study was to determine the effects of ERT (oral conjugated estrogen: Prema...

journal_title：Experimental gerontology

authors： Gudmundsson A,Goodman B,Lent S,Barczi S,Grace A,Boyle L,Ershler WB,Carnes M

更新日期：1999-09-01 00:00:00

abstract：:Mitochondria generate much of the cellular energy through the process of oxidative phosphorylation (OXPHOS). OXPHOS function may be affected by a mutation in any of the mitochondrial (mt) DNA encoded genes and/or nuclear encoded genes that produce proteins imported into the mitochondrion that form (or assemble) the fi...

journal_title：Experimental gerontology

authors： Ballard JW

更新日期：2005-10-01 00:00:00

abstract：:This study was aimed at determining the effect of exercise and vitamin E on age-associated changes in the superoxide dismutase (SOD), lipid (LPO) and protein oxidations (PO) in the cerebral cortex (CC), cerebellum (CB) and hippocampus (HC) of rat brain. For this, male Wistar albino rats of 4- (adult), 12- (middle-age)...

journal_title：Experimental gerontology

authors： Jolitha AB,Subramanyam MV,Asha Devi S

更新日期：2006-08-01 00:00:00

abstract：:The gangliosides in human diploid fibroblasts--TIG-1, TIG-7, and IMR-90--were analysed at different cell densities at early and late passages to clarify the relationship between age and cell density dependent changes of the gangliosides. In early passages, the ganglioside concentrations increased with increase in cell...

journal_title：Experimental gerontology

authors： Ohsawa T

更新日期：1989-01-01 00:00:00

abstract：:Dietary restriction extends lifespan in a variety of organisms, but the key nutritional components driving this process and how they interact remain uncertain. In Drosophila, while a substantial body of research suggests that protein is the major dietary component affecting longevity, recent studies claim that carbohy...

journal_title：Experimental gerontology

authors： Bruce KD,Hoxha S,Carvalho GB,Yamada R,Wang HD,Karayan P,He S,Brummel T,Kapahi P,Ja WW

更新日期：2013-10-01 00:00:00

abstract：:The aging of the skin is the most visible and obvious manifestation of organismal aging and may serve as a predictor of life expectancy and health. It is, however, also the human desire for long-lasting beauty that further raises interests in the topic, and thus considerable means and efforts are put into studying the...

journal_title：Experimental gerontology

authors： Gruber F,Kremslehner C,Eckhart L,Tschachler E

更新日期：2020-02-01 00:00:00

abstract：:Raw bioelectrical impedance analysis (BIA) data [resistance (R); reactance (Xc)] through bioelectrical impedance vector analysis (BIVA) and phase angle (PhA) have been used to evaluate cellular function and hydration status. The purpose of this investigation was to examine the effects of resistance training (RT) on cl...

journal_title：Experimental gerontology

authors： Fukuda DH,Stout JR,Moon JR,Smith-Ryan AE,Kendall KL,Hoffman JR

更新日期：2016-02-01 00:00:00

abstract：:Fetal and placental weights and peripheral blood progestagen concentrations were examined on days 13, 16 and 22 of gestation in young (3-5 month) nulliparous and old (9-12 month) multiparous, albino Wistar rats. There was no difference in fetal weights at any stage examined whereas placental weights were significantly...

journal_title：Experimental gerontology

authors： Rahima A,Bruce NW

更新日期：1987-01-01 00:00:00

abstract：:Maintaining physical mobility is important for preventing age-related comorbidities in older adults. Endurance and resistance training prevent mobility loss in aging, but exercise alone does not always achieve the expected improvements in physical and cardiopulmonary function. Recent preclinical evidence suggests that...

journal_title：Experimental gerontology

authors： Custodero C,Saini SK,Shin MJ,Jeon YK,Christou DD,McDermott MM,Leeuwenburgh C,Anton SD,Mankowski RT

更新日期：2020-08-01 00:00:00

abstract：:Alzheimer's disease is one of the most devastating neurodegenerative diseases. The exact cause of the disease is still not known although many scientists believe in the beta amyloid hypothesis which states that the accumulation of the amyloid peptide beta (Aβ) in brain is the initial cause which consequently leads to ...

journal_title：Experimental gerontology

authors： Le Page A,Dupuis G,Frost EH,Larbi A,Pawelec G,Witkowski JM,Fulop T

更新日期：2018-07-01 00:00:00

abstract：:Inducible nitric oxide synthase (iNOS) is involved in obesity-induced insulin resistance. Since aging is accompanied by increased iNOS expression, the effect of iNOS gene deletion on aging-associated insulin resistance was investigated in 7-month-old (adult) and 22-month-old (old) iNOS knockout and wild-type mice usin...

journal_title：Experimental gerontology

authors： Cha HN,Kim YW,Kim JY,Kim YD,Song IH,Min KN,Park SY

更新日期：2010-09-01 00:00:00

abstract：:In order to clarify immunogenetic markers contributing to successful aging, HLA and cytokine gene profiles were analyzed in healthy elderly Bulgarians. Family segregation analysis was performed to define combined effect of haplotypes and immunophenotype profiles. The results of this study did not reveal any statistica...

journal_title：Experimental gerontology

authors： Naumova E,Mihaylova A,Ivanova M,Michailova S,Penkova K,Baltadjieva D

更新日期：2004-04-01 00:00:00

abstract：:Measuring physiological dysregulation during aging could be a key tool both to understand underlying aging mechanisms and to predict clinical outcomes in patients. However, most existing indices are either circular or hard to interpret biologically. Recently, we showed that statistical distance of 14 common blood biom...

journal_title：Experimental gerontology

authors： Cohen AA,Milot E,Li Q,Legault V,Fried LP,Ferrucci L

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:Mitochondria produce cellular energy via oxidative phosphorylation (OXPHOS), mediated by respiratory chain complexes I to IV and ATP synthase (complex V). Mitochondrial respiratory complexes have been shown to decline with age in several tissues. As the intestinal epithelium is a tissue with a high energy dem...

journal_title：Experimental gerontology

authors： Özsoy M,Zimmermann FA,Feichtinger RG,Mayr JA,Kofler B,Neureiter D,Klieser E,Schütz S,Weghuber D,Schneider AM

更新日期：2020-07-01 00:00:00