Oxytocin effects on osteoblastic differentiation of Bone Marrow Mesenchymal Stem Cells from adult and aging female Wistar rats.


:Recently, it has been suggested that oxytocin (OT) might play a role in the control of bone remodeling and in bone health of young and adult females. The purpose of this study was to evaluate the effect of osteogenic medium (OM) plus OT (OM + OT; 100 nmol/L) on osteoblastic differentiation of bone marrow mesenchymal stem cells (BMMSCs) from cyclic adult (12 months old) and acyclic aging (24 months old) female Wistar rats. After 14 days, OM + OT increased the oxytocin and oxytocin receptor in the BMMSCs from animals of both age groups relative to OM controls. Alkaline phosphatase activity was higher in the OM + OT than OM group in BMMSCs from 24-month-old female rats. OM + OT improved osteogenic differentiation, observed by anticipated mineralization and increased gene expression of bone morphogenetic protein 2, bone sialoprotein, osteopontin and osteocalcin in both aged relative to OM controls. These findings suggest a role for OT as an adjuvant to induce osteoblastic differentiation of BMMSCs from aged female rat.


Exp Gerontol


Experimental gerontology


Santos LF,Singulani MP,Stringhetta-Garcia CT,Oliveira SHP,Chaves-Neto AH,Dornelles RCM




Has Abstract


2018-11-01 00:00:00












  • Experimental design and husbandry.

    abstract::Rodent gerontology experiments should be carefully designed and correctly analyzed so as to provide the maximum amount of information for the minimum amount of work. There are five criteria for a "good" experimental design. These are applicable both to in vivo and in vitro experiments: (1) The experiment should be unb...

    journal_title:Experimental gerontology

    pub_type: 杂志文章,评审


    authors: Festing MF

    更新日期:1997-01-01 00:00:00

  • Treadmill exercise alleviates motor deficits and improves mitochondrial import machinery in an MPTP-induced mouse model of Parkinson's disease.

    abstract::Alpha-synuclein (α-Syn) accumulation is significantly correlated with motor deficits and mitochondrial dysfunction in Parkinson's disease (PD), but the molecular mechanism underlying its pathogenesis is unclear. In this study, we investigated the effects of treadmill exercise on motor deficits and mitochondrial dysfun...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Koo JH,Cho JY,Lee UB

    更新日期:2017-03-01 00:00:00

  • Effects of chronic fentanyl administration on physical performance of aged rats.

    abstract::There is growing concern over the increasing use of opioids to treat chronic pain in the elderly primarily because of the potential increased sensitivity to the adverse side effects. Here, we use a preclinical model (male Brown Norway X F344 rats aged 12, 18, 24, and 30 months) to describe the outcome of chronic fenta...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Mitzelfelt JD,Dupree JP,Seo DO,Carter CS,Morgan D

    更新日期:2011-01-01 00:00:00

  • A novel technique for transforming the theft of mortal human cells into praiseworthy federal policy.

    abstract::A revolution has occurred in the attitude of biologists toward their intellectual property rights. What today is patentable and highly profitable was, 20 years ago, unpatentable and given away for nothing. The history of this revolution began in the early 1960s when we made the first effort to have self-duplicating ce...

    journal_title:Experimental gerontology

    pub_type: 杂志文章,评审


    authors: Hayflick L

    更新日期:1998-01-01 00:00:00

  • CD69, CD25, and HLA-DR activation antigen expression on CD3+ lymphocytes and relationship to serum TNF-alpha, IFN-gamma, and sIL-2R levels in aging.

    abstract::Aging is associated with changes in lymphocyte subsets and unexplained HLA-DR upregulation on T-lymphocytes. We further investigated this activation, by measuring early (CD69), middle (CD25), and late (HLA-DR) T-lymphocyte activation markers on CD3+ lymphocytes, across subjects (20-100 years) together with serum tumor...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Rea IM,McNerlan SE,Alexander HD

    更新日期:1999-01-01 00:00:00

  • Repeated exposure to the threat of perturbation induces emotional, cognitive, and postural adaptations in young and older adults.

    abstract::Threat-related changes in postural control and their associations with changes in emotional and cognitive states are influenced by postural threat experience, however, limited work has explored individuals' capacity to adapt threat-related responses over longer periods of threat exposure. This study examined the effec...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Johnson KJ,Zaback M,Tokuno CD,Carpenter MG,Adkin AL

    更新日期:2019-07-15 00:00:00

  • Sex hormones and psychological functioning in postmenopausal women.

    abstract::Women who seek medical care around the time of menopause frequently report changes in one or more aspects of psychological functioning. The etiology of these symptoms is likely multifactorial and, undoubtedly, individual and sociocultural factors are important determinants. The known psychotropic properties of the sex...

    journal_title:Experimental gerontology

    pub_type: 杂志文章,评审


    authors: Sherwin BB

    更新日期:1994-05-01 00:00:00

  • Altered mitochondrial quality control signaling in muscle of old gastric cancer patients with cachexia.

    abstract::Mitochondrial dysfunction is involved in the loss of muscle featuring both aging and cancer cachexia (CC). Whether mitochondrial quality control (MQC) is altered in skeletal myocytes of old patients with CC is unclear. The present investigation therefore sought to preliminarily characterize MQC pathways in muscle of o...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Marzetti E,Lorenzi M,Landi F,Picca A,Rosa F,Tanganelli F,Galli M,Doglietto GB,Pacelli F,Cesari M,Bernabei R,Calvani R,Bossola M

    更新日期:2017-01-01 00:00:00

  • Differential stimulation of muscle protein synthesis in elderly humans following isocaloric ingestion of amino acids or whey protein.

    abstract::To counteract the debilitating progression of sarcopenia, a protein supplement should provide an energetically efficient anabolic stimulus. We quantified net muscle protein synthesis in healthy elderly individuals (65-79 yrs) following ingestion of an isocaloric intact whey protein supplement (WY; n=8) or an essential...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Paddon-Jones D,Sheffield-Moore M,Katsanos CS,Zhang XJ,Wolfe RR

    更新日期:2006-02-01 00:00:00

  • The crosstalk between cellular reprogramming and senescence in aging and regeneration.

    abstract::Aging is associated with diminished regenerative capacity and increased risk of chronic diseases. There is now compelling evidence suggests that aging process is reversible. Besides metabolic modification and systematic factors, both senescence elimination and cellular reprogramming showed beneficial effects on tissue...

    journal_title:Experimental gerontology

    pub_type: 杂志文章,评审


    authors: Chiche A,Chen C,Li H

    更新日期:2020-09-01 00:00:00

  • Diabetic neuropathies influence recovery from hip-fracture surgery in older persons with diabetes.

    abstract:BACKGROUND/OBJECTIVES:To explore the impact of diabetic peripheral neuropathy (DPN) on the recovery of older persons with diabetes mellitus (DM) after hip-fracture surgery. DESIGN, SETTING, PARTICIPANTS:Secondary data for this study came from a clinical trial on the effectiveness of a DM-specific care model for 176 ol...

    journal_title:Experimental gerontology

    pub_type: 临床试验,杂志文章


    authors: Tseng MY,Huang YF,Liang J,Wang JS,Yang CT,Wu CC,Cheng HS,Chen CY,Lin YE,Wang WS,Shyu YL

    更新日期:2019-05-01 00:00:00

  • The sites and topology of mitochondrial superoxide production.

    abstract::Mitochondrial superoxide production is an important source of reactive oxygen species in cells, and may cause or contribute to ageing and the diseases of ageing. Seven major sites of superoxide production in mammalian mitochondria are known and widely accepted. In descending order of maximum capacity they are the ubiq...

    journal_title:Experimental gerontology

    pub_type: 杂志文章,评审


    authors: Brand MD

    更新日期:2010-08-01 00:00:00

  • In vitro erythrocidal activity of activated spleen cells from young and old mice.

    abstract::We have recently reported that activated mouse spleen mononuclear cells (MNCs) efficiently lyse autologous erythrocytes in vitro (Saxena and Chandrasekhar, 2000). In the present study, we have investigated erythrocyte-depleting ability (EDA) of spleen MNCs from young and old mice. Time kinetics of survival of erythroc...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Saxena RK,Adler WH

    更新日期:2000-05-01 00:00:00

  • Immoderate inhibition of estrogen by anastrozole enhances the severity of experimental polyarthritis.

    abstract::Aromatase inhibitors have become the standard of care for the adjuvant treatment of postmenopausal, hormone-sensitive breast cancer. Meanwhile, more and more breast cancer patients who are treated with aromatase inhibitors as adjuvant therapies often experience arthralgias and musculoskeletal aching, in some cases, ha...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Wang J,Zhang Q,Jin S,Feng M,Kang X,Zhao S,Liu S,Zhao W

    更新日期:2009-06-01 00:00:00

  • Evidence that V+ fibronectin, GFAP and S100 beta mRNAs are increased in the hippocampus of aged rats.

    abstract::In the present study, using RNA gel-blot analysis, we characterized the developmental changes in the prevalence of mRNA coding for fibronectin (FN), glial fibrillary acidic protein (GFAP), neurotrophic protein S100 beta, and beta-actin mRNA in rat hippocampus and forebrain from 1 to 720 days of age. We found that the ...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Wagner AP,Reck G,Platt D

    更新日期:1993-03-01 00:00:00

  • Lipid hydroperoxide-mediated DNA damage.

    abstract::Lipid hydroperoxides are formed in vivo through free radical pathways from the action of reactive oxygen species on polyunsaturated fatty acids. They are also formed as specific products of lipoxygenases and cyclooxygenases. Homolytic decomposition of lipid hydroperoxides to the alpha,beta-unsaturated aldehyde genotox...

    journal_title:Experimental gerontology

    pub_type: 杂志文章,评审


    authors: Blair IA

    更新日期:2001-09-01 00:00:00

  • Non-shivering thermogenesis activation and maintenance in the aging gray mouse lemur (Microcebus murinus).

    abstract::The cold-induced enhancement of non-shivering thermogenesis (NST), involving brown-adipose tissue (BAT) metabolism, could participate to impair energy balance in the aged gray mouse lemur (Microcebus murinus). We first investigated the age-related modulations of cold-stimulated BAT cell morphology and contents. Then, ...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Terrien J,Ambid L,Nibbelink M,Saint-Charles A,Aujard F

    更新日期:2010-06-01 00:00:00

  • The two-process model of cellular aging.

    abstract::To understand the mechanism of aging at the cellular level, cellular senescence has been extensively studied as an experimental model of aging in vitro. Although several hypotheses have been proposed for the mechanism of cellular senescence, none of them could give a comprehensive framework to the mechanism. In this s...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Kitano H,Imai S

    更新日期:1998-08-01 00:00:00

  • Age-related neuromuscular fatigue and recovery after cycling: Measurements in isometric and dynamic modes.

    abstract::Studies have suggested that older individuals are more fatigable than young adults when power loss, measured during single-joint contractions, is considered the fatigue index; however, age-related differences in fatigue considering power measurements during multi-joint movements (e.g., cycling) have not been fully elu...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Krüger RL,Aboodarda SJ,Jaimes LM,Vaz MA,Samozino P,Millet GY

    更新日期:2020-05-01 00:00:00

  • Moderate 'multivitamin' supplementation improved folate and vitamin B12 status in the elderly.

    abstract::The dependent elderly are widely considered to be at higher risk of nutritional problems. Suboptimal micronutrient intake might put the elderly, especially those living in nursing homes, at high risk of morbidity. So far, no public authority, except for the Israel Ministry of Health, has issued particular recommendati...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Tal S,Stern F,Polyak Z,Ichelzon I,Dror Y

    更新日期:2016-11-01 00:00:00

  • Vector bioimpedance detects situations of malnutrition not identified by the indicators commonly used in geriatric nutritional assessment: A pilot study.

    abstract:OBJECTIVE:To compare body composition as assessed by conventional and vector bioelectrical impedance analysis according to the nutritional cataloging using body mass index (BMI) in a group of institutionalized elderly. METHODS:Cross-sectional study in 38 institutionalized elderly. Body composition was estimated by bio...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Redondo-Del-Río MP,Camina-Martín MA,Moya-Gago L,de-la-Cruz-Marcos S,Malafarina V,de-Mateo-Silleras B

    更新日期:2016-12-01 00:00:00

  • Can 24 weeks strength training reduce feelings of depression and increase neurotransmitter in elderly females?

    abstract:BACKGROUND:Geriatric depression is common due to the high rate of chronic diseases suffered by the older population. There is a well-established effect of exercise on one's wellbeing, however, for the elderly females there is dearth in research addressing exercise and its effect on their neurotransmitters and depressio...

    journal_title:Experimental gerontology

    pub_type: 杂志文章,随机对照试验


    authors: Kim YS,O'Sullivan DM,Shin SK

    更新日期:2019-01-01 00:00:00

  • Muscle fatigability measured with Pneumatic and Hydraulic handgrip systems are not interchangeable.

    abstract:BACKGROUND:Fatigue resistance (FR) was here defined as the time during which grip strength (GS) drops to 50% of its maximum during sustained contraction. Since different GS systems exist, we compared FR obtained with Pneumatic (Pneu) and Hydraulic (Hydr) handgrip systems. Hand pain induced by both systems was also inve...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: De Dobbeleer L,Beckwée D,Arnold P,Baudry S,Beyer I,Demarteau J,Lieten S,Punie Y,Bautmans I

    更新日期:2020-07-15 00:00:00

  • Aging-related changes in human T-cell repertoire over 20years delineated by deep sequencing of peripheral T-cell receptors.

    abstract::Recent deep sequencing studies on T-cell receptor (TCR) repertoire have provided robust data to characterize diversity of T-cell immune responsiveness to a wide variety of peptide antigens, including viral and tumor antigens. The human TCR repertoire declines with age, but this decline has not been fully investigated ...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Yoshida K,Cologne JB,Cordova K,Misumi M,Yamaoka M,Kyoizumi S,Hayashi T,Robins H,Kusunoki Y

    更新日期:2017-10-01 00:00:00

  • Intermittent bout exercise training down-regulates age-associated inflammation in skeletal muscles.

    abstract::Aging is characterized by the progressive decline in mass and function of the skeletal muscle along with increased susceptibility to inflammation, oxidative stress, and atrophy. In this study, we investigate the effect of intermittent bout and single bout exercise training on inflammatory molecules in young (3 months)...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Kim JS,Yi HK

    更新日期:2015-12-01 00:00:00

  • Apoptosis detection: an overview.

    abstract::As the analysis of apoptosis is of interest in many basic and clinically oriented investigations, we intend to give a brief overview on the recently most-used methods for detection of apoptotic cells, including the study of morphology, analysis of DNA degradation, DNA end-labeling techniques, flow cytometric analysis,...

    journal_title:Experimental gerontology

    pub_type: 杂志文章,评审


    authors: Sgonc R,Gruber J

    更新日期:1998-09-01 00:00:00

  • Norepinephrine treatment and aging lead to systemic and intracellular oxidative stress in rats.

    abstract::Reactive oxygen species (ROS) play important roles in cellular senescence and organismic aging. Furthermore, they have been implicated in some of the adverse effects of chronic stress due to elevated peripheral levels of catecholamines. Here, we applied three different techniques to individually compare the systemic a...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Schraml E,Quan P,Stelzer I,Fuchs R,Skalicky M,Viidik A,Schauenstein K

    更新日期:2007-11-01 00:00:00

  • The exceptional longevity of an egg-laying mammal, the short-beaked echidna (Tachyglossus aculeatus) is associated with peroxidation-resistant membrane composition.

    abstract::The echidna Tachyglossus aculeatus is a monotreme mammal from Australia that is exceptionally long-living. Its documented maximum lifespan of 50 years is 3.7 times that predicted from its body mass. Other exceptionally long-living mammals (naked mole-rats and humans) are known to have peroxidation-resistant membrane c...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Hulbert AJ,Beard LA,Grigg GC

    更新日期:2008-08-01 00:00:00

  • Age-related changes in melatonin levels in humans and its potential consequences for sleep disorders.

    abstract::Prior to three months of age there is little melatonin (MLT) secretion in humans. MLT production then commences, becomes circadian, and reaches its highest nocturnal blood levels between the ages of one to three years. During the remainder of childhood, nocturnal peak levels drop progressively by 80%. In adults, these...

    journal_title:Experimental gerontology

    pub_type: 杂志文章,评审


    authors: Waldhauser F,Kovács J,Reiter E

    更新日期:1998-11-01 00:00:00

  • Nicotinamide riboside-A missing piece in the puzzle of exercise therapy for older adults?

    abstract::Maintaining physical mobility is important for preventing age-related comorbidities in older adults. Endurance and resistance training prevent mobility loss in aging, but exercise alone does not always achieve the expected improvements in physical and cardiopulmonary function. Recent preclinical evidence suggests that...

    journal_title:Experimental gerontology

    pub_type: 杂志文章,评审


    authors: Custodero C,Saini SK,Shin MJ,Jeon YK,Christou DD,McDermott MM,Leeuwenburgh C,Anton SD,Mankowski RT

    更新日期:2020-08-01 00:00:00