Oxytocin effects on osteoblastic differentiation of Bone Marrow Mesenchymal Stem Cells from adult and aging female Wistar rats.


:Recently, it has been suggested that oxytocin (OT) might play a role in the control of bone remodeling and in bone health of young and adult females. The purpose of this study was to evaluate the effect of osteogenic medium (OM) plus OT (OM + OT; 100 nmol/L) on osteoblastic differentiation of bone marrow mesenchymal stem cells (BMMSCs) from cyclic adult (12 months old) and acyclic aging (24 months old) female Wistar rats. After 14 days, OM + OT increased the oxytocin and oxytocin receptor in the BMMSCs from animals of both age groups relative to OM controls. Alkaline phosphatase activity was higher in the OM + OT than OM group in BMMSCs from 24-month-old female rats. OM + OT improved osteogenic differentiation, observed by anticipated mineralization and increased gene expression of bone morphogenetic protein 2, bone sialoprotein, osteopontin and osteocalcin in both aged relative to OM controls. These findings suggest a role for OT as an adjuvant to induce osteoblastic differentiation of BMMSCs from aged female rat.


Exp Gerontol


Experimental gerontology


Santos LF,Singulani MP,Stringhetta-Garcia CT,Oliveira SHP,Chaves-Neto AH,Dornelles RCM




Has Abstract


2018-11-01 00:00:00












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    journal_title:Experimental gerontology

    pub_type: 杂志文章,评审


    authors: Marzban L,Park K,Verchere CB

    更新日期:2003-04-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:2015-12-01 00:00:00

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    pub_type: 杂志文章,评审


    authors: Galioto A,Dominguez LJ,Pineo A,Ferlisi A,Putignano E,Belvedere M,Costanza G,Barbagallo M

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    pub_type: 杂志文章,随机对照试验


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    更新日期:2016-06-15 00:00:00

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    pub_type: 杂志文章


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    journal_title:Experimental gerontology

    pub_type: 杂志文章,评审


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    更新日期:2018-07-01 00:00:00

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    pub_type: 杂志文章


    authors: Meisel DL,Skobe Z,Prostak KS,Shklar G

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    authors: Vo TK,Godard P,de Saint-Hubert M,Morrhaye G,Bauwens E,Debacq-Chainiaux F,Glupczynski Y,Swine C,Geenen V,Martens HJ,Toussaint O

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    pub_type: 杂志文章,随机对照试验


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    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Danon D,Bologna NB,Gavendo S

    更新日期:1992-01-01 00:00:00

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    authors: Solovev I,Dobrovolskaya E,Shaposhnikov M,Sheptyakov M,Moskalev A

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    pub_type: 杂志文章


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    更新日期:2017-02-01 00:00:00

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    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Tateishi T,Yoshimine N,Kuzuya F

    更新日期:1987-01-01 00:00:00

  • Effects of estrogen replacement therapy on the circadian rhythms of serum cortisol and body temperature in postmenopausal women.

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    journal_title:Experimental gerontology

    pub_type: 临床试验,杂志文章


    authors: Gudmundsson A,Goodman B,Lent S,Barczi S,Grace A,Boyle L,Ershler WB,Carnes M

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  • Drosophila simulans as a novel model for studying mitochondrial metabolism and aging.

    abstract::Mitochondria generate much of the cellular energy through the process of oxidative phosphorylation (OXPHOS). OXPHOS function may be affected by a mutation in any of the mitochondrial (mt) DNA encoded genes and/or nuclear encoded genes that produce proteins imported into the mitochondrion that form (or assemble) the fi...

    journal_title:Experimental gerontology

    pub_type: 杂志文章,评审


    authors: Ballard JW

    更新日期:2005-10-01 00:00:00

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    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Jolitha AB,Subramanyam MV,Asha Devi S

    更新日期:2006-08-01 00:00:00

  • Age and cell density dependent changes of gangliosides in human diploid fibroblasts.

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    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Ohsawa T

    更新日期:1989-01-01 00:00:00

  • High carbohydrate-low protein consumption maximizes Drosophila lifespan.

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    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Bruce KD,Hoxha S,Carvalho GB,Yamada R,Wang HD,Karayan P,He S,Brummel T,Kapahi P,Ja WW

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  • Cell aging and cellular senescence in skin aging - Recent advances in fibroblast and keratinocyte biology.

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    pub_type: 杂志文章


    authors: Gruber F,Kremslehner C,Eckhart L,Tschachler E

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  • Effects of resistance training on classic and specific bioelectrical impedance vector analysis in elderly women.

    abstract::Raw bioelectrical impedance analysis (BIA) data [resistance (R); reactance (Xc)] through bioelectrical impedance vector analysis (BIVA) and phase angle (PhA) have been used to evaluate cellular function and hydration status. The purpose of this investigation was to examine the effects of resistance training (RT) on cl...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Fukuda DH,Stout JR,Moon JR,Smith-Ryan AE,Kendall KL,Hoffman JR

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    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Rahima A,Bruce NW

    更新日期:1987-01-01 00:00:00

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    journal_title:Experimental gerontology

    pub_type: 杂志文章,评审


    authors: Custodero C,Saini SK,Shin MJ,Jeon YK,Christou DD,McDermott MM,Leeuwenburgh C,Anton SD,Mankowski RT

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    journal_title:Experimental gerontology

    pub_type: 杂志文章,评审


    authors: Le Page A,Dupuis G,Frost EH,Larbi A,Pawelec G,Witkowski JM,Fulop T

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    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Cha HN,Kim YW,Kim JY,Kim YD,Song IH,Min KN,Park SY

    更新日期:2010-09-01 00:00:00

  • Immunological markers contributing to successful aging in Bulgarians.

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    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Naumova E,Mihaylova A,Ivanova M,Michailova S,Penkova K,Baltadjieva D

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    journal_title:Experimental gerontology

    pub_type: 杂志文章,多中心研究


    authors: Cohen AA,Milot E,Li Q,Legault V,Fried LP,Ferrucci L

    更新日期:2014-09-01 00:00:00

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    journal_title:Experimental gerontology

    pub_type: 杂志文章


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    更新日期:2020-07-01 00:00:00