Abstract:
:Alpha-synuclein (α-Syn) accumulation is significantly correlated with motor deficits and mitochondrial dysfunction in Parkinson's disease (PD), but the molecular mechanism underlying its pathogenesis is unclear. In this study, we investigated the effects of treadmill exercise on motor deficits and mitochondrial dysfunction in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD. Treadmill exercise inhibited dopaminergic neuron loss by promoting the expression of tyrosine hydroxylase (TH) and dopamine transporter (DAT) and seemed to improve cell survival by reducing α-Syn expression. Most importantly, treadmill exercise increased expression of the mitochondrial import machinery proteins TOM-40, TOM-20, and TIM-23. This was associated with decreased α-Syn expression and subsequent upregulation of the mitochondrial proteins COX-I, COX-IV, and mtHSP70. Taken together, these results indicate that treadmill exercise may ameliorate motor deficits and improve mitochondrial dysfunction by reducing α-Syn expression in the MPTP-induced mouse model of PD.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Koo JH,Cho JY,Lee UBdoi
10.1016/j.exger.2017.01.001subject
Has Abstractpub_date
2017-03-01 00:00:00pages
20-29eissn
0531-5565issn
1873-6815pii
S0531-5565(16)30369-2journal_volume
89pub_type
杂志文章abstract::The achievement that cytokines and all the related "transducing machinery" are expressed within the central nervous system and play a consistent role in the modulation of neurological functions and dysfunctions, has allowed a novel interpretation of brain behaviour. In this view, neuroinflammation and cytokines produc...
journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2010.09.008
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abstract::The age-dependent modifications of both basal and lymphokine-induced natural killer (NK) activity were analyzed in Balb/c inbred mice by measuring either the percentage of specific lytic activity in a 51 Cr release assay or the percentage of cells capable of binding the YAC-1 target cells. The basal lytic activity of ...
journal_title:Experimental gerontology
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journal_title:Experimental gerontology
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pub_type: 临床试验,杂志文章
doi:10.1016/j.exger.2019.02.004
更新日期:2019-05-01 00:00:00
abstract::Proteomic analysis is defined as the characterization of the entire set of proteins encoded by a genome. Two-dimensional (2D) electrophoresis and matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) are key technologies used in proteomic analysis to gain information about protein...
journal_title:Experimental gerontology
pub_type: 杂志文章
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更新日期:2004-08-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2008.11.005
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2013.07.015
更新日期:2013-11-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2005.10.010
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2008.10.007
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journal_title:Experimental gerontology
pub_type: 杂志文章
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2017.03.002
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journal_title:Experimental gerontology
pub_type: 杂志文章
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2009.08.009
更新日期:2009-11-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,多中心研究
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(94)00041-z
更新日期:1995-05-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2006.04.006
更新日期:2006-08-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/s0531-5565(02)00118-3
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journal_title:Experimental gerontology
pub_type: 杂志文章
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
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journal_title:Experimental gerontology
pub_type: 杂志文章
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journal_title:Experimental gerontology
pub_type: 杂志文章,随机对照试验
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更新日期:2018-06-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
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journal_title:Experimental gerontology
pub_type: 杂志文章,随机对照试验
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更新日期:2015-10-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(89)90030-2
更新日期:1989-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2014.11.013
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pub_type: 杂志文章,评审
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