Abstract：
:Accumulation of CD28(-)CD8 T cells that are defective in response to antigenic stimulation is a hallmark of age-associated decline in T cell function. However, the underlying mechanism of this age-associated change is not fully understood. We recently analyzed the global gene expression profiles of CD8 T cell subsets from nai ve to memory (CD28(+) to CD28(-)) cells and the growth of CD28(+) and CD28(-)CD8 memory T cells in response to homeostatic cytokine interleukin 15 (IL-15). At the gene expression level, one of the most striking changes is the altered expression of some co-stimulatory receptors and various NK cell receptors in CD28(-)CD8 T cells. Furthermore, CD28(-)CD8 T cells appear to have a normal proliferation response to IL-15 in vitro. Interestingly, IL-15 is also capable of inducing stable loss of CD28 expression in actively dividing CD28(+)CD8 memory T cells. Together, these findings provide the gene expression features of CD28(-)CD8 T cells that differ from their CD28(+) counterparts and suggest a possible role of IL-15 in the increase of CD28(-)CD8 T cells that occurs with aging.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Godlove J,Chiu WK,Weng NPdoi
10.1016/j.exger.2006.11.015subject
Has Abstractpub_date
2007-05-01 00:00:00pages
412-5issue
5eissn
0531-5565issn
1873-6815pii
S0531-5565(06)00410-4journal_volume
42pub_type
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pub_type： 杂志文章,评审
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2005.02.005
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(00)00210-2
更新日期：2001-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.06.008
更新日期：2013-09-01 00:00:00
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journal_title：Experimental gerontology
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doi：10.1016/j.exger.2016.05.015
更新日期：2016-09-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2005.06.006
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2006.10.012
更新日期：2007-05-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2016.04.015
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journal_title：Experimental gerontology
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pub_type： 杂志文章
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.08.003
更新日期：2013-11-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：1996-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
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更新日期：1982-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2003.09.010
更新日期：2003-11-01 00:00:00
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更新日期：2020-03-01 00:00:00
