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SV40-mediated immortalization of human fibroblasts.

Abstract：

:We have identified a multistep mechanism by which the DNA virus SV40 overcomes cellular senescence. Expression of SV40 T antigen is required for both transient extension of life span and unlimited life span or immortalization. These effects are mediated through inactivation of function of growth suppressors pRB and p53 via complex formation with T antigen. However, immortalization additionally requires inactivation of a novel growth suppressor gene, which has recently been identified to be on the distal portion of the long arm of chromosome 6, designated SEN6. We propose that SEN6 is responsible for cellular senescence in fibroblasts and other cells.

journal_name

Exp Gerontol

journal_title

Experimental gerontology

authors

Ozer HL,Banga SS,Dasgupta T,Houghton J,Hubbard K,Jha KK,Kim SH,Lenahan M,Pang Z,Pardinas JR,Patsalis PC

doi

10.1016/0531-5565(95)00024-0

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

303-10

issue

1-2

eissn

0531-5565

issn

1873-6815

pii

0531-5565(95)00024-0

journal_volume

31

pub_type

杂志文章,评审

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