Abstract：
:The field of toxicology adopted the threshold dose response in the early decades of the 20th century. The model was rapidly incorporated into governmental regulatory assessment procedures and became a central feature of chemical evaluation and assessment. The toxicological community never validated the capacity of this model to make accurate predictions throughout the remainder of the 20th century. A series of recent investigations have demonstrated that the threshold and linear dose response model failed to make accurate predictions in the low dose zone. Such findings demonstrate a profound failure by the toxicology community on the central pillar of its discipline and one with profound public health, medical and economic implications. Ironically, the hormetic dose response, which was rejected by the toxicology community during the early decades of the 20th century, accurately predicted responses in the low dose zone in the same three large-scale validation assessments. Within the past two decades hormetic dose responses have been frequently reported in the experimental biogerontology literature, associated with endpoints associated enhancing healthy aging and longevity. The low dose stimulatory response of the hormetic dose response model represents the quantification of enhanced biological performance in the experimental facilitation of aging quality via multiple endpoints and mechanisms and in the extension of lifespan in such animal models research.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Calabrese EJdoi
10.1016/j.exger.2012.02.004subject
Has Abstractpub_date
2013-01-01 00:00:00pages
99-102issue
1eissn
0531-5565issn
1873-6815pii
S0531-5565(12)00035-6journal_volume
48pub_type
历史文章,杂志文章abstract：:In the present paper, we investigated whether the phenotype, the antigen-presenting capacity, and the migration of antigen-presenting cells (APCs), are affected by the aging process. APCs were obtained incubating peritoneal monocyte-macrophage cells with granulocyte-macrophage colony-stimulating factor (GM-CSF) (immat...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(02)00087-6
更新日期：2002-08-01 00:00:00
abstract：:This article gives some information on the French research on aging using a survey of the European Commission on research on aging in Europe and the answers to a questionnaire sent to the laboratories involved in aging research. France is involved in the European effort, but to a lesser degree than could be expected f...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(00)00164-9
更新日期：2000-10-01 00:00:00
abstract：:Rapamycin consistently increases longevity in mice although the mechanism of action of this drug is unknown. In the present investigation we studied the effect of rapamycin on mitochondrial oxidative stress at the same dose that is known to increase longevity in mice (14mgofrapamycin/kg of diet). Middle aged mice (16m...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2016.08.002
更新日期：2016-10-01 00:00:00
abstract：:Measuring physiological dysregulation during aging could be a key tool both to understand underlying aging mechanisms and to predict clinical outcomes in patients. However, most existing indices are either circular or hard to interpret biologically. Recently, we showed that statistical distance of 14 common blood biom...
journal_title：Experimental gerontology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.exger.2014.04.016
更新日期：2014-09-01 00:00:00
abstract：:Age-related changes of immune functions have been extensively investigated in both humans and animal models; nevertheless, the literature on potential alterations of dendritic cells, potent antigen presenting cells responsible for initiating immune responses, with aging is very scarce. We studied the immuno-phenotype ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(99)00089-3
更新日期：2000-03-01 00:00:00
abstract：AIM:Sirtuins are proteins that connect energy metabolism, oxidative stress and aging. Expression of heat shock proteins (Hsps) is regulated by heat shock factors (HSFs) in response to various environmental and physiological stresses, such as oxidative stress. Oxidative stress accumulates during aging which makes cells ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2016.03.015
更新日期：2016-06-15 00:00:00
abstract：:To study the several elements and causes of ageing, diverse model organisms and methodologies are required. The most frequently used models are Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster and rodents. All have their advantages and disadvantages and allow studying particular aspects of the...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2008.11.007
更新日期：2009-04-01 00:00:00
abstract：OBJECTIVE:Depression is common in hemodialysis patients. Reduced DHEA-S levels have been shown to be associated with depression in general population. Abnormalities in hormone production and metabolism are found in hemodialysis patients. However, the association between DHEA-S levels and depression in hemodialysis pati...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2009.08.009
更新日期：2009-11-01 00:00:00
abstract：:Skeletal muscle atrophy reduces quality of life and increases morbidity and mortality in patients with chronic conditions. Oxidative stress is a key factor contributing to skeletal muscle atrophy by altering both protein synthesis and protein degradation pathways. Beta-lapachone (Beta-L) is known to act as a pro-oxida...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2019.110711
更新日期：2019-10-15 00:00:00
abstract：:Age-related changes in cancer mortality risk are important for understanding the processes of disease and aging interaction. The extent to which these age changes differ by sex further contributes to this understanding but has not been well studied to date. We conducted a systematic examination of dynamics and heterog...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2012.06.009
更新日期：2012-09-01 00:00:00
abstract：:Aromatase inhibitors have become the standard of care for the adjuvant treatment of postmenopausal, hormone-sensitive breast cancer. Meanwhile, more and more breast cancer patients who are treated with aromatase inhibitors as adjuvant therapies often experience arthralgias and musculoskeletal aching, in some cases, ha...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2009.03.003
更新日期：2009-06-01 00:00:00
abstract：:During aging declining maximum force capacity with more or less unchanged fatigability is observed with the underlying mechanisms still not fully understood. Therefore, we compared morphology and function of skeletal muscles between different age groups. Changes in high-energy phosphate turnover (PCr, Pi and pH) and m...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2015.02.016
更新日期：2015-05-01 00:00:00
abstract：:Reflective of age-associated decline in immune function among elderly individuals is a decrease in in vitro T cell proliferative ability. Impaired T cell proliferation in the elderly may result from disruption of the well-balanced network of regulatory cytokines produced during an immune response. The purpose of this ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(98)00064-3
更新日期：1999-04-01 00:00:00
abstract：:Stiffening of large elastic arteries with age increases the risk of cardiovascular diseases (CVD), but the underlying mechanisms are incompletely understood. We investigated the role of mitochondrial quality control (QC, i.e., mitophagy and biogenesis) in arterial stiffening with aging. In C57BL6 mice, aging was assoc...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2014.07.008
更新日期：2014-10-01 00:00:00
abstract：:Indigenous DNA adducts (I-compounds) are considered to be a biomarker of aging tissues. Thus far, few studies have been conducted to investigate the accumulation patterns of I-compounds in the brain during aging. Particularly, identities of age-dependent I-compounds have largely remained unknown. In the current study,...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(95)02027-6
更新日期：1996-05-01 00:00:00
abstract：:The purpose of this study was to examine the combined cardiorespiratory and cerebrovascular responses to head-up tilt (HUT) in young and older trained and untrained humans following moderate-duration exercise. Middle cerebral artery blood flow velocity (MCAv; transcranial Doppler ultrasound), blood pressure (BP; Finom...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2010.06.004
更新日期：2011-01-01 00:00:00
abstract：:A decline in instrumental activities of daily living has been described as the earliest functional deficit in patients with neurodegenerative disease. It embraces specific competencies such as: "recalling the date and telephone calls, orienting to new places, remembering the location of objects at home, understanding ...
journal_title：Experimental gerontology
pub_type： 评论,杂志文章
doi：10.1016/j.exger.2016.08.008
更新日期：2016-10-01 00:00:00
abstract：:This study investigated the effects of two training programmes of 6 weeks combining strength and balance exercises in different proportions. One training programme [n=10; 71.4 (6.3) years] consisted mainly of strength exercises (ST) and the other programme [n=8; 71.4 (6.4) years] included a majority of balance exercis...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2014.11.013
更新日期：2015-01-01 00:00:00
abstract：:Dietary restriction extends lifespan in a variety of organisms, but the key nutritional components driving this process and how they interact remain uncertain. In Drosophila, while a substantial body of research suggests that protein is the major dietary component affecting longevity, recent studies claim that carbohy...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.02.003
更新日期：2013-10-01 00:00:00
abstract：:Even though Alzheimer's disease (AD) is the most common cause of dementia, the mechanisms governing the establishment and progression of the disease remain largely unknown. Here, we investigated the implication of the neuroprotective protein BMI1 (B lymphoma Mo-MLV insertion region 1 homolog) in AD and the possibility...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2020.111178
更新日期：2021-02-01 00:00:00
abstract：:A growing body of evidence indicates that dysregulation of cerebral biometals (Fe, Cu, Zn) and their interactions with APP and Abeta amyloid may contribute to the Alzheimer's amyloid pathology, and thus metal chelation could be a rational therapeutic approach for interdicting AD pathogenesis. However, poor target spec...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2004.08.016
更新日期：2004-11-01 00:00:00
abstract：:It is now widely recognized that in order to optimize bone health in the later years, bone healthy behaviors should begin at a young age and continue throughout life. Prescribed orally to lower lipid levels in adults of all ages, statins have also been shown to stimulate bone formation in vitro by promoting bone morph...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.04.007
更新日期：2013-08-01 00:00:00
abstract：:Mitochondria isolated from the livers of old rats (26-30 months) were found to incorporate 41% less leucine into mitochondrial proteins as compared to those from young rats (2-3 months). The initial rates of incorporation of label were 145 cpm/mg/min for the "old" animals, and 320 cpm/mg/min for the young animal. No d...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(82)80004-1
更新日期：1982-01-01 00:00:00
abstract：INTRODUCTION:Right ventricular dysfunction (RVD), submassive pulmonary embolism (PE), elevated systolic pulmonary artery pressure (sPAP), elevated cardiac troponin I (cTnI) and old age are well-known risk factors for poor outcome in acute normotensive PE. The aim of this analysis was to calculate age cut-off values to ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2015.05.007
更新日期：2015-09-01 00:00:00
abstract：:We investigated the effects of angiotensin-converting enzyme (ACE) inhibition and aerobic physical training on the heart of old female rats (82-wk-old) submitted to premature ovarian failure (10-wk.-old). We used different approaches: morphology and function by echocardiography, reactivity of the coronary bed and left...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2017.04.003
更新日期：2018-08-01 00:00:00
abstract：:The balance between the activities of matrix metalloproteinases (MMPs) and the tissue inhibitors of metalloproteinases (TIMPs) is an important control point in tissue remodeling. Previous studies have demonstrated elevated expression of the MMPs collagenase and stromelysin-1 by aged human diploid fibroblasts compared ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(95)02010-1
更新日期：1996-01-01 00:00:00
abstract：:Aging is associated with a change in membrane composition that includes a decrease in membrane polyunsaturated fatty acids, including arachidonic acid, and an increase in membrane cholesterol. Alterations in membrane structure are likely to impact on transmitter release, which relies on the fusion of synaptic plasma a...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(97)00130-7
更新日期：1998-06-01 00:00:00
abstract：:Aging adipose tissues (ATs) manifest reduced vascularity and increased hypoxia and inflammation that contribute to local and systemic metabolic dysfunction. However, the mechanisms that underlie these age-related changes are incompletely understood. In this study, we sought to examine insulin-stimulated vasodilation a...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2020.111126
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:Resistance exercise training (RET) has proven effective at reducing the risk of chronic disease in older populations, and it appears to regulate redox homeostasis. AIMS:To determine the effects of RET on redox homeostasis in older people. STUDY DESIGN:A systematic review and meta-analysis of randomized cli...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2020.111012
更新日期：2020-09-01 00:00:00
abstract：:The interrelationship between muscle strength, motor unit (MU) number, and age is poorly understood, and in this study we sought to determine whether age-related differences in muscle strength are moderated by estimates of functioning MU number and size. Eighteen older adults (OA; 67 ± 1.20 years) and 24 young adults ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.06.008
更新日期：2013-09-01 00:00:00
