Abstract：
:To study the several elements and causes of ageing, diverse model organisms and methodologies are required. The most frequently used models are Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster and rodents. All have their advantages and disadvantages and allow studying particular aspects of the ageing process. During the last few years, several ageing studies focussed on stem cells and their role in tissue homeostasis. Here we present a new model organism which can study this relation where other model systems fail. The flatworm Macrostomum lignano possesses a dynamic population of likely totipotent somatic stem cells known as neoblasts. Several characteristics qualify M. lignano as a suitable model system for ageing studies in general and more specifically for gaining more insight in the causal relation between stem cells, ageing and rejuvenation. In this review, we will briefly describe the species and its life history, and discuss the role of its stem cells in ageing and rejuvenation. We also give an overview of the available experimental tools that allow a multidisciplinary approach for studying ageing in M. lignano.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Mouton S,Willems M,Braeckman BP,Egger B,Ladurner P,Schärer L,Borgonie Gdoi
10.1016/j.exger.2008.11.007subject
Has Abstractpub_date
2009-04-01 00:00:00pages
243-9issue
4eissn
0531-5565issn
1873-6815pii
S0531-5565(08)00404-Xjournal_volume
44pub_type
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journal_title：Experimental gerontology
pub_type： 杂志文章
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journal_title：Experimental gerontology
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doi：10.1016/j.exger.2005.12.004
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journal_title：Experimental gerontology
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pub_type： 杂志文章,评审
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2020.111098
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2010.01.009
更新日期：2010-03-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.02.003
更新日期：2013-10-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0531-5565(00)00169-8
更新日期：2000-09-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2020.111005
更新日期：2020-09-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2008.02.005
更新日期：2008-06-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2009.06.008
更新日期：2009-09-01 00:00:00
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journal_title：Experimental gerontology
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更新日期：2018-07-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Experimental gerontology
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更新日期：2005-03-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
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更新日期：2007-03-01 00:00:00
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journal_title：Experimental gerontology
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journal_title：Experimental gerontology
pub_type： 杂志文章,多中心研究
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更新日期：2015-10-01 00:00:00
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更新日期：2019-07-01 00:00:00
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更新日期：2020-04-01 00:00:00
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更新日期：1998-09-01 00:00:00
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