Abstract：
:Male life history and resource allocation is not frequently studied in aging and life span research. Here, we verify that males of long-lived fruit-feeding butterfly species have reduced longevity on restricted diets [Beck, J., 2007. The importance of amino acids in the adult diet of male tropical rainforest butterflies. Oecologia 151, 741-747], in contrast to the common finding of longevity extension in dietary restriction experiments in Drosophila and some other organisms. Males of some of the most long-lived species of fruit-feeding butterflies were collected from Kibale Forest, Uganda, and kept on diets of either sugar or mashed banana. Seven out of eight species had non-significantly longer life spans on mashed banana diets. Data analysis using a time-varying Cox-model with species as covariate showed that males had reduced survival on the sugar diet during the first 35 days of captive life, but the effect was absent or reversed at more advanced ages. These results challenge the generality of dietary restriction as a way to extend life span in animals. We argue that such studies on males are promising tools for better understanding life history evolution and aging because males display a wider variety of tactics for obtaining reproductive success than females.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Molleman F,Ding J,Boggs CL,Carey JR,Arlet MEdoi
10.1016/j.exger.2009.06.008subject
Has Abstractpub_date
2009-09-01 00:00:00pages
601-6issue
9eissn
0531-5565issn
1873-6815pii
S0531-5565(09)00121-1journal_volume
44pub_type
杂志文章abstract：:The achievement that cytokines and all the related "transducing machinery" are expressed within the central nervous system and play a consistent role in the modulation of neurological functions and dysfunctions, has allowed a novel interpretation of brain behaviour. In this view, neuroinflammation and cytokines produc...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2010.09.008
更新日期：2011-02-01 00:00:00
abstract：:Type 2 diabetes is associated with progressive beta-cell failure manifest as a decline in insulin secretion and increasing hyperglycemia. A growing body of evidence suggests that beta-cell failure in type 2 diabetes correlates with the formation of pancreatic islet amyloid deposits, indicating that islet amyloid may h...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(03)00004-4
更新日期：2003-04-01 00:00:00
abstract：:In this study, spontaneous multiple unit activity (MUA, action potentials derived simultaneously from a number of neurons in a given brain region) was recorded through electrodes chronically implanted in the parietal cerebral cortex of the rats of 1, 3, 6, 9, 12, and 26 months of age (cross-sectional study). Electroph...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(88)90003-4
更新日期：1988-01-01 00:00:00
abstract：:In many eukaryotes oxidative phosphorylation via the mitochondrial electron transport chain provides the major means of ATP production. Complete removal of this capacity often results in premature death. Recent studies using the nematode Caenorhabditis elegans are surprising because they have revealed that disruption ...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2005.06.015
更新日期：2005-11-01 00:00:00
abstract：:Perimenopause is a period in a woman's life that precedes menopause and is characterized by hormonal changes that result in increased oxidative stress. Since oxidative stress is associated with age-related diseases and perimenopausal symptoms including somato-vegetative manifestations, nutritional antioxidant suppleme...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2017.01.011
更新日期：2017-04-01 00:00:00
abstract：:Cytogenetic analysis of the X chromosome in phytohaemagglutinin stimulated peripheral blood lymphocytes was evaluated in 12 sporadic Alzheimer disease (AD) patients and in 11 healthy subjects. For chromosome analysis two methods were used: (1) standard analysis of G-banded metaphase chromosomes and; (2) fluorescent in...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2004.01.012
更新日期：2004-05-01 00:00:00
abstract：:Serum lipid peroxide (LPO) in 72 healthy male subjects was studied using a newly developed assay method based on the reaction of LPO with methylene blue derivative (MCDP; 10-N-Methylcarbamoyl-3,7-dimethylamino-10 H-phenothiazine). This method is specific for lipid hydroperoxide and the relation is equimolar. The value...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(87)90045-3
更新日期：1987-01-01 00:00:00
abstract：:The goal of these experiments was to determine if the increased longevity characteristics of our genetically selected long lived line of Drosophila could be attributed to metabolic differences. The data shows an inverse relationship between life span and temperature for both the long lived (L) and normal (R) strains; ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(88)90020-4
更新日期：1988-01-01 00:00:00
abstract：:We have isolated a senescence-specific clone (pSEN) from a cDNA library constructed from late passage WI-38 human diploid fibroblast that accounts for approximately 1% of the recombinants. Nucleotide sequence analysis of the partial cDNA clone has led to the identification of pSEN as elongation factor I alpha. Norther...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(89)90056-9
更新日期：1989-01-01 00:00:00
abstract：:Coronary heart disease is less prevalent in pre-menopausal women than in men, but increases at the onset of menopause. This delay is due to estrogen protective effects. The rise of cholesterolemia is one of the main risk factors for coronary disease. Since 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) is the ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2009.10.014
更新日期：2010-02-01 00:00:00
abstract：:For more than 60 years the only dietary manipulation known to retard aging was caloric restriction, in which a variety of species respond to a reduction in energy intake by demonstrating extended median and maximum life span. More recently, two alternative dietary manipulations have been reported to also extend surviv...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(02)00149-3
更新日期：2003-01-01 00:00:00
abstract：:A micromethod was used to study myelin from individual rat optic nerves as a function of age. Protein and galactolipid content as well as 2',3'-cyclic nucleotide phosphohydrolase (CNPase) activity at ages 2, 4, 22, and 28 months were determined. Protein content increased significantly at 22 months and decreased at adv...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(89)90013-2
更新日期：1989-01-01 00:00:00
abstract：:Given the increased concerns about the degenerative decline in the physical performance of the elderly, there is a need for developing effective strategies to suppress the age-related loss of skeletal muscle mass and functional capacity through a lifestyle intervention. This randomized controlled trial examined whethe...
journal_title：Experimental gerontology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.exger.2016.11.003
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Physical activity and sedentary behavior are modifiable risk factors for non-communicable disease and healthy ageing, however the majority of older adults remain insufficiently active. Digital behavior change interventions (DBCI) have the potential to reach many older adults to promote physical activity and ...
journal_title：Experimental gerontology
pub_type： 杂志文章,meta分析
doi：10.1016/j.exger.2019.02.020
更新日期：2019-06-01 00:00:00
abstract：:Accumulation of myeloid-derived suppressor cells (MDSCs) in aged hosts contribute to the age-related increase of susceptibility to murine breast adenocarcinoma and co-stimulatory molecules expressed in MDSCs are essential for MDSCs-mediated immune suppression. However, the co-stimulatory molecules that exert a direct ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2014.12.001
更新日期：2015-01-01 00:00:00
abstract：:Age-related changes in cancer mortality risk are important for understanding the processes of disease and aging interaction. The extent to which these age changes differ by sex further contributes to this understanding but has not been well studied to date. We conducted a systematic examination of dynamics and heterog...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2012.06.009
更新日期：2012-09-01 00:00:00
abstract：:Coenzyme Q10 supplementation increases life-span of rats fed on a diet enriched with polyunsaturated fatty acids (Quiles, J.L., Ochoa, J.J., Huertas, J.R., Mataix, J., 2004b. Coenzyme Q supplementation protects from age-related DNA double-strand breaks and increased lifespan in rats fed on a PUFA-rich diet. Exp. Geron...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2005.07.003
更新日期：2005-08-01 00:00:00
abstract：:Aging is associated with increased cellular levels of lipid peroxides and reactive oxygen species. This increase in the radical species may affect membrane fluidity and consequently membrane functions. We attempted to determine whether age-related increases in lipid peroxide and reactive oxygen species levels affect t...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(01)00164-4
更新日期：2001-12-01 00:00:00
abstract：:The retrograde response (RR) is a compensatory mechanism by which mutant strains of yeast are able to cope with mitochondrial DNA (mtDNA) impairments by up-regulating the expression of the stress-responder nuclear genes and significantly increasing lifespan. Starting from the observation that both mtDNA variability an...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(00)00169-8
更新日期：2000-09-01 00:00:00
abstract：:Previous studies have indicated that genetic variations in the factors of insulin/insulin-like growth factor 1 (IGF-1) signaling pathway could influence human life-span by affecting IGF-1 levels. The promoter region of the IGF-1 gene is an obvious candidate and has not been studied clearly. To explore the potential ro...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2008.08.004
更新日期：2008-10-01 00:00:00
abstract：:We investigated the telomere lengths of individual cell types in lingual mucosa using an improved tissue quantitative fluorescence in situ hybridization (Q-FISH) method. Our tissue Q-FISH method compensates for partially cut nuclei in a tissue section by using the telomere:centromere ratio (TCR). We normalized our TCR...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2008.06.001
更新日期：2008-09-01 00:00:00
abstract：:Aging is associated with a decline in immune functions. Among them, T-cell activation is altered at several points of the signaling cascade following TCR engagement. Recent findings suggest that lipid rafts act as a platform in the initiation of T-cell activation. We have previously demonstrated that cholesterol conte...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2003.10.031
更新日期：2004-04-01 00:00:00
abstract：:The ascorbic acid content of Drosophila melanogaster was found to be high in the absence of a dietary source. The amount of ascorbic acid per fly declined with aging in both the Oregon R and Swedish C strains. The median life span at 25 degrees C was 45 days for Swedish C and 59 days for Oregon R. The amount of ascorb...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(91)90037-m
更新日期：1991-01-01 00:00:00
abstract：BACKGROUND:Epidemiological and objective studies report an association between sedentary time and lower risk of the metabolic syndrome (MetS) and its risk factors in young and middle-age adults. To date, there is a lack of objective data on the association between sedentary time and MetS among older adults. METHODS:Th...
journal_title：Experimental gerontology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.exger.2015.06.018
更新日期：2015-10-01 00:00:00
abstract：OBJECTIVE:Mitochondria produce cellular energy via oxidative phosphorylation (OXPHOS), mediated by respiratory chain complexes I to IV and ATP synthase (complex V). Mitochondrial respiratory complexes have been shown to decline with age in several tissues. As the intestinal epithelium is a tissue with a high energy dem...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2020.110924
更新日期：2020-07-01 00:00:00
abstract：INTRODUCTION:Chronically elevated circulating inflammatory markers are common in older persons but mechanisms are unclear. Many blood transcripts (>800 genes) are associated with interleukin-6 protein levels (IL6) independent of age. We aimed to identify gene transcripts statistically mediating, as drivers or responder...
journal_title：Experimental gerontology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.exger.2015.05.012
更新日期：2015-10-01 00:00:00
abstract：:Intrinsic exercise capacity is predictive of both lifespan and healthspan but whether adaptive exercise capacity influences the benefits achieved from aerobic training implemented later in life is not known. AIM:To determine if exercise late in life provides any functional improvements or underlying beneficial bioche...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2019.110657
更新日期：2019-10-01 00:00:00
abstract：:Diabetes mellitus (DM) is considered a risk factor for the development of Alzheimer disease (AD); however, how DM favors evolution of AD is still insufficiently understood. Hyperglycemia in DM is associated to an increase in mitochondrial reactive oxygen species (ROS) generation, as well as damage of hippocampal cells...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2014.08.008
更新日期：2014-10-01 00:00:00
abstract：:Lipid hydroperoxides are formed in vivo through free radical pathways from the action of reactive oxygen species on polyunsaturated fatty acids. They are also formed as specific products of lipoxygenases and cyclooxygenases. Homolytic decomposition of lipid hydroperoxides to the alpha,beta-unsaturated aldehyde genotox...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(01)00133-4
更新日期：2001-09-01 00:00:00
abstract：:Aging is known to be associated with a decrease of learning and memory. Little is known on the specificity of this process. In Drosophila, two forms of consolidated memory have been observed. Anesthesia-resistant memory (ARM) is formed after one or several consecutive training sessions whereas long-term memory (LTM) i...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2006.06.004
更新日期：2007-01-01 00:00:00
