Relationship between age-related increases in rat liver lipid peroxidation and bile canalicular plasma membrane fluidity.

abstract：:Mitochondrial DNA 5178 adenine/cytosine (mt5178 A/C) polymorphism is one of the longevity-associated mitochondrial DNA polymorphisms. The frequency of the mt5178A genotype is significantly higher in Japanese centenarians than in the general population. We previously reported that serum high-density lipoprotein cholest...

journal_title：Experimental gerontology

authors： Kokaze A,Ishikawa M,Matsunaga N,Yoshida M,Sekine Y,Sekiguchi K,Satoh M,Harada M,Teruya K,Takeda N,Uchida Y,Tsunoda T,Takashima Y

更新日期：2003-10-01 00:00:00

abstract：:To counteract the debilitating progression of sarcopenia, a protein supplement should provide an energetically efficient anabolic stimulus. We quantified net muscle protein synthesis in healthy elderly individuals (65-79 yrs) following ingestion of an isocaloric intact whey protein supplement (WY; n=8) or an essential...

journal_title：Experimental gerontology

authors： Paddon-Jones D,Sheffield-Moore M,Katsanos CS,Zhang XJ,Wolfe RR

更新日期：2006-02-01 00:00:00

abstract：:Indigenous DNA adducts (I-compounds) are considered to be a biomarker of aging tissues. Thus far, few studies have been conducted to investigate the accumulation patterns of I-compounds in the brain during aging. Particularly, identities of age-dependent I-compounds have largely remained unknown. In the current study,...

journal_title：Experimental gerontology

authors： Cai Q,Tian L,Wei H

更新日期：1996-05-01 00:00:00

abstract：:Aging associates with a decline of physiological functions, including the function of the nervous and the immune system. These aged-related changes occur in various degrees in different members of a mouse outbred population. Accordingly, we have proposed a model of premature immunosenescence in mice, based on the demo...

journal_title：Experimental gerontology

authors： Guayerbas N,Puerto M,Víctor VM,Miquel J,De la Fuente M

更新日期：2002-01-01 00:00:00

abstract：:Arterial stiffness, an independent predictor of cardiovascular disease, is increased in aging, but the underlying mechanisms are not completely understood. Mineralocorticoid receptors (MR) may contribute to oxidative stress and arterial stiffness in healthy older adults. To test the hypothesis that short-term MR block...

journal_title：Experimental gerontology

authors： Hwang MH,Yoo JK,Luttrell M,Kim HK,Meade TH,English M,Nichols WW,Christou DD

更新日期：2013-08-01 00:00:00

abstract：:This study aimed to analyze the effects of resistance training associated with testosterone administration in the neuromuscular junction (NMJ) postsynaptic region of different skeletal muscle types of aged rats. Wistar rats were divided into: SEI - 20-months-old control, SEF - 24-months-old control, T - 20-months-old ...

journal_title：Experimental gerontology

authors： Krause Neto W,de Assis Silva W,Ciena AP,Anaruma CA,Gama EF

更新日期：2017-11-01 00:00:00

abstract：:Aging is one of the most basic properties of living organisms. Abundant evidence supports the idea that cell senescence underlies organismal aging in higher mammals. Therefore, examining the molecular mechanisms that control cell and replicative senescence is of great interest for biology and medicine. Several discove...

journal_title：Experimental gerontology

authors： Vidacek NS,Cukusić A,Ivanković M,Fulgosi H,Huzak M,Smith JR,Rubelj I

更新日期：2010-03-01 00:00:00

abstract：:Since the reproducible production of microscope objectives was enabled by the lens calculations of Ernst Abbe in 1872, various attempts have been made to further increase the resolution of light microscopes. Apart from the improvements on the optical side, especially the introduction of fluorescence methods, the use o...

journal_title：Experimental gerontology

authors： Malkusch W,Bauch H,Schäfer L

更新日期：2001-07-01 00:00:00

abstract：:The maximal lifespan (MLS) of mammals is inversely correlated with the peroxidation index, a measure of the proportion and level of unsaturation of polyunsaturated fatty acids (PUFA) in membranes. This relationship is likely related to the fact that PUFA are highly susceptible to damage by peroxidation. Previous compa...

journal_title：Experimental gerontology

authors： Cortie CH,Hulbert AJ,Hancock SE,Mitchell TW,McAndrew D,Else PL

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Self-report questionnaires are widely used to assess physical function in older adults. However, they often lack a clear frame of reference and hence interpreting and rating task difficulty levels can be problematic for the responder. Consequently, the usefulness of traditional self-report questionnaires for...

journal_title：Experimental gerontology

authors： Balachandran A,N Verduin C,Potiaumpai M,Ni M,Signorile JF

更新日期：2016-08-01 00:00:00

abstract：:Orally-administered catechin has long been known to have several beneficial effects on the mammalian host, however, the effects of orally supplemented catechin on the host through gingival tissues have not yet been established. Here, we elucidated the effects of orally supplemented catechin in the rat heart blood mito...

journal_title：Experimental gerontology

authors： Cueno ME,Tamura M,Imai K,Ochiai K

更新日期：2013-11-01 00:00:00

abstract：:Ageing is a complex process that in muscle in usually associated with a decrease in mass, strength, and velocity of contraction. One of the most striking effects of ageing on muscle is known as sarcopenia, a process that is the result of many cellular changes, such as a reduction in the number of motor units coupled w...

journal_title：Experimental gerontology

authors： Fulle S,Protasi F,Di Tano G,Pietrangelo T,Beltramin A,Boncompagni S,Vecchiet L,Fanò G

更新日期：2004-01-01 00:00:00

abstract：:Dystrophin-deficiency causes cardiomyopathies and shortens the life expectancy of Duchenne and Becker muscular dystrophy patients. Restoring Dystrophin expression in the heart by gene transfer is a promising avenue to explore as a therapy. Truncated Dystrophin gene constructs have been engineered and shown to alleviat...

journal_title：Experimental gerontology

authors： Taghli-Lamallem O,Jagla K,Chamberlain JS,Bodmer R

更新日期：2014-01-01 00:00:00

abstract：:Despite well-documented evidence for lifespan extension by methionine restriction (MR), underlying mechanisms remain unknown. As methionine can alter S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH), the substrate and product of DNA methyltransferase-1 (DNMT1), we hypothesized that MR diet alters DNA methyl...

journal_title：Experimental gerontology

authors： Mattocks DA,Mentch SJ,Shneyder J,Ables GP,Sun D,Richie JP Jr,Locasale JW,Nichenametla SN

更新日期：2017-02-01 00:00:00

abstract：:It has been suggested that alterations in Na(+),K(+)-ATPase mediate the development of several aging-related pathologies, such as hypertension and diabetes. Thus, we evaluated Na(+),K(+)-ATPase function and H(2)O(2) production in the renal cortex and medulla of Wistar Kyoto (WKY) rats at 13, 52 and 91 weeks of age. Cr...

journal_title：Experimental gerontology

authors： Silva E,Pinto V,Simão S,Serrão MP,Afonso J,Amaral J,Pinho MJ,Gomes P,Soares-da-Silva P

更新日期：2010-12-01 00:00:00

abstract：:Neural correlates of placebo analgesia (PA) in patients with neurocognitive disorders have not yet been elucidated. The present study aimed to evaluate how and to what extent executive (dys)functions of the medial prefrontal cortex (MPFC) may be related to PA. To this end, twenty-three subjects complaining of differen...

journal_title：Experimental gerontology

authors： Palermo S,Rainero I,Stanziano M,Vase L,D'Agata F,Rubino E,Fonio P,Sardanelli F,Amanzio M

更新日期：2019-04-01 00:00:00

abstract：:Accumulation of CD28(-)CD8 T cells that are defective in response to antigenic stimulation is a hallmark of age-associated decline in T cell function. However, the underlying mechanism of this age-associated change is not fully understood. We recently analyzed the global gene expression profiles of CD8 T cell subsets ...

journal_title：Experimental gerontology

authors： Godlove J,Chiu WK,Weng NP

更新日期：2007-05-01 00:00:00

abstract：:The visual appearance of humans derives predominantly from their skin and hair color. The phylogenetically ancient biochemical [corrected] pathway underling this phenomenon is called melanogenesis and results in the production of melanin pigments in neural crest-derived melanocytes, followed by its transfer to epithel...

journal_title：Experimental gerontology

authors： Tobin DJ,Paus R

更新日期：2001-01-01 00:00:00

abstract：:Estrogen replacement therapy (ERT) seems to enhance longevity in women. Both gender and aging have been shown to influence the regulation of circadian rhythms, yet little is known about the effect of ERT on circadian regulation. The aim of this study was to determine the effects of ERT (oral conjugated estrogen: Prema...

journal_title：Experimental gerontology

authors： Gudmundsson A,Goodman B,Lent S,Barczi S,Grace A,Boyle L,Ershler WB,Carnes M

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:Epidemiological and objective studies report an association between sedentary time and lower risk of the metabolic syndrome (MetS) and its risk factors in young and middle-age adults. To date, there is a lack of objective data on the association between sedentary time and MetS among older adults. METHODS:Th...

journal_title：Experimental gerontology

authors： Mankowski RT,Aubertin-Leheudre M,Beavers DP,Botoseneanu A,Buford TW,Church T,Glynn NW,King AC,Liu C,Manini TM,Marsh AP,McDermott M,Nocera JR,Pahor M,Strotmeyer ES,Anton SD,LIFE Research Group.

更新日期：2015-10-01 00:00:00

abstract：BACKGROUNDS:Elucidating the causal effects of common intermediate risk factors on the onset of age-related diseases is indispensable for developing prevention and intervention procedures. METHODS:We conducted two-stage time-to-event Mendelian randomization meta-analyses combining five large-scale longitudinal cohorts ...

journal_title：Experimental gerontology

authors： He L,Culminskaya I,Loika Y,Arbeev KG,Bagley O,Duan M,Yashin AI,Kulminski AM

更新日期：2018-07-01 00:00:00

abstract：:Initial velocity of GABA uptake in hypothalamic synaptosomes has been measured in aged animals as a function of both sodium and GABA concentration and compared to previous studies in young animals. The data give good fit to the model found previously to give minimal best fit to control data. Thus it appears that aging...

journal_title：Experimental gerontology

authors： Wheeler DD

更新日期：1983-01-01 00:00:00

abstract：:In this study we report the identification of FAH domain containing protein 1 (FAHD1), a recently described member of the fumarylacetoacetate hydrolase (FAH) superfamily of metabolic enzymes, as a novel player in the regulation of cellular senescence. FAHD1 was found in a proteomic screen searching for mitochondrial p...

journal_title：Experimental gerontology

authors： Petit M,Koziel R,Etemad S,Pircher H,Jansen-Dürr P

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Oxidative stress and inflammation may contribute to anabolic resistance in response to protein and exercise in older adults. We investigated whether consumption of montmorency cherry concentrate (MCC) increased anabolic sensitivity to protein ingestion and resistance exercise in healthy older men. METHODS:S...

journal_title：Experimental gerontology

authors： Jackman SR,Brook MS,Pulsford RM,Cockcroft EJ,Campbell MI,Rankin D,Atherton P,Smith K,Bowtell JL

更新日期：2018-09-01 00:00:00

abstract：:Reactive oxygen species (ROS) are formed in all living organisms as a by-product of normal metabolism (endogenous sources) and as a consequence of exposure to environmental compounds (exogenous sources). Endogenous ROS are largely formed during oxidative phosphorylation in the mitochondria and, therefore, mitochondria...

journal_title：Experimental gerontology

authors： Stevnsner T,Thorslund T,de Souza-Pinto NC,Bohr VA

更新日期：2002-10-01 00:00:00

abstract：:Accumulating evidence from diverse experiments, including heterochronic parabiosis-the surgical joining of two animals of different ages-has highlighted the importance of systemic factors in the progressive functional decline of various organs and tissues during aging. The major metabolic pathway of tryptophan, an ess...

journal_title：Experimental gerontology

authors： Kim BJ,Lee SH,Koh JM

更新日期：2020-02-01 00:00:00

abstract：PURPOSE:The elderly lose skeletal muscle mass with age, which may be detrimental for function and quality of life. Both inactivity and heavy resistance exercise are known to have marked but opposite effects upon muscle mass. However, the potential effects of daily physical activity upon muscle protein synthesis (MPS) a...

journal_title：Experimental gerontology

authors： Bülow J,Agergaard J,Kjaer M,Holm L,Reitelseder S

更新日期：2016-06-15 00:00:00

abstract：:The aim of this study was to compare the functional and structural changes in similarly identified neurons of the small parietal ganglion in 56 molluscs (Lymnaea stagnalis) of two age groups: adult (10-12 months) and old (20-22 months). No age changes were found in the values of membrane potential, resistance of the n...

journal_title：Experimental gerontology

authors： Frolkis VV,Kvitnitskaya-Ryzhova TYu,Martynenko OA

更新日期：1995-09-01 00:00:00

abstract：:Aging is a physiological process characterized by an age-progressive decline in intrinsic physiological functions, with an increased risk of developing chronic metabolic conditions, such as insulin resistance and diabetes. Furthermore, from a physiopathological point of view, several authors describe an association be...

journal_title：Experimental gerontology

authors： Zoico E,Rizzatti V,Policastro G,Tebon M,Darra E,Rossi AP,Mazzali G,Fantin F,Zamboni M

更新日期：2019-07-01 00:00:00

abstract：:Senescent cells accumulate with age and contribute to pathologies associated to old age. The senescent program can be induced by pro-cancer stimuli or is developmentally controlled. In cells forced to senesce by expression of oncogenes or short telomeres, aberrant activation of the ERK/MAP kinase signaling pathway lea...

journal_title：Experimental gerontology

authors： Ferbeyre G

更新日期：2018-07-01 00:00:00