Abstract：
:Accumulating evidence from diverse experiments, including heterochronic parabiosis-the surgical joining of two animals of different ages-has highlighted the importance of systemic factors in the progressive functional decline of various organs and tissues during aging. The major metabolic pathway of tryptophan, an essential amino acid in humans, is the kynurenine pathway (KP) in which indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) catalyze the conversion of tryptophan into kynurenine. Importantly, circulating kynurenine produced by this enzymatic breakdown, as a primary driver of the aging process, has been linked to higher mortality in humans. This review discusses the potential roles of tryptophan derivatives as biomarkers for the risk of frailty in the elderly, based on human observational studies as well as the KP as a therapeutic target for age-related diseases.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Kim BJ,Lee SH,Koh JMdoi
10.1016/j.exger.2019.110793subject
Has Abstractpub_date
2020-02-01 00:00:00pages
110793eissn
0531-5565issn
1873-6815pii
S0531-5565(19)30570-4journal_volume
130pub_type
杂志文章,评审abstract：:Aberrant mineralization of soft connective tissues (ectopic calcification) may occur as a frequent age-related complication. Still, it remains unclear the role of mesenchymal cell donor's age and of replicative senescence on ectopic calcification. Therefore, the ability of cells to deposit in-vitro hydroxyapatite crys...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2015.10.009
更新日期：2015-12-01 00:00:00
abstract：:Lipid hydroperoxides are formed in vivo through free radical pathways from the action of reactive oxygen species on polyunsaturated fatty acids. They are also formed as specific products of lipoxygenases and cyclooxygenases. Homolytic decomposition of lipid hydroperoxides to the alpha,beta-unsaturated aldehyde genotox...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(01)00133-4
更新日期：2001-09-01 00:00:00
abstract：:Ageing is highly complex, involving multiple mechanisms at different levels. Nevertheless, recent evidence suggests that several of the most important mechanisms are linked via endogenous stress-induced DNA damage caused by reactive oxygen species (ROS). Understanding how such damage contributes to age-related changes...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(01)00111-5
更新日期：2001-07-01 00:00:00
abstract：:Delirium is an acute-onset syndrome that exacerbates patients' condition and significantly increases consequential morbidity and mortality. There is no comprehensive, cellular and tissue-level, pathophysiological theory. The melatonin hormone imbalance has been shown to be linked to circadian rhythms, sleep-wake cycle...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2015.09.007
更新日期：2015-12-01 00:00:00
abstract：:Centenarians are people who escaped from major common diseases, including cancer, and reached the extreme limits of human life-span. The analysis of demographic data indicates that cancer incidence and mortality show a levelling off around the age of 85-90 years, and suggests that oldest old people and centenarians ar...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(02)00137-7
更新日期：2002-10-01 00:00:00
abstract：:Permethrin is a synthetic pyrethroid extensively used as anti-woodworm agent and for indoor and outdoor pest control. The main route of human exposure is through fruit, vegetable and milk intake. Low dosage exposure to permethrin during neonatal brain development (from postnatal day 6 to postnatal day 21) leads to dop...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2019.06.002
更新日期：2019-09-01 00:00:00
abstract：:Understanding telomere biology is of utmost importance for aging and cancer research. An essential tool is the determination of telomere length, which traditionally is done by telomere restriction fragment analysis, a laborious and time consuming method. Therefore, large efforts have been made to establish alternative...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2005.09.013
更新日期：2006-02-01 00:00:00
abstract：:The purposes of this study were to examine the age-related differences in absolute and normalized torque-time parameters in five distinct groups across the adult lifespan, and the relationship between rapid strength and limb acceleration capacities across the lifespan. One-hundred and thirty-six healthy men were categ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2019.110819
更新日期：2020-03-01 00:00:00
abstract：:Changes associated with the age-related decline of physiological functions, and their relation with mortality rates, are thoroughly being investigated in the aging research field. We used the Mediterranean fruit fly Ceratitis capitata, largely studied by biodemographers, as a model for functional senescence studies. T...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2012.04.001
更新日期：2012-06-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:To explore the impact of diabetic peripheral neuropathy (DPN) on the recovery of older persons with diabetes mellitus (DM) after hip-fracture surgery. DESIGN, SETTING, PARTICIPANTS:Secondary data for this study came from a clinical trial on the effectiveness of a DM-specific care model for 176 ol...
journal_title：Experimental gerontology
pub_type： 临床试验,杂志文章
doi：10.1016/j.exger.2019.02.004
更新日期：2019-05-01 00:00:00
abstract：:The binding of advanced glycation endproducts (AGEs) to their receptors is known to cause changes in cell function during normal ageing and is implicated in the pathogenesis of cardiovascular disease. In this study, expression of the AGE-receptor 3 (AGE-R3) and the receptor for AGEs (RAGE) was compared on the mRNA and...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2003.12.006
更新日期：2004-03-01 00:00:00
abstract：:The importance of maintaining physical fitness by engaging in exercise in a life-long perspective as well as the avoidance of obesity has been emphasised in recent years by epidemiological studies on human populations as well as studies on laboratory rodents. In laboratory studies, voluntary running in wheels and forc...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(01)00145-0
更新日期：2001-11-01 00:00:00
abstract：:The field of toxicology adopted the threshold dose response in the early decades of the 20th century. The model was rapidly incorporated into governmental regulatory assessment procedures and became a central feature of chemical evaluation and assessment. The toxicological community never validated the capacity of thi...
journal_title：Experimental gerontology
pub_type： 历史文章,杂志文章
doi：10.1016/j.exger.2012.02.004
更新日期：2013-01-01 00:00:00
abstract：:Human diploid lung fibroblasts (IMR-90) were used to investigate the reported increase in beta-adrenergic-stimulated cyclic adenosine 3',5'-monophosphate (cAMP) levels in fibroblasts aged in culture. Under basal conditions cellular cAMP was 34.2 +/- 5.6 and 38.4 +/- 9.1 pmol/mg protein in early (PDL 22-24) and late (P...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(92)90056-6
更新日期：1992-01-01 00:00:00
abstract：:A mathematical model of cellular metabolism is used to relate the rates of cell division and waste production to the concentrations of oxygen and glucose in the medium in which a normal diploid cell culture is grown. The metabolic model in tandem with an earlier waste-content model based on the waste-product theory of...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(91)90073-u
更新日期：1991-01-01 00:00:00
abstract：:A summary of the Eleventh International Symposium on the Neurobiology and Neuroendocrinology of Aging that was held in July 29-August 3 in Bregenz, Austria, is presented. Sixteen of the speakers who presented at the conference submitted review papers covering the topic of their presentation as well as an overview of t...
journal_title：Experimental gerontology
pub_type： 社论
doi：10.1016/j.exger.2013.01.003
更新日期：2013-07-01 00:00:00
abstract：OBJECTIVES:To examine the individual association between BMI and level of serum uric acid (SUA) among the very elderly Chinese population. METHODS:A survey was conducted on 870 long-lived subjects (aged ≥90years). Subjects were divided into four groups according to quartile of BMI (<16.6, 16.6-18.9, 18.9-21.1, ≥21.1kg...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2012.05.008
更新日期：2012-08-01 00:00:00
abstract：:Light and electron microscope comparisons were made of parotid and submandibular glands from male Swiss-Webster white mice 3, 13, and 18 months old. The glands from the 13- and 18-month-old mice were less organized and the parenchyma was not as dense. Fibrous connective tissue, intracellular lipofuscin granules, and r...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(88)90007-1
更新日期：1988-01-01 00:00:00
abstract：:Mitochondrial DNA 5178 adenine/cytosine (mt5178 A/C) polymorphism is one of the longevity-associated mitochondrial DNA polymorphisms. The frequency of the mt5178A genotype is significantly higher in Japanese centenarians than in the general population. We previously reported that serum high-density lipoprotein cholest...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(03)00211-0
更新日期：2003-10-01 00:00:00
abstract：:We have recently reported that activated mouse spleen mononuclear cells (MNCs) efficiently lyse autologous erythrocytes in vitro (Saxena and Chandrasekhar, 2000). In the present study, we have investigated erythrocyte-depleting ability (EDA) of spleen MNCs from young and old mice. Time kinetics of survival of erythroc...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(00)00091-7
更新日期：2000-05-01 00:00:00
abstract：:An age-related increase of DNA damage/mutation has been previously reported in human lymphocytes. The high copy number and mutation rate make the mtDNA genome an ideal candidate for assessing damage and to act as a potential biomarker of ageing. In the present study, two assays were developed to evaluate the level of ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(01)00200-5
更新日期：2002-01-01 00:00:00
abstract：:Temporal discounting occurs when a greater delayed reward is forsaken for a smaller immediate reward, and has been associated with a number of financial and health care outcomes important for older adults. Using resting-state fMRI and seed regions of interest in the left and right fronto-insular (FI) cortices, we expl...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2013.10.003
更新日期：2013-12-01 00:00:00
abstract：:A decline in instrumental activities of daily living has been described as the earliest functional deficit in patients with neurodegenerative disease. It embraces specific competencies such as: "recalling the date and telephone calls, orienting to new places, remembering the location of objects at home, understanding ...
journal_title：Experimental gerontology
pub_type： 评论,杂志文章
doi：10.1016/j.exger.2016.08.008
更新日期：2016-10-01 00:00:00
abstract：:Apolipoprotein E knockout (apoE-KO) mice have been utilized for decades as a model of atherosclerosis. However, in addition to atherosclerosis, apoE-KO mice develop extensive cutaneous xanthomatosis, accelerated skin aging and frailty when fed a high fat diet. Granzyme B (GrB) is a pro-apoptotic serine protease that h...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2011.02.004
更新日期：2011-06-01 00:00:00
abstract：:At 11 and 30 degrees C there was no change in the amount or in the buoyant density of nuclear DNA of male Oregon R Drosophila melanogaster with aging. When normal flies were maintained at 11 degrees C (at which temperature they do not fly), mitochondrial DNA content declined gradually with aging and 39.4% of the origi...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(87)90048-9
更新日期：1987-01-01 00:00:00
abstract：:This study aimed to analyze the effects of resistance training associated with testosterone administration in the neuromuscular junction (NMJ) postsynaptic region of different skeletal muscle types of aged rats. Wistar rats were divided into: SEI - 20-months-old control, SEF - 24-months-old control, T - 20-months-old ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2017.08.018
更新日期：2017-11-01 00:00:00
abstract：:While influenza immunization significantly reduces the risk of pneumonia and associated deaths, vaccination of elderly only affords 30-50% protection against influenza disease. The purpose of this study was to: (1) evaluate the consistency of immune responses across multiple years in young and elderly; (2) determine t...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(01)00210-8
更新日期：2002-01-01 00:00:00
abstract：:Age-related sleep impairments are chronic and common, occurring even in the absence of diagnosable disorders. Additional loss of sleep occurs with clinical sleep disorders, many of which can be ameliorated. This literature, reviewed below, raises the question of the possible biological consequences of age-related, chr...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2004.06.023
更新日期：2004-11-01 00:00:00
abstract：:Reactive oxygen species (ROS) play important roles in cellular senescence and organismic aging. Furthermore, they have been implicated in some of the adverse effects of chronic stress due to elevated peripheral levels of catecholamines. Here, we applied three different techniques to individually compare the systemic a...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2007.08.003
更新日期：2007-11-01 00:00:00
abstract：:In muscles, sarcopenia, the loss of muscle mass, is the major cause of aging-related functional decline and frailty. Several factors are correlated with sarcopenia during aging, including contraction-related cellular injury, oxidative stress, endocrine changes and reduced regenerative potential. However the involvemen...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2005.12.004
更新日期：2006-03-01 00:00:00
