Abstract：
:To counteract the debilitating progression of sarcopenia, a protein supplement should provide an energetically efficient anabolic stimulus. We quantified net muscle protein synthesis in healthy elderly individuals (65-79 yrs) following ingestion of an isocaloric intact whey protein supplement (WY; n=8) or an essential amino acid supplement (EAA; n=7). Femoral arterio-venous blood samples and vastus lateralis muscle biopsy samples were obtained during a primed, constant infusion of L-[ring-2H5]phenylalanine. Net phenylalanine uptake and mixed muscle fractional synthetic rate (FSR) were calculated during the post-absorptive period and for 3.5 h following ingestion of 15 g EAA or 15 g whey. After accounting for the residual increase in the intracellular phenylalanine pool, net post-prandial phenylalanine uptake was 53.4+/-9.7 mg phe leg-1 (EAA) and 21.7+/-4.6 mg phe leg-1 (WY), (P<0.05). Postabsorptive FSR values were 0.056+/-0.004% h-1 (EAA) and 0.049+/-0.006% h-1 (WY), (P>0.05). Both supplements stimulated FSR (P<0.05), but the increase was greatest in the EAA group with values of 0.088+/-0.011% h-1 (EAA) and 0.066+/-0.004% h-1 (WY), (P<0.05). While both EAA and WY supplements stimulated muscle protein synthesis, EAAs may provide a more energetically efficient nutritional supplement for elderly individuals.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Paddon-Jones D,Sheffield-Moore M,Katsanos CS,Zhang XJ,Wolfe RRdoi
10.1016/j.exger.2005.10.006keywords:
subject
Has Abstractpub_date
2006-02-01 00:00:00pages
215-9issue
2eissn
0531-5565issn
1873-6815pii
S0531-5565(05)00254-8journal_volume
41pub_type
杂志文章abstract：:There are three general categories of causes of the cognitive decline associated with aging: disuse, disease, and aging per se. People tend to use certain skills or abilities less with age and, thus, those skills decline due to the disuse. Physical illnesses tend to increase with age, which will tend to compromise cog...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/0531-5565(94)00066-c
更新日期：1995-05-01 00:00:00
abstract：:Progressive neuronal deterioration accompanied by sensory functions decline is typically observed during aging. On the other hand, structural or functional alterations of specific sensory neurons extend lifespan in the nematode Caenorhabditis elegans. Hormesis is a phenomenon by which the body benefits from moderate s...
journal_title：Experimental gerontology
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journal_title：Experimental gerontology
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doi：10.1016/j.exger.2019.110799
更新日期：2020-03-01 00:00:00
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journal_title：Experimental gerontology
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
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journal_title：Experimental gerontology
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journal_title：Experimental gerontology
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更新日期：1995-11-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：1992-09-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
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更新日期：1995-03-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2008.11.007
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journal_title：Experimental gerontology
pub_type： 杂志文章
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更新日期：1983-01-01 00:00:00
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journal_title：Experimental gerontology
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doi：10.1016/j.exger.2020.110871
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journal_title：Experimental gerontology
pub_type： 杂志文章
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更新日期：1984-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2004.10.002
更新日期：2005-03-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2005.07.006
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doi：10.1016/0531-5565(90)90032-w
更新日期：1990-01-01 00:00:00
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journal_title：Experimental gerontology
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journal_title：Experimental gerontology
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2011.06.001
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pub_type： 杂志文章
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journal_title：Experimental gerontology
pub_type： 杂志文章
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2008.05.006
更新日期：2009-01-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
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journal_title：Experimental gerontology
pub_type： 杂志文章,meta分析
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更新日期：2019-06-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
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abstract：:The CG9940 gene, which encodes the NAD(+) synthase protein in Drosophila, is conserved in human, zebra fish, and mosquito. NAD(+) synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD(+)) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic a...
journal_title：Experimental gerontology
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