Recovery of slow skeletal muscle after injury in the senescent rat.

abstract：:We previously reported that lysophosphatidylcholine (LPC) is a mediator of endothelial dysfunction in the expression of adhesion molecules (AMs) during aging. This study aimed at investigating the effects of betaine on LPC-related expression of AMs and the molecular modulation of nuclear factor-κB (NF-κB) activation i...

journal_title：Experimental gerontology

authors： Lee EK,Jang EJ,Jung KJ,Kim DH,Yu BP,Chung HY

更新日期：2013-05-01 00:00:00

abstract：:Aging is the primary risk factor for functional decline; thus, understanding and preventing disability among older adults has emerged as an important public health challenge of the 21st century. The science of gerontology - or geroscience - has the practical purpose of "adding life to the years." The overall goal of g...

journal_title：Experimental gerontology

authors： Anton SD,Cruz-Almeida Y,Singh A,Alpert J,Bensadon B,Cabrera M,Clark DJ,Ebner NC,Esser KA,Fillingim RB,Goicolea SM,Han SM,Kallas H,Johnson A,Leeuwenburgh C,Liu AC,Manini TM,Marsiske M,Moore F,Qiu P,Mankowski RT,M

更新日期：2020-12-01 00:00:00

abstract：:Studies have suggested that older individuals are more fatigable than young adults when power loss, measured during single-joint contractions, is considered the fatigue index; however, age-related differences in fatigue considering power measurements during multi-joint movements (e.g., cycling) have not been fully elu...

journal_title：Experimental gerontology

authors： Krüger RL,Aboodarda SJ,Jaimes LM,Vaz MA,Samozino P,Millet GY

更新日期：2020-05-01 00:00:00

abstract：:The gangliosides in human diploid fibroblasts--TIG-1, TIG-7, and IMR-90--were analysed at different cell densities at early and late passages to clarify the relationship between age and cell density dependent changes of the gangliosides. In early passages, the ganglioside concentrations increased with increase in cell...

journal_title：Experimental gerontology

authors： Ohsawa T

更新日期：1989-01-01 00:00:00

abstract：:Neuroblastoma cells (N1E-115) were used as models of transient (T) and long-lasting (L) Ca++ channels. The whole cell version of the patch clamp technique was used to measure inward Ca++ currents, and the fluorescent indicator, Fura-2, was used to measure changes in intracellular Ca++. Cells were cultured and selected...

journal_title：Experimental gerontology

authors： Pang PK,Wang R,Wu LY,Karpinski E,Shan J,Benishin CG

更新日期：1990-01-01 00:00:00

abstract：:Ageing is highly complex, involving multiple mechanisms at different levels. Nevertheless, recent evidence suggests that several of the most important mechanisms are linked via endogenous stress-induced DNA damage caused by reactive oxygen species (ROS). Understanding how such damage contributes to age-related changes...

journal_title：Experimental gerontology

authors： von Zglinicki T,Bürkle A,Kirkwood TB

更新日期：2001-07-01 00:00:00

abstract：:A crucial assumption of evolutionary theories of aging is that age-specific differences of life history traits may have genetic causes. The present study focuses on the existence of such differences between eight freshly caught populations of Drosophila melanogaster. A highly significant differentiation of the populat...

journal_title：Experimental gerontology

authors： Draye X,Lints FA

更新日期：1996-11-01 00:00:00

abstract：OBJECTIVE:To assess the 24-h endogenous secretory growth hormone (GH) profile and serum insulin-like growth factor-I (IGF-I) response to exogenous recombinant human growth hormone (rhGH) in a patient with Werner's syndrome. DESIGN:Blood sampling every 20 min for 24 h followed by three daily injections of growth hormon...

journal_title：Experimental gerontology

authors： Rubin CD,Reed B

更新日期：1996-09-01 00:00:00

abstract：:The aim of this study was to compare the functional and structural changes in similarly identified neurons of the small parietal ganglion in 56 molluscs (Lymnaea stagnalis) of two age groups: adult (10-12 months) and old (20-22 months). No age changes were found in the values of membrane potential, resistance of the n...

journal_title：Experimental gerontology

authors： Frolkis VV,Kvitnitskaya-Ryzhova TYu,Martynenko OA

更新日期：1995-09-01 00:00:00

abstract：INTRODUCTION:Aging leads to poorer neuromuscular control that may impact mobility. However, the specific decades when these changes occur, and whether these time-based changes are sex-specific, are unclear. METHODS:Adults aged 20-82 years (N = 93, 51 females) walked six gait trials at their preferred speed over a 10-m...

journal_title：Experimental gerontology

authors： Bailey CA,Corona F,Pilloni G,Porta M,Fastame MC,Hitchcott PK,Penna MP,Pau M,Côté JN

更新日期：2018-09-01 00:00:00

abstract：:Women who seek medical care around the time of menopause frequently report changes in one or more aspects of psychological functioning. The etiology of these symptoms is likely multifactorial and, undoubtedly, individual and sociocultural factors are important determinants. The known psychotropic properties of the sex...

journal_title：Experimental gerontology

authors： Sherwin BB

更新日期：1994-05-01 00:00:00

abstract：:Age-related changes of immune functions have been extensively investigated in both humans and animal models; nevertheless, the literature on potential alterations of dendritic cells, potent antigen presenting cells responsible for initiating immune responses, with aging is very scarce. We studied the immuno-phenotype ...

journal_title：Experimental gerontology

authors： Pietschmann P,Hahn P,Kudlacek S,Thomas R,Peterlik M

更新日期：2000-03-01 00:00:00

abstract：:The effect of age on brain muscarinic receptor density is unclear. Some in vivo neuroimaging studies have reported a large age-related reduction in muscarinic receptor density; however, others have reported increases or no change. The variability in these results most likely arises because of the heterogeneity of the ...

journal_title：Experimental gerontology

authors： Norbury R,Travis MJ,Erlandsson K,Waddington W,Owens J,Pimlott S,Ell PJ,Murphy DG

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Oxidative stress and inflammation may contribute to anabolic resistance in response to protein and exercise in older adults. We investigated whether consumption of montmorency cherry concentrate (MCC) increased anabolic sensitivity to protein ingestion and resistance exercise in healthy older men. METHODS:S...

journal_title：Experimental gerontology

authors： Jackman SR,Brook MS,Pulsford RM,Cockcroft EJ,Campbell MI,Rankin D,Atherton P,Smith K,Bowtell JL

更新日期：2018-09-01 00:00:00

abstract：:Although galanin has been shown to increase GLUT4 expression in the cardiac muscle of rats, there is no literature available about the effect of GalR1 on GLUT4 expression in the cardiac muscle of type 2 diabetic rats. The aim of this study was to determine whether intracerebroventricular injection of GalR1 agonist M61...

journal_title：Experimental gerontology

authors： Fang P,Shi M,Zhu Y,Zhang Z,Bo P

更新日期：2015-05-01 00:00:00

abstract：:The APOE epsilon4 allele has been associated with a number of neurodegenerative disorders e.g. Alzheimer's disease. Inconsistent results have been obtained for cognitive decline in 'normal' aging. We investigated whether specific aspects of cognitive decline were associated with APOE epsilon4 among 620 'healthy' elder...

journal_title：Experimental gerontology

authors： De Blasi S,Montesanto A,Martino C,Dato S,De Rango F,Bruni AC,Mari V,Feraco E,Passarino G

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:Self-report questionnaires are widely used to assess physical function in older adults. However, they often lack a clear frame of reference and hence interpreting and rating task difficulty levels can be problematic for the responder. Consequently, the usefulness of traditional self-report questionnaires for...

journal_title：Experimental gerontology

authors： Balachandran A,N Verduin C,Potiaumpai M,Ni M,Signorile JF

更新日期：2016-08-01 00:00:00

abstract：:Mitochondrial superoxide production is an important source of reactive oxygen species in cells, and may cause or contribute to ageing and the diseases of ageing. Seven major sites of superoxide production in mammalian mitochondria are known and widely accepted. In descending order of maximum capacity they are the ubiq...

journal_title：Experimental gerontology

authors： Brand MD

更新日期：2010-08-01 00:00:00

abstract：:The achievement that cytokines and all the related "transducing machinery" are expressed within the central nervous system and play a consistent role in the modulation of neurological functions and dysfunctions, has allowed a novel interpretation of brain behaviour. In this view, neuroinflammation and cytokines produc...

journal_title：Experimental gerontology

authors： Viviani B,Boraso M

更新日期：2011-02-01 00:00:00

abstract：:The interrelationship between muscle strength, motor unit (MU) number, and age is poorly understood, and in this study we sought to determine whether age-related differences in muscle strength are moderated by estimates of functioning MU number and size. Eighteen older adults (OA; 67 ± 1.20 years) and 24 young adults ...

journal_title：Experimental gerontology

authors： Kaya RD,Nakazawa M,Hoffman RL,Clark BC

更新日期：2013-09-01 00:00:00

abstract：:Indigenous DNA adducts (I-compounds) are considered to be a biomarker of aging tissues. Thus far, few studies have been conducted to investigate the accumulation patterns of I-compounds in the brain during aging. Particularly, identities of age-dependent I-compounds have largely remained unknown. In the current study,...

journal_title：Experimental gerontology

authors： Cai Q,Tian L,Wei H

更新日期：1996-05-01 00:00:00

abstract：:Stem cells are located throughout the adult body of higher organisms, supporting a continuous renewal and repair of tissues. Unique abilities of stem cells are self-renewal and multipotential differentiation. It is, therefore, of critical importance for an organism to maintain and control quantity and quality of stem ...

journal_title：Experimental gerontology

authors： Fehrer C,Lepperdinger G

更新日期：2005-12-01 00:00:00

abstract：:DNA methylation patterns change as individuals grow older, and DNA methylation appears susceptible to modification by the diet. Thus DNA methylation may be a mechanism through which diet can affect aging and longevity. We propose that effects on DNA methylation also contribute to the extension in lifespan observed in ...

journal_title：Experimental gerontology

authors： Ford D

更新日期：2013-07-01 00:00:00

abstract：:Mitochondrial DNA 5178 adenine/cytosine (mt5178 A/C) polymorphism is one of the longevity-associated mitochondrial DNA polymorphisms. The frequency of the mt5178A genotype is significantly higher in Japanese centenarians than in the general population. We previously reported that serum high-density lipoprotein cholest...

journal_title：Experimental gerontology

authors： Kokaze A,Ishikawa M,Matsunaga N,Yoshida M,Sekine Y,Sekiguchi K,Satoh M,Harada M,Teruya K,Takeda N,Uchida Y,Tsunoda T,Takashima Y

更新日期：2003-10-01 00:00:00

abstract：:Over the last 40 years it has become clear that telomeres, the end of the chromosomes, and the enzyme telomerase reverse transcriptase (TERT), which is required to counteract their shortening, play a pivotal role in senescence and aging. However, over the last years several studies demonstrated that TERT belongs to th...

journal_title：Experimental gerontology

authors： Ale-Agha N,Dyballa-Rukes N,Jakob S,Altschmied J,Haendeler J

更新日期：2014-08-01 00:00:00

abstract：:The immune response declines with age. This decline correlates with thymic involution and involves primarily a loss in T-cell function, whereas humoral immunity is more variably affected. In the current experiments we have measured immunoglobulin synthesis in vitro after mitogen stimulation, and specific antibody resp...

journal_title：Experimental gerontology

authors： Ershler WB,Robbins DL,Moore AL,Hebert JC

更新日期：1986-01-01 00:00:00

abstract：:Male life history and resource allocation is not frequently studied in aging and life span research. Here, we verify that males of long-lived fruit-feeding butterfly species have reduced longevity on restricted diets [Beck, J., 2007. The importance of amino acids in the adult diet of male tropical rainforest butterfli...

journal_title：Experimental gerontology

authors： Molleman F,Ding J,Boggs CL,Carey JR,Arlet ME

更新日期：2009-09-01 00:00:00

abstract：:Increased lifespan can be associated with greater resistance to many different stressors, most notably thermal stress. Such hormetic effects have also been found in C. elegans where short-term exposure to heat lengthens the lifespan. Genetic investigations have been carried out using mutation perturbations in a single...

journal_title：Experimental gerontology

authors： Rodriguez M,Snoek LB,Riksen JA,Bevers RP,Kammenga JE

更新日期：2012-08-01 00:00:00

abstract：:Estrogen replacement therapy (ERT) seems to enhance longevity in women. Both gender and aging have been shown to influence the regulation of circadian rhythms, yet little is known about the effect of ERT on circadian regulation. The aim of this study was to determine the effects of ERT (oral conjugated estrogen: Prema...

journal_title：Experimental gerontology

authors： Gudmundsson A,Goodman B,Lent S,Barczi S,Grace A,Boyle L,Ershler WB,Carnes M

更新日期：1999-09-01 00:00:00

abstract：:Telomere length is considered as a biological marker for aging. It is expected that telomeres shorten with age and with conditions associated with oxidative stress and inflammation. Both are present in patients with chronic kidney disease (CKD) who have a very high cardiovascular risk. We investigated whether CKD dura...

journal_title：Experimental gerontology

authors： Raschenberger J,Kollerits B,Titze S,Köttgen A,Bärthlein B,Ekici AB,Forer L,Schönherr S,Weissensteiner H,Haun M,Wanner C,Eckardt KU,Kronenberg F,GCKD study Investigators.

更新日期：2015-12-01 00:00:00