Abstract:
:Telomere length is considered as a biological marker for aging. It is expected that telomeres shorten with age and with conditions associated with oxidative stress and inflammation. Both are present in patients with chronic kidney disease (CKD) who have a very high cardiovascular risk. We investigated whether CKD duration is associated with relative telomere length (RTL) in 4802 patients from the German Chronic Kidney Disease (GCKD) study. We measured RTL in each sample in quadruplicates using a quantitative polymerase chain reaction (qPCR). We observed a U-shaped association of RTL with CKD duration: the longest RTL was found in those 339 patients who reported the shortest disease duration (<6 months) and shorter RTL in 2108 patients with duration between 6 months and less than 5 years. Most importantly, those 2331 patients who reported a CKD duration of 5 years and more had significantly longer RTL compared to those with intermediate CKD duration (6 months to less than 5 years): mean 0.954, 95%CI 0.946-0.961 versus 0.937, 95%CI 0.929-0.944, p=0.002). Due to the cross-sectional nature of the study these surprising results have to be considered with caution and as hypothesis-generating. Whether the longer RTL in patients with long-lasting disease is caused by an activation of telomerase to counteract the shortening of RTL due to oxidative stress and inflammation or whether they are caused by a survival bias needs to be investigated in longitudinal studies. Our data are in support of a higher plasticity of shortening and elongations of RTL as until recently anticipated.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Raschenberger J,Kollerits B,Titze S,Köttgen A,Bärthlein B,Ekici AB,Forer L,Schönherr S,Weissensteiner H,Haun M,Wanner C,Eckardt KU,Kronenberg F,GCKD study Investigators.doi
10.1016/j.exger.2015.09.019subject
Has Abstractpub_date
2015-12-01 00:00:00pages
162-6eissn
0531-5565issn
1873-6815pii
S0531-5565(15)30061-9journal_volume
72pub_type
杂志文章abstract::Rodent animal models take at least 18months to develop aging phenotypes for researchers to investigate the mechanism of age-related metabolic complications. Senescence-accelerated mouse prone 8 (SAMP8) shortens the process of aging and may facilitate an alternative model for studying age-related insulin resistance. Th...
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pub_type: 杂志文章,多中心研究
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journal_title:Experimental gerontology
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journal_title:Experimental gerontology
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doi:10.1016/j.exger.2009.07.002
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pub_type: 杂志文章
doi:10.1016/j.exger.2015.04.002
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pub_type: 杂志文章,评审
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更新日期:1985-01-01 00:00:00
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doi:10.1016/s0531-5565(00)00157-1
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/0531-5565(95)02010-1
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doi:10.1016/0531-5565(90)90006-n
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journal_title:Experimental gerontology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.exger.2015.06.018
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journal_title:Experimental gerontology
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pub_type: 杂志文章,随机对照试验
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
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journal_title:Experimental gerontology
pub_type: 杂志文章,随机对照试验
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journal_title:Experimental gerontology
pub_type: 杂志文章,meta分析
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2003.09.018
更新日期:2004-01-01 00:00:00
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更新日期:1998-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
doi:10.1016/j.exger.2020.110937
更新日期:2020-07-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2018.05.005
更新日期:2018-09-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
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